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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2011-0-1-89-98</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-249</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTIONS</subject></subj-group></article-categories><title-group><article-title>ДИАГНОСТИКА, ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА И ЛЕЧЕНИЕ БРОНХООБСТРУКТИВНОГО СИНДРОМА: МЕСТО КОМБИНИРОВАННЫХ ПРЕПАРАТОВ Β2-АГОНИСТОВ И ИНГАЛЯЦИОННЫХ ГЛЮКОКОРТИКОСТЕРОИДОВ</article-title><trans-title-group xml:lang="en"><trans-title>DIAGNOSIS, DIFFERENTIATION AND MANAGEMENT OF BRONCHIAL OBSTRUCTIVE SYNDROME: A ROLE OF Β2-AGONISTS AND INHALED STEROIDS COMBINED IN A SINGLE INHALER</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Татарский</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Tatarsky</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф. кафедры госпитальной терапии педиатрического факультета</p><p>117997, Москва, ул. Островитянова, 1.</p><p>Тел.: (495) 465-52-64.</p></bio><bio xml:lang="en"><p>д. м. н., проф. кафедры госпитальной терапии педиатрического факультета</p><p>117997, Москва, ул. Островитянова, 1.</p><p>Тел.: (495) 465-52-64.</p></bio><email xlink:type="simple">aleksey.tatarsky@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОУ ВПО "Российский государственный медицинский университет им. Н.И.Пирогова"</institution><country>Россия</country></aff><aff xml:lang="en"><institution>ГОУ ВПО "Российский государственный медицинский университет им. Н.И.Пирогова"</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2011</year></pub-date><volume>0</volume><issue>1</issue><fpage>89</fpage><lpage>98</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Татарский А.Р., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Татарский А.Р.</copyright-holder><copyright-holder xml:lang="en">Tatarsky A.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/249">https://journal.pulmonology.ru/pulm/article/view/249</self-uri><abstract><p>Диагностика, дифференциальная диагностика и лечение бронхообструктивного синдрома: место комбинированных препаратов β2-агонистов и ингаляционных глюкокортикостероидов</p></abstract><trans-abstract xml:lang="en"><p>Diagnosis, differentiation and management of bronchial obstructive syndrome: a role of β2-agonists and inhaled steroids combined in a single inhaler</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>хроническая обструктивная болезнь легких</kwd><kwd>диагностика</kwd><kwd>комбинированные глюкокортикостероиды</kwd><kwd>пролонгированные β2-агонисты</kwd></kwd-group><funding-group><funding-statement xml:lang="en">bronchial asthma; chronic obstructive pulmonary disease; diagnosis; inhaled corticosteroids; long-acting β2-agonists;</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Global initiative for asthma. Global Strategy for Asthma Management and Prevention Update 2009: www.gin asthma.org</mixed-citation><mixed-citation xml:lang="en">Global initiative for asthma. Global Strategy for Asthma Management and Prevention Update 2009: www.gin asthma.org</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Global initiative for chronic obstructive lung disease (GOLD). Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease.NHLBI / WHO workshop report / Last update 2009. www.goldcopd.org</mixed-citation><mixed-citation xml:lang="en">Global initiative for chronic obstructive lung disease (GOLD). Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease.NHLBI / WHO workshop report / Last update 2009. www.goldcopd.org</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cazzola M., MacNee W., Martinez F.J. et al. Outcomes for COPD pharmacological trials: from lung functions to biomarkers. Eur. Respir. J. 2008; 31 (2): 416–469.</mixed-citation><mixed-citation xml:lang="en">Cazzola M., MacNee W., Martinez F.J. et al. Outcomes for COPD pharmacological trials: from lung functions to biomarkers. Eur. Respir. J. 2008; 31 (2): 416–469.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Chetta A., Zanini A., Foresi A. et al. Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. Am. J. Respir. Crit. Care Med. 2003; 167 (5):751–757.</mixed-citation><mixed-citation xml:lang="en">Chetta A., Zanini A., Foresi A. et al. Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. Am. J. Respir. Crit. Care Med. 2003; 167 (5):751–757.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hoshino M.Comparison of effectiveness in ciclesonide and fluticasone propionate on small airway function in mild asthma. Allergol. Int. 2010; 59 (1): 59–66.</mixed-citation><mixed-citation xml:lang="en">Hoshino M.Comparison of effectiveness in ciclesonide and fluticasone propionate on small airway function in mild asthma. Allergol. Int. 2010; 59 (1): 59–66.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lundbäck B., Rönmark E., Lindberg A. et al. Control of mild to moderate asthma over 1-year with the combination of salmeterol and fluticasone propionate. Respir. Med. 2006; 100(1): 2–10.</mixed-citation><mixed-citation xml:lang="en">Lundbäck B., Rönmark E., Lindberg A. et al. Control of mild to moderate asthma over 1-year with the combination of salmeterol and fluticasone propionate. Respir. Med. 2006; 100(1): 2–10.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Woolcock A.J., Bastiampillai S.A., Marks G.B., Keena V.A.The burden of asthma in Australia. Med. J. Aust. 2001; 175(3): 141–145.</mixed-citation><mixed-citation xml:lang="en">Woolcock A.J., Bastiampillai S.A., Marks G.B., Keena V.A.The burden of asthma in Australia. Med. J. Aust. 2001; 175(3): 141–145.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bateman E.D., Boushey H.A., Bousquet J. et al. Can guide line-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am. J. Respir. Crit. Care Med. 2004; 170 (8): 836–844.</mixed-citation><mixed-citation xml:lang="en">Bateman E.D., Boushey H.A., Bousquet J. et al. Can guide line-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am. J. Respir. Crit. Care Med. 2004; 170 (8): 836–844.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A. The effect of inhaled beta2-agonists on clinical outcomes in chronic obstructive pulmonary disease.J. Allergy Clin. Immunol. 2002; 110 (6, Suppl.): S298–S303.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A. The effect of inhaled beta2-agonists on clinical outcomes in chronic obstructive pulmonary disease.J. Allergy Clin. Immunol. 2002; 110 (6, Suppl.): S298–S303.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A., Wire P., Horstman D. et al. Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2002;166 (8): 1084–1091.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A., Wire P., Horstman D. et al. Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2002;166 (8): 1084–1091.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Vestbo J., Pauwels R., Anderson J.A. et al. Early onset of effect of salmeterol and fluticasone propionate in chronic obstructive pulmonary disease. Thorax 2005; 60: 301–304.</mixed-citation><mixed-citation xml:lang="en">Vestbo J., Pauwels R., Anderson J.A. et al. Early onset of effect of salmeterol and fluticasone propionate in chronic obstructive pulmonary disease. Thorax 2005; 60: 301–304.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Vestbo J. New thinking and COPD. Ugeskr. Laeg. 2003; 165 (45): 4319.</mixed-citation><mixed-citation xml:lang="en">Vestbo J. New thinking and COPD. Ugeskr. Laeg. 2003; 165 (45): 4319.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Vestbo J. The TORCH (towards a revolution in COPD health) survival study protocol. TORCH Study Group. Eur.Respir. J. 2004; 24 (2): 206–210.</mixed-citation><mixed-citation xml:lang="en">Vestbo J. The TORCH (towards a revolution in COPD health) survival study protocol. TORCH Study Group. Eur.Respir. J. 2004; 24 (2): 206–210.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Calverley P.M., Anderson J.A., Celli B. TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N. Engl. J. Med.2007; 356 (8): 775–789.</mixed-citation><mixed-citation xml:lang="en">Calverley P.M., Anderson J.A., Celli B. TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N. Engl. J. Med.2007; 356 (8): 775–789.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wedzicha J.A., Calverley P.M., Seemungal T.A. et al. The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol / fluticasone propionate or tiotropium bromide. Am. J. Respir. Crit. Care Med. 2008; 177 (1):19–26.</mixed-citation><mixed-citation xml:lang="en">Wedzicha J.A., Calverley P.M., Seemungal T.A. et al. The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol / fluticasone propionate or tiotropium bromide. Am. J. Respir. Crit. Care Med. 2008; 177 (1):19–26.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Jenkins C.R., Jones P.W., Calverley P.M. et al. Efficacy of salmeterol / fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study. Respir. Res.2009; 10: 59.</mixed-citation><mixed-citation xml:lang="en">Jenkins C.R., Jones P.W., Calverley P.M. et al. Efficacy of salmeterol / fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study. Respir. Res.2009; 10: 59.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Calverley P., Pauwels R., Vestbo J. et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003; 361 (9356): 449–456. Erratum in: Lancet 2003; 361(9369): 1660.</mixed-citation><mixed-citation xml:lang="en">Calverley P., Pauwels R., Vestbo J. et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003; 361 (9356): 449–456. Erratum in: Lancet 2003; 361(9369): 1660.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Calverley P.M., Walker P. Chronic obstructive pulmonary disease. Lancet 2003; 362 (9389): 1053–1061.</mixed-citation><mixed-citation xml:lang="en">Calverley P.M., Walker P. Chronic obstructive pulmonary disease. Lancet 2003; 362 (9389): 1053–1061.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Vestbo J., Pauwels R., Anderson J.A. et al. Early onset of effect of salmeterol and fluticasone propionate in chronic obstructive pulmonary disease. Thorax 2005; 60 (4): 301–304.</mixed-citation><mixed-citation xml:lang="en">Vestbo J., Pauwels R., Anderson J.A. et al. Early onset of effect of salmeterol and fluticasone propionate in chronic obstructive pulmonary disease. Thorax 2005; 60 (4): 301–304.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Celli B.R., Thomas N.E., Anderson J.A. et al. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am. J. Respir. Crit. Care Med. 2008; 178 (4):332–338.</mixed-citation><mixed-citation xml:lang="en">Celli B.R., Thomas N.E., Anderson J.A. et al. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am. J. Respir. Crit. Care Med. 2008; 178 (4):332–338.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Calverley P.M., Anderson J.A., Celli B. et al. Cardiovascular events in patients with COPD: TORCH study results.Thorax 2010; 65 (8): 719–725.</mixed-citation><mixed-citation xml:lang="en">Calverley P.M., Anderson J.A., Celli B. et al. Cardiovascular events in patients with COPD: TORCH study results.Thorax 2010; 65 (8): 719–725.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Welte T. Inhaled corticosteroids in COPD and the risk ofpneumonia. Lancet 2009; 374 (9691): 668–670.</mixed-citation><mixed-citation xml:lang="en">Welte T. Inhaled corticosteroids in COPD and the risk ofpneumonia. Lancet 2009; 374 (9691): 668–670.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Singh S., Loke Y.K. An overview of the benefits and drawbacks of inhaled corticosteroids in chronic obstructive pulmonary disease. Int. J. COPD 2010; 5: 189–195.</mixed-citation><mixed-citation xml:lang="en">Singh S., Loke Y.K. An overview of the benefits and drawbacks of inhaled corticosteroids in chronic obstructive pulmonary disease. Int. J. COPD 2010; 5: 189–195.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Drummond M. B., Dasenbrook E.C., Pitz M.W. et al. Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease a systematic review and meta-analysis.J.A.M.A. 2008; 300 (20): 2407–2416.</mixed-citation><mixed-citation xml:lang="en">Drummond M. B., Dasenbrook E.C., Pitz M.W. et al. Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease a systematic review and meta-analysis.J.A.M.A. 2008; 300 (20): 2407–2416.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm</mixed-citation><mixed-citation xml:lang="en">http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
