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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2014-0-1-91-96</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-201</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>СОВРЕМЕННЫЕ ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ АНТИЛЕЙКОТРИЕНОВЫХ ПРЕПАРАТОВ В ЛЕЧЕНИИ БРОНХИАЛЬНОЙ АСТМЫ У ВЗРОСЛЫХ</article-title><trans-title-group xml:lang="en"><trans-title>CURRENT ADMINISTRATION OF ANTILEUKOTRIENES IN ADULTS WITH ASTHMA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранова</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranova</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор кафедры госпитальной терапии педиатрического факультета РГМУ; тел.: (495) 965-45-20</p></bio><email xlink:type="simple">baranova@ro.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО "РНИМУ им. Н.И.Пирогова" Росздрава: 117997, Москва, ул. Островитянова, 1</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2014</year></pub-date><volume>0</volume><issue>1</issue><fpage>91</fpage><lpage>96</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баранова И.А., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Баранова И.А.</copyright-holder><copyright-holder xml:lang="en">Baranova I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/201">https://journal.pulmonology.ru/pulm/article/view/201</self-uri><abstract><p>О современных возможностях применения антилейкотриеновых препаратов в лечении бронхиальной астмы у взрослых.</p></abstract><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>антилейкотриеновые препараты</kwd><kwd>монтелукаст</kwd><kwd>аспириновая бронхиальная астма</kwd><kwd>аллергический ринит</kwd><kwd>астма физического усилия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>asthma</kwd><kwd>antileukotrienes</kwd><kwd>montelukast</kwd><kwd>aspirin-induced asthma</kwd><kwd>allergic rhinitis</kwd><kwd>exercise-induced asthma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Curschmann H. Ueber Bronchiolitis exsudative und ihr Verhaltniss zum Asthma nervosum. Dtsch. Arch. Klin. Med. 1882; 32: 1–34.</mixed-citation><mixed-citation xml:lang="en">Curschmann H. Ueber Bronchiolitis exsudative und ihr Verhaltniss zum Asthma nervosum. Dtsch. Arch. Klin. Med. 1882; 32: 1–34.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hay D.W. Pharmacology of leukotriene receptor antagonists. More than inhibitors of bronchoconstriction. Chest 1997; 111 (2, Suppl.): 35S–45S.</mixed-citation><mixed-citation xml:lang="en">Hay D.W. Pharmacology of leukotriene receptor antagonists. More than inhibitors of bronchoconstriction. Chest 1997; 111 (2, Suppl.): 35S–45S.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Lipworth B.J. Leukotriene-receptor antagonists. Lancet 1999; 353 (9146): 57–62.</mixed-citation><mixed-citation xml:lang="en">Lipworth B.J. Leukotriene-receptor antagonists. Lancet 1999; 353 (9146): 57–62.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Drazen J.M., Israel E., O'Byrne P.M. Treatment of asthma with drugs modifying the leukotriene pathway. N. Engl. J. Med. 1999; 340 (3): 197–206.</mixed-citation><mixed-citation xml:lang="en">Drazen J.M., Israel E., O'Byrne P.M. Treatment of asthma with drugs modifying the leukotriene pathway. N. Engl. J. Med. 1999; 340 (3): 197–206.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes N.C., Miller C.J. Effect of leukotriene receptor antagonist therapy on the risk of asthma exacerbations in patients with mild to moderate asthma: an integrated analysis of zafirlukast trials. Thorax 2000; 55 (6): 478–483.</mixed-citation><mixed-citation xml:lang="en">Barnes N.C., Miller C.J. Effect of leukotriene receptor antagonist therapy on the risk of asthma exacerbations in patients with mild to moderate asthma: an integrated analysis of zafirlukast trials. Thorax 2000; 55 (6): 478–483.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chauhan B.F., Ducharme F.M. Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and / or chronic asthma in adults and children. Cochrane Database Syst. Rev. 2012; 5: CD002314.</mixed-citation><mixed-citation xml:lang="en">Chauhan B.F., Ducharme F.M. Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and / or chronic asthma in adults and children. Cochrane Database Syst. Rev. 2012; 5: CD002314.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Глобальная стратегия лечения и профилактики бронхиальной астмы. Пересмотр 2011 г.: Пер. с англ. Под ред. А.С.Белевского. М.: Российское респираторное общество; 2012.</mixed-citation><mixed-citation xml:lang="en">Глобальная стратегия лечения и профилактики бронхиальной астмы. Пересмотр 2011 г.: Пер. с англ. Под ред. А.С.Белевского. М.: Российское респираторное общество; 2012.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson H.S., Busse W.W., Kerwin E. et al. Fluticasone propionate / salmeterol combination provides more effective asthma control than low-dose inhaled corticosteroid plus montelukast. J. Allergy Clin. Immunol. 2000; 106 (6):1088–1095.</mixed-citation><mixed-citation xml:lang="en">Nelson H.S., Busse W.W., Kerwin E. et al. Fluticasone propionate / salmeterol combination provides more effective asthma control than low-dose inhaled corticosteroid plus montelukast. J. Allergy Clin. Immunol. 2000; 106 (6):1088–1095.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Fish J.E., Israel E., Murray J.J. et al. Salmeterol powder provides significantly better benefit than montelukast in asthmatic patients receiving concomitant inhaled corticosteroid therapy. Chest 2001; 120 (2): 423–430.</mixed-citation><mixed-citation xml:lang="en">Fish J.E., Israel E., Murray J.J. et al. Salmeterol powder provides significantly better benefit than montelukast in asthmatic patients receiving concomitant inhaled corticosteroid therapy. Chest 2001; 120 (2): 423–430.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ringdal N., Eliraz A., Pruzinec R. et al. The salmeterol / fluticasone combination is more effective than fluticasone plus oral montelukast in asthma. Respir. Med. 2003; 97 (3):234–241.</mixed-citation><mixed-citation xml:lang="en">Ringdal N., Eliraz A., Pruzinec R. et al. The salmeterol / fluticasone combination is more effective than fluticasone plus oral montelukast in asthma. Respir. Med. 2003; 97 (3):234–241.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Deykin A., Wechsler M.E., Boushey H.A. et al. Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma. Am. J. Respir. Crit. Care Med. 2007; 175 (3): 228–234.</mixed-citation><mixed-citation xml:lang="en">Deykin A., Wechsler M.E., Boushey H.A. et al. Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma. Am. J. Respir. Crit. Care Med. 2007; 175 (3): 228–234.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Kraft M., Djukanovic R., Wilson S. et al. Alveolar tissue inflammation in asthma. Am. J. Respir. Crit. Care Med. 1996; 154 (5): 1505–1510.</mixed-citation><mixed-citation xml:lang="en">Kraft M., Djukanovic R., Wilson S. et al. Alveolar tissue inflammation in asthma. Am. J. Respir. Crit. Care Med. 1996; 154 (5): 1505–1510.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bjermer L. The role of small airway disease in asthma. Curr. Opin. Pulm. Med. 2014; 20 (1): 23–30.</mixed-citation><mixed-citation xml:lang="en">Bjermer L. The role of small airway disease in asthma. Curr. Opin. Pulm. Med. 2014; 20 (1): 23–30.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bjermer L. History and future perspectives of treating asthma as a systemic and small airways disease. Respir. Med. 2001; 95 (9): 703–719.</mixed-citation><mixed-citation xml:lang="en">Bjermer L. History and future perspectives of treating asthma as a systemic and small airways disease. Respir. Med. 2001; 95 (9): 703–719.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Balzar S., Chu H.W., Strand M., Wenzel S. Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am. J. Respir. Crit. Care Med. 2005; 171 (5): 431–439.</mixed-citation><mixed-citation xml:lang="en">Balzar S., Chu H.W., Strand M., Wenzel S. Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am. J. Respir. Crit. Care Med. 2005; 171 (5): 431–439.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Wenzel S.E., Szefler S.J., Leung D.Y. et al. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am. J. Respir. Crit. Care Med. 1997; 156 (3, Pt 1): 737–743.</mixed-citation><mixed-citation xml:lang="en">Wenzel S.E., Szefler S.J., Leung D.Y. et al. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am. J. Respir. Crit. Care Med. 1997; 156 (3, Pt 1): 737–743.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Chen X., Wang K., Jiang M., Nong G.M. Leukotriene receptor antagonists for small-airway abnormalities in asthmatics: a systematic review and meta-analysis. J. Asthma 2013; 50 (7): 695–704.</mixed-citation><mixed-citation xml:lang="en">Chen X., Wang K., Jiang M., Nong G.M. Leukotriene receptor antagonists for small-airway abnormalities in asthmatics: a systematic review and meta-analysis. J. Asthma 2013; 50 (7): 695–704.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Yasui H., Fujisawa T., Inui N. et al. Impact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammation. Respir. Med. 2012; 106 (4): 508–514.</mixed-citation><mixed-citation xml:lang="en">Yasui H., Fujisawa T., Inui N. et al. Impact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammation. Respir. Med. 2012; 106 (4): 508–514.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Abdel Aziz R.R., Helaly N.Y., Zalata K.R., Gameil N.M. Influence of inhaled beclomethasone and montelukast on airway remodeling in mice. Inflammopharmacology 2013; 21 (1): 55–66.</mixed-citation><mixed-citation xml:lang="en">Abdel Aziz R.R., Helaly N.Y., Zalata K.R., Gameil N.M. Influence of inhaled beclomethasone and montelukast on airway remodeling in mice. Inflammopharmacology 2013; 21 (1): 55–66.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bousquet J., Khaltaev N., Cruz A.A. et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008; 63 (Suppl. 86): 8–160.</mixed-citation><mixed-citation xml:lang="en">Bousquet J., Khaltaev N., Cruz A.A. et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008; 63 (Suppl. 86): 8–160.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Greisner W.A. 3rd, Settipane R.J., Settipane G.A. Co-existence of asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Asthma Proc. 1998; 19 (4): 185–188.</mixed-citation><mixed-citation xml:lang="en">Greisner W.A. 3rd, Settipane R.J., Settipane G.A. Co-existence of asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Asthma Proc. 1998; 19 (4): 185–188.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Philip G., Nayak A.S., Berger W.E. et al. The effect of montelukast on rhinitis symptoms in patients with asthma and seasonal allergic rhinitis. Curr. Med. Res. Opin. 2004; 20:1549–1558.</mixed-citation><mixed-citation xml:lang="en">Philip G., Nayak A.S., Berger W.E. et al. The effect of montelukast on rhinitis symptoms in patients with asthma and seasonal allergic rhinitis. Curr. Med. Res. Opin. 2004; 20:1549–1558.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Busse W.W., Casale T.B., Dykewicz M.S. et al. Efficacy of montelukast during the allergy season in patients with chronic asthma and seasonal aeroallergen sensitivity. Ann. Allergy Asthma Immunol. 2006; 96: 60–68.</mixed-citation><mixed-citation xml:lang="en">Busse W.W., Casale T.B., Dykewicz M.S. et al. Efficacy of montelukast during the allergy season in patients with chronic asthma and seasonal aeroallergen sensitivity. Ann. Allergy Asthma Immunol. 2006; 96: 60–68.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Price D.B., Swern A., Tozzi C.A. et al. Effect of montelukast on lung function in asthma patients with allergic rhinitis: analysis from the COMPACT trial. Allergy 2006; 61 (6):737–742.</mixed-citation><mixed-citation xml:lang="en">Price D.B., Swern A., Tozzi C.A. et al. Effect of montelukast on lung function in asthma patients with allergic rhinitis: analysis from the COMPACT trial. Allergy 2006; 61 (6):737–742.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Wenzel S.E., Szefler S.J., Leung D.Y. et al. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am. J. Respir. Crit. Care Med. 1997; 156(3, Pt 1): 737–743.</mixed-citation><mixed-citation xml:lang="en">Wenzel S.E., Szefler S.J., Leung D.Y. et al. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am. J. Respir. Crit. Care Med. 1997; 156(3, Pt 1): 737–743.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Green R.H., Brightling C.E., Woltmann G. et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002; 57 (10): 875–879.</mixed-citation><mixed-citation xml:lang="en">Green R.H., Brightling C.E., Woltmann G. et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002; 57 (10): 875–879.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J. Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 2013; 131 (3): 636–645. DOI: 10.1016/j.jaci. 2012.12.1564.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J. Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 2013; 131 (3): 636–645. DOI: 10.1016/j.jaci. 2012.12.1564.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Thomson N.C., Chaudhuri R. Asthma in smokers: challenges and opportunities. Curr. Opin. Pulm. Med. 2009; 15 (1):39–45.</mixed-citation><mixed-citation xml:lang="en">Thomson N.C., Chaudhuri R. Asthma in smokers: challenges and opportunities. Curr. Opin. Pulm. Med. 2009; 15 (1):39–45.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Moore A.R., Willoughby D.A. The role of cAMP regulation in controlling inflammation. Clin. Exp. Immunol. 1995; 101:387–389.</mixed-citation><mixed-citation xml:lang="en">Moore A.R., Willoughby D.A. The role of cAMP regulation in controlling inflammation. Clin. Exp. Immunol. 1995; 101:387–389.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson M. Effects of b2-agonists on resident and infiltrating inflammatory cells. J. Allergy Clin. Immunol. 2002; 110 (Suppl.): S282–S290.</mixed-citation><mixed-citation xml:lang="en">Johnson M. Effects of b2-agonists on resident and infiltrating inflammatory cells. J. Allergy Clin. Immunol. 2002; 110 (Suppl.): S282–S290.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Tintinger G.R., Theron A.J., Anderson R. et al. Comparison of the effects of selective and non-selective b-adrenergic agonists on the pro-inflammatory activities of human neutrophils in vitro. Inflammation 2000; 24: 239–249.</mixed-citation><mixed-citation xml:lang="en">Tintinger G.R., Theron A.J., Anderson R. et al. Comparison of the effects of selective and non-selective b-adrenergic agonists on the pro-inflammatory activities of human neutrophils in vitro. Inflammation 2000; 24: 239–249.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson R., Theron A.J., Gravett C.M. et al. Montelukast inhibits neutrophil pro-inflammatory activity by a cyclic AMP-dependent mechanism. Br. J. Pharmacol. 2009; 156:105–115.</mixed-citation><mixed-citation xml:lang="en">Anderson R., Theron A.J., Gravett C.M. et al. Montelukast inhibits neutrophil pro-inflammatory activity by a cyclic AMP-dependent mechanism. Br. J. Pharmacol. 2009; 156:105–115.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Gravett C.M., Theron A.J., Steel H.C. et al. Interactive inhibitory effects of formoterol and montelukast on activated human neutrophils. Eur. Respir. J. 2010; 36 (6):1417–1424.</mixed-citation><mixed-citation xml:lang="en">Gravett C.M., Theron A.J., Steel H.C. et al. Interactive inhibitory effects of formoterol and montelukast on activated human neutrophils. Eur. Respir. J. 2010; 36 (6):1417–1424.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Thomson N.C., Chaudhuri R. Asthma in smokers: challenges and opportunities. Curr. Opin. Pulm. Med. 2009; 15 (1):39–45.</mixed-citation><mixed-citation xml:lang="en">Thomson N.C., Chaudhuri R. Asthma in smokers: challenges and opportunities. Curr. Opin. Pulm. Med. 2009; 15 (1):39–45.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Price D., Popov T.A., Bjermer L. et al. Effect of montelukast for treatment of asthma in cigarette smokers. J. Allergy Clin. Immunol. 2013; 131 (3): 763–771.</mixed-citation><mixed-citation xml:lang="en">Price D., Popov T.A., Bjermer L. et al. Effect of montelukast for treatment of asthma in cigarette smokers. J. Allergy Clin. Immunol. 2013; 131 (3): 763–771.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Takemura M., Niimi A., Matsumoto H. et al. Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma. Respiration 2012; 83 (4): 308–315.</mixed-citation><mixed-citation xml:lang="en">Takemura M., Niimi A., Matsumoto H. et al. Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma. Respiration 2012; 83 (4): 308–315.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Picado C. Aspirin-intolerant asthma: role of cyclo-oxygenase enzymes. Allergy 2002; Suppl. 72: 58–60.</mixed-citation><mixed-citation xml:lang="en">Picado C. Aspirin-intolerant asthma: role of cyclo-oxygenase enzymes. Allergy 2002; Suppl. 72: 58–60.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Arm J.P., O'Hickey S.P., Spur B.W., Lee T.H. Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma. Am. Rev. Respir. Dis. 1989; 140: 148–153.</mixed-citation><mixed-citation xml:lang="en">Arm J.P., O'Hickey S.P., Spur B.W., Lee T.H. Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma. Am. Rev. Respir. Dis. 1989; 140: 148–153.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlen S.E., Malmstrom K., Nizankowska E. et al. Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebocontrolled trial. Am. J. Respir. Crit. Care Med. 2002; 165 (1): 9–14.</mixed-citation><mixed-citation xml:lang="en">Dahlen S.E., Malmstrom K., Nizankowska E. et al. Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebocontrolled trial. Am. J. Respir. Crit. Care Med. 2002; 165 (1): 9–14.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Park J.S., Jang A.S., Park S.W. et al. Protection of leukotriene receptor antagonist against aspirin-induced bronchospasm in asthmatics. Allergy Asthma Immunol. Res. 2010; 2 (1): 48–54.</mixed-citation><mixed-citation xml:lang="en">Park J.S., Jang A.S., Park S.W. et al. Protection of leukotriene receptor antagonist against aspirin-induced bronchospasm in asthmatics. Allergy Asthma Immunol. Res. 2010; 2 (1): 48–54.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Schäper C., Noga O., Koch B. et al. Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis. J. Invest. Allergol. Clin. Immunol. 2011; 21 (1): 51–58.</mixed-citation><mixed-citation xml:lang="en">Schäper C., Noga O., Koch B. et al. Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis. J. Invest. Allergol. Clin. Immunol. 2011; 21 (1): 51–58.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Nonaka M., Sakanushi A., Kusama K. et al. One-year evaluation of combined treatment with an intranasal corticosteroid and montelukast for chronic rhinosinusitis associated with asthma. J. Nippon Med. Sch. 2010; 77 (1): 21–28.</mixed-citation><mixed-citation xml:lang="en">Nonaka M., Sakanushi A., Kusama K. et al. One-year evaluation of combined treatment with an intranasal corticosteroid and montelukast for chronic rhinosinusitis associated with asthma. J. Nippon Med. Sch. 2010; 77 (1): 21–28.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">de Benedictis F.M., Vaccher S., de Benedictis D. Montelukast sodium for exercise-induced asthma. Drugs Today (Barc). 2008; 44 (11): 845–855.</mixed-citation><mixed-citation xml:lang="en">de Benedictis F.M., Vaccher S., de Benedictis D. Montelukast sodium for exercise-induced asthma. Drugs Today (Barc). 2008; 44 (11): 845–855.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Kaminsky D.A., Bates J.H., Irvin C.G. Effects of cool, dry air stimulation on peripheral lung mechanics in asthma. Am. J. Respir. Crit. Care Med. 2000;162 (1): 179–186.</mixed-citation><mixed-citation xml:lang="en">Kaminsky D.A., Bates J.H., Irvin C.G. Effects of cool, dry air stimulation on peripheral lung mechanics in asthma. Am. J. Respir. Crit. Care Med. 2000;162 (1): 179–186.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Kemp J.P., Dockhorn R.J., Busse W.W. et al. Prolonged effect of inhaled salmeterol against exercise-induced bronchospasm. Am. J. Respir. Crit. Care Med. 1994; 150 (6, Pt 1):1612–1615.</mixed-citation><mixed-citation xml:lang="en">Kemp J.P., Dockhorn R.J., Busse W.W. et al. Prolonged effect of inhaled salmeterol against exercise-induced bronchospasm. Am. J. Respir. Crit. Care Med. 1994; 150 (6, Pt 1):1612–1615.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">de Benedictis F.M., Vaccher S., de Benedictis D. Montelukast sodium for exercise-induced asthma. Drugs Today (Barc) 2008; 44 (11): 845–855.</mixed-citation><mixed-citation xml:lang="en">de Benedictis F.M., Vaccher S., de Benedictis D. Montelukast sodium for exercise-induced asthma. Drugs Today (Barc) 2008; 44 (11): 845–855.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Villaran C., O'Neill S.J., Helbling A. et al. Montelukast versus salmeterol in patients with asthma and exercise-induced bronchoconstriction. Montelukast / Salmeterol Exercise Study Group. J. Allergy Clin. Immunol. 1999; 104 (3, Pt 1):547–553.</mixed-citation><mixed-citation xml:lang="en">Villaran C., O'Neill S.J., Helbling A. et al. Montelukast versus salmeterol in patients with asthma and exercise-induced bronchoconstriction. Montelukast / Salmeterol Exercise Study Group. J. Allergy Clin. Immunol. 1999; 104 (3, Pt 1):547–553.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Edelman J.M., Turpin J.A., Bronsky E.A. et al. Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction. A randomized, doubleblind trial. Exercise Study Group. Ann. Intern. Med. 2000; 132 (2): 97–104.</mixed-citation><mixed-citation xml:lang="en">Edelman J.M., Turpin J.A., Bronsky E.A. et al. Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction. A randomized, doubleblind trial. Exercise Study Group. Ann. Intern. Med. 2000; 132 (2): 97–104.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Storms W., Chervinsky P., Ghannam A.F. et al. A comparison of the effects of oral montelukast and inhaled salmeterol on response to rescue bronchodilation after challenge. Respir. Med. 2004; 98 (11): 1051–1062.</mixed-citation><mixed-citation xml:lang="en">Storms W., Chervinsky P., Ghannam A.F. et al. A comparison of the effects of oral montelukast and inhaled salmeterol on response to rescue bronchodilation after challenge. Respir. Med. 2004; 98 (11): 1051–1062.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Camargo C.A. Jr, Gurner D.M., Smithline H.A. et al. A randomized placebo-controlled study of intravenous montelukast for the treatment of acute asthma. J. Allergy Clin. Immunol. 2010; 125 (2): 374–380.</mixed-citation><mixed-citation xml:lang="en">Camargo C.A. Jr, Gurner D.M., Smithline H.A. et al. A randomized placebo-controlled study of intravenous montelukast for the treatment of acute asthma. J. Allergy Clin. Immunol. 2010; 125 (2): 374–380.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Watts K., Chavasse R.J. Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children. Cochrane Database Syst. Rev. 2012; 5: CD006100.</mixed-citation><mixed-citation xml:lang="en">Watts K., Chavasse R.J. Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children. Cochrane Database Syst. Rev. 2012; 5: CD006100.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson S.R., Strub P., Buist A.S. et al. Shared treatment decision making improves adherence and outcomes in poorly controlled asthma. Am. J. Respir. Crit. Care Med. 2010; 181: 566–577.</mixed-citation><mixed-citation xml:lang="en">Wilson S.R., Strub P., Buist A.S. et al. Shared treatment decision making improves adherence and outcomes in poorly controlled asthma. Am. J. Respir. Crit. Care Med. 2010; 181: 566–577.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Storms W., Michele T.M., Knorr B. et al. Clinical safety and tolerability of montelukast, a leukotriene receptor antagonist, in controlled clinical trials in patients aged &gt; or = 6 years. Clin. Exp. Allergy 2001; 31 (1): 77–87.</mixed-citation><mixed-citation xml:lang="en">Storms W., Michele T.M., Knorr B. et al. Clinical safety and tolerability of montelukast, a leukotriene receptor antagonist, in controlled clinical trials in patients aged &gt; or = 6 years. Clin. Exp. Allergy 2001; 31 (1): 77–87.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Bakhireva L.N., Jones K.L., Schatz M. et al. Safety of leukotriene receptor antagonists in pregnancy. J. Allergy Clin. Immunol. 2007; 119 (3): 618–625.</mixed-citation><mixed-citation xml:lang="en">Bakhireva L.N., Jones K.L., Schatz M. et al. Safety of leukotriene receptor antagonists in pregnancy. J. Allergy Clin. Immunol. 2007; 119 (3): 618–625.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Sarkar M., Koren G., Kalra S. et al. Montelukast use during pregnancy: a multicentre, prospective, comparative study of infant outcomes. Eur. J. Clin. Pharmacol. 2009; 65 (12):1259–1264.</mixed-citation><mixed-citation xml:lang="en">Sarkar M., Koren G., Kalra S. et al. Montelukast use during pregnancy: a multicentre, prospective, comparative study of infant outcomes. Eur. J. Clin. Pharmacol. 2009; 65 (12):1259–1264.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
