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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pulmo-2500</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Кларитромицин: настоящее и будущее</article-title><trans-title-group xml:lang="en"><trans-title>Clarithromycin: the present and the future</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белов</surname><given-names>Б. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Belov</surname><given-names>B. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Институт ревматологии РАМН</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2004</year></pub-date><pub-date pub-type="epub"><day>17</day><month>08</month><year>2021</year></pub-date><volume>0</volume><issue>5</issue><fpage>118</fpage><lpage>126</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Белов Б.С., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Белов Б.С.</copyright-holder><copyright-holder xml:lang="en">Belov B.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/2500">https://journal.pulmonology.ru/pulm/article/view/2500</self-uri><abstract><p>.</p></abstract><kwd-group xml:lang="ru"><kwd>кларитромицин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>clarithromycin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kees F, Wellembofer М., Grobecker Н. Serum and cellular pharmacokinetics of clarithromycin 500 mg oid and 250 mg bid in volunteers. Infection 1995; 23: 168-172.</mixed-citation><mixed-citation xml:lang="en">Kees F, Wellembofer М., Grobecker Н. Serum and cellular pharmacokinetics of clarithromycin 500 mg oid and 250 mg bid in volunteers. Infection 1995; 23: 168-172.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Каманин Е.И., Егорова О.А. Острый средний отит у детей: клиническое значение и антибактериальная терапия. Клин. антимикроб. химиотер. 2000; 2 (2): 57-62.</mixed-citation><mixed-citation xml:lang="en">Каманин Е.И., Егорова О.А. Острый средний отит у детей: клиническое значение и антибактериальная терапия. Клин. антимикроб. химиотер. 2000; 2 (2): 57-62.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Choi Y.S., Choo MJ. Evaluation of the efficacy and safety of clarithromycin in the treatment of outpatients with acute maxillary sinusitis. In: The 3rd International conference on the macrolides, azalides and streptogramins. Lisbon; 1996. abstr. 13.05.</mixed-citation><mixed-citation xml:lang="en">Choi Y.S., Choo MJ. Evaluation of the efficacy and safety of clarithromycin in the treatment of outpatients with acute maxillary sinusitis. In: The 3rd International conference on the macrolides, azalides and streptogramins. Lisbon; 1996. abstr. 13.05.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Holm S.E. Reasons for failures in penicillin treatment of streptococcal tonsillitis and possible alternatives. Pediatr. Infect. Dis. J. 1994; 13 (suppl. 1): 66-70.</mixed-citation><mixed-citation xml:lang="en">Holm S.E. Reasons for failures in penicillin treatment of streptococcal tonsillitis and possible alternatives. Pediatr. Infect. Dis. J. 1994; 13 (suppl. 1): 66-70.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Brook I, Gober A.E. Role of bacterial interference and β-lacta-mase-producing bacteria in the failure of penicillin to eradicate Group A streptococcal pharyngotonsillitis. Arch. Otolaryngol. Head Neck Surg. 1995; 121 (12): 1405-1409.</mixed-citation><mixed-citation xml:lang="en">Brook I, Gober A.E. Role of bacterial interference and β-lacta-mase-producing bacteria in the failure of penicillin to eradicate Group A streptococcal pharyngotonsillitis. Arch. Otolaryngol. Head Neck Surg. 1995; 121 (12): 1405-1409.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kaplan E.L., Gooch W.M., Notario G.E. et al. Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). Clin. Infect. Dis. 2001; 32: 1798-1802.</mixed-citation><mixed-citation xml:lang="en">Kaplan E.L., Gooch W.M., Notario G.E. et al. Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). Clin. Infect. Dis. 2001; 32: 1798-1802.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Peters D.H, Clissold S.P. Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. Drugs 1993; 44 (1): 117-164.</mixed-citation><mixed-citation xml:lang="en">Peters D.H, Clissold S.P. Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. Drugs 1993; 44 (1): 117-164.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rico Mendez F.G., Sanchez J., Abate E. et al. Efficacy and safety of clarithromycin in the treatment of ambulatory patients with acute bacterial exacerbations of chronic bronchitis. In: 3rd International conference macrolides azalides streptogramins. Lisbon; 1996. abstr. 11.07.</mixed-citation><mixed-citation xml:lang="en">Rico Mendez F.G., Sanchez J., Abate E. et al. Efficacy and safety of clarithromycin in the treatment of ambulatory patients with acute bacterial exacerbations of chronic bronchitis. In: 3rd International conference macrolides azalides streptogramins. Lisbon; 1996. abstr. 11.07.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Adam D. Clarithromycin 250 mg b.i.d. for 5 of 10 days in the treatment of adult patients with purulent bronchitis. Infection 1993; 21 (4): 265-271.</mixed-citation><mixed-citation xml:lang="en">Adam D. Clarithromycin 250 mg b.i.d. for 5 of 10 days in the treatment of adult patients with purulent bronchitis. Infection 1993; 21 (4): 265-271.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Notario G, Reitmeyer R, Horn R. Clarithromycin 250 mg BID in the treatment of patients with acute exacerbation of chronic bronchitis with COPD. In: 3rd International conference macrolides, azalides streptogramins. Lisbon; 1996. abstr. 11.06.</mixed-citation><mixed-citation xml:lang="en">Notario G, Reitmeyer R, Horn R. Clarithromycin 250 mg BID in the treatment of patients with acute exacerbation of chronic bronchitis with COPD. In: 3rd International conference macrolides, azalides streptogramins. Lisbon; 1996. abstr. 11.06.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Spiritus E. Clarithromycin in the treatment of bacterial exacerbations of chronic bronchitis in smokers. Curr. Ther. Res. 1995; 56: 16-23.</mixed-citation><mixed-citation xml:lang="en">Spiritus E. Clarithromycin in the treatment of bacterial exacerbations of chronic bronchitis in smokers. Curr. Ther. Res. 1995; 56: 16-23.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ziering W., McElvaine P. Randomized comparison of once-daily ceftibuten and twice-daily clarithromycin in the treatment of acute exacerbation of chronic bronchitis. Infection 1998; 26 (1): 68-75.</mixed-citation><mixed-citation xml:lang="en">Ziering W., McElvaine P. Randomized comparison of once-daily ceftibuten and twice-daily clarithromycin in the treatment of acute exacerbation of chronic bronchitis. Infection 1998; 26 (1): 68-75.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Leophonte P., Chauvin J.P. Safety and efficacy of clarithromycin compared with cefpodoxim proxetil in the treatment of acute exacerbation of chronic obstructive pulmonary disease. In: 3rd International conference macrolides azalides streptogramins. Lisbon; 1996. abstr. 11.05.</mixed-citation><mixed-citation xml:lang="en">Leophonte P., Chauvin J.P. Safety and efficacy of clarithromycin compared with cefpodoxim proxetil in the treatment of acute exacerbation of chronic obstructive pulmonary disease. In: 3rd International conference macrolides azalides streptogramins. Lisbon; 1996. abstr. 11.05.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Anzueto A., Niederman M.S., Tillotson G.S. Etiology, susceptibility, and treatment of acute bacterial exacerbations of complicated chronic bronchitis in the primary care setting ciprofloxacin 750 mg b.i.d. versus clarithromycin 500 mg b.i.d. Bronchitis study Group. Clin. Ther. 1998; 20 (5): 885-900.</mixed-citation><mixed-citation xml:lang="en">Anzueto A., Niederman M.S., Tillotson G.S. Etiology, susceptibility, and treatment of acute bacterial exacerbations of complicated chronic bronchitis in the primary care setting ciprofloxacin 750 mg b.i.d. versus clarithromycin 500 mg b.i.d. Bronchitis study Group. Clin. Ther. 1998; 20 (5): 885-900.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lipsky B.A., Unowsky J., Zhang H. et al. Treating acute bacterial exacerbations of chronic bronchitis in patients unresponsive to previous therapy: sparfloxacin versus clarithromycin. Clin. Ther. 1999; 21 (6): 954-965.</mixed-citation><mixed-citation xml:lang="en">Lipsky B.A., Unowsky J., Zhang H. et al. Treating acute bacterial exacerbations of chronic bronchitis in patients unresponsive to previous therapy: sparfloxacin versus clarithromycin. Clin. Ther. 1999; 21 (6): 954-965.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson R., Kubin R., Ballin J. et al. Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis. J. Antimicrob. Chemother. 1999; 44 (4): 501-513.</mixed-citation><mixed-citation xml:lang="en">Wilson R., Kubin R., Ballin J. et al. Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis. J. Antimicrob. Chemother. 1999; 44 (4): 501-513.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffken G., Meyer H.P., Winter J. et al. The efficacy and safety of two oral moxifloxacin regimens to oral clarithromycin in the treatment of community-acquired pneumonia. Respir. Med. 2001; 95: 553-564.</mixed-citation><mixed-citation xml:lang="en">Hoffken G., Meyer H.P., Winter J. et al. The efficacy and safety of two oral moxifloxacin regimens to oral clarithromycin in the treatment of community-acquired pneumonia. Respir. Med. 2001; 95: 553-564.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Чучалин А.Г., Синопальников А.И., Яковлев С.В. и др. Внебольничная пневмония у взрослых: практические рекомендации по диагностике, лечению и профилактике. (Пособие для врачей). Клин. микробиол. антимикроб. химиотер. 2003; 5 (3): 198-224.</mixed-citation><mixed-citation xml:lang="en">Чучалин А.Г., Синопальников А.И., Яковлев С.В. и др. Внебольничная пневмония у взрослых: практические рекомендации по диагностике, лечению и профилактике. (Пособие для врачей). Клин. микробиол. антимикроб. химиотер. 2003; 5 (3): 198-224.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Labro М.Т. Antiinflammatory activity of macrolides: a new therapeutic potential? J. Antimicrob. Chemother. 1998; 41 (suppl. B): 37-46.</mixed-citation><mixed-citation xml:lang="en">Labro М.Т. Antiinflammatory activity of macrolides: a new therapeutic potential? J. Antimicrob. Chemother. 1998; 41 (suppl. B): 37-46.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Labro M.T. Macrolide antibiotics: current and future uses. Expert Opin Pharmacother. 2004; 5 (3): 541-550.</mixed-citation><mixed-citation xml:lang="en">Labro M.T. Macrolide antibiotics: current and future uses. Expert Opin Pharmacother. 2004; 5 (3): 541-550.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Basyigit I., Yildiz F., Ozkara S.K. et al. The effect of clarithromycin on inflammatory markers in chronic obstructive pulmonary disease: preliminary data. Ann. Pharmacother. 2004; 38 (9): 1400-1405.</mixed-citation><mixed-citation xml:lang="en">Basyigit I., Yildiz F., Ozkara S.K. et al. The effect of clarithromycin on inflammatory markers in chronic obstructive pulmonary disease: preliminary data. Ann. Pharmacother. 2004; 38 (9): 1400-1405.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Tagaya E., Tamaoki J., Kondo M. et al. Effect of a short course of clarithromycin therapy on sputum production in patients with chronic airway hypersecretion. Chest 2002; 122 (1): 213-218.</mixed-citation><mixed-citation xml:lang="en">Tagaya E., Tamaoki J., Kondo M. et al. Effect of a short course of clarithromycin therapy on sputum production in patients with chronic airway hypersecretion. Chest 2002; 122 (1): 213-218.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Garey K.W., Rubinstein I., Gotfried M.H. et al. Long-term clarithromycin decreases prednisone requirements in elderly patients with prednisone-dependent asthma. Chest 2000t 118 (6): 1826-1827.</mixed-citation><mixed-citation xml:lang="en">Garey K.W., Rubinstein I., Gotfried M.H. et al. Long-term clarithromycin decreases prednisone requirements in elderly patients with prednisone-dependent asthma. Chest 2000t 118 (6): 1826-1827.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kostadima E., Tsiodras S., Alexopoulos E.I. et al. Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma. Eur. Respir. J. 2004; 23 (5): 714-717.</mixed-citation><mixed-citation xml:lang="en">Kostadima E., Tsiodras S., Alexopoulos E.I. et al. Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma. Eur. Respir. J. 2004; 23 (5): 714-717.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Hatippglu J. Rubinstein I. Low-dose, long-term macroiide therapy in asthma: An overview. Clin. Mol. Allergy 2004; 2(1): 2-4.</mixed-citation><mixed-citation xml:lang="en">Hatippglu J. Rubinstein I. Low-dose, long-term macroiide therapy in asthma: An overview. Clin. Mol. Allergy 2004; 2(1): 2-4.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Saviola G. Abdi All L. Rossini P. et al. Clarithromycin in rheumatoid arthritis patients not responsive to disease-modifying antirheumatic drugs: an open, uncontrolled pilot study. Clin. Exp. Rheumatol. 2002; 20 (3): 373-378.</mixed-citation><mixed-citation xml:lang="en">Saviola G. Abdi All L. Rossini P. et al. Clarithromycin in rheumatoid arthritis patients not responsive to disease-modifying antirheumatic drugs: an open, uncontrolled pilot study. Clin. Exp. Rheumatol. 2002; 20 (3): 373-378.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Saviola G., Abdi Ali L., Shams Eddin S. et al. Clarithromycin in adult-onset Still's disease. Case report with a 1-year follow-up. Clin. Exp. Rheumatol. 2004; 22 (3): 379-379.</mixed-citation><mixed-citation xml:lang="en">Saviola G., Abdi Ali L., Shams Eddin S. et al. Clarithromycin in adult-onset Still's disease. Case report with a 1-year follow-up. Clin. Exp. Rheumatol. 2004; 22 (3): 379-379.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Сазыкин Ю.О., Крестьянова И.Н., Иванов В.П. Кларитромицин и химиотерапия опухолей Антибиотики и химиотер. 2000; 45 (11): 3-5.</mixed-citation><mixed-citation xml:lang="en">Сазыкин Ю.О., Крестьянова И.Н., Иванов В.П. Кларитромицин и химиотерапия опухолей Антибиотики и химиотер. 2000; 45 (11): 3-5.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Guay D.R.P., Patterson D.R., Seipman N. et al. Overview of the tolerability profile of clarithromycin in preclinical and clinical trials. Drug Safety 1993; 8 (5): 350-364.</mixed-citation><mixed-citation xml:lang="en">Guay D.R.P., Patterson D.R., Seipman N. et al. Overview of the tolerability profile of clarithromycin in preclinical and clinical trials. Drug Safety 1993; 8 (5): 350-364.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Craft J.C., Siepman N. Overview of the safety profile of clarithromycin suspension in pediatric patients. Pediatr. Infect. Dis. J. 1993; 12 (suppl.): 142-147.</mixed-citation><mixed-citation xml:lang="en">Craft J.C., Siepman N. Overview of the safety profile of clarithromycin suspension in pediatric patients. Pediatr. Infect. Dis. J. 1993; 12 (suppl.): 142-147.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Bensoa C.A., Williams P.L., Crohn D.L. et al. Clarithromycin or rifabutin alone or in combination for primary prophylaxis of Mycobacterium avium complex disease in patients with AIDS: a randomized double-blind placebo-controlled trial. J. Infect. Dis. 2000; 181: 1289-1297.</mixed-citation><mixed-citation xml:lang="en">Bensoa C.A., Williams P.L., Crohn D.L. et al. Clarithromycin or rifabutin alone or in combination for primary prophylaxis of Mycobacterium avium complex disease in patients with AIDS: a randomized double-blind placebo-controlled trial. J. Infect. Dis. 2000; 181: 1289-1297.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Pai M.P, Graci D.M., Amsden G.W. Macrolide drug interactions: an update. Ann. Pharmacother. 2000; 34: 495-513.</mixed-citation><mixed-citation xml:lang="en">Pai M.P, Graci D.M., Amsden G.W. Macrolide drug interactions: an update. Ann. Pharmacother. 2000; 34: 495-513.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Яковлев В.П. Новый макролидный антибиотик кларитромицин. Клин. антимикроб. химиотер. 1999; 2: 56-61.</mixed-citation><mixed-citation xml:lang="en">Яковлев В.П. Новый макролидный антибиотик кларитромицин. Клин. антимикроб. химиотер. 1999; 2: 56-61.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Zhanel G.G., Dueck М, Hoban D.J. et al. Review of macrolides and ketolides: focus an respiratory tract infections. Drugs 2001; 61 (4): 443-498.</mixed-citation><mixed-citation xml:lang="en">Zhanel G.G., Dueck М, Hoban D.J. et al. Review of macrolides and ketolides: focus an respiratory tract infections. Drugs 2001; 61 (4): 443-498.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Yang H.S., Kim Y.J., Kim C.G. Clinical efficacy of clarithromycin in the treatment of acute maxillary sinusitis. In: The 3rd International conference on the macrolides, azalides and strep-togramins. Lisbon; 1996. abstr. 13.06.</mixed-citation><mixed-citation xml:lang="en">Yang H.S., Kim Y.J., Kim C.G. Clinical efficacy of clarithromycin in the treatment of acute maxillary sinusitis. In: The 3rd International conference on the macrolides, azalides and strep-togramins. Lisbon; 1996. abstr. 13.06.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Marchi E. Comparative efficacy and tolerability of clarithromycin and amoxicillin in the treatment of outpatient with acute maxillary sinusitis. Curr. Med. Res. Opin.1990; 12: 19-24.</mixed-citation><mixed-citation xml:lang="en">Marchi E. Comparative efficacy and tolerability of clarithromycin and amoxicillin in the treatment of outpatient with acute maxillary sinusitis. Curr. Med. Res. Opin.1990; 12: 19-24.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Karma P, Pukander J, Penttila M. et al. The comparative efficacy and safety of clarithromycin and amoxicillin in the treatment of outpatients with acute maxillary sinusitis. J. Antimicrob. Chemother. 1991; 27 (suppl. A): 83-90.</mixed-citation><mixed-citation xml:lang="en">Karma P, Pukander J, Penttila M. et al. The comparative efficacy and safety of clarithromycin and amoxicillin in the treatment of outpatients with acute maxillary sinusitis. J. Antimicrob. Chemother. 1991; 27 (suppl. A): 83-90.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Calhoun K.H., Hokanson J.A. Multicenter comparison of clarithromycin and amoxicillin in the treatment of acute maxillary sinusitis. Arch. Fam. Med. 1993; 2 (8): 837-840.</mixed-citation><mixed-citation xml:lang="en">Calhoun K.H., Hokanson J.A. Multicenter comparison of clarithromycin and amoxicillin in the treatment of acute maxillary sinusitis. Arch. Fam. Med. 1993; 2 (8): 837-840.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Dubois J, Saint-Pierre C., Tremblay C. Efficacy of clarithromycin vs. amoxiciilln/clavulanate in the treatment of acute maxillary sinusitis. Ear Nose Throat J. 1993; 72 (12): 804-810.</mixed-citation><mixed-citation xml:lang="en">Dubois J, Saint-Pierre C., Tremblay C. Efficacy of clarithromycin vs. amoxiciilln/clavulanate in the treatment of acute maxillary sinusitis. Ear Nose Throat J. 1993; 72 (12): 804-810.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Gehanno P, Barry B, Chauvin J.P. et al. [Clarithromycin versus amoxicillin-clavulanic acid in the treatment of acute maxillary sinusitis in adults]. Pathol.Biol. (Paris) 1996; 44 (4): 293-297.</mixed-citation><mixed-citation xml:lang="en">Gehanno P, Barry B, Chauvin J.P. et al. [Clarithromycin versus amoxicillin-clavulanic acid in the treatment of acute maxillary sinusitis in adults]. Pathol.Biol. (Paris) 1996; 44 (4): 293-297.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Lasko B, Lau C.Y., Saint-Pierre C. et al. Efficacy and safety of oral levofloxacin compared with clarithromycin in the treatment of acute sinusitis in adults: a multicenter. double-blind, randomized study. The Canadian Sinusitis Study Group. J. Intern. Med. Res. 1998; 26 (6): 281-291.</mixed-citation><mixed-citation xml:lang="en">Lasko B, Lau C.Y., Saint-Pierre C. et al. Efficacy and safety of oral levofloxacin compared with clarithromycin in the treatment of acute sinusitis in adults: a multicenter. double-blind, randomized study. The Canadian Sinusitis Study Group. J. Intern. Med. Res. 1998; 26 (6): 281-291.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Stefansson P, Jacovides A., Jablonicky P. et al. Cefuroxime axetil versus clarithromycin in the treatment of acute maxillary sinusitis. Rhinology 1998; 36 (4): 173-178.</mixed-citation><mixed-citation xml:lang="en">Stefansson P, Jacovides A., Jablonicky P. et al. Cefuroxime axetil versus clarithromycin in the treatment of acute maxillary sinusitis. Rhinology 1998; 36 (4): 173-178.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Clifford K, Huck W, Shan M. et al. Double blind comparative trial of ciprofloxacin versus clarithromycin in the treatment of acute bacterial sinusitis. Sinusitis infection study group. Ann.Otol. Rhinol. Laryngol. 1999; 108 (4): 360-377.</mixed-citation><mixed-citation xml:lang="en">Clifford K, Huck W, Shan M. et al. Double blind comparative trial of ciprofloxacin versus clarithromycin in the treatment of acute bacterial sinusitis. Sinusitis infection study group. Ann.Otol. Rhinol. Laryngol. 1999; 108 (4): 360-377.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Henry D.C., Moller D.J.Jr, Adelglass J. et al. Comparison of sparfloxacin and clarithromycin in the treatment of acute bacterial maxillary sinusitis. Sparfloxacin Multicenter AMS Study Group. Clin. Ther. 1999; 21 (2): 340-352.</mixed-citation><mixed-citation xml:lang="en">Henry D.C., Moller D.J.Jr, Adelglass J. et al. Comparison of sparfloxacin and clarithromycin in the treatment of acute bacterial maxillary sinusitis. Sparfloxacin Multicenter AMS Study Group. Clin. Ther. 1999; 21 (2): 340-352.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Levenstein J.H. Clarithromycin versus penicillin V in the treatment of streptococcal pharyngitis. J. Antimicrob. Chemother'. 1991; 27 (suppl. A): 67-74.</mixed-citation><mixed-citation xml:lang="en">Levenstein J.H. Clarithromycin versus penicillin V in the treatment of streptococcal pharyngitis. J. Antimicrob. Chemother'. 1991; 27 (suppl. A): 67-74.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Bachand R.T.Jr. Comparative study of clarithromycin and ampicillin in the treatment of patients with acute bacterial exacerbations of chronic bronchitis. J. Antimicrob. Chemother. 1991; 27 (suppl. A): 91-100.</mixed-citation><mixed-citation xml:lang="en">Bachand R.T.Jr. Comparative study of clarithromycin and ampicillin in the treatment of patients with acute bacterial exacerbations of chronic bronchitis. J. Antimicrob. Chemother. 1991; 27 (suppl. A): 91-100.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Stein G.E., Christensen S., Mummaw N. Comparative study of clarithromycin and penicillin V in the treatment of streptococcal pharyngitis.. Eur. J. Clin. Microbiol. Infect. Dis. 1991; 10 (11): 949-953.</mixed-citation><mixed-citation xml:lang="en">Stein G.E., Christensen S., Mummaw N. Comparative study of clarithromycin and penicillin V in the treatment of streptococcal pharyngitis.. Eur. J. Clin. Microbiol. Infect. Dis. 1991; 10 (11): 949-953.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Still J.G., Hubbard W.C., Poole J.M. et al. Comparison of clarithromycin and penicillin VK suspensions in the treatment of children with streptococcal pharyngitis and review of currently available alternative antibiotic therapies. Pediatr. Infect. Dis. J. 1993; 12 (suppl. 3): 134-141.</mixed-citation><mixed-citation xml:lang="en">Still J.G., Hubbard W.C., Poole J.M. et al. Comparison of clarithromycin and penicillin VK suspensions in the treatment of children with streptococcal pharyngitis and review of currently available alternative antibiotic therapies. Pediatr. Infect. Dis. J. 1993; 12 (suppl. 3): 134-141.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Padilla N., Figueroa R., Munos M. Analysis of clarithromycin and propicillin in the management of streptococcal pharyngoton-sillitis in children. Clin. Drug Invect. 1999; 18 (3): 183-188.</mixed-citation><mixed-citation xml:lang="en">Padilla N., Figueroa R., Munos M. Analysis of clarithromycin and propicillin in the management of streptococcal pharyngoton-sillitis in children. Clin. Drug Invect. 1999; 18 (3): 183-188.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Kearsley N.L., Campbell A., Sanderson A.A. et al. Comparison of clarithromycin suspension and amoxicillin syrup for the treatment of children with pharyngitis and/or tonsillitis. Br. J. Gen. Pract. 1977; 51 (3): 133-137.</mixed-citation><mixed-citation xml:lang="en">Kearsley N.L., Campbell A., Sanderson A.A. et al. Comparison of clarithromycin suspension and amoxicillin syrup for the treatment of children with pharyngitis and/or tonsillitis. Br. J. Gen. Pract. 1977; 51 (3): 133-137.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Scaglione F. Comparison of the clinical and bacteriological efficacy of clarithromycin and erythromycin in the treatment of streptococcal pharyngitis. Curr. Med. Res. Opin. 1990; 12: 25-33.</mixed-citation><mixed-citation xml:lang="en">Scaglione F. Comparison of the clinical and bacteriological efficacy of clarithromycin and erythromycin in the treatment of streptococcal pharyngitis. Curr. Med. Res. Opin. 1990; 12: 25-33.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Padilla N. Diaz R., Munos M. et al. Streptococcal pharyngo-tonsillitis in children: management with clarithromycin, azithromycin and propicillin. In: 5th International conference macrolides azalides streptogramins. Seville; 2000. abstr. 6.15.</mixed-citation><mixed-citation xml:lang="en">Padilla N. Diaz R., Munos M. et al. Streptococcal pharyngo-tonsillitis in children: management with clarithromycin, azithromycin and propicillin. In: 5th International conference macrolides azalides streptogramins. Seville; 2000. abstr. 6.15.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Padilla N., Figueroa R., Del Rosario M. et al. Management of pediatric streptococcal pharyngotonsillitis: a comparative analysis of clarithromycin. In: 2nd European congress chemotherapy 7th Biennale conference antimicrobial agents chemotherapy. Hamburg; 1998. abstr. M.201.</mixed-citation><mixed-citation xml:lang="en">Padilla N., Figueroa R., Del Rosario M. et al. Management of pediatric streptococcal pharyngotonsillitis: a comparative analysis of clarithromycin. In: 2nd European congress chemotherapy 7th Biennale conference antimicrobial agents chemotherapy. Hamburg; 1998. abstr. M.201.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Craft J.C., Aynilian G., Cox S. Clarithromycin in the treatment of community-acquired pneumonia due to M. pneumoniae in adult and pediatric patients. In: 3rd International conference macrolides azalides streptogramins. Lisbon; 1996. abstr.2.15.</mixed-citation><mixed-citation xml:lang="en">Craft J.C., Aynilian G., Cox S. Clarithromycin in the treatment of community-acquired pneumonia due to M. pneumoniae in adult and pediatric patients. In: 3rd International conference macrolides azalides streptogramins. Lisbon; 1996. abstr.2.15.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Hatipoglu O.N., Tasan Y. A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia. Yonsei Med. J. 2000; 41 (3): 340-344.</mixed-citation><mixed-citation xml:lang="en">Hatipoglu O.N., Tasan Y. A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia. Yonsei Med. J. 2000; 41 (3): 340-344.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Straneo G., Scarpazza G. Efficacy and safety of clarithromycin versus josamycin in the treatment of hospitalized patients with bacterial pneumonia. J. Intern. Med. Res. 1990; 18 (2): 164-170.</mixed-citation><mixed-citation xml:lang="en">Straneo G., Scarpazza G. Efficacy and safety of clarithromycin versus josamycin in the treatment of hospitalized patients with bacterial pneumonia. J. Intern. Med. Res. 1990; 18 (2): 164-170.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Genne D., Siegrist H.H., Humair L. et al. A comparative analysis of clarithromycin iv and amoxicillin-clavulanic acid iv in the treatment of community-acquired pneumonia. In: 4th International conference macrolides azalides streptogramins ketolides. Barcelona; 1998. abstr.10.16.</mixed-citation><mixed-citation xml:lang="en">Genne D., Siegrist H.H., Humair L. et al. A comparative analysis of clarithromycin iv and amoxicillin-clavulanic acid iv in the treatment of community-acquired pneumonia. In: 4th International conference macrolides azalides streptogramins ketolides. Barcelona; 1998. abstr.10.16.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Fogarty C., Grossman C., Williams J.W. et al. Efficacy and safety of moxifloxacin vs clarithromycin for community-acquired pneumonia. Infect. Med. 1999; 16 (1): 748-753.</mixed-citation><mixed-citation xml:lang="en">Fogarty C., Grossman C., Williams J.W. et al. Efficacy and safety of moxifloxacin vs clarithromycin for community-acquired pneumonia. Infect. Med. 1999; 16 (1): 748-753.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Ramirez J., Unowsky J., Talbot G. et al. Sparfloxacin versus clarithromycin in the treatment of community-acquired pneumonia. Clin Ther. 1999; 21 (1): 103-117.</mixed-citation><mixed-citation xml:lang="en">Ramirez J., Unowsky J., Talbot G. et al. Sparfloxacin versus clarithromycin in the treatment of community-acquired pneumonia. Clin Ther. 1999; 21 (1): 103-117.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Mathers Dunbar L., Hassman J., Tellier G. Efficacy and tolerability of once-daily oral telithromycin compared with clarithromycin for the treatment of community-acquired pneumonia in adults. Clin. Ther. 2004; 26 (1): 48-62.</mixed-citation><mixed-citation xml:lang="en">Mathers Dunbar L., Hassman J., Tellier G. Efficacy and tolerability of once-daily oral telithromycin compared with clarithromycin for the treatment of community-acquired pneumonia in adults. Clin. Ther. 2004; 26 (1): 48-62.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
