pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2007-0-5-94-99pulmo-1984Research ArticleОБЗОРЫREVIEWРоль клеток Клара в гистофизиологии бронхиолярного эпителия и их значение в развитии легочной патологииRole of Clara cells in histophysiology of bronchiolar epithelium and in lung pathologyБоркинаА. Н.BorkinaA. N.
г. Оренбург
Оренбургская государственная медицинская академия, Областная клиническая больница № 2Russian Federation200728102007059499Copyright © Боркина А.Н., 20072007Боркина А.Н.Borkina A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/1984
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ReferencesClara M. Zur Histobiologie des Bronchialepithels. Z. Mikr. Anat. Forsch. 1937; 4: 321–347.Clara M. Zur Histobiologie des Bronchialepithels. Z. Mikr. Anat. Forsch. 1937; 4: 321–347.Plopper C.G., Hyde D.M., Buckpitt A.R. Clara cells. In: Crystal R. G. and J. B. West, editors. The lung: scientific foundations. New York: Raven Press; 1991. 215–228.Plopper C.G., Hyde D.M., Buckpitt A.R. Clara cells. In: Crystal R. G. and J. B. West, editors. The lung: scientific foundations. New York: Raven Press; 1991. 215–228.Романова Л.К., Горячкина В.Л. Цитофизиология секреторных бронхиолярных клеток легкого — источника "антимедиаторов" воспаления. Арх. пат. 1999; 2: 20–27.Романова Л.К., Горячкина В.Л. Цитофизиология секреторных бронхиолярных клеток легкого — источника "антимедиаторов" воспаления. Арх. пат. 1999; 2: 20–27.Boers J.E., Ambergen A.W., Thunnissen F.B. Number and proliferation of Clara cells in normal human airway epithelium. Am. J. Respir. Crit. Care Med. 1999; 159: 1585–1591.Boers J.E., Ambergen A.W., Thunnissen F.B. Number and proliferation of Clara cells in normal human airway epithelium. Am. J. Respir. Crit. Care Med. 1999; 159: 1585–1591.Shijubo N., Itoh T., Yamaguchi Y. et al. Serum and BAL Clara cell 10 kDa protein (CC10) levels and CC10-positive bronchiolar cells are decreased in smokers. Eur. Respir. J. 1997; 10: 1108–1114.Shijubo N., Itoh T., Yamaguchi Y. et al. Serum and BAL Clara cell 10 kDa protein (CC10) levels and CC10-positive bronchiolar cells are decreased in smokers. Eur. Respir. J. 1997; 10: 1108–1114.Романова Л.К., Серебряков И.С., Лебедев Д.Б. и др. Особенности секреторной активности клеток респираторного отдела в легких мышей после частичной "химической симпатэктомии". Бюл. экспер. биол. 1988; 2: 231–234.Романова Л.К., Серебряков И.С., Лебедев Д.Б. и др. Особенности секреторной активности клеток респираторного отдела в легких мышей после частичной "химической симпатэктомии". Бюл. экспер. биол. 1988; 2: 231–234.Серебряков И.С. Клеточный состав и секреторная активность легочного эпителия в норме и при изменении функционального состояния вегетативной нервной системы: Дис.... канд. биол. наук. М.; 1984.Серебряков И.С. Клеточный состав и секреторная активность легочного эпителия в норме и при изменении функционального состояния вегетативной нервной системы: Дис.... канд. биол. наук. М.; 1984.Singh G., Katyal S.L. An immunologic study of the secretory products of rat Clara cells. J. Histochem. Cytochem. 1984; 32: 49–54.Singh G., Katyal S.L. An immunologic study of the secretory products of rat Clara cells. J. Histochem. Cytochem. 1984; 32: 49–54.Singh G., Katyal S.L., Brown W.E. et al. Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein [published erratum appears in Biochim. Biophys. Acta 1989; 1007 (2):243]. Biochim. Biophys. Acta 1988; 950: 329–337.Singh G., Katyal S.L., Brown W.E. et al. Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein [published erratum appears in Biochim. Biophys. Acta 1989; 1007 (2):243]. Biochim. Biophys. Acta 1988; 950: 329–337.Singh G., Katyal S.L. Clara cells and Clara cell 10 kD protein (CC10). Am. J. Respir. Cell Mol. Biol. 1997; 17: 141–143.Singh G., Katyal S.L. Clara cells and Clara cell 10 kD protein (CC10). Am. J. Respir. Cell Mol. Biol. 1997; 17: 141–143.Lesur O., Bernard A., Arsalane K. et al. Clara cell protein (CC-16) induces a phospholipase A2-mediated inhibition of fibroblast migration in vitro. Am. J. Respir. Crit. Care Med. 1995; 152: 290–297.Lesur O., Bernard A., Arsalane K. et al. Clara cell protein (CC-16) induces a phospholipase A2-mediated inhibition of fibroblast migration in vitro. Am. J. Respir. Crit. Care Med. 1995; 152: 290–297.Nomori H., Morinaga S., Kobayashi R. et al. Protein 1 and Clara cell 10-kDa protein distribution in normal and neoplastic tissues with emphasis on the respiratory system. Virch. Arch. 1994; (424): 517–523.Nomori H., Morinaga S., Kobayashi R. et al. Protein 1 and Clara cell 10-kDa protein distribution in normal and neoplastic tissues with emphasis on the respiratory system. Virch. Arch. 1994; (424): 517–523.Halatek T., Hermans C., Broeckaert F. et al. Quantification of Clara cell protein in rat and mouse biological fluids using a sensitive immunoassay. Eur. Respir. J. 1998; 11: 726–733.Halatek T., Hermans C., Broeckaert F. et al. Quantification of Clara cell protein in rat and mouse biological fluids using a sensitive immunoassay. Eur. Respir. J. 1998; 11: 726–733.Broers J.L., Jensen S.M., Travis W.D. et al. Expression of surfactant associated protein-A and Clara cell 10 kilodalton mRNA in neoplastic and non-neoplastic human lung tissue as detected by in situ hybridization. Lab. Invest. 1992; 66: 337–346.Broers J.L., Jensen S.M., Travis W.D. et al. Expression of surfactant associated protein-A and Clara cell 10 kilodalton mRNA in neoplastic and non-neoplastic human lung tissue as detected by in situ hybridization. Lab. Invest. 1992; 66: 337–346.Peri A., Cordella E., Miele L. Miele et al. Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein. J. Clin. Invest. 1993; 92: 2099–2109.Peri A., Cordella E., Miele L. Miele et al. Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein. J. Clin. Invest. 1993; 92: 2099–2109.Itoh Y., Ishii S., Okutani R. et al. Protein 1: its purification and application in clinical medicine. J. Clin. Lab. Anal. 1993; 7: 394–400.Itoh Y., Ishii S., Okutani R. et al. Protein 1: its purification and application in clinical medicine. J. Clin. Lab. Anal. 1993; 7: 394–400.Bernard A., Lauwerys R., Noel A. et al. Determination by latex immunoassay of protein 1 in normal and pathological urine. Clin. Chim. Acta 1991; 201: 231–245.Bernard A., Lauwerys R., Noel A. et al. Determination by latex immunoassay of protein 1 in normal and pathological urine. Clin. Chim. Acta 1991; 201: 231–245.Ishii S., Itoh Y., Okutani R. et al. Sex-associated differences in protein 1 values in urine: immunochemical detection of protein 1 in genital tissues. Eur. J. Clin. Chem. Clin. Biochem. 1994; 32: 31–36.Ishii S., Itoh Y., Okutani R. et al. Sex-associated differences in protein 1 values in urine: immunochemical detection of protein 1 in genital tissues. Eur. J. Clin. Chem. Clin. Biochem. 1994; 32: 31–36.Hackett B.P., Shimizu N., Gitlin J.D. Clara cell secretory protein gene expression in bronchiolar epithelium. Am. J. Physiol. 1992; 262: 399–404.Hackett B.P., Shimizu N., Gitlin J.D. Clara cell secretory protein gene expression in bronchiolar epithelium. Am. J. Physiol. 1992; 262: 399–404.Bernard A., Dumont X., Roels H. The molecular mass and concentrations of protein 1 or Clara cell protein in biological fluids: a reappraisal. Clin. Chim. Acta 1993; 223: 189–191.Bernard A., Dumont X., Roels H. The molecular mass and concentrations of protein 1 or Clara cell protein in biological fluids: a reappraisal. Clin. Chim. Acta 1993; 223: 189–191.Jackson P.J., Turner R., Keen J.N. et al. Purification and partial amino acid sequence of human urine protein 1: evidence for homology with rabbit uteroglobin. J. Chromatogr. 1988; 452: 359–367.Jackson P.J., Turner R., Keen J.N. et al. Purification and partial amino acid sequence of human urine protein 1: evidence for homology with rabbit uteroglobin. J. Chromatogr. 1988; 452: 359–367.Bernard A., Roels H., Lauwerys R. et al. Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions. Clin. Chim. Acta 1992; 207: 239–249.Bernard A., Roels H., Lauwerys R. et al. Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions. Clin. Chim. Acta 1992; 207: 239–249.Singh G., Singh J., Katyal S.L. et al. Identification, cellular localization, isolation, and characterization of human Clara cell-specific 10 KD protein. J. Histochem. Cytochem. 1988; 36: 73–80.Singh G., Singh J., Katyal S.L. et al. Identification, cellular localization, isolation, and characterization of human Clara cell-specific 10 KD protein. J. Histochem. Cytochem. 1988; 36: 73–80.Bernard A., Marchandise F.X., Depelchin S. et al. Clara cell protein in serum and bronchoalveolar lavage. Eur. Respir. J. 1992; 5: 1231–1238.Bernard A., Marchandise F.X., Depelchin S. et al. Clara cell protein in serum and bronchoalveolar lavage. Eur. Respir. J. 1992; 5: 1231–1238.Bernard A., Thielemans N., Lauwerys R. et al. The renal handling of protein 1 (Clara cell protein): effect of age, sex and renal dysfunction. Contrib. Nephrol 1993; 101: 66–70.Bernard A., Thielemans N., Lauwerys R. et al. The renal handling of protein 1 (Clara cell protein): effect of age, sex and renal dysfunction. Contrib. Nephrol 1993; 101: 66–70.Hermans C., Aly O., Nyberg B.I. et al. Determinants of Clara cell protein (CC16) concentration in serum: a reasessment with two different immunoassays. Clin. Chim. Acta 1998; 272: 101–110.Hermans C., Aly O., Nyberg B.I. et al. Determinants of Clara cell protein (CC16) concentration in serum: a reasessment with two different immunoassays. Clin. Chim. Acta 1998; 272: 101–110.Nomori H., Horio H., Takagi M. et al. Clara cell protein correlation with hyperlipidemia. Chest 1996; 110: 680–684.Nomori H., Horio H., Takagi M. et al. Clara cell protein correlation with hyperlipidemia. Chest 1996; 110: 680–684.Bernard A.M., Lauwerys R.R., Noel A. et al. Urine protein 1: a sex-dependent marker of tubular or glomerular dysfunction. Clin. Chem. 1989; 35: 2141–2142.Bernard A.M., Lauwerys R.R., Noel A. et al. Urine protein 1: a sex-dependent marker of tubular or glomerular dysfunction. Clin. Chem. 1989; 35: 2141–2142.Kabanda A., Goffin E., Bernard A. et al. Factors influencing serum levels and peritoneal clearances of low molecular weight proteins in continuous ambulatory peritoneal dialysis. Kidney Int. 1995; 48: 1946–1952.Kabanda A., Goffin E., Bernard A. et al. Factors influencing serum levels and peritoneal clearances of low molecular weight proteins in continuous ambulatory peritoneal dialysis. Kidney Int. 1995; 48: 1946–1952.Bernard A.M., Roels H.A., Buchet J.P. et al. Serum Clara cell protein: an indicator of bronchial cell dysfunction caused by tobacco smoking. Environ. Res. 1994; 66: 96–104.Bernard A.M., Roels H.A., Buchet J.P. et al. Serum Clara cell protein: an indicator of bronchial cell dysfunction caused by tobacco smoking. Environ. Res. 1994; 66: 96–104.Bernard A., Hermans C., Van Houte G. Transient increase of serum Clara cell protein (CC16) after exposure to smoke. Occup. Environ. Med. 1997; 54: 63–65.Bernard A., Hermans C., Van Houte G. Transient increase of serum Clara cell protein (CC16) after exposure to smoke. Occup. Environ. Med. 1997; 54: 63–65.Okutani R., Itoh Y., Hirata H. et al. Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein. J. Chromatogr. 1992; 577: 25–35.Okutani R., Itoh Y., Hirata H. et al. Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein. J. Chromatogr. 1992; 577: 25–35.Bernard A., Roels H., Lauwerys R. et al. Protein 1 is a secretory protein of the respiratory and urogenital tracts identical to the Clara cell protein. Clin. Chem. 1992; 38: 434–435.Bernard A., Roels H., Lauwerys R. et al. Protein 1 is a secretory protein of the respiratory and urogenital tracts identical to the Clara cell protein. Clin. Chem. 1992; 38: 434–435.Bernard A.M., Thielemans N.O., Lauwerys R.R. Urinary protein 1 or Clara cell protein: a new sensitive marker of proximal tubular dysfunction. Kidney. Int. 1994; 47: 34–37.Bernard A.M., Thielemans N.O., Lauwerys R.R. Urinary protein 1 or Clara cell protein: a new sensitive marker of proximal tubular dysfunction. Kidney. Int. 1994; 47: 34–37.Hagen G., Wolf M., Katyal S.L. et al. Tissue-specific expression, hormonal regulation and 5'-flanking gene region of the rat Clara cell 10 kDa protein: comparison to rabbit uteroglobin. Nucleic Acids Res. 1990; 18: 2939–2946.Hagen G., Wolf M., Katyal S.L. et al. Tissue-specific expression, hormonal regulation and 5'-flanking gene region of the rat Clara cell 10 kDa protein: comparison to rabbit uteroglobin. Nucleic Acids Res. 1990; 18: 2939–2946.Wolf M., Klug J., Hackenberg R. et al. Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. Hum. Mol. Genet. 1992; 1 (6): 371–378.Wolf M., Klug J., Hackenberg R. et al. Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. Hum. Mol. Genet. 1992; 1 (6): 371–378.Ray M.K., Magdaleno S., O'Malley B.W. et al. Cloning and characterization of the mouse Clara cell specific 10 kDa protein gene: comparison of the 5'-flanking region with the human rat and rabbit gene. Biochem. Biophys. Res. Commun. 1993; 197: 163–171.Ray M.K., Magdaleno S., O'Malley B.W. et al. Cloning and characterization of the mouse Clara cell specific 10 kDa protein gene: comparison of the 5'-flanking region with the human rat and rabbit gene. Biochem. Biophys. Res. Commun. 1993; 197: 163–171.Hay J.G., Danel C., Chu C.S. et al. Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease. Am. J. Physiol. 1995; 268: 565–575.Hay J.G., Danel C., Chu C.S. et al. Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease. Am. J. Physiol. 1995; 268: 565–575.Singh G., Katyal S.L., Brown W.E. et al. Clara cell 10 kDa protein (CC10): comparison of structure and function to uteroglobin. Biochim. Biophys. Acta 1990; 1039: 348–355.Singh G., Katyal S.L., Brown W.E. et al. Clara cell 10 kDa protein (CC10): comparison of structure and function to uteroglobin. Biochim. Biophys. Acta 1990; 1039: 348–355.Singh G., Katyal S.L. Clara cells and Clara cell 10 kD protein (CC10). Am. J. Respir. Cell Mol. Biol. 1997; 17: 141–143.Singh G., Katyal S.L. Clara cells and Clara cell 10 kD protein (CC10). Am. J. Respir. Cell Mol. Biol. 1997; 17: 141–143.Mantile G., Miele L., Cordella E. et al. Human Clara cell 10kDa protein is the counterpart of rabbit uteroglobin. J. Biol. Chem. 1993; 268: 20343–20351.Mantile G., Miele L., Cordella E. et al. Human Clara cell 10kDa protein is the counterpart of rabbit uteroglobin. J. Biol. Chem. 1993; 268: 20343–20351.Miele L., Cordella E., Miele G. et al. Uteroglobin: structure, molecular biology, and new perspectives on its function as a phospholipase A2 inhibitor. Endocr. Rev. 1987; 98: 474–490.Miele L., Cordella E., Miele G. et al. Uteroglobin: structure, molecular biology, and new perspectives on its function as a phospholipase A2 inhibitor. Endocr. Rev. 1987; 98: 474–490.Levin S. W., Butler J.D., Schumacher U.K. et al. Uteroglobin inhibits phospholipase A2 activity. Life Sci. 1986; 38: 1813–1819.Levin S. W., Butler J.D., Schumacher U.K. et al. Uteroglobin inhibits phospholipase A2 activity. Life Sci. 1986; 38: 1813–1819.Dierynck I., Bernard A., Roels H. et al. Potent inhibition of both human interferon-gamma production and biologic activity by the Clara cell protein CC16. Am. J. Respir. Cell Mol. Biol. 1995; 12: 205–210.Dierynck I., Bernard A., Roels H. et al. Potent inhibition of both human interferon-gamma production and biologic activity by the Clara cell protein CC16. Am. J. Respir. Cell Mol. Biol. 1995; 12: 205–210.Johnston C.J., Mango G.W., Finkelstein J.N. et al. Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. Am. J. Respir. Cell Mol. Biol. 1997; 17: 147–155.Johnston C.J., Mango G.W., Finkelstein J.N. et al. Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. Am. J. Respir. Cell Mol. Biol. 1997; 17: 147–155.Mango G. W., Johnston C.J., Reynolds S.D. et al. Clara cell secretory protein deficiency increases oxidant stress response in conducting airways. Am. J. Physiol. 1998; 275: 348–356.Mango G. W., Johnston C.J., Reynolds S.D. et al. Clara cell secretory protein deficiency increases oxidant stress response in conducting airways. Am. J. Physiol. 1998; 275: 348–356.Nordlund Moller L., Andersson O., Ahlgren R. et al. Cloning, structure, and expression of a rat binding protein for polychlorinated biphenyls: homology to the hormonally regulated progesterone-binding protein uteroglobin. J. Biol. Chem. 1990; 265: 12690–12693.Nordlund Moller L., Andersson O., Ahlgren R. et al. Cloning, structure, and expression of a rat binding protein for polychlorinated biphenyls: homology to the hormonally regulated progesterone-binding protein uteroglobin. J. Biol. Chem. 1990; 265: 12690–12693.Umland T.C., Swaminathan S., Singh G. et al. Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9 A resolution. Nat. Struct. Biol. 1994; 1: 538–545.Umland T.C., Swaminathan S., Singh G. et al. Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9 A resolution. Nat. Struct. Biol. 1994; 1: 538–545.Полякова В.С., Завалеева С.М., Стадников А.А. Структурная реорганизация воздухоносных и респираторных отделов легких при воздействии неблагоприятных факторов воздушной среды. Вестн. ОГУ 2003; 1: 66–69.Полякова В.С., Завалеева С.М., Стадников А.А. Структурная реорганизация воздухоносных и респираторных отделов легких при воздействии неблагоприятных факторов воздушной среды. Вестн. ОГУ 2003; 1: 66–69.Boers J.E., den Brok J.L.M., Koudstaal J. et al. Number and proliferation of neuroendocrine cells in normal human airway epithelium. Am. J. Respir. Crit. Care Med. 1996; 154: 758–763.Boers J.E., den Brok J.L.M., Koudstaal J. et al. Number and proliferation of neuroendocrine cells in normal human airway epithelium. Am. J. Respir. Crit. Care Med. 1996; 154: 758–763.Boers J.E., Ambergen A.W., Thunnissen F.B. Number and proliferation of basal and parabasal cells in normal human airway epithelium. Am. J. Respir. Crit. Care Med. 1998; 157: 2000–2006.Boers J.E., Ambergen A.W., Thunnissen F.B. Number and proliferation of basal and parabasal cells in normal human airway epithelium. Am. J. Respir. Crit. Care Med. 1998; 157: 2000–2006.Plopper C.G., George J.St., Pinkerton K.E. et al. Tracheobronchial epithelium in vivo: composition, differentiation and response to hormones. In: Thomassen D. G., Nettesheim P., eds. Biology, toxicology and carcinogenesis in the respiratory epithelium. New York; 1990. 308.Plopper C.G., George J.St., Pinkerton K.E. et al. Tracheobronchial epithelium in vivo: composition, differentiation and response to hormones. In: Thomassen D. G., Nettesheim P., eds. Biology, toxicology and carcinogenesis in the respiratory epithelium. New York; 1990. 308.Breuer R., Zajicek G., Christensen T.G. et al. Cell kinetics of normal adult hamster bronchial epithelium. Am. J. Respir. Cell Mol. Biol. 1990; 2: 51–58.Breuer R., Zajicek G., Christensen T.G. et al. Cell kinetics of normal adult hamster bronchial epithelium. Am. J. Respir. Cell Mol. Biol. 1990; 2: 51–58.Evans M.J., Cabral!Anderson L.J., Freeman G. Role of the Clara cell in the renewal of the bronchiolar epithelium. Lab. Invest. 1978; 38: 648–653.Evans M.J., Cabral!Anderson L.J., Freeman G. Role of the Clara cell in the renewal of the bronchiolar epithelium. Lab. Invest. 1978; 38: 648–653.Lum H., Schartz L.W., Dungworth D.L. et al. A comparative study of cell renewal after exposure to ozone or oxygen. Am. Rev. Respir. Dis. 1978; 118: 335–345.Lum H., Schartz L.W., Dungworth D.L. et al. A comparative study of cell renewal after exposure to ozone or oxygen. Am. Rev. Respir. Dis. 1978; 118: 335–345.Massaro G.D., Singh G., Mason R. et al. Biology of the Clara cell. Am. J. Physiol. 1994; 266: 101–106.Massaro G.D., Singh G., Mason R. et al. Biology of the Clara cell. Am. J. Physiol. 1994; 266: 101–106.Van Vyve T., Chanez P., Bernard A. et al. Protein content in bronchoalveolar lavage fluid of patients with asthma and control subjects. J. Allergy Clin. Immunol. 1995; 95: 60–68.Van Vyve T., Chanez P., Bernard A. et al. Protein content in bronchoalveolar lavage fluid of patients with asthma and control subjects. J. Allergy Clin. Immunol. 1995; 95: 60–68.Jorens P.G., Sibille Y., Goulding N.J. et al. Potential role of Clara cell protein, an endogenous phospholipase A2 inhibitor, in acute lung injury. Eur. Respir. J. 1995; 8: 1647–1653.Jorens P.G., Sibille Y., Goulding N.J. et al. Potential role of Clara cell protein, an endogenous phospholipase A2 inhibitor, in acute lung injury. Eur. Respir. J. 1995; 8: 1647–1653.Lesur O., Bernard A.M., Begin R.O. Clara cell protein (CC-16) and surfactant-associated protein A (SP-A) in asbestosexposed workers. Chest 1996; 109: 467–474.Lesur O., Bernard A.M., Begin R.O. Clara cell protein (CC-16) and surfactant-associated protein A (SP-A) in asbestosexposed workers. Chest 1996; 109: 467–474.Bernard A.M., Gonzalez J.M., Lorenzo E. et al. Early decrease of serum Clara cell protein in silica-exposed workers. Eur. Respir. J. 1994; 7: 1932–1937.Bernard A.M., Gonzalez J.M., Lorenzo E. et al. Early decrease of serum Clara cell protein in silica-exposed workers. Eur. Respir. J. 1994; 7: 1932–1937.Bernard A., Hermans C. Biomonitoring of early effects on the kidney or the lung. Sci. Total Environ. 1997; 199: 205–211.Bernard A., Hermans C. Biomonitoring of early effects on the kidney or the lung. Sci. Total Environ. 1997; 199: 205–211.Bernard A., Roels H., Buchet J.P. et al. Decrease of serum Clara cell protein in smokers (letter). Lancet 1992; 339: 1620.Bernard A., Roels H., Buchet J.P. et al. Decrease of serum Clara cell protein in smokers (letter). Lancet 1992; 339: 1620.Guy J., Dhanireddy R., Mukherjee A.B. Surfactant-producing rabbit pulmonary alveolar type II cells synthesize and secrete an antiinflammatory protein, uteroglobin. Biochem. Biophys. Res. Commun. 1992; 189: 662–669.Guy J., Dhanireddy R., Mukherjee A.B. Surfactant-producing rabbit pulmonary alveolar type II cells synthesize and secrete an antiinflammatory protein, uteroglobin. Biochem. Biophys. Res. Commun. 1992; 189: 662–669.
The authors declare that there are no conflicts of interest present.