<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2007-0-6-110-118</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-2008</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Небулайзерная терапия суспензией будесонида при обострениях бронхиальной астмы и хронической обструктивной болезни легких</article-title><trans-title-group xml:lang="en"><trans-title>Nebulized therapy with suspension of budesonide in exacerbations of asthma and chronic obstructive pulmonary disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авдеев</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Avdeev</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГУ НИИ пульмонологии Росздрава</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2007</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2007</year></pub-date><volume>0</volume><issue>6</issue><fpage>110</fpage><lpage>118</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Авдеев С.Н., 2007</copyright-statement><copyright-year>2007</copyright-year><copyright-holder xml:lang="ru">Авдеев С.Н.</copyright-holder><copyright-holder xml:lang="en">Avdeev S.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/2008">https://journal.pulmonology.ru/pulm/article/view/2008</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Global Initiative for Chronic Obstructive Lung Diseas (GOLD). Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO workshop report. The 2006 report is available on www.goldcopd.com</mixed-citation><mixed-citation xml:lang="en">Global Initiative for Chronic Obstructive Lung Diseas (GOLD). Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO workshop report. The 2006 report is available on www.goldcopd.com</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Global strategy for asthma management and prevention NHLBI/WHO Workshop Report: NIH Publication No 02–3659. The 2006 report is available on www.ginasthma.com</mixed-citation><mixed-citation xml:lang="en">Global strategy for asthma management and prevention NHLBI/WHO Workshop Report: NIH Publication No 02–3659. The 2006 report is available on www.ginasthma.com</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998; 351: 1225–1232.</mixed-citation><mixed-citation xml:lang="en">International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998; 351: 1225–1232.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Buist A.S., McBurnie M.A., Vollmer W.M. et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet 2007; 370: 741–750.</mixed-citation><mixed-citation xml:lang="en">Buist A.S., McBurnie M.A., Vollmer W.M. et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet 2007; 370: 741–750.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Rowe B.H., Keller J.L., Oxman A.D. Effectiveness of steroid therapy in acute exacerbations of asthma: a meta-analysis. Am. J. Emerg. Med. 1992; 10: 301–310.</mixed-citation><mixed-citation xml:lang="en">Rowe B.H., Keller J.L., Oxman A.D. Effectiveness of steroid therapy in acute exacerbations of asthma: a meta-analysis. Am. J. Emerg. Med. 1992; 10: 301–310.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Rowe B.H., Bota G.W., Fabris L. et al. Inhaled budesonide in addition to oral corticosteroids to prevent asthma relapse following discharge from the emergency department: a randomized controlled trial. J. A. M. A. 1999; 281: 2119–2126.</mixed-citation><mixed-citation xml:lang="en">Rowe B.H., Bota G.W., Fabris L. et al. Inhaled budesonide in addition to oral corticosteroids to prevent asthma relapse following discharge from the emergency department: a randomized controlled trial. J. A. M. A. 1999; 281: 2119–2126.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Davies L., Angus R.M., Calverley P.M. Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial. Lancet 1999; 354: 456–460.</mixed-citation><mixed-citation xml:lang="en">Davies L., Angus R.M., Calverley P.M. Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial. Lancet 1999; 354: 456–460.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Niewoehner D.E., Erbland M.L., Deupree R.H. et al. Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group. N. Engl. J. Med. 1999; 340: 1941–1947.</mixed-citation><mixed-citation xml:lang="en">Niewoehner D.E., Erbland M.L., Deupree R.H. et al. Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group. N. Engl. J. Med. 1999; 340: 1941–1947.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Shee C.D. Risk factors for hydrocortisone myopathy in acute severe asthma. Respir. Med. 1990; 84: 229–233.</mixed-citation><mixed-citation xml:lang="en">Shee C.D. Risk factors for hydrocortisone myopathy in acute severe asthma. Respir. Med. 1990; 84: 229–233.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Matsumoto H., Ishihara K., Hasegawa T. et al. Effects of inhaled corticosteroid and short courses of oral corticosteroids on bone mineral density in asthmatic patients: a 4year longitudinal study. Chest 2001; 120: 1468–1473.</mixed-citation><mixed-citation xml:lang="en">Matsumoto H., Ishihara K., Hasegawa T. et al. Effects of inhaled corticosteroid and short courses of oral corticosteroids on bone mineral density in asthmatic patients: a 4year longitudinal study. Chest 2001; 120: 1468–1473.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Rodrigo G., Rodrigo C. Corticosteroids in the emergency department therapy of acute adult asthma: аn evidencebased evaluation. Chest 1999; 116: 285–295.</mixed-citation><mixed-citation xml:lang="en">Rodrigo G., Rodrigo C. Corticosteroids in the emergency department therapy of acute adult asthma: аn evidencebased evaluation. Chest 1999; 116: 285–295.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Pedersen S., O’Byrne P. A comparison of the efficacy and safety of inhaled corticosteroids in asthma. Allergy 1997; 52 (suppl. 39): 1–34.</mixed-citation><mixed-citation xml:lang="en">Pedersen S., O’Byrne P. A comparison of the efficacy and safety of inhaled corticosteroids in asthma. Allergy 1997; 52 (suppl. 39): 1–34.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rodrigo G., Rodrigo C. Inhaled flunisolide for acute severe asthma. Am. J. Respir. Crit. Care Med. 1998; 157: 698–703.</mixed-citation><mixed-citation xml:lang="en">Rodrigo G., Rodrigo C. Inhaled flunisolide for acute severe asthma. Am. J. Respir. Crit. Care Med. 1998; 157: 698–703.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rodrigo G.J. Rapid effects of inhaled corticosteroids in acute asthma. An evidence-based evaluation. Chest 2006; 130; 1301–1311.</mixed-citation><mixed-citation xml:lang="en">Rodrigo G.J. Rapid effects of inhaled corticosteroids in acute asthma. An evidence-based evaluation. Chest 2006; 130; 1301–1311.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Belda J., Margarit G., Martinez C. et al. Anti-inflammatory effects of high-dose inhaled fluticasone versus oral prednisone in asthma exacerbations. Eur. Respir. J. 2007; 30: 1143–1149.</mixed-citation><mixed-citation xml:lang="en">Belda J., Margarit G., Martinez C. et al. Anti-inflammatory effects of high-dose inhaled fluticasone versus oral prednisone in asthma exacerbations. Eur. Respir. J. 2007; 30: 1143–1149.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Авдеев С.Н. Использование небулайзеров в клинической практике. Рус. мед. журн. 2001; 9 (5): 189–196.</mixed-citation><mixed-citation xml:lang="en">Авдеев С.Н. Использование небулайзеров в клинической практике. Рус. мед. журн. 2001; 9 (5): 189–196.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Packe G.E., Douglas J.G., McDonald A.F. et al. Bone density in asthmatic patients taking high dose inhaled beclomethasone dipropionate and intermittent systemic corticosteroids. Thorax 1992; 47: 414–417.</mixed-citation><mixed-citation xml:lang="en">Packe G.E., Douglas J.G., McDonald A.F. et al. Bone density in asthmatic patients taking high dose inhaled beclomethasone dipropionate and intermittent systemic corticosteroids. Thorax 1992; 47: 414–417.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Dolan L.M., Kesarwala H.H., Holroyde J.C., Fischer T.J. Short-term, high-dose, systemic steroids in children with asthma: the effect on the hypothalamic–pituitary–adrenal axis. J. Allergy Clin. Immunol. 1987; 80: 81–87.</mixed-citation><mixed-citation xml:lang="en">Dolan L.M., Kesarwala H.H., Holroyde J.C., Fischer T.J. Short-term, high-dose, systemic steroids in children with asthma: the effect on the hypothalamic–pituitary–adrenal axis. J. Allergy Clin. Immunol. 1987; 80: 81–87.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Henzen C., Suter A., Lerch E. et al. Suppression and recovery of adrenal response after short-term, high-dose glucocorticoid treatment. Lancet 2000; 355: 542–545.</mixed-citation><mixed-citation xml:lang="en">Henzen C., Suter A., Lerch E. et al. Suppression and recovery of adrenal response after short-term, high-dose glucocorticoid treatment. Lancet 2000; 355: 542–545.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">McEvoy C.E., Niewoehner D.E. Adverse effects of corticosteroid therapy for COPD. A critical review. Chest 1997; 111: 732–743.</mixed-citation><mixed-citation xml:lang="en">McEvoy C.E., Niewoehner D.E. Adverse effects of corticosteroid therapy for COPD. A critical review. Chest 1997; 111: 732–743.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Messer J., Reitman D., Sacks H. et al. Association of adrenocorticosteroid therapy and peptic-ulcer disease. N. Engl. J. Med. 1983; 309: 21–24.</mixed-citation><mixed-citation xml:lang="en">Messer J., Reitman D., Sacks H. et al. Association of adrenocorticosteroid therapy and peptic-ulcer disease. N. Engl. J. Med. 1983; 309: 21–24.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Boston Collaborative Drug Surveillance Program. Acute adverse reactions to prednisone in relation to dosage. Clin. Pharmacol. Ther. 1972; 13: 694–702.</mixed-citation><mixed-citation xml:lang="en">Boston Collaborative Drug Surveillance Program. Acute adverse reactions to prednisone in relation to dosage. Clin. Pharmacol. Ther. 1972; 13: 694–702.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Decramer M., Lacquet L.M., Fagard R. et al. Corticosteroids contribute to muscle weakness in chronic airflow obstruction. Am. Rev. Respir. Dis. 1994; 150: 11–16.</mixed-citation><mixed-citation xml:lang="en">Decramer M., Lacquet L.M., Fagard R. et al. Corticosteroids contribute to muscle weakness in chronic airflow obstruction. Am. Rev. Respir. Dis. 1994; 150: 11–16.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Nava S., Fracchia C., Callegari G. et al. Weakness of respiratory and sceletal muscles after a short course of steroids in patients with acute lung rejection. Eur. Respir. J. 2002; 20: 497–499.</mixed-citation><mixed-citation xml:lang="en">Nava S., Fracchia C., Callegari G. et al. Weakness of respiratory and sceletal muscles after a short course of steroids in patients with acute lung rejection. Eur. Respir. J. 2002; 20: 497–499.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Bulpa P.A., Dive A.M., Garrino M.2G. et al. Chronic obstructive pulmonary disease patients with invasive pulmonary aspergillosis: benefits of intensive care? Intensive Care Med. 2001; 27: 59–67.</mixed-citation><mixed-citation xml:lang="en">Bulpa P.A., Dive A.M., Garrino M.2G. et al. Chronic obstructive pulmonary disease patients with invasive pulmonary aspergillosis: benefits of intensive care? Intensive Care Med. 2001; 27: 59–67.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bulpa P., Dive A., Sibille Y. Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease. Eur. Respir. J. 2007; 30: 782–800.</mixed-citation><mixed-citation xml:lang="en">Bulpa P., Dive A., Sibille Y. Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease. Eur. Respir. J. 2007; 30: 782–800.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Aberdein J., Singer M. Clinical review: а systematic review of corticosteroid use in infections. Critical Care 2006, 10: 203 (doi:10.1186/cc3904).</mixed-citation><mixed-citation xml:lang="en">Aberdein J., Singer M. Clinical review: а systematic review of corticosteroid use in infections. Critical Care 2006, 10: 203 (doi:10.1186/cc3904).</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Wood2Baker R., Walters J., Walters E.H. Systemic corticosteroids in chronic obstructive pulmonary disease: аn overview of Cochrane systematic reviews. Respir. Med. 2007; 101: 371–377.</mixed-citation><mixed-citation xml:lang="en">Wood2Baker R., Walters J., Walters E.H. Systemic corticosteroids in chronic obstructive pulmonary disease: аn overview of Cochrane systematic reviews. Respir. Med. 2007; 101: 371–377.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Nehme O., Rachoin J.2S., Azar M. et al. Glycemic control during inhospital corticosteroid treatment for exaxerbations of obstructive airway disease. Chest Meet. Abstr. 2006; 130: 184S-d–185S-d.</mixed-citation><mixed-citation xml:lang="en">Nehme O., Rachoin J.2S., Azar M. et al. Glycemic control during inhospital corticosteroid treatment for exaxerbations of obstructive airway disease. Chest Meet. Abstr. 2006; 130: 184S-d–185S-d.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Baker E.H., Janaway C.H., Philips B.J. et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax 2006; 61: 284–289.</mixed-citation><mixed-citation xml:lang="en">Baker E.H., Janaway C.H., Philips B.J. et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax 2006; 61: 284–289.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Huiart L., Ernst P., Ranouil X., Suissa S. Oral corticosteroid use and the risk of acute myocardial infarction in chronic obstructive pulmonary disease. Can. Respir. J. 2006; 13: 134–138.</mixed-citation><mixed-citation xml:lang="en">Huiart L., Ernst P., Ranouil X., Suissa S. Oral corticosteroid use and the risk of acute myocardial infarction in chronic obstructive pulmonary disease. Can. Respir. J. 2006; 13: 134–138.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson A.M., McFarlane L.C., Lipworth B.J. Systemic bioactivity profiles of oral prednisolone and nebulized budesonide in adult asthmatics. Chest 1998; 114: 1022–1029.</mixed-citation><mixed-citation xml:lang="en">Wilson A.M., McFarlane L.C., Lipworth B.J. Systemic bioactivity profiles of oral prednisolone and nebulized budesonide in adult asthmatics. Chest 1998; 114: 1022–1029.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Morice A.H., Morris D., Lawson2Matthew P. A comparison of nebulized budesonide wiyth oral prednisolone in the treatment of exacerbations of obstructive pulmonary disease. Clin. Pharmacol. Ther. 1996; 60: 675–678.</mixed-citation><mixed-citation xml:lang="en">Morice A.H., Morris D., Lawson2Matthew P. A comparison of nebulized budesonide wiyth oral prednisolone in the treatment of exacerbations of obstructive pulmonary disease. Clin. Pharmacol. Ther. 1996; 60: 675–678.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">McFadden E.R. Inhaled corticosteroids and acute asthma. Therapeutic breakthrough or nonspecific effect? Am. J. Respir. Crit. Care Med. 1998; 157: 677–678.</mixed-citation><mixed-citation xml:lang="en">McFadden E.R. Inhaled corticosteroids and acute asthma. Therapeutic breakthrough or nonspecific effect? Am. J. Respir. Crit. Care Med. 1998; 157: 677–678.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar S.D., Emery M.J., Atkins N.D. et al. Airway mucosal blood flow in bronchial asthma. Am. J. Respir. Crit. Care Med. 1998; 158: 153–156.</mixed-citation><mixed-citation xml:lang="en">Kumar S.D., Emery M.J., Atkins N.D. et al. Airway mucosal blood flow in bronchial asthma. Am. J. Respir. Crit. Care Med. 1998; 158: 153–156.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar S.D., Brieva J.L., Danta I. et al. Transient effect of inhaled fluticasone on airway mucosal blood flow in subjects with and without asthma. Am. J. Respir. Crit. Care Med. 2000; 161: 918–921.</mixed-citation><mixed-citation xml:lang="en">Kumar S.D., Brieva J.L., Danta I. et al. Transient effect of inhaled fluticasone on airway mucosal blood flow in subjects with and without asthma. Am. J. Respir. Crit. Care Med. 2000; 161: 918–921.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Mendes E.S., Pereira A., Danta I. et al. Comparative bronchial vasoconstrictive efficacy of inhaled glucocorticosteroids. Eur. Respir. J. 2003; 21: 989–993.</mixed-citation><mixed-citation xml:lang="en">Mendes E.S., Pereira A., Danta I. et al. Comparative bronchial vasoconstrictive efficacy of inhaled glucocorticosteroids. Eur. Respir. J. 2003; 21: 989–993.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Horvath G., Wanner A. Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma. Eur. Respir. J. 2006; 27: 172–187.</mixed-citation><mixed-citation xml:lang="en">Horvath G., Wanner A. Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma. Eur. Respir. J. 2006; 27: 172–187.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Wanner A., Horvath G., Brieva J.L. et al. Nongenomic actions of glucocorticosteroids on the airway vasculature in asthma. Proc. Am. Thorac. Soc. 2004; 1: 235–238.</mixed-citation><mixed-citation xml:lang="en">Wanner A., Horvath G., Brieva J.L. et al. Nongenomic actions of glucocorticosteroids on the airway vasculature in asthma. Proc. Am. Thorac. Soc. 2004; 1: 235–238.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Aziz I., Lipworth B.J. A bolus of inhaled budesonide rapidly reverses airway subsensitivity and 2-adrenoreceptor downregulation after regular inhaled formoterol. Chest 1999; 115: 623–628.</mixed-citation><mixed-citation xml:lang="en">Aziz I., Lipworth B.J. A bolus of inhaled budesonide rapidly reverses airway subsensitivity and 2-adrenoreceptor downregulation after regular inhaled formoterol. Chest 1999; 115: 623–628.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Lin R.Y., Newman T.G., Sauter D. et al. Association between reported use of inhaled triamcinolone and differential shortterm responses to aerosolized albuterol in asthmatics in an emergency department setting. Chest 1994; 106: 452–457.</mixed-citation><mixed-citation xml:lang="en">Lin R.Y., Newman T.G., Sauter D. et al. Association between reported use of inhaled triamcinolone and differential shortterm responses to aerosolized albuterol in asthmatics in an emergency department setting. Chest 1994; 106: 452–457.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Gibson P.G., Saltos N., Fakes K. Acute anti-inflammatory effects of inhaled budesonide in asthma. A randomized controlled trial. Am. J. Respir. Crit. Care Med. 2001; 163: 32–36.</mixed-citation><mixed-citation xml:lang="en">Gibson P.G., Saltos N., Fakes K. Acute anti-inflammatory effects of inhaled budesonide in asthma. A randomized controlled trial. Am. J. Respir. Crit. Care Med. 2001; 163: 32–36.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Rowe B.H., Vethanayagam D. The role of inhaled corticosteroids in the management of acute asthma. Eur. Respir. J. 2007; 30: 1035–1037.</mixed-citation><mixed-citation xml:lang="en">Rowe B.H., Vethanayagam D. The role of inhaled corticosteroids in the management of acute asthma. Eur. Respir. J. 2007; 30: 1035–1037.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Rodrigo G.J. Comparison of inhaled fluticasone with intravenous hydrocortisone in the treatment of adult acute asthma. Am. J. Respir. Crit. Care Med. 2005; 171: 1231–1236.</mixed-citation><mixed-citation xml:lang="en">Rodrigo G.J. Comparison of inhaled fluticasone with intravenous hydrocortisone in the treatment of adult acute asthma. Am. J. Respir. Crit. Care Med. 2005; 171: 1231–1236.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Pansegrouw D.F. Acute resistant asthma caused by excessive β2 -adrenoceptor agonist inhalation and reversed by inhalation of beclomethasone. S. Afr. Med. J. 1992; 82: 179–182.</mixed-citation><mixed-citation xml:lang="en">Pansegrouw D.F. Acute resistant asthma caused by excessive β2 -adrenoceptor agonist inhalation and reversed by inhalation of beclomethasone. S. Afr. Med. J. 1992; 82: 179–182.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Rodrigo G.J., Rodrigo C. Triple inhaled drug protocol for the treatment of acute severe asthma. Chest 2003; 123: 1908–1915.</mixed-citation><mixed-citation xml:lang="en">Rodrigo G.J., Rodrigo C. Triple inhaled drug protocol for the treatment of acute severe asthma. Chest 2003; 123: 1908–1915.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Цой А.Н., Аржакова Л.С., Архипов В.В. Фармакодинамика и клиническая эффективность ингаляционных глюкокортикостероидов у больных с обострением бронхиальной астмы. Пульмонология 2002; 3: 88–92.</mixed-citation><mixed-citation xml:lang="en">Цой А.Н., Аржакова Л.С., Архипов В.В. Фармакодинамика и клиническая эффективность ингаляционных глюкокортикостероидов у больных с обострением бронхиальной астмы. Пульмонология 2002; 3: 88–92.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Овчаренко С.И., Передельская О.А., Морозова Н.В., Ма2 колкин В.И. Небулайзерная терапия бронхолитиками и суспензией пульмикорта в лечении тяжелого обострения бронхиальной астмы. Пульмонология 2003; 6: 75–83.</mixed-citation><mixed-citation xml:lang="en">Овчаренко С.И., Передельская О.А., Морозова Н.В., Ма2 колкин В.И. Небулайзерная терапия бронхолитиками и суспензией пульмикорта в лечении тяжелого обострения бронхиальной астмы. Пульмонология 2003; 6: 75–83.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Mitchell C.A., Alpers J.H., Morton S.M. et al. Comparison of nebulized budesonide with oral prednisolone in the treatment of severe acute asthma. Eur. Respir. J. 1995; 8 (suppl. 19): 490s.</mixed-citation><mixed-citation xml:lang="en">Mitchell C.A., Alpers J.H., Morton S.M. et al. Comparison of nebulized budesonide with oral prednisolone in the treatment of severe acute asthma. Eur. Respir. J. 1995; 8 (suppl. 19): 490s.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Higgenbottam T.W., Britton J., Lawrence D. et al. On behalf of the Pulmicort Respules versus oral steroids: A prospective clinical trial in acute asthma. Comparison of nebulised budesonide and prednisolone in severe asthma exacerbation in adults. BioDrugs 2000; 14: 247–254.</mixed-citation><mixed-citation xml:lang="en">Higgenbottam T.W., Britton J., Lawrence D. et al. On behalf of the Pulmicort Respules versus oral steroids: A prospective clinical trial in acute asthma. Comparison of nebulised budesonide and prednisolone in severe asthma exacerbation in adults. BioDrugs 2000; 14: 247–254.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Ediger D., Coskun F., Kunt Uzaslan E. et al. Clinical effectiveness of nebulised budesonide in the treatment of acute asthma attacks. Tuberkuloz ve Toraks Dergisi 2006; 54: 128–136.</mixed-citation><mixed-citation xml:lang="en">Ediger D., Coskun F., Kunt Uzaslan E. et al. Clinical effectiveness of nebulised budesonide in the treatment of acute asthma attacks. Tuberkuloz ve Toraks Dergisi 2006; 54: 128–136.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Авдеев С.Н., Жестков А.В., Лещенко И.В. и др. Небулизированный будесонид при тяжелом обострении бронхиальной астмы: сравнение с системными стероидами. Мультицентровое рандомизированное контролируемое исследование. Пульмонология 2006; 4: 58–67.</mixed-citation><mixed-citation xml:lang="en">Авдеев С.Н., Жестков А.В., Лещенко И.В. и др. Небулизированный будесонид при тяжелом обострении бронхиальной астмы: сравнение с системными стероидами. Мультицентровое рандомизированное контролируемое исследование. Пульмонология 2006; 4: 58–67.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Maltais F., Ostinelli J., Bourbeau J. Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial. Am. J. Respir. Crit. Care Med. 2002; 165: 698–703.</mixed-citation><mixed-citation xml:lang="en">Maltais F., Ostinelli J., Bourbeau J. Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial. Am. J. Respir. Crit. Care Med. 2002; 165: 698–703.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Авдеев С.Н., Суточникова О.А., Белевский А.С., Чучалин А.Г. Применение небулизированного будесонида при тяжелом обострении хронической обструктивной болезни легких. Рандомизированное контролируемое исследование. Пульмонология 2003; 5: 81–88.</mixed-citation><mixed-citation xml:lang="en">Авдеев С.Н., Суточникова О.А., Белевский А.С., Чучалин А.Г. Применение небулизированного будесонида при тяжелом обострении хронической обструктивной болезни легких. Рандомизированное контролируемое исследование. Пульмонология 2003; 5: 81–88.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Gunen H., Hacievliyagil S.S., Yetkin O., Gulbas G. The role of nebulised budesonide in the treatment of acute exacerbations of COPD. Eur. Respir. J. 2007; 30: 399–400.</mixed-citation><mixed-citation xml:lang="en">Gunen H., Hacievliyagil S.S., Yetkin O., Gulbas G. The role of nebulised budesonide in the treatment of acute exacerbations of COPD. Eur. Respir. J. 2007; 30: 399–400.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Toogood J.H., Baskerville J., Jennings B. et al. Bioequivalent doses of budesonide and prednisone in moderate and severe asthma. J. Allergy Clin. Immunol. 1989; 84: 688–700.</mixed-citation><mixed-citation xml:lang="en">Toogood J.H., Baskerville J., Jennings B. et al. Bioequivalent doses of budesonide and prednisone in moderate and severe asthma. J. Allergy Clin. Immunol. 1989; 84: 688–700.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">British Thoracic Society and Scottish Intercollegiate Guidelines Network Guidelines on Asthma. Thorax 2003; 58 (suppl. I): i1–i94.</mixed-citation><mixed-citation xml:lang="en">British Thoracic Society and Scottish Intercollegiate Guidelines Network Guidelines on Asthma. Thorax 2003; 58 (suppl. I): i1–i94.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Harriman A.2M., Purcell N., Fleming S. et al. Can we mixt nebulizer solutions? Stability of drug admixtures in solutions for nebulizations. Pharm. Pract. 1996; 6: 347–348.</mixed-citation><mixed-citation xml:lang="en">Harriman A.2M., Purcell N., Fleming S. et al. Can we mixt nebulizer solutions? Stability of drug admixtures in solutions for nebulizations. Pharm. Pract. 1996; 6: 347–348.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Grцnberg S., Magnusson P., Bladh N. Chemical compartibility of budesonide inhalation suspension (Pulmicort Respules) with other nebulization products. Am. J. Respir. Crit. Care Med. 2001; 163: A558.</mixed-citation><mixed-citation xml:lang="en">Grцnberg S., Magnusson P., Bladh N. Chemical compartibility of budesonide inhalation suspension (Pulmicort Respules) with other nebulization products. Am. J. Respir. Crit. Care Med. 2001; 163: A558.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">McKenzie J.E., Cruz2Rivera M. Compatibility of budesonide inhalation suspension with four nebulizing solutions. Ann. Pharmacother. 2004; 38: 967–972.</mixed-citation><mixed-citation xml:lang="en">McKenzie J.E., Cruz2Rivera M. Compatibility of budesonide inhalation suspension with four nebulizing solutions. Ann. Pharmacother. 2004; 38: 967–972.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
