<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2008-0-6-90-94</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-1882</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Влияние длительного применения тиотропия на функцию легких у больных хронической обструктивной болезнью легких: исследование UPLIFT</article-title><trans-title-group xml:lang="en"><trans-title>Effect of long-term treatment with tiotropium bromide on lung function in patients with chronic obstructive pulmonary disease (the UPLIFT trial)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанян</surname><given-names>И. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanyan</surname><given-names>I. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГУ ЦНИИ туберкулеза РАМН</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2008</year></pub-date><volume>0</volume><issue>6</issue><fpage>90</fpage><lpage>94</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Степанян И.Э., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Степанян И.Э.</copyright-holder><copyright-holder xml:lang="en">Stepanyan I.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/1882">https://journal.pulmonology.ru/pulm/article/view/1882</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Celli B.R., MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS / ERS position paper. Eur. Respir. J. 2004; 23: 932–946.</mixed-citation><mixed-citation xml:lang="en">Celli B.R., MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS / ERS position paper. Eur. Respir. J. 2004; 23: 932–946.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Tashkin D.P., Cooper C.B. The role of long-acting bronchodilators in the management of stable COPD. Chest 2004; 125: 249–251.</mixed-citation><mixed-citation xml:lang="en">Tashkin D.P., Cooper C.B. The role of long-acting bronchodilators in the management of stable COPD. Chest 2004; 125: 249–251.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">van Noord J. A., Aumann J. L., Janssens E. et al. Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD. Eur. Respir. J. 2005; 26: 214–222.</mixed-citation><mixed-citation xml:lang="en">van Noord J. A., Aumann J. L., Janssens E. et al. Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD. Eur. Respir. J. 2005; 26: 214–222.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rabe K.F., Timmer W., Sagriotis A., Viel K. Comparison of a combination of tiotropium and formoterol to salmeterol and fluticasone in moderate COPD. Eur. Respir. J. 2005; 26 (suppl. 49): 14s.</mixed-citation><mixed-citation xml:lang="en">Rabe K.F., Timmer W., Sagriotis A., Viel K. Comparison of a combination of tiotropium and formoterol to salmeterol and fluticasone in moderate COPD. Eur. Respir. J. 2005; 26 (suppl. 49): 14s.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Fletcher C., Peto R. The natural history of chronic airflow obstruction. Br. Med. J. 1977; 1: 1645–1648.</mixed-citation><mixed-citation xml:lang="en">Fletcher C., Peto R. The natural history of chronic airflow obstruction. Br. Med. J. 1977; 1: 1645–1648.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Tashkin D.P. The role of patient-centered outcomes in the course of chronic obstructive pulmonary disease: how long-term studies contribute to our understanding. Am. J. Med. 2006; 119 (10, suppl.1): 63–72.</mixed-citation><mixed-citation xml:lang="en">Tashkin D.P. The role of patient-centered outcomes in the course of chronic obstructive pulmonary disease: how long-term studies contribute to our understanding. Am. J. Med. 2006; 119 (10, suppl.1): 63–72.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Anzueto A. Clinical course of chronic obstructive pulmonary disease: review of therapeutic interventions. Am. J. Med. 2006; 119 (10, suppl. 1): 46–53.</mixed-citation><mixed-citation xml:lang="en">Anzueto A. Clinical course of chronic obstructive pulmonary disease: review of therapeutic interventions. Am. J. Med. 2006; 119 (10, suppl. 1): 46–53.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Vestbo J., TORCH Study Group. The TORCH (towards a revolution in COPD health) survival study protocol. Eur. Respir. J. 2004; 24: 206–210.</mixed-citation><mixed-citation xml:lang="en">Vestbo J., TORCH Study Group. The TORCH (towards a revolution in COPD health) survival study protocol. Eur. Respir. J. 2004; 24: 206–210.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Calverley P.M., Anderson J.A., Celli B. et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N. Engl. J. Med. 2007; 356: 775–789.</mixed-citation><mixed-citation xml:lang="en">Calverley P.M., Anderson J.A., Celli B. et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N. Engl. J. Med. 2007; 356: 775–789.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Celli B.R., Thomas N.E., Anderson J.A. et al. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am. J. Respir. Crit. Care Med. 2008; 178: 332–338.</mixed-citation><mixed-citation xml:lang="en">Celli B.R., Thomas N.E., Anderson J.A. et al. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am. J. Respir. Crit. Care Med. 2008; 178: 332–338.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Rabe K. Treating COPD – the TORCH trial, P value and the Dodo. N. Engl. J. Med. 2007; 356: 851–854.</mixed-citation><mixed-citation xml:lang="en">Rabe K. Treating COPD – the TORCH trial, P value and the Dodo. N. Engl. J. Med. 2007; 356: 851–854.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Suissa S., Ernst P., Vandemheen K.L., Aaron S.D. Methodological issues in therapeutic trials of COPD. Eur. Respir. J. 2008; 31: 927–933.</mixed-citation><mixed-citation xml:lang="en">Suissa S., Ernst P., Vandemheen K.L., Aaron S.D. Methodological issues in therapeutic trials of COPD. Eur. Respir. J. 2008; 31: 927–933.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hodder R., Kesten S., Menjoge S., Viel K. Outcomes in COPD patients receiving tiotropium or salmeterol plus treatment with inhaled corticosteroids. Int. J. Chron. Obstruct. Pulm. Dis. 2007; 2: 157–167.</mixed-citation><mixed-citation xml:lang="en">Hodder R., Kesten S., Menjoge S., Viel K. Outcomes in COPD patients receiving tiotropium or salmeterol plus treatment with inhaled corticosteroids. Int. J. Chron. Obstruct. Pulm. Dis. 2007; 2: 157–167.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Decramer M., Celli B., Tashkin D.P. et al. Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial. J. COPD 2004; 1: 303–312.</mixed-citation><mixed-citation xml:lang="en">Decramer M., Celli B., Tashkin D.P. et al. Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial. J. COPD 2004; 1: 303–312.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Casaburi R., Mahler D.A., Jones P.A. et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur. Respir. J. 2002; 19: 217–224.</mixed-citation><mixed-citation xml:lang="en">Casaburi R., Mahler D.A., Jones P.A. et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur. Respir. J. 2002; 19: 217–224.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Vincken W., van Noord J.A., Greefhorst A.P.M. et al. Improved health outcomes in patients with COPD during 1 year's treatment with tiotropium. Eur. Respir. J. 2002; 19: 209–216.</mixed-citation><mixed-citation xml:lang="en">Vincken W., van Noord J.A., Greefhorst A.P.M. et al. Improved health outcomes in patients with COPD during 1 year's treatment with tiotropium. Eur. Respir. J. 2002; 19: 209–216.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Brusasco V., Hodder R., Miravitlles M. et al. Health out comes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003; 58: 399–404.</mixed-citation><mixed-citation xml:lang="en">Brusasco V., Hodder R., Miravitlles M. et al. Health out comes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003; 58: 399–404.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell D., Fluge T., Gerken F. et al. Effects of tiotropium on lung hyperinflation, dyspnea and exercise tolerance in patients with COPD. Eur. Respir. J. 2004; 23: 832–840.</mixed-citation><mixed-citation xml:lang="en">O'Donnell D., Fluge T., Gerken F. et al. Effects of tiotropium on lung hyperinflation, dyspnea and exercise tolerance in patients with COPD. Eur. Respir. J. 2004; 23: 832–840.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Dusser D., Bravo M-L., Iacono P. on behalf of the MISTRAL study group. The effect of tiotropium on exacerbations and airflow in patients with COPD. Eur. Respir. J. 2006; 27: 547–555.</mixed-citation><mixed-citation xml:lang="en">Dusser D., Bravo M-L., Iacono P. on behalf of the MISTRAL study group. The effect of tiotropium on exacerbations and airflow in patients with COPD. Eur. Respir. J. 2006; 27: 547–555.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Anzueto A., Menjoge S.S., Kesten S. Changes in FEV I overtime in one year clinical trials of tiotropium in COPD. Am. J. Respir. Crit. Care Med. 2001; 163: A280.</mixed-citation><mixed-citation xml:lang="en">Anzueto A., Menjoge S.S., Kesten S. Changes in FEV I overtime in one year clinical trials of tiotropium in COPD. Am. J. Respir. Crit. Care Med. 2001; 163: A280.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Anzueto A. Disease modification in chronic obstructive pulmonary disease. Clin. Chest Med. 2007; 28: 609–616.</mixed-citation><mixed-citation xml:lang="en">Anzueto A. Disease modification in chronic obstructive pulmonary disease. Clin. Chest Med. 2007; 28: 609–616.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Tashkin D.P., Celli B., Decramer M. D. et al. Bronchodilator responsiveness in patients with COPD. Eur. Respir. J. 2008; 31: 742–750.</mixed-citation><mixed-citation xml:lang="en">Tashkin D.P., Celli B., Decramer M. D. et al. Bronchodilator responsiveness in patients with COPD. Eur. Respir. J. 2008; 31: 742–750.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Tashkin D.P., Celli B., Senn S. et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N. Engl. J. Med. 2008; 359: 1543–1554.</mixed-citation><mixed-citation xml:lang="en">Tashkin D.P., Celli B., Senn S. et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N. Engl. J. Med. 2008; 359: 1543–1554.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
