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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2008-0-2-111-116</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-1780</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Фармакогенетические аспекты тяжелой астмы</article-title><trans-title-group xml:lang="en"><trans-title>Pharmacogenetic aspects of severe asthma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трофимов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Trofimov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра госпитальной терапии имени акад. М.В.Черноруцкого</p><p>Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронова</surname><given-names>Ж. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironova</surname><given-names>Zh. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра госпитальной терапии имени акад. М.В.Черноруцкого</p><p>Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Янчина</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Yantchina</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>отдел молекулярно-генетических технологий</p><p>Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дубина</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dubina</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>отдел молекулярно-генетических технологий</p><p>Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО СПбГМУ им. акад. И.П.Павлова Росздрава</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2008</year></pub-date><volume>0</volume><issue>2</issue><fpage>111</fpage><lpage>116</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Трофимов В.И., Миронова Ж.А., Янчина Е.Д., Дубина М.В., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Трофимов В.И., Миронова Ж.А., Янчина Е.Д., Дубина М.В.</copyright-holder><copyright-holder xml:lang="en">Trofimov V.I., Mironova Z.A., Yantchina E.D., Dubina M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/1780">https://journal.pulmonology.ru/pulm/article/view/1780</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Global Initiative for Asthma. 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