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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2012-0-1-88-94</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-23</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Хроническая легочная гипертония и система оксида азота</article-title><trans-title-group xml:lang="en"><trans-title>Chronic pulmonary hypertension and nitric oxide</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марков</surname><given-names>Х. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Markov</surname><given-names>Kh. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф.</p><p>119991, Москва, Ломоносовский пр-т, 2. Тел.: (499) 241-53-89.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБУ "Научный центр здоровья детей" РАМН</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2012</year></pub-date><volume>0</volume><issue>1</issue><fpage>88</fpage><lpage>94</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Марков Х.М., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Марков Х.М.</copyright-holder><copyright-holder xml:lang="en">Markov K.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/23">https://journal.pulmonology.ru/pulm/article/view/23</self-uri><abstract><p>Хроническая легочная гипертония и система оксида азота.</p></abstract><trans-abstract xml:lang="en"><p>Chronic pulmonary hypertension and nitric oxide.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>легочная гипертония</kwd><kwd>система оксида азота</kwd><kwd>дефицит оксида азота</kwd><kwd>фармакотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pulmonary hypertension</kwd><kwd>nitric oxide</kwd><kwd>nitric oxide deficiency</kwd><kwd>pharmacotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Romberg E. Uber sclerose der lungenarterie. Dtsch. Arch. Klin. Med. 1891; 48: 197–206.</mixed-citation><mixed-citation xml:lang="en">Romberg E. Uber sclerose der lungenarterie. Dtsch. Arch. Klin. Med. 1891; 48: 197–206.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Coggion M.P., Bloch K. Nitric oxide in the pulmonary vasculature. Arterioscler. Thromb. Vasc. Biol. 2007; 27: 1877–1885.</mixed-citation><mixed-citation xml:lang="en">Coggion M.P., Bloch K. Nitric oxide in the pulmonary vasculature. Arterioscler. Thromb. Vasc. Biol. 2007; 27: 1877–1885.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Steudel O.V., Scherrer-Grosbi M., Bloch K.D. et al. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of eNOS. J. Clin. Invest. 1998; 101: 2468–2477.</mixed-citation><mixed-citation xml:lang="en">Steudel O.V., Scherrer-Grosbi M., Bloch K.D. et al. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of eNOS. J. Clin. Invest. 1998; 101: 2468–2477.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Fagan K.A., Nyler R.C., Sato K. et al. Relative contribution of eNOS, iNOS and nNOS to (tone) in the marine pulmonary circulation. Am. J. Physiol. 1999; 277: L472–L478.</mixed-citation><mixed-citation xml:lang="en">Fagan K.A., Nyler R.C., Sato K. et al. Relative contribution of eNOS, iNOS and nNOS to (tone) in the marine pulmonary circulation. Am. J. Physiol. 1999; 277: L472–L478.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hampl V., Herget J. Role of NO in the pathogenesis of pulmonary hypertension. Physiol. Rev. 2000; 80: 1337–1372.</mixed-citation><mixed-citation xml:lang="en">Hampl V., Herget J. Role of NO in the pathogenesis of pulmonary hypertension. Physiol. Rev. 2000; 80: 1337–1372.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Moutgil R., Michelakis E.D., Archer S.L. Hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 2005; 98: 390–403.</mixed-citation><mixed-citation xml:lang="en">Moutgil R., Michelakis E.D., Archer S.L. Hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 2005; 98: 390–403.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Murata T., Sato K., Hori M. et al. Decreased eNOS activity resulting from abnormal interaction between eNOS and its regulatory protein in hyxoxia-induced oulmonary hypertension. J. Biol. Chem. 2002; 277: 1485–1492.</mixed-citation><mixed-citation xml:lang="en">Murata T., Sato K., Hori M. et al. Decreased eNOS activity resulting from abnormal interaction between eNOS and its regulatory protein in hyxoxia-induced oulmonary hypertension. J. Biol. Chem. 2002; 277: 1485–1492.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Naage J., Valen G. Preconditioning and cardiac surgery. Ann. Thorac. Surg. 2003; 75: S709–S714.</mixed-citation><mixed-citation xml:lang="en">Naage J., Valen G. Preconditioning and cardiac surgery. Ann. Thorac. Surg. 2003; 75: S709–S714.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kielstein J.T., Bode-Boger S.M., Hesse G. et al. Asymmetric dimethylarginine in idiopatic pulmonary arterial hypertension. Arterioscler. Thromb. Vasc. Biol. 2005; 25: 1414–1418.</mixed-citation><mixed-citation xml:lang="en">Kielstein J.T., Bode-Boger S.M., Hesse G. et al. Asymmetric dimethylarginine in idiopatic pulmonary arterial hypertension. Arterioscler. Thromb. Vasc. Biol. 2005; 25: 1414–1418.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Leiper J., Nandi M., Torondel B. et al. Disrubtion of methylarginine metabolism impairs vascular homeostasis. Nature Med. 2007; 13: 198–203.</mixed-citation><mixed-citation xml:lang="en">Leiper J., Nandi M., Torondel B. et al. Disrubtion of methylarginine metabolism impairs vascular homeostasis. Nature Med. 2007; 13: 198–203.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Khoo L.P., Zhao L., Alp N.J. et al. Role of endothelial tetrahydrobiopterin in pulmonary hypertension. Circulation 2008; 111: 2126–2133.</mixed-citation><mixed-citation xml:lang="en">Khoo L.P., Zhao L., Alp N.J. et al. Role of endothelial tetrahydrobiopterin in pulmonary hypertension. Circulation 2008; 111: 2126–2133.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Giaid A., Salch D. Reduced expression of eNOS in the lung of patients with pulmonary hypertension. Am. J. Respir. Crit. Care Med. 2005; 172: 352–357.</mixed-citation><mixed-citation xml:lang="en">Giaid A., Salch D. Reduced expression of eNOS in the lung of patients with pulmonary hypertension. Am. J. Respir. Crit. Care Med. 2005; 172: 352–357.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zeiher A.M., Schachinger V., Minners J. Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function. Circulation 1995; 92: 1094–1100.</mixed-citation><mixed-citation xml:lang="en">Zeiher A.M., Schachinger V., Minners J. Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function. Circulation 1995; 92: 1094–1100.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Barbera J.A., Peinado V.I., Santos S. et al. Reduced expression of endothelial nitric oxide synthase in pulmonary arteries of smokers. Am. J. Respir. Crit. Care Med. 2001; 164 (4): 709–713.</mixed-citation><mixed-citation xml:lang="en">Barbera J.A., Peinado V.I., Santos S. et al. Reduced expression of endothelial nitric oxide synthase in pulmonary arteries of smokers. Am. J. Respir. Crit. Care Med. 2001; 164 (4): 709–713.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Assreuy J., Cunha F.Q., Liew F.Y., Moncada S. Feedback inhibition of NOS-activity by nitric oxide. Br. J. Pharmacol. 1993; 108: 833–837.</mixed-citation><mixed-citation xml:lang="en">Assreuy J., Cunha F.Q., Liew F.Y., Moncada S. Feedback inhibition of NOS-activity by nitric oxide. Br. J. Pharmacol. 1993; 108: 833–837.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Su Y., Han W., Giraldo C. et al. Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells. Am. J. Respir. Cell Mol. Biol. 1998; 19: 819–825.</mixed-citation><mixed-citation xml:lang="en">Su Y., Han W., Giraldo C. et al. Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells. Am. J. Respir. Cell Mol. Biol. 1998; 19: 819–825.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Griffits M.J.D., Evans T.W. Inhaled NO therapy in adults. N. Engl. J. Med. 2005; 353: 2683–2695.</mixed-citation><mixed-citation xml:lang="en">Griffits M.J.D., Evans T.W. Inhaled NO therapy in adults. N. Engl. J. Med. 2005; 353: 2683–2695.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ishinose F., Roberts J.D., Zapol W.M. Inhaled NO: a selective pulmonary vasodilator current uses and therapeutic potential. Circulation 2004; 109: 3106–3111.</mixed-citation><mixed-citation xml:lang="en">Ishinose F., Roberts J.D., Zapol W.M. Inhaled NO: a selective pulmonary vasodilator current uses and therapeutic potential. Circulation 2004; 109: 3106–3111.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sitbon O., Brenot F., Denjean A. et al. Inhaled NO as a screening vasodilator agent in primary pulmonary hypertension. Am. J. Respir. Crit. Care Med. 1995; 151: 384–389.</mixed-citation><mixed-citation xml:lang="en">Sitbon O., Brenot F., Denjean A. et al. Inhaled NO as a screening vasodilator agent in primary pulmonary hypertension. Am. J. Respir. Crit. Care Med. 1995; 151: 384–389.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor R.W., Zimmerman J.L., Dellinger R.P. et al. Low-dose inhaled NO in patients with acute lung injury: a randomized controlled trial. J.A.M.A. 2004; 291: 1603–1609.</mixed-citation><mixed-citation xml:lang="en">Taylor R.W., Zimmerman J.L., Dellinger R.P. et al. Low-dose inhaled NO in patients with acute lung injury: a randomized controlled trial. J.A.M.A. 2004; 291: 1603–1609.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Brandler M.D., Powell S.C., Craig D.M. et al. A novel inhaled organic nitrate that affects pulmonary vascular tone in a piglet model of hypoxia-induced pulmonary hypertension. Pediatr. Res. 2005; 58: 531–536.</mixed-citation><mixed-citation xml:lang="en">Brandler M.D., Powell S.C., Craig D.M. et al. A novel inhaled organic nitrate that affects pulmonary vascular tone in a piglet model of hypoxia-induced pulmonary hypertension. Pediatr. Res. 2005; 58: 531–536.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hanter C.J., Dejam A., Blood A.B. et al. Inhaled nebulized nitrit is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nature Med. 2004; 10: 1122–1127.</mixed-citation><mixed-citation xml:lang="en">Hanter C.J., Dejam A., Blood A.B. et al. Inhaled nebulized nitrit is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nature Med. 2004; 10: 1122–1127.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Michelakis E.D. Soluble guanylate cyclase as a potential therapy for pulmonary arterial hypertension. Eur. Respir. J. 2009; 33 (4): 717–721.</mixed-citation><mixed-citation xml:lang="en">Michelakis E.D. Soluble guanylate cyclase as a potential therapy for pulmonary arterial hypertension. Eur. Respir. J. 2009; 33 (4): 717–721.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Wilkens H., Guth A., Konig J. et al. Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary circulation. Circulation 2001; 104: 1218–1222.</mixed-citation><mixed-citation xml:lang="en">Wilkens H., Guth A., Konig J. et al. Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary circulation. Circulation 2001; 104: 1218–1222.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Fesler P., Pagnamenta A., Rondelet B. et al. Effects of sildenafil on hypoxic pulmonary vascular function in dogs. J. Appl. Physiol. 2006; 101: 1085–1090.</mixed-citation><mixed-citation xml:lang="en">Fesler P., Pagnamenta A., Rondelet B. et al. Effects of sildenafil on hypoxic pulmonary vascular function in dogs. J. Appl. Physiol. 2006; 101: 1085–1090.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Mermuly R.T., Kreisselmeier K.P., Chofrani H.A. et al. Chronic sildenafil treatment inhibits monocrotalineinduced pulmonary hypertension. Am. J. Respir. Crit. Care Med. 2004; 169: 39–45.</mixed-citation><mixed-citation xml:lang="en">Mermuly R.T., Kreisselmeier K.P., Chofrani H.A. et al. Chronic sildenafil treatment inhibits monocrotalineinduced pulmonary hypertension. Am. J. Respir. Crit. Care Med. 2004; 169: 39–45.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Mondelet B., Kerbanl F., Fireston L. et al. Signaling molecules in overcirculation-induced pulmonary hypertension in piglets: effect of sildenafil therapie. Circulation 2004; 110: 2220–2225.</mixed-citation><mixed-citation xml:lang="en">Mondelet B., Kerbanl F., Fireston L. et al. Signaling molecules in overcirculation-induced pulmonary hypertension in piglets: effect of sildenafil therapie. Circulation 2004; 110: 2220–2225.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ghofrani H.A., Schermuly R.T., Rose F. et al. Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension. Am. J. Respir. Crit. Care Med. 2003; 167: 1139–1141.</mixed-citation><mixed-citation xml:lang="en">Ghofrani H.A., Schermuly R.T., Rose F. et al. Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension. Am. J. Respir. Crit. Care Med. 2003; 167: 1139–1141.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Ghofrani H.A., Grimminger F. Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy. Eur. Respir. Rev. 2009; 18: 35–41.</mixed-citation><mixed-citation xml:lang="en">Ghofrani H.A., Grimminger F. Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy. Eur. Respir. Rev. 2009; 18: 35–41.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Grimminger F., Weimann G., Frey R. et al. First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension. Eur. Respir. J. 2009; 33: 785–792.</mixed-citation><mixed-citation xml:lang="en">Grimminger F., Weimann G., Frey R. et al. First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension. Eur. Respir. J. 2009; 33: 785–792.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Girgis R.E., Zhan X., Garcia J.G.N. et al. Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Am. J. Physiol. 2003; 285: H938–H945.</mixed-citation><mixed-citation xml:lang="en">Girgis R.E., Zhan X., Garcia J.G.N. et al. Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Am. J. Physiol. 2003; 285: H938–H945.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Murata T., Kinoshita K., Hori M. et al. Statin protects eNOS activity in hypoxia-induced pulmonary hypertension. Arterioscler. Thromb. Vasc. Biol. 2005; 25: 2335–2342.</mixed-citation><mixed-citation xml:lang="en">Murata T., Kinoshita K., Hori M. et al. Statin protects eNOS activity in hypoxia-induced pulmonary hypertension. Arterioscler. Thromb. Vasc. Biol. 2005; 25: 2335–2342.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Champion H.C., Bivalacqwa T.J., Greenberg S.S. et al. Adenoviral gene transfer of eNOS partially restores normal pulmonary arterial pressure in eNOS-deficient micc. Proc. Natl Acad. Sci. USA 2002; 92: 13248–13253.</mixed-citation><mixed-citation xml:lang="en">Champion H.C., Bivalacqwa T.J., Greenberg S.S. et al. Adenoviral gene transfer of eNOS partially restores normal pulmonary arterial pressure in eNOS-deficient micc. Proc. Natl Acad. Sci. USA 2002; 92: 13248–13253.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sata M. Role of circulating vascular progenitors in angiogenesis vascular healing and pulmonary hypertension: lessons from animal models. Arterioscler. Thromb. Vasc. Biol. 2006; 26: 1008–1014.</mixed-citation><mixed-citation xml:lang="en">Sata M. Role of circulating vascular progenitors in angiogenesis vascular healing and pulmonary hypertension: lessons from animal models. Arterioscler. Thromb. Vasc. Biol. 2006; 26: 1008–1014.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao Y.D., Courtman D.W., Deng Y. et al. Rescue of pulmonary hypertension using endothelial-like progenitor cells. Circ. Res. 2005; 96: 442–450.</mixed-citation><mixed-citation xml:lang="en">Zhao Y.D., Courtman D.W., Deng Y. et al. Rescue of pulmonary hypertension using endothelial-like progenitor cells. Circ. Res. 2005; 96: 442–450.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kanki-Horimoto S., Horimoto H., Mieno S. et al. Implantation of mesenchimal stem cell overexpressing eNOS improves right ventricular impairments caused by pulmonary hypertension. Circulation 2006; 114: 181–185.</mixed-citation><mixed-citation xml:lang="en">Kanki-Horimoto S., Horimoto H., Mieno S. et al. Implantation of mesenchimal stem cell overexpressing eNOS improves right ventricular impairments caused by pulmonary hypertension. Circulation 2006; 114: 181–185.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Russwurm M., Mergia E., Mulleshausen F. et al. Inhibition of deactivation of NO-sensitive guanylyl cyclase account for the sensitizing effect of YC-1. J. Biol. Chem. 2002; 277: 24883–24888.</mixed-citation><mixed-citation xml:lang="en">Russwurm M., Mergia E., Mulleshausen F. et al. Inhibition of deactivation of NO-sensitive guanylyl cyclase account for the sensitizing effect of YC-1. J. Biol. Chem. 2002; 277: 24883–24888.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
