References

pulmo

Пульмонология

PULMONOLOGIYA

0869-01892541-9617

Scientific and Practical Journal “PULMONOLOGIYA” LLC

10.18093/0869-0189-2022-2356

pulmo-2356

Research Article

ОБЗОРЫ

REVIEW

О повышении эффективности вакцинации против вирусных и бактериальных патогенов посредством дотаций микронутриентов

Improving the effectiveness of vaccination against viral and bacterial pathogens through micronutrient supplementation

https://orcid.org/0000-0002-2659-7998

Торшин

И. Ю.

Torshin

I. Yu.

Торшин Иван Юрьевич – кандидат физико-математических наук, кандидат химических наук, старший научный сотрудник отдела интеллектуальных систем Института фармакоинформатики, Author ID: 7003300274; Author ID: 54104; WOS ID: C-7683-2018.

119333, Москва, ул. Вавилова, 42; тел.: (499) 135-24-89

Ivan Yu. Torshin - Candidate of Physics & Mathematics, Candidate of Chemistry, Senior Researcher, Department of Intellectual Systems, Institute of Pharmacoinformatics, Author ID: 7003300274; Author ID: 54104; WOS ID: C-7683-2018.

Ul. Vavilova 42, Moscow, 119333; tel.: (499) 135-24-89

tiy135@yahoo.com

https://orcid.org/0000-0002-7663-710X

Громова

О. А.

Gromova

O. A.

Громова Ольга Алексеевна – доктор медицинских наук, профессор, ведущий научный сотрудник Института фармакоинформатики; Author ID: 94901; Author ID: 7003589812; WOS ID: J-4946-2017.

119333, Москва, ул. Вавилова, 42; тел.: (499) 135-24-89

Olga A. Gromova - Doctor of Medicine, Professor, Leading Researcher, Institute of Pharmacoinformatics; Author ID: 94901; Author ID: 7003589812; WOS ID: J-4946-2017.

Ul. Vavilova 42, Moscow, 119333; tel.: (499) 135-24-89

unesco.gromova@gmail.com

https://orcid.org/0000-0003-4120-1071

Максимов

В. А.

Maksimov

V. A.

Максимов Валерий Алексеевич – доктор медицинских наук, профессор кафедры диетологии и нутрициологии.

125993, Москва, ул. Баррикадная, 2 / 1, стр. 1; тел.: (495) 680-05-99

Valeriy A. Maksimov - Doctor of Medicine, Professor, Department of Dietology and Nutrition.

Ul. Barrikadnaya 2/1, build. 1, Moscow, 123995; tel.: (495) 680-05-99

uta03@yandex.ru

https://orcid.org/0000-0002-6808-5528

Чучалин

А. Г.

Chuchalin

A. G.

Чучалин Александр Григорьевич – доктор медицинских наук, профессор, академик Российской академии наук, заведующий кафедрой госпитальной терапии педиатрического факультета, председатель правления Российского респираторного общества.

117997, Москва, ул. Островитянова, 1; тел.: (499) 780-08-50

Alexander G. Chuchalin - Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Head of Department of Hospital Internal Medicine, Pediatric Faculty; Chairman of the Executive Board of Russian Respiratory Society

Ul. Ostrovityanova 1, Moscow, 117997; tel.: (499) 780-08-50

pulmomoskva@mail.ru

Федеральное государственное учреждение Федеральный исследовательский центр Информатика и управление, Российская академия наукРоссияFederal Research Center Computer Science and Control, Russian Academy of SciencesRussian Federation

Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования Российская медицинская академия непрерывного профессионального образования, Министерство здравоохранения Российской ФедерацииРоссияRussian Medical Academy of Continuous Professional Education, Healthcare Ministry of Russian FederationRussian Federation

Федеральное государственное автономное образовательное учреждение высшего образования Российский национальный исследовательский медицинский университет имени Н.И. Пирогова, Министерство здравоохранения Российской ФедерацииРоссияPirogov Russian National Research Medical University (Pirogov Medical University), Ministry of Health of the Russian FederationRussian Federation

2023

10022023

3316575

2023

Торшин И.Ю., Громова О.А., Максимов В.А., Чучалин А.Г.

Torshin I.Y., Gromova O.A., Maksimov V.A., Chuchalin A.G.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.pulmonology.ru/pulm/article/view/2356

При недостаточной обеспеченности рядом микронутриентов (МН) нарушается функционирование систем приобретенного иммунитета, что может негативно сказываться на эффективности и безопасности вакцинации. По результатам клинико-эпидемиологических исследований показано, что при дотации МН перед вакцинацией повышаются ее эффективность (увеличение титра антител к вирусным / бактериальным патогенам) и безопасность (предотвращение недомогания, снижение тяжести течения и смертности от соответствующей инфекции в случае заболевания пациента после вакцинации).

Целью работы явился анализ доступных к настоящему времени исследований по взаимосвязи обеспеченности МН с результатами вакцинации против бактерий и вирусов.

Заключение. Дотации МН способствуют формированию адекватного поствакцинального иммунитета и повышению безопасности вакцинации. Применение витаминно-минеральных комплексов является экономически выгодной процедурой, позволяющей снизить риски при вакцинации пациентов с полигиповитаминозами.

Deficiency of certain micronutrients interferes with the functioning of acquired immunity, which may negatively affect the efficacy and safety of vaccinations. The results of clinical and epidemiological studies have shown that micronutrient supplementation before vaccination increases its efficacy (antibody titers against viral/bacterial pathogens) and safety (prevention of malaise, reduction of disease severity and mortality in case of post-vaccination infection).

The aim of the study was to analyze the currently available studies on the relationship between micronutrient status and the results of vaccination against bacteria and viruses.

Conclusion. Micronutrient supplementation contributes to the formation of adequate immunity after vaccination and increases the safety of vaccination. Vitamin-mineral complexes represent a cost-effective method to reduce the risks of vaccination in patients with polyhypovitaminosis.

фармакоаналитикавитаминымикроэлементыэффективность и безопасность вакцинации

pharmacoanalyticsvitaminsmicroelementsvaccination efficacy and safety

Работа выполнялась по государственному заданию № 0063-2019-0003 «Математические методы анализа данных и прогнозирования» с использованием инфраструктуры Центра коллективного пользования «Высокопроизводительные вычисления и большие данные» Федерального государственного учреждения «Федеральный исследовательский центр «Информатика и управление» Российской академии наук (Москва)

The work was carried out according to the state assignment No.0063-2019-0003 “Mathematical methods for data analysis and forecasting” at the Research Equipment Sharing Center “High-Performance Computing and Big Data”, Federal Research Center “Computer Science and Control” of the Russian Academy of Sciences (Moscow)

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The authors declare that there are no conflicts of interest present.