<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2012-0-1-95-102</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-24</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Перспективы терапии легочной артериальной гипертензии ингаляционным илопростом</article-title><trans-title-group xml:lang="en"><trans-title>Future development of therapy with inhaled iloprost in pulmonary arterial hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авдеев</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Avdeev</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф., руководитель клинического отдела </p><p>105077, Москва, ул. 11-я Парковая, 32, корп. 4. Тел. / факс: (495) 465-52-64.</p></bio><email xlink:type="simple">serg-avdeev@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГУ "НИИ пульмонологии" ФМБА России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2012</year></pub-date><volume>0</volume><issue>1</issue><fpage>95</fpage><lpage>102</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Авдеев С.Н., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Авдеев С.Н.</copyright-holder><copyright-holder xml:lang="en">Avdeev S.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/24">https://journal.pulmonology.ru/pulm/article/view/24</self-uri><abstract><p>Перспективы терапии легочной артериальной гипертензии ингаляционным илопростом.</p></abstract><trans-abstract xml:lang="en"><p>Future development of therapy with inhaled iloprost in pulmonary arterial hypertension.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>легочная артериальная гипертензия</kwd><kwd>простациклины</kwd><kwd>ингаляционный илопрост</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pulmonary arterial hypertension</kwd><kwd>prostacyclines</kwd><kwd>inhaled iloprost</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Galié N., Hoeper M., Humbert M. et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur. Heart J. 2009; 30: 2493–2537.</mixed-citation><mixed-citation xml:lang="en">Galié N., Hoeper M., Humbert M. et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur. Heart J. 2009; 30: 2493–2537.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Galie N., Hoeper M.M., Humbert M. et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur. Respir. J. 2009; 34: 1219–1263.</mixed-citation><mixed-citation xml:lang="en">Galie N., Hoeper M.M., Humbert M. et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur. Respir. J. 2009; 34: 1219–1263.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Galie N., Palazzini M., Manes A. Pulmonary hypertension and pulmonary arterial hypertension: a clarification is needed. Eur. Respir. J. 2010; 36: 986–990.</mixed-citation><mixed-citation xml:lang="en">Galie N., Palazzini M., Manes A. Pulmonary hypertension and pulmonary arterial hypertension: a clarification is needed. Eur. Respir. J. 2010; 36: 986–990.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">McLaughlin V.V., Shillington A., Rich S. Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. Circulation 2002; 106: 1477–1482.</mixed-citation><mixed-citation xml:lang="en">McLaughlin V.V., Shillington A., Rich S. Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. Circulation 2002; 106: 1477–1482.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sitbon O., Humbert M., Nunes H. et al. Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. J. Am. Coll. Cardiol. 2002; 40: 780–788.</mixed-citation><mixed-citation xml:lang="en">Sitbon O., Humbert M., Nunes H. et al. Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. J. Am. Coll. Cardiol. 2002; 40: 780–788.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gomberg-Maitland M., Olschewski H. Prostacyclin therapies for the treatment of pulmonary arterial hypertension. Eur. Respir. J. 2008; 31: 891–901.</mixed-citation><mixed-citation xml:lang="en">Gomberg-Maitland M., Olschewski H. Prostacyclin therapies for the treatment of pulmonary arterial hypertension. Eur. Respir. J. 2008; 31: 891–901.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hara S., Morishita R., Tone Y. et al. Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 1995; 216: 862–867.</mixed-citation><mixed-citation xml:lang="en">Hara S., Morishita R., Tone Y. et al. Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 1995; 216: 862–867.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Boxer L.A., Allen J.M., Schmidt M. et al. Inhibition of polymorphonuclear leukocyte adherence by prostacyclin. J. Lab. Clin. Med. 1980; 95: 672–678.</mixed-citation><mixed-citation xml:lang="en">Boxer L.A., Allen J.M., Schmidt M. et al. Inhibition of polymorphonuclear leukocyte adherence by prostacyclin. J. Lab. Clin. Med. 1980; 95: 672–678.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tuder R.M., Cool C.D., Geraci M.W. et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am. J. Respir. Crit. Care Med. 1999; 159: 1925–1932.</mixed-citation><mixed-citation xml:lang="en">Tuder R.M., Cool C.D., Geraci M.W. et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am. J. Respir. Crit. Care Med. 1999; 159: 1925–1932.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Christman B.W., McPherson C.D., Newman J.H. et al. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl. J. Med. 1992; 327: 70–75.</mixed-citation><mixed-citation xml:lang="en">Christman B.W., McPherson C.D., Newman J.H. et al. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl. J. Med. 1992; 327: 70–75.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Olschewski H., Walmrath D., Schermuly R. et al. Aerosolized Prostacyclin and Iloprost in Severe Pulmonary Hypertension. Ann. Intern. Med. 1996; 124: 820–824.</mixed-citation><mixed-citation xml:lang="en">Olschewski H., Walmrath D., Schermuly R. et al. Aerosolized Prostacyclin and Iloprost in Severe Pulmonary Hypertension. Ann. Intern. Med. 1996; 124: 820–824.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Krause W., Krais T. Pharmacokinetics and pharmacodynamics of the prostacyclin analogue iloprost in man. Eur. J. Clin. Pharmacol. 1986; 30: 61–68.</mixed-citation><mixed-citation xml:lang="en">Krause W., Krais T. Pharmacokinetics and pharmacodynamics of the prostacyclin analogue iloprost in man. Eur. J. Clin. Pharmacol. 1986; 30: 61–68.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Sablotzki A., Hentschel T., Gruenig E. et al. Hemodynamic effects of inhaled aerosolized iloprost and inhaled nitric oxide in heart transplant candidates with elevated pulmonary vascular resistance. Eur. J. Cardiothorac. Surg. 2002; 22: 746–752.</mixed-citation><mixed-citation xml:lang="en">Sablotzki A., Hentschel T., Gruenig E. et al. Hemodynamic effects of inhaled aerosolized iloprost and inhaled nitric oxide in heart transplant candidates with elevated pulmonary vascular resistance. Eur. J. Cardiothorac. Surg. 2002; 22: 746–752.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Steudel W., Hurford W.E., Zapol W.M. Inhaled nitric oxide: basic biology and clinical applications. Anesthesiology 1999; 91: 1090–1121.</mixed-citation><mixed-citation xml:lang="en">Steudel W., Hurford W.E., Zapol W.M. Inhaled nitric oxide: basic biology and clinical applications. Anesthesiology 1999; 91: 1090–1121.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gessler T., Schmehl T., Hoeper M.M. et al. Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension. Eur. Respir. J. 2001; 17: 14–19.</mixed-citation><mixed-citation xml:lang="en">Gessler T., Schmehl T., Hoeper M.M. et al. Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension. Eur. Respir. J. 2001; 17: 14–19.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hoeper M.M., Schwarze M., Ehlerding S. et al. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N. Engl. J. Med. 2000; 343: 1866–1870.</mixed-citation><mixed-citation xml:lang="en">Hoeper M.M., Schwarze M., Ehlerding S. et al. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N. Engl. J. Med. 2000; 343: 1866–1870.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ventavis (iloprost). South San Francisco, Calif: Actelion Pharmaceuticals US Inc.; 2006.</mixed-citation><mixed-citation xml:lang="en">Ventavis (iloprost). South San Francisco, Calif: Actelion Pharmaceuticals US Inc.; 2006.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Schermuly R.T., Schulz A., Ghofrani A. et al. Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs. J. Pharmacol. Exp. Ther. 2002; 303: 741–745.</mixed-citation><mixed-citation xml:lang="en">Schermuly R.T., Schulz A., Ghofrani A. et al. Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs. J. Pharmacol. Exp. Ther. 2002; 303: 741–745.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Olschewski H., Simonneau G., Galie N. et al. Inhaled iloprost for severe pulmonary hypertension. N. Engl. J. Med. 2002; 347: 322–329.</mixed-citation><mixed-citation xml:lang="en">Olschewski H., Simonneau G., Galie N. et al. Inhaled iloprost for severe pulmonary hypertension. N. Engl. J. Med. 2002; 347: 322–329.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Van Dyke R.E., Nikander K. Delivery of iloprost inhalation solution with the halolite, prodose, and I-neb adaptive aerosol delivery systems: an in vitro study. Respir. Care 2007; 52: 184–190.</mixed-citation><mixed-citation xml:lang="en">Van Dyke R.E., Nikander K. Delivery of iloprost inhalation solution with the halolite, prodose, and I-neb adaptive aerosol delivery systems: an in vitro study. Respir. Care 2007; 52: 184–190.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Krug S., Sablotzki A., Hammerschmidt S. et al. Inhaled iloprost for the control of pulmonary hypertension. Vascular Health and Risk Management 2009; 5: 465–474.</mixed-citation><mixed-citation xml:lang="en">Krug S., Sablotzki A., Hammerschmidt S. et al. Inhaled iloprost for the control of pulmonary hypertension. Vascular Health and Risk Management 2009; 5: 465–474.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Walmrath D., Olschewski H., Grimminger F., Seeger W. NO and alternative inhalational therapy approaches in pulmonary hypertension. Internist (Berl) 1997; 38: 453–460.</mixed-citation><mixed-citation xml:lang="en">Walmrath D., Olschewski H., Grimminger F., Seeger W. NO and alternative inhalational therapy approaches in pulmonary hypertension. Internist (Berl) 1997; 38: 453–460.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ewert R., Opitz C., Wensel R. et al. Iloprost as inhalational and intravenous long-term treatment of patients with primary pulmonary hypertension. Register of the Berlin Study Group for Pulmonary Hypertension. Z. Kardiol. 2000; 89: 987–999.</mixed-citation><mixed-citation xml:lang="en">Ewert R., Opitz C., Wensel R. et al. Iloprost as inhalational and intravenous long-term treatment of patients with primary pulmonary hypertension. Register of the Berlin Study Group for Pulmonary Hypertension. Z. Kardiol. 2000; 89: 987–999.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Olschewski H., Ghofrani H.A., Schmehl T. et al. Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group. Ann. Intern. Med. 2000; 132: 435–443.</mixed-citation><mixed-citation xml:lang="en">Olschewski H., Ghofrani H.A., Schmehl T. et al. Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group. Ann. Intern. Med. 2000; 132: 435–443.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Olschewski H., Ghofrani H.A., Walmrath D. et al. Recovery from circulatory shock in severe primary pulmonary hypertension (PPH) with aerosolization of iloprost. Intens. Care Med. 1998; 24: 631–634.</mixed-citation><mixed-citation xml:lang="en">Olschewski H., Ghofrani H.A., Walmrath D. et al. Recovery from circulatory shock in severe primary pulmonary hypertension (PPH) with aerosolization of iloprost. Intens. Care Med. 1998; 24: 631–634.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">McLaughlin V.V., Oudiz R.J., Frost A. et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 2006; 174: 1257–1263.</mixed-citation><mixed-citation xml:lang="en">McLaughlin V.V., Oudiz R.J., Frost A. et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 2006; 174: 1257–1263.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Hoeper M.M., Leuchte H., Halank M. et al. Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. Eur. Respir. J. 2006; 28: 691–694.</mixed-citation><mixed-citation xml:lang="en">Hoeper M.M., Leuchte H., Halank M. et al. Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. Eur. Respir. J. 2006; 28: 691–694.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Opitz C.F., Wensel R., Winkler J. et al. Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension. Eur. Heart J. 2005; 26: 1895–1902.</mixed-citation><mixed-citation xml:lang="en">Opitz C.F., Wensel R., Winkler J. et al. Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension. Eur. Heart J. 2005; 26: 1895–1902.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">D'Alonzo G.E., Barst R.J., Ayres S.M. et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann. Intern. Med. 1991; 115: 343–349.</mixed-citation><mixed-citation xml:lang="en">D'Alonzo G.E., Barst R.J., Ayres S.M. et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann. Intern. Med. 1991; 115: 343–349.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Bayer Schering Pharma AG. Open-label, uncontrolled, long-term surveillance study of iloprost aerosol inhalation therapy in the treatment of patients with primary or secondary pulmonary hypertension. Date last updated: May 2007.</mixed-citation><mixed-citation xml:lang="en">Bayer Schering Pharma AG. Open-label, uncontrolled, long-term surveillance study of iloprost aerosol inhalation therapy in the treatment of patients with primary or secondary pulmonary hypertension. Date last updated: May 2007.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Olschewski H., Hoeper M.M., Behr J. et al. Long-term therapy with inhaled iloprost in patients with pulmonary hypertension. Respir. Med. 2010; 104: 731–740.</mixed-citation><mixed-citation xml:lang="en">Olschewski H., Hoeper M.M., Behr J. et al. Long-term therapy with inhaled iloprost in patients with pulmonary hypertension. Respir. Med. 2010; 104: 731–740.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Frost A.E., the STEP investigators. STEP-open label extension: long-term benefits of inhaled iloprost (ILO) addition to bosentan for treatment of pulmonary arterial hypertension (PAH). Am. J. Respir. Crit. Care Med. 2007; 175 (Suppl.): A1001.</mixed-citation><mixed-citation xml:lang="en">Frost A.E., the STEP investigators. STEP-open label extension: long-term benefits of inhaled iloprost (ILO) addition to bosentan for treatment of pulmonary arterial hypertension (PAH). Am. J. Respir. Crit. Care Med. 2007; 175 (Suppl.): A1001.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Dernaika T.A., Beavin M., Kinasewitz G.T. Iloprost improves gas exchange and exercise tolerance in patients with pulmonary hypertension and chronic obstructive pulmonary disease. Respiration 2010; 79: 377–382.</mixed-citation><mixed-citation xml:lang="en">Dernaika T.A., Beavin M., Kinasewitz G.T. Iloprost improves gas exchange and exercise tolerance in patients with pulmonary hypertension and chronic obstructive pulmonary disease. Respiration 2010; 79: 377–382.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Hegewald M.J., Elliott C.G. Sustained improvement with iloprost in a COPD patient with severe pulmonary hypertension. Chest 2009; 135: 536–537.</mixed-citation><mixed-citation xml:lang="en">Hegewald M.J., Elliott C.G. Sustained improvement with iloprost in a COPD patient with severe pulmonary hypertension. Chest 2009; 135: 536–537.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Olschewski H., Ghofrani H.A., Walmrath D. et al. Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis. Am. J. Respir. Crit. Care Med. 1999; 160: 600–607.</mixed-citation><mixed-citation xml:lang="en">Olschewski H., Ghofrani H.A., Walmrath D. et al. Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis. Am. J. Respir. Crit. Care Med. 1999; 160: 600–607.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Baughman R.P., Judson M.A., Lower E.E. et al. Inhaled iloprost for sarcoidosis associated pulmonary hypertension. Sarcoidosis. Vasc. Diffuse Lung Dis. 2009; 26: 110–120.</mixed-citation><mixed-citation xml:lang="en">Baughman R.P., Judson M.A., Lower E.E. et al. Inhaled iloprost for sarcoidosis associated pulmonary hypertension. Sarcoidosis. Vasc. Diffuse Lung Dis. 2009; 26: 110–120.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
