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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2010-1-13-65</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-1611</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Показатели, оцениваемые в фармакологических
исследованиях ХОБЛ: от легочной функции до биомаркеров</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казолла</surname><given-names>М. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мак-Ни</surname><given-names>В. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мартинес</surname><given-names>Ф. Дж.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рабе</surname><given-names>К. Ф.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Франчиози</surname><given-names>Л. Дж.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барнс</surname><given-names>П. Дж.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Брусаско</surname><given-names>В. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурдж</surname><given-names>П. С.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калверлей</surname><given-names>П. М.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селли</surname><given-names>Б. Р.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джонс</surname><given-names>П. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малер</surname><given-names>Д. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мейк</surname><given-names>Б. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миравиттлс</surname><given-names>М. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пейдж</surname><given-names>С. П.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Паланьи</surname><given-names>П. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Парр</surname><given-names>Д. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пистолези</surname><given-names>М. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Реннард</surname><given-names>С. И.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Руттен Ван Мелькен</surname><given-names>М. П.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стокли</surname><given-names>Р. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салливан</surname><given-names>С. Д.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ведзича</surname><given-names>Дж. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воутерс</surname><given-names>Е. Ф.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2010</year></pub-date><volume>0</volume><issue>1</issue><fpage>13</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Казолла М..., Мак-Ни В..., Мартинес Ф.Д., Рабе К.Ф., Франчиози Л.Д., Барнс П.Д., Брусаско В..., Бурдж П.С., Калверлей П.М., Селли Б.Р., Джонс П.В., Малер Д.А., Мейк Б..., Миравиттлс М..., Пейдж С.П., Паланьи П..., Парр Д..., Пистолези М..., Реннард С.И., Руттен Ван Мелькен М.П., Стокли Р..., Салливан С.Д., Ведзича Д.А., Воутерс Е.Ф., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Казолла М..., Мак-Ни В..., Мартинес Ф.Д., Рабе К.Ф., Франчиози Л.Д., Барнс П.Д., Брусаско В..., Бурдж П.С., Калверлей П.М., Селли Б.Р., Джонс П.В., Малер Д.А., Мейк Б..., Миравиттлс М..., Пейдж С.П., Паланьи П..., Парр Д..., Пистолези М..., Реннард С.И., Руттен Ван Мелькен М.П., Стокли Р..., Салливан С.Д., Ведзича Д.А., Воутерс Е.Ф.</copyright-holder><copyright-holder xml:lang="en">Казолла М..., Мак-Ни В..., Мартинес Ф.Д., Рабе К.Ф., Франчиози Л.Д., Барнс П.Д., Брусаско В..., Бурдж П.С., Калверлей П.М., Селли Б.Р., Джонс П.В., Малер Д.А., Мейк Б..., Миравиттлс М..., Пейдж С.П., Паланьи П..., Парр Д..., Пистолези М..., Реннард С.И., Руттен Ван Мелькен М.П., Стокли Р..., Салливан С.Д., Ведзича Д.А., Воутерс Е.Ф.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/1611">https://journal.pulmonology.ru/pulm/article/view/1611</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Committee for Proprietary Medicinal Products. Points to consider on clinical investigation of medicinal products in the chronic treatment of patients with chronic obstructive pulmonary disease (COPD). London; 1999. CPMP / EWP / 562 / 98.</mixed-citation><mixed-citation xml:lang="en">Committee for Proprietary Medicinal Products. Points to consider on clinical investigation of medicinal products in the chronic treatment of patients with chronic obstructive pulmonary disease (COPD). London; 1999. CPMP / EWP / 562 / 98.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Celli B.R., MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS / ERS position paper. Eur. Respir. J. 2004; 23: 932-946.</mixed-citation><mixed-citation xml:lang="en">Celli B.R., MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS / ERS position paper. Eur. Respir. J. 2004; 23: 932-946.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Edwards N. A framework for future trials: Guidelines on developing COPD drugs. Good Clin. Pract. J. 2004; 11: 1-5.</mixed-citation><mixed-citation xml:lang="en">Edwards N. A framework for future trials: Guidelines on developing COPD drugs. Good Clin. Pract. J. 2004; 11: 1-5.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Jones P.W., Agusti A.G.N. Outcomes and markers in the assessment of chronic obstructive pulmonary disease. Eur. Respir. J. 2006; 27: 822-832.</mixed-citation><mixed-citation xml:lang="en">Jones P.W., Agusti A.G.N. Outcomes and markers in the assessment of chronic obstructive pulmonary disease. Eur. Respir. J. 2006; 27: 822-832.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Celli B.R., Calverley P.M., Rennard S.I. et al. Proposal for a multidimensional staging system for chronic obstructive pulmonary disease. Respir. Med. 2005; 99: 1546-1554.</mixed-citation><mixed-citation xml:lang="en">Celli B.R., Calverley P.M., Rennard S.I. et al. Proposal for a multidimensional staging system for chronic obstructive pulmonary disease. Respir. Med. 2005; 99: 1546-1554.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">ZuWallack R.L., Haggerty M.C., Jones P. Clinically meaningful outcomes in patients with chronic obstructive pulmonary disease. Am. J. Med. 2004; 117 (suppl. 12A): 49S-59S.</mixed-citation><mixed-citation xml:lang="en">ZuWallack R.L., Haggerty M.C., Jones P. Clinically meaningful outcomes in patients with chronic obstructive pulmonary disease. Am. J. Med. 2004; 117 (suppl. 12A): 49S-59S.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Miller M.R., Hankinson J., Brusasco V. et al. Standardisation of spirometry. Eur. Respir. J. 2005; 26: 319-338.</mixed-citation><mixed-citation xml:lang="en">Miller M.R., Hankinson J., Brusasco V. et al. Standardisation of spirometry. Eur. Respir. J. 2005; 26: 319-338.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lung function testing: selection of reference values and interpretative strategies. American Thoracic Society. Am. Rev. Respir. Dis. 1991; 144: 1202-1218.</mixed-citation><mixed-citation xml:lang="en">Lung function testing: selection of reference values and interpretative strategies. American Thoracic Society. Am. Rev. Respir. Dis. 1991; 144: 1202-1218.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Quanjer P.H., Tammeling G.J., Cotes J.E. et al. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur. Respir. J. 1993; 16 (suppl. 16): 5-40.</mixed-citation><mixed-citation xml:lang="en">Quanjer P.H., Tammeling G.J., Cotes J.E. et al. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur. Respir. J. 1993; 16 (suppl. 16): 5-40.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pellegrino R., Viegi G., Brusasco V. et al. Interpretative strategies for lung function tests. Eur. Respir. J. 2005; 26: 948-968.</mixed-citation><mixed-citation xml:lang="en">Pellegrino R., Viegi G., Brusasco V. et al. Interpretative strategies for lung function tests. Eur. Respir. J. 2005; 26: 948-968.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. NHLBI / WHO Workshop Report 2005. www.goldcopd.com Date last accessed: November 2, 2007.</mixed-citation><mixed-citation xml:lang="en">Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. NHLBI / WHO Workshop Report 2005. www.goldcopd.com Date last accessed: November 2, 2007.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Anthonisen N.R., Connett J.E., Kiley J.P. et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. J. A. M. A. 1994; 272: 1497-1505.</mixed-citation><mixed-citation xml:lang="en">Anthonisen N.R., Connett J.E., Kiley J.P. et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. J. A. M. A. 1994; 272: 1497-1505.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Anonymous. GSK's Ariflo gets US approvable letter for COPD. Scrip Wld Pharmaceut. News 2003; 21: Oct. 31, 2898.</mixed-citation><mixed-citation xml:lang="en">Anonymous. GSK's Ariflo gets US approvable letter for COPD. Scrip Wld Pharmaceut. News 2003; 21: Oct. 31, 2898.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Swanney M.P., Jensen R.L., Crichton D.A. et al. FEV6 is an acceptable surrogate for FVC in the spirometric diagnosis of airway obstruction and restriction. Am. J. Respir. Crit. Care Med. 2000; 162: 917-919.</mixed-citation><mixed-citation xml:lang="en">Swanney M.P., Jensen R.L., Crichton D.A. et al. FEV6 is an acceptable surrogate for FVC in the spirometric diagnosis of airway obstruction and restriction. Am. J. Respir. Crit. Care Med. 2000; 162: 917-919.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hankinson J.L., Crapo R.O., Jensen R.L. Spirometric reference values for the 6-s FVC maneuver. Chest 2003; 124: 1805-1811.</mixed-citation><mixed-citation xml:lang="en">Hankinson J.L., Crapo R.O., Jensen R.L. Spirometric reference values for the 6-s FVC maneuver. Chest 2003; 124: 1805-1811.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia-Rio F., Pino J.M., Dorgham A. et al. Spirometric reference equations for European females and males aged 65-85 yrs. Eur. Respir. J. 2004; 24: 397-405.</mixed-citation><mixed-citation xml:lang="en">Garcia-Rio F., Pino J.M., Dorgham A. et al. Spirometric reference equations for European females and males aged 65-85 yrs. Eur. Respir. J. 2004; 24: 397-405.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Vandevoorde J., Verbanck S., Schuermans D. et al. FEV1 / FEV6 and FEV6 as an alternative for FEV1 / FVC and FVC in the spirometric detection of airway obstruction and restriction. Chest 2005; 127: 1560-1564.</mixed-citation><mixed-citation xml:lang="en">Vandevoorde J., Verbanck S., Schuermans D. et al. FEV1 / FEV6 and FEV6 as an alternative for FEV1 / FVC and FVC in the spirometric detection of airway obstruction and restriction. Chest 2005; 127: 1560-1564.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Akpinar-Elci M., Fedan K.B., Enright P.L. FEV6 as a surrogate for FVC in detecting airways obstruction and restriction in the workplace. Eur. Respir. J. 2006; 27: 374-377.</mixed-citation><mixed-citation xml:lang="en">Akpinar-Elci M., Fedan K.B., Enright P.L. FEV6 as a surrogate for FVC in detecting airways obstruction and restriction in the workplace. Eur. Respir. J. 2006; 27: 374-377.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Pedersen O.F. FEV6: a shortcut in spirometry? Eur. Respir. J. 2006; 27: 245-247.</mixed-citation><mixed-citation xml:lang="en">Pedersen O.F. FEV6: a shortcut in spirometry? Eur. Respir. J. 2006; 27: 245-247.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Vandevoorde J., Verbanck S., Schuermans D. et al. Obstructive and restrictive spirometric patterns: fixed cut-offs for FEV1 / FEV6 and FEV6. Eur. Respir. J. 2006; 27: 378-383.</mixed-citation><mixed-citation xml:lang="en">Vandevoorde J., Verbanck S., Schuermans D. et al. Obstructive and restrictive spirometric patterns: fixed cut-offs for FEV1 / FEV6 and FEV6. Eur. Respir. J. 2006; 27: 378-383.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bang K.M., Gergen P.J., Kramer R., Cohen B. The effect of pulmonary impairment on all-cause mortality in a national cohort. Chest 1993; 103: 536-540.</mixed-citation><mixed-citation xml:lang="en">Bang K.M., Gergen P.J., Kramer R., Cohen B. The effect of pulmonary impairment on all-cause mortality in a national cohort. Chest 1993; 103: 536-540.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Neas L.M., Schwartz J. Pulmonary function levels as predictors of mortality in a national sample of US adults. Am. J. Epidemiol. 1998; 147: 1011-1018.</mixed-citation><mixed-citation xml:lang="en">Neas L.M., Schwartz J. Pulmonary function levels as predictors of mortality in a national sample of US adults. Am. J. Epidemiol. 1998; 147: 1011-1018.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Knuiman M.W., James A.L., Divitini M.L. et al. Lung function, respiratory symptoms, and mortality: results from the Busselton Health Study. Ann. Epidemiol. 1999; 9: 297-306.</mixed-citation><mixed-citation xml:lang="en">Knuiman M.W., James A.L., Divitini M.L. et al. Lung function, respiratory symptoms, and mortality: results from the Busselton Health Study. Ann. Epidemiol. 1999; 9: 297-306.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Schunemann H.J., Dorn J., Grant B.J. et al. Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study. Chest 2000; 118: 656-664.</mixed-citation><mixed-citation xml:lang="en">Schunemann H.J., Dorn J., Grant B.J. et al. Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study. Chest 2000; 118: 656-664.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Stavem K., Aaser E., Sandvik L. et al. Lung function, smoking and mortality in a 26-year follow-up of healthy middle-aged males. Eur. Respir. J. 2005; 25: 618-625.</mixed-citation><mixed-citation xml:lang="en">Stavem K., Aaser E., Sandvik L. et al. Lung function, smoking and mortality in a 26-year follow-up of healthy middle-aged males. Eur. Respir. J. 2005; 25: 618-625.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Wolkove N., Dajczman E., Colacone A., Kreisman H. The relationship between pulmonary function and dyspnea in obstructive lung disease. Chest 1989; 96: 1247-1251.</mixed-citation><mixed-citation xml:lang="en">Wolkove N., Dajczman E., Colacone A., Kreisman H. The relationship between pulmonary function and dyspnea in obstructive lung disease. Chest 1989; 96: 1247-1251.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Hay J.G., Stone P., Carter J. et al. Bronchodilator reversibility, exercise performance and breathlessness in stable chronic obstructive pulmonary disease. Eur. Respir. J. 1992; 5: 659-664.</mixed-citation><mixed-citation xml:lang="en">Hay J.G., Stone P., Carter J. et al. Bronchodilator reversibility, exercise performance and breathlessness in stable chronic obstructive pulmonary disease. Eur. Respir. J. 1992; 5: 659-664.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Bauerle O., Chrusch C.A., Younes M. Mechanisms by which COPD affects exercise tolerance. Am. J. Respir. Crit. Care Med. 1998; 157: 57-68.</mixed-citation><mixed-citation xml:lang="en">Bauerle O., Chrusch C.A., Younes M. Mechanisms by which COPD affects exercise tolerance. Am. J. Respir. Crit. Care Med. 1998; 157: 57-68.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell D.E., Lam M., Webb K.A. Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1999; 160: 542-549.</mixed-citation><mixed-citation xml:lang="en">O'Donnell D.E., Lam M., Webb K.A. Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1999; 160: 542-549.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrer M., Alonso J., Prieto L. et al. Validity and reliability of the St George's Respiratory Questionnaire after adaptation to a different language and culture: the Spanish example. Eur. Respir. J. 1996; 9: 1160-1166.</mixed-citation><mixed-citation xml:lang="en">Ferrer M., Alonso J., Prieto L. et al. Validity and reliability of the St George's Respiratory Questionnaire after adaptation to a different language and culture: the Spanish example. Eur. Respir. J. 1996; 9: 1160-1166.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Hajiro T., Nishimura K., Tsukino M. et al. Comparison of discriminative properties among disease-specific questionnaires for measuring healthrelated quality of life in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 157: 785-790.</mixed-citation><mixed-citation xml:lang="en">Hajiro T., Nishimura K., Tsukino M. et al. Comparison of discriminative properties among disease-specific questionnaires for measuring healthrelated quality of life in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 157: 785-790.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Pellegrino R., Rodarte J.R., Brusasco V. Assessing the reversibility of airway obstruction. Chest 1998; 114: 1607-1612.</mixed-citation><mixed-citation xml:lang="en">Pellegrino R., Rodarte J.R., Brusasco V. Assessing the reversibility of airway obstruction. Chest 1998; 114: 1607-1612.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Calverley P.M., Burge P.S., Spencer S. et al. Bronchodilator reversibility testing in chronic obstructive pulmonary disease. Thorax 2003; 58: 659-664.</mixed-citation><mixed-citation xml:lang="en">Calverley P.M., Burge P.S., Spencer S. et al. Bronchodilator reversibility testing in chronic obstructive pulmonary disease. Thorax 2003; 58: 659-664.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">TheNational Emphysema Treatment Trial Research Group. Rationale and design of The National Emphysema Treatment Trial: a prospective randomized trial of lung volume reduction surgery. Chest 1999; 116: 1750-1761.</mixed-citation><mixed-citation xml:lang="en">TheNational Emphysema Treatment Trial Research Group. Rationale and design of The National Emphysema Treatment Trial: a prospective randomized trial of lung volume reduction surgery. Chest 1999; 116: 1750-1761.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Seemungal T.A., Donaldson G.C., Bhowmik A. et al. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2000; 161: 1608-1613.</mixed-citation><mixed-citation xml:lang="en">Seemungal T.A., Donaldson G.C., Bhowmik A. et al. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2000; 161: 1608-1613.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Aaron S.D., Vandemheen K.L., Clinch J.J. et al. Measurement of short-term changes in dyspnea and disease-specific quality of life following an acute COPD exacerbation. Chest 2002; 121: 688-696.</mixed-citation><mixed-citation xml:lang="en">Aaron S.D., Vandemheen K.L., Clinch J.J. et al. Measurement of short-term changes in dyspnea and disease-specific quality of life following an acute COPD exacerbation. Chest 2002; 121: 688-696.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Niewoehner D.E., Collins D., Erbland M.L. Relation of FEV1 to clinical outcomes during exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group. Am. J. Respir. Crit. Care Med. 2000; 161: 1201-1205.</mixed-citation><mixed-citation xml:lang="en">Niewoehner D.E., Collins D., Erbland M.L. Relation of FEV1 to clinical outcomes during exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group. Am. J. Respir. Crit. Care Med. 2000; 161: 1201-1205.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Parker C.M., Voduc N., Aaron S.D. et al. Physiological changes during symptom recovery from moderate exacerbations of COPD. Eur. Respir. J. 2005; 26: 420-428.</mixed-citation><mixed-citation xml:lang="en">Parker C.M., Voduc N., Aaron S.D. et al. Physiological changes during symptom recovery from moderate exacerbations of COPD. Eur. Respir. J. 2005; 26: 420-428.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Cerveri I., Pellegrino R., Dore R., et al. Mechanisms for isolated volume response to a bronchodilator in patients with COPD. J. Appl. Physiol. 2000; 88: 1989-1995.</mixed-citation><mixed-citation xml:lang="en">Cerveri I., Pellegrino R., Dore R., et al. Mechanisms for isolated volume response to a bronchodilator in patients with COPD. J. Appl. Physiol. 2000; 88: 1989-1995.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">van Schayck C.P., Loozen J.M., Wagena E. et al. Detecting patients at a high risk of developing chronic obstructive pulmonary disease in general practice: cross sectional case finding study. Br. Med. J. 2002; 324: 1370.</mixed-citation><mixed-citation xml:lang="en">van Schayck C.P., Loozen J.M., Wagena E. et al. Detecting patients at a high risk of developing chronic obstructive pulmonary disease in general practice: cross sectional case finding study. Br. Med. J. 2002; 324: 1370.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Miller M.R., Crapo R., Hankinson J. et al. General considerations for lung function testing. Eur. Respir. J. 2005; 26: 153-161.</mixed-citation><mixed-citation xml:lang="en">Miller M.R., Crapo R., Hankinson J. et al. General considerations for lung function testing. Eur. Respir. J. 2005; 26: 153-161.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Wanger J., Clausen J.L., Coates A. et al. Standardisation of the measurement of lung volumes. Eur. Respir. J. 2005; 26: 511-522.</mixed-citation><mixed-citation xml:lang="en">Wanger J., Clausen J.L., Coates A. et al. Standardisation of the measurement of lung volumes. Eur. Respir. J. 2005; 26: 511-522.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Stocks J., Quanjer P.H. Reference values for residual volume, functional residual capacity and total lung capacity. ATS Workshop on Lung Volume Measurements. Official Statement of The European Respiratory Society. Eur. Respir. J. 1995; 8: 492-506.</mixed-citation><mixed-citation xml:lang="en">Stocks J., Quanjer P.H. Reference values for residual volume, functional residual capacity and total lung capacity. ATS Workshop on Lung Volume Measurements. Official Statement of The European Respiratory Society. Eur. Respir. J. 1995; 8: 492-506.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Hankinson J.L., Stocks J., Peslin R. Reproducibility of lung volume measurements. Eur. Respir. J. 1998; 11: 787-790.</mixed-citation><mixed-citation xml:lang="en">Hankinson J.L., Stocks J., Peslin R. Reproducibility of lung volume measurements. Eur. Respir. J. 1998; 11: 787-790.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell D.E., Revill S.M., Webb K.A. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 164: 770-777.</mixed-citation><mixed-citation xml:lang="en">O'Donnell D.E., Revill S.M., Webb K.A. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 164: 770-777.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Boni E., Corda L., Franchini D. et al. Volume effect and exertional dyspnoea after bronchodilator in patients with COPD with and without expiratory flow limitation at rest. Thorax 2002; 57: 528-532.</mixed-citation><mixed-citation xml:lang="en">Boni E., Corda L., Franchini D. et al. Volume effect and exertional dyspnoea after bronchodilator in patients with COPD with and without expiratory flow limitation at rest. Thorax 2002; 57: 528-532.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell D.E., Webb K.A. Exertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflation. Am. Rev. Respir. Dis. 1993; 148: 1351-1357.</mixed-citation><mixed-citation xml:lang="en">O'Donnell D.E., Webb K.A. Exertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflation. Am. Rev. Respir. Dis. 1993; 148: 1351-1357.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell D.E., Webb K.A., Bertley J.C. et al. Mechanisms of relief of exertional breathlessness following unilateral bullectomy and lung volume reduction surgery in emphysema. Chest 1996; 110: 18-27.</mixed-citation><mixed-citation xml:lang="en">O'Donnell D.E., Webb K.A., Bertley J.C. et al. Mechanisms of relief of exertional breathlessness following unilateral bullectomy and lung volume reduction surgery in emphysema. Chest 1996; 110: 18-27.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell D.E., Fluge T., Gerken F., et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur. Respir. J. 2004; 23: 832-840.</mixed-citation><mixed-citation xml:lang="en">O'Donnell D.E., Fluge T., Gerken F., et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur. Respir. J. 2004; 23: 832-840.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell D.E., Voduc N., Fitzpatrick M., Webb K.A. Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease. Eur. Respir. J. 2004; 24: 86-94.</mixed-citation><mixed-citation xml:lang="en">O'Donnell D.E., Voduc N., Fitzpatrick M., Webb K.A. Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease. Eur. Respir. J. 2004; 24: 86-94.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Diaz O., Villafranca C., Ghezzo H. et al. Role of inspiratory capacity on exercise tolerance in COPD patients with and without tidal expiratory flow limitation at rest. Eur. Respir. J. 2000; 16: 269-275.</mixed-citation><mixed-citation xml:lang="en">Diaz O., Villafranca C., Ghezzo H. et al. Role of inspiratory capacity on exercise tolerance in COPD patients with and without tidal expiratory flow limitation at rest. Eur. Respir. J. 2000; 16: 269-275.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Marin J.M., Carrizo S.J., Gascon M. et al. Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 163: 1395-1399.</mixed-citation><mixed-citation xml:lang="en">Marin J.M., Carrizo S.J., Gascon M. et al. Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 163: 1395-1399.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Newton M.F., O'Donnell D.E., Forkert L. Response of lung volumes to inhaled salbutamol in a large population of patients with severe hyperinflation. Chest 2002; 121: 1042-1050.</mixed-citation><mixed-citation xml:lang="en">Newton M.F., O'Donnell D.E., Forkert L. Response of lung volumes to inhaled salbutamol in a large population of patients with severe hyperinflation. Chest 2002; 121: 1042-1050.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Murciano D., Ferretti A., Boczkowski J. et al. Flow limitation and dynamic hyperinflation during exercise in COPD patients after single lung transplantation. Chest 2000; 118: 1248-1254.</mixed-citation><mixed-citation xml:lang="en">Murciano D., Ferretti A., Boczkowski J. et al. Flow limitation and dynamic hyperinflation during exercise in COPD patients after single lung transplantation. Chest 2000; 118: 1248-1254.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Casanova C., Cote C., de Torres J.P. et al. Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2005; 171: 591-597.</mixed-citation><mixed-citation xml:lang="en">Casanova C., Cote C., de Torres J.P. et al. Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2005; 171: 591-597.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Ingenito E.P., Loring S.H., Moy M.L. et al. Physiological characterization of variability in response to lung volume reduction surgery. J. Appl. Physiol. 2003; 94: 20-30.</mixed-citation><mixed-citation xml:lang="en">Ingenito E.P., Loring S.H., Moy M.L. et al. Physiological characterization of variability in response to lung volume reduction surgery. J. Appl. Physiol. 2003; 94: 20-30.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Tantucci C., Duguet A., Similowski T. et al. Effect of salbutamol on dynamic hyperinflation in chronic obstructive pulmonary disease patients. Eur. Respir. J. 1998; 12: 799-804.</mixed-citation><mixed-citation xml:lang="en">Tantucci C., Duguet A., Similowski T. et al. Effect of salbutamol on dynamic hyperinflation in chronic obstructive pulmonary disease patients. Eur. Respir. J. 1998; 12: 799-804.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Maltais F., Hamilton A., Marciniuk D. et al. Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD. Chest 2005; 128: 1168-1178.</mixed-citation><mixed-citation xml:lang="en">Maltais F., Hamilton A., Marciniuk D. et al. Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD. Chest 2005; 128: 1168-1178.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell D.E. Is sustained pharmacologic lung volume reduction now possible in COPD? Chest 2006; 129: 501-503.</mixed-citation><mixed-citation xml:lang="en">O'Donnell D.E. Is sustained pharmacologic lung volume reduction now possible in COPD? Chest 2006; 129: 501-503.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Celli B., ZuWallack R., Wang S., Kesten S. Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes. Chest 2003; 124: 1743-1748.</mixed-citation><mixed-citation xml:lang="en">Celli B., ZuWallack R., Wang S., Kesten S. Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes. Chest 2003; 124: 1743-1748.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">van Noord J.A., Aumann J.L., Janssens E. et al. Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD. Chest 2006; 129: 509-517.</mixed-citation><mixed-citation xml:lang="en">van Noord J.A., Aumann J.L., Janssens E. et al. Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD. Chest 2006; 129: 509-517.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Stevenson N.J., Walker P.P., Costello R.W., Calverley P.M. Lung mechanics and dyspnea during exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2005; 172: 1510-1516.</mixed-citation><mixed-citation xml:lang="en">Stevenson N.J., Walker P.P., Costello R.W., Calverley P.M. Lung mechanics and dyspnea during exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2005; 172: 1510-1516.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Duranti R., Filippelli M., Bianchi R. et al. Inspiratory capacity and decrease in lung hyperinflation with albuterol in COPD. Chest 2002; 122: 2009-2014.</mixed-citation><mixed-citation xml:lang="en">Duranti R., Filippelli M., Bianchi R. et al. Inspiratory capacity and decrease in lung hyperinflation with albuterol in COPD. Chest 2002; 122: 2009-2014.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Dolmage T.E., Goldstein R.S. Repeatability of inspiratory capacity during incremental exercise in patients with severe COPD. Chest 2002; 121: 708-714.</mixed-citation><mixed-citation xml:lang="en">Dolmage T.E., Goldstein R.S. Repeatability of inspiratory capacity during incremental exercise in patients with severe COPD. Chest 2002; 121: 708-714.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Yan S., Kaminski D., Sliwinski P. Reliability of inspiratory capacity for estimating end-expiratory lung volume changes during exercise in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1997; 156: 55-59.</mixed-citation><mixed-citation xml:lang="en">Yan S., Kaminski D., Sliwinski P. Reliability of inspiratory capacity for estimating end-expiratory lung volume changes during exercise in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1997; 156: 55-59.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">American Thoracic Society. Single-breath carbon monoxide diffusing capacity (transfer factor). Recommendations for a standard technique - 1995 update. Am. J. Respir. Crit. Care Med. 1995; 152: 2185-2198.</mixed-citation><mixed-citation xml:lang="en">American Thoracic Society. Single-breath carbon monoxide diffusing capacity (transfer factor). Recommendations for a standard technique - 1995 update. Am. J. Respir. Crit. Care Med. 1995; 152: 2185-2198.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Cramer D. Standardization of the measurement of transfer factor. Eur. Respir. J. 1993; 6: 1577-1578.</mixed-citation><mixed-citation xml:lang="en">Cramer D. Standardization of the measurement of transfer factor. Eur. Respir. J. 1993; 6: 1577-1578.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Macintyre N., Crapo R.O., Viegi G. et al. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur. Respir. J. 2005; 26: 720-735.</mixed-citation><mixed-citation xml:lang="en">Macintyre N., Crapo R.O., Viegi G. et al. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur. Respir. J. 2005; 26: 720-735.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Paoletti P., Viegi G., Pistelli G. et al. Reference equations for the single-breath diffusing capacity. A cross-sectional analysis and effect of body size and age. Am. Rev. Respir. Dis. 1985; 132: 806-813.</mixed-citation><mixed-citation xml:lang="en">Paoletti P., Viegi G., Pistelli G. et al. Reference equations for the single-breath diffusing capacity. A cross-sectional analysis and effect of body size and age. Am. Rev. Respir. Dis. 1985; 132: 806-813.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Knudson R.J., Kaltenborn W.T., Knudson D.E., Burrows B. The single-breath carbon monoxide diffusing capacity. Reference equations derived from a healthy nonsmoking population and effects of hematocrit. Am. Rev. Respir. Dis. 1987; 135: 805-811.</mixed-citation><mixed-citation xml:lang="en">Knudson R.J., Kaltenborn W.T., Knudson D.E., Burrows B. The single-breath carbon monoxide diffusing capacity. Reference equations derived from a healthy nonsmoking population and effects of hematocrit. Am. Rev. Respir. Dis. 1987; 135: 805-811.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Roca J., Rodriguez-Roisin R., Cobo E. et al. Single-breath carbon monoxide diffusing capacity prediction equations from a Mediterranean population. Am. Rev. Respir. Dis. 1990; 141: 1026-1032.</mixed-citation><mixed-citation xml:lang="en">Roca J., Rodriguez-Roisin R., Cobo E. et al. Single-breath carbon monoxide diffusing capacity prediction equations from a Mediterranean population. Am. Rev. Respir. Dis. 1990; 141: 1026-1032.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Cerveri I., Dore R., Corsico A. et al. Assessment of emphysema in COPD: a functional and radiologic study. Chest 2004; 125: 1714-1718.</mixed-citation><mixed-citation xml:lang="en">Cerveri I., Dore R., Corsico A. et al. Assessment of emphysema in COPD: a functional and radiologic study. Chest 2004; 125: 1714-1718.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Goldberg R., Hillberg R., Reinecker L., Goldstein R. Evaluation of patients with severe pulmonary disease before and after pulmonary rehabilitation. Disabil. and Rehabil. 2004; 26: 641-648.</mixed-citation><mixed-citation xml:lang="en">Goldberg R., Hillberg R., Reinecker L., Goldstein R. Evaluation of patients with severe pulmonary disease before and after pulmonary rehabilitation. Disabil. and Rehabil. 2004; 26: 641-648.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Trow T.K. Lung-volume reduction surgery for severe emphysema: appraisal of its current status. Curr. Opin. Pulm. Med. 2004; 10: 128-132.</mixed-citation><mixed-citation xml:lang="en">Trow T.K. Lung-volume reduction surgery for severe emphysema: appraisal of its current status. Curr. Opin. Pulm. Med. 2004; 10: 128-132.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Meyers B.F., Yusen R.D., Guthrie T.J. et al. Results of lung volume reduction surgery in patients meeting a national emphysema treatment trial high-risk criterion. J. Thorac. Cardiovasc. Surg. 2004; 127: 829-835.</mixed-citation><mixed-citation xml:lang="en">Meyers B.F., Yusen R.D., Guthrie T.J. et al. Results of lung volume reduction surgery in patients meeting a national emphysema treatment trial high-risk criterion. J. Thorac. Cardiovasc. Surg. 2004; 127: 829-835.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Wanger J., Irvin C. Comparability of pulmonary function results from 13 laboratories in a metropolitan area. Respir. Care 1991; 36: 1375-1382.</mixed-citation><mixed-citation xml:lang="en">Wanger J., Irvin C. Comparability of pulmonary function results from 13 laboratories in a metropolitan area. Respir. Care 1991; 36: 1375-1382.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Gaensler E.A., Smith A.A. Attachment for automated single breath diffusing capacity measurement. Chest 1973; 63: 136-145.</mixed-citation><mixed-citation xml:lang="en">Gaensler E.A., Smith A.A. Attachment for automated single breath diffusing capacity measurement. Chest 1973; 63: 136-145.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Punjabi N.M., Shade D., Patel A.M., Wise R.A. Measurement variability in single-breath diffusing capacity of the lung. Chest 2003; 123: 1082-1089.</mixed-citation><mixed-citation xml:lang="en">Punjabi N.M., Shade D., Patel A.M., Wise R.A. Measurement variability in single-breath diffusing capacity of the lung. Chest 2003; 123: 1082-1089.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Hathaway E.H., Tashkin D.P., Simmons M.S. Intraindividual variability in serial measurements of DL,CO and alveolar volume over one year in eight healthy subjects using three independent measuring systems. Am. Rev. Respir. Dis. 1989; 140: 1818-1822.</mixed-citation><mixed-citation xml:lang="en">Hathaway E.H., Tashkin D.P., Simmons M.S. Intraindividual variability in serial measurements of DL,CO and alveolar volume over one year in eight healthy subjects using three independent measuring systems. Am. Rev. Respir. Dis. 1989; 140: 1818-1822.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Bolliger C.T., Koegelenberg C.F., Kendal R. Preoperative assessment for lung cancer surgery. Curr. Opin. Pulm. Med. 2005; 11: 301-306.</mixed-citation><mixed-citation xml:lang="en">Bolliger C.T., Koegelenberg C.F., Kendal R. Preoperative assessment for lung cancer surgery. Curr. Opin. Pulm. Med. 2005; 11: 301-306.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Schluchter M.D., Stoller J.K., Barker A.F. et al. Feasibility of a clinical trial of augmentation therapy for a1-antitrypsin deficiency. The a1-Antitrypsin Deficiency Registry Study Group. Am. J. Respir. Crit. Care Med. 2000; 161: 796-801.</mixed-citation><mixed-citation xml:lang="en">Schluchter M.D., Stoller J.K., Barker A.F. et al. Feasibility of a clinical trial of augmentation therapy for a1-antitrypsin deficiency. The a1-Antitrypsin Deficiency Registry Study Group. Am. J. Respir. Crit. Care Med. 2000; 161: 796-801.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Stoller J.K., Snider G.L., Brantly M.L. et al. American Thoracic Society / European Respiratory Society Statement: Standards for the diagnosis and management of individuals with a1-antitrypsin deficiency. Pneumologie 2005; 59: 36-68.</mixed-citation><mixed-citation xml:lang="en">Stoller J.K., Snider G.L., Brantly M.L. et al. American Thoracic Society / European Respiratory Society Statement: Standards for the diagnosis and management of individuals with a1-antitrypsin deficiency. Pneumologie 2005; 59: 36-68.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Eaton T., Rudkin S., Garrett J.E. The clinical utility of arterialized earlobe capillary blood in the assessment of patients for long-term oxygen therapy. Respir. Med. 2001; 95: 655-660.</mixed-citation><mixed-citation xml:lang="en">Eaton T., Rudkin S., Garrett J.E. The clinical utility of arterialized earlobe capillary blood in the assessment of patients for long-term oxygen therapy. Respir. Med. 2001; 95: 655-660.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Fajac I., Texereau J., Rivoal V. et al. Blood gas measurement during exercise: a comparative study between arterialized earlobe sampling and direct arterial puncture in adults. Eur. Respir. J. 1998; 11: 712-715.</mixed-citation><mixed-citation xml:lang="en">Fajac I., Texereau J., Rivoal V. et al. Blood gas measurement during exercise: a comparative study between arterialized earlobe sampling and direct arterial puncture in adults. Eur. Respir. J. 1998; 11: 712-715.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Williams A.J. ABC of oxygen: assessing and interpreting arterial blood gases and acid-base balance. Br. Med. J. 1998; 317: 1213-1216.</mixed-citation><mixed-citation xml:lang="en">Williams A.J. ABC of oxygen: assessing and interpreting arterial blood gases and acid-base balance. Br. Med. J. 1998; 317: 1213-1216.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Raff H. The significance of the blood gas analyzer. J. Appl. Physiol. 2004; 97: 1597-1598.</mixed-citation><mixed-citation xml:lang="en">Raff H. The significance of the blood gas analyzer. J. Appl. Physiol. 2004; 97: 1597-1598.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Severinghaus J.W. First electrodes for blood PO2 and PCO2 determination. J. Appl. Physiol. 2004; 97: 1599-1600.</mixed-citation><mixed-citation xml:lang="en">Severinghaus J.W. First electrodes for blood PO2 and PCO2 determination. J. Appl. Physiol. 2004; 97: 1599-1600.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Aoyagi T. Pulse oximetry: its invention, theory, and future. J. Anesth. 2003; 17: 259-266.</mixed-citation><mixed-citation xml:lang="en">Aoyagi T. Pulse oximetry: its invention, theory, and future. J. Anesth. 2003; 17: 259-266.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Jubran A. Pulse oximetry. Intensive Care Med. 2004; 30: 2017-2020.</mixed-citation><mixed-citation xml:lang="en">Jubran A. Pulse oximetry. Intensive Care Med. 2004; 30: 2017-2020.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Sinex J.E. Pulse oximetry: principles and limitations. Am. J. Emerg. Med. 1999; 17: 59-67.</mixed-citation><mixed-citation xml:lang="en">Sinex J.E. Pulse oximetry: principles and limitations. Am. J. Emerg. Med. 1999; 17: 59-67.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Welch J. Pulse oximeters. Biomed Instrum Technol 2005; 39: 125-130.</mixed-citation><mixed-citation xml:lang="en">Welch J. Pulse oximeters. Biomed Instrum Technol 2005; 39: 125-130.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Cerveri I., Zoia M.C., Fanfulla F. et al. Reference values of arterial oxygen tension in the middle-aged and elderly. Am. J. Respir. Crit. Care Med. 1995; 152: 934-941.</mixed-citation><mixed-citation xml:lang="en">Cerveri I., Zoia M.C., Fanfulla F. et al. Reference values of arterial oxygen tension in the middle-aged and elderly. Am. J. Respir. Crit. Care Med. 1995; 152: 934-941.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Hardie J.A., Vollmer W.M., Buist A.S. et al. Reference values for arterial blood gases in the elderly. Chest 2004; 125: 2053-2060.</mixed-citation><mixed-citation xml:lang="en">Hardie J.A., Vollmer W.M., Buist A.S. et al. Reference values for arterial blood gases in the elderly. Chest 2004; 125: 2053-2060.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Soler-Cataluña J.J., Martínez-García M.A., Román Sánchez P. et al. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax 2005; 60: 925-931.</mixed-citation><mixed-citation xml:lang="en">Soler-Cataluña J.J., Martínez-García M.A., Román Sánchez P. et al. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax 2005; 60: 925-931.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Gunen H., Hacievliyagil S.S., Kosar F. et al. Factors affecting survival of hospitalised patients with COPD. Eur. Respir. J. 2005; 26: 234-241.</mixed-citation><mixed-citation xml:lang="en">Gunen H., Hacievliyagil S.S., Kosar F. et al. Factors affecting survival of hospitalised patients with COPD. Eur. Respir. J. 2005; 26: 234-241.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Gay P.C. Chronic obstructive pulmonary disease and sleep. Respir. Care 2004; 49: 39-51.</mixed-citation><mixed-citation xml:lang="en">Gay P.C. Chronic obstructive pulmonary disease and sleep. Respir. Care 2004; 49: 39-51.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Littner M.R. Portable monitoring in the diagnosis of the obstructive sleep apnea syndrome. Semin. Respir. Crit. Care Med. 2005; 26: 56-67.</mixed-citation><mixed-citation xml:lang="en">Littner M.R. Portable monitoring in the diagnosis of the obstructive sleep apnea syndrome. Semin. Respir. Crit. Care Med. 2005; 26: 56-67.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Datta D., Vitale A., Lahiri B., ZuWallack R. An evaluation of nebulized levalbuterol in stable COPD. Chest 2003; 124: 844-849.</mixed-citation><mixed-citation xml:lang="en">Datta D., Vitale A., Lahiri B., ZuWallack R. An evaluation of nebulized levalbuterol in stable COPD. Chest 2003; 124: 844-849.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Sans-Torres J., Domingo C., Moron A. et al. Long-term effects of almitrine bismesylate in COPD patients with chronic hypoxaemia. Respir. Med. 2003; 97: 599-605.</mixed-citation><mixed-citation xml:lang="en">Sans-Torres J., Domingo C., Moron A. et al. Long-term effects of almitrine bismesylate in COPD patients with chronic hypoxaemia. Respir. Med. 2003; 97: 599-605.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Cazzola M., Santus P., Matera M.G. et al. A single high dose of formoterol is as effective as the same dose administered in a cumulative manner in patients with acute exacerbation of COPD. Respir. Med. 2003; 97: 458-462.</mixed-citation><mixed-citation xml:lang="en">Cazzola M., Santus P., Matera M.G. et al. A single high dose of formoterol is as effective as the same dose administered in a cumulative manner in patients with acute exacerbation of COPD. Respir. Med. 2003; 97: 458-462.</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Cazzola M., Santus P., di Marco F. et al. Bronchodilator effect of an inhaled combination therapy with salmeterol + fluticasone and formoterol + budesonide in patients with COPD. Respir. Med. 2003; 97: 453-457.</mixed-citation><mixed-citation xml:lang="en">Cazzola M., Santus P., di Marco F. et al. Bronchodilator effect of an inhaled combination therapy with salmeterol + fluticasone and formoterol + budesonide in patients with COPD. Respir. Med. 2003; 97: 453-457.</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Jaen Díaz J.I., de Castro M.C., Cordero G.B. et al. Effectiveness of treatment with tiotropium in patients who suffer from COPD. Med. Clin. (Barc.) 2005; 124: 1-3.</mixed-citation><mixed-citation xml:lang="en">Jaen Díaz J.I., de Castro M.C., Cordero G.B. et al. Effectiveness of treatment with tiotropium in patients who suffer from COPD. Med. Clin. (Barc.) 2005; 124: 1-3.</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Soto F.J., Varkey B. Evidence-based approach to acute exacerbations of COPD. Curr. Opin. Pulm. Med. 2003; 9: 117-124.</mixed-citation><mixed-citation xml:lang="en">Soto F.J., Varkey B. Evidence-based approach to acute exacerbations of COPD. Curr. Opin. Pulm. Med. 2003; 9: 117-124.</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">Higgins D. Pulse oximetry. Nurs. Times 2005; 101: 34-35.</mixed-citation><mixed-citation xml:lang="en">Higgins D. Pulse oximetry. Nurs. Times 2005; 101: 34-35.</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">Lawrence J.P. Advances and new insights in monitoring. Thorac. Surg. Clin. 2005; 15: 55-70.</mixed-citation><mixed-citation xml:lang="en">Lawrence J.P. Advances and new insights in monitoring. Thorac. Surg. Clin. 2005; 15: 55-70.</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">Hildick-Smith D.J., Lowe M.D., Walsh J.T. et al. Coronary angiography from the radial artery - experience, complications and limitations. Int. J. Cardiol. 1998; 64: 231-239.</mixed-citation><mixed-citation xml:lang="en">Hildick-Smith D.J., Lowe M.D., Walsh J.T. et al. Coronary angiography from the radial artery - experience, complications and limitations. Int. J. Cardiol. 1998; 64: 231-239.</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">Fabbri L.M., Hurd S.S. Global Strategy for the diagnosis, management and prevention of COPD: 2003 update. Eur. Respir. J. 2003; 22: 1-2.</mixed-citation><mixed-citation xml:lang="en">Fabbri L.M., Hurd S.S. Global Strategy for the diagnosis, management and prevention of COPD: 2003 update. Eur. Respir. J. 2003; 22: 1-2.</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">Arnold R., Ranchor A.V., Koeter G.H. et al. Consequences of chronic obstructive pulmonary disease and chronic heart failure: the relationship between objective and subjective health. Soc. Sci. Med. 2005; 61: 2144-2154.</mixed-citation><mixed-citation xml:lang="en">Arnold R., Ranchor A.V., Koeter G.H. et al. Consequences of chronic obstructive pulmonary disease and chronic heart failure: the relationship between objective and subjective health. Soc. Sci. Med. 2005; 61: 2144-2154.</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">Jones P., Lareau S., Mahler D.A. Measuring the effects of COPD on the patient. Respir. Med. 2005; 99 (suppl. 2): S11-S18.</mixed-citation><mixed-citation xml:lang="en">Jones P., Lareau S., Mahler D.A. Measuring the effects of COPD on the patient. Respir. Med. 2005; 99 (suppl. 2): S11-S18.</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">Hickey A.M., Bury G., O'Boyle C.A. et al. A new short form individual quality of life measure (SEIQoL-DW): application in a cohort of individuals with HIV / AIDS. Br. Med. J. 1996; 313: 29-33.</mixed-citation><mixed-citation xml:lang="en">Hickey A.M., Bury G., O'Boyle C.A. et al. A new short form individual quality of life measure (SEIQoL-DW): application in a cohort of individuals with HIV / AIDS. Br. Med. J. 1996; 313: 29-33.</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">American Thoracic Society. Quality of Life Resource. www.atsqol.org Date last accessed: October 25, 2007.</mixed-citation><mixed-citation xml:lang="en">American Thoracic Society. Quality of Life Resource. www.atsqol.org Date last accessed: October 25, 2007.</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">Ware J.E. Jr., Gandek B. Overview of the SF-36 Health Survey and the International Quality of Life Assessment (IQoLA) project. J. Clin. Epidemiol. 1998; 51: 903-912.</mixed-citation><mixed-citation xml:lang="en">Ware J.E. Jr., Gandek B. Overview of the SF-36 Health Survey and the International Quality of Life Assessment (IQoLA) project. J. Clin. Epidemiol. 1998; 51: 903-912.</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">Bergner M. The sickness impact profile. In: Walker S.R., ed. Quality of life: Assessment and application. Boston: M. T. P.; 1987. 79-94.</mixed-citation><mixed-citation xml:lang="en">Bergner M. The sickness impact profile. In: Walker S.R., ed. Quality of life: Assessment and application. Boston: M. T. P.; 1987. 79-94.</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">Hunt S.M., McEwen J. The development of a subjective health indicator. Soc. Hlth Illn. 1980; 2: 231-246.</mixed-citation><mixed-citation xml:lang="en">Hunt S.M., McEwen J. The development of a subjective health indicator. Soc. Hlth Illn. 1980; 2: 231-246.</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">Guyatt G.H., Berman L.B., Townsend M. et al. A measure of quality of life for clinical trials in chronic lung disease. Thorax 1987; 42: 773-778.</mixed-citation><mixed-citation xml:lang="en">Guyatt G.H., Berman L.B., Townsend M. et al. A measure of quality of life for clinical trials in chronic lung disease. Thorax 1987; 42: 773-778.</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">Schunemann H.J., Goldstein R., Mador M.J. et al. A randomised trial to evaluate the self-administered standardized chronic respiratory questionnaire. Eur. Respir. J. 2005; 25: 31-40.</mixed-citation><mixed-citation xml:lang="en">Schunemann H.J., Goldstein R., Mador M.J. et al. A randomised trial to evaluate the self-administered standardized chronic respiratory questionnaire. Eur. Respir. J. 2005; 25: 31-40.</mixed-citation></citation-alternatives></ref><ref id="cit117"><label>117</label><citation-alternatives><mixed-citation xml:lang="ru">Puhan M.A., Behnke M., Frey M. et al. Self-administration and interviewer-administration of the German Chronic Respiratory Questionnaire: instrument development and assessment of validity and reliability in two randomized studies. Hlth Qual. Life Outcomes 2004; 2: 1.</mixed-citation><mixed-citation xml:lang="en">Puhan M.A., Behnke M., Frey M. et al. Self-administration and interviewer-administration of the German Chronic Respiratory Questionnaire: instrument development and assessment of validity and reliability in two randomized studies. Hlth Qual. Life Outcomes 2004; 2: 1.</mixed-citation></citation-alternatives></ref><ref id="cit118"><label>118</label><citation-alternatives><mixed-citation xml:lang="ru">Wyrwich K.W., Tierney W.M., Wolinsky F.D. Further evidence supporting an SEM-based criterion for identifying meaningful intra-individual changes in health-related quality of life. J. Clin. Epidemiol. 1999; 52: 861-873.</mixed-citation><mixed-citation xml:lang="en">Wyrwich K.W., Tierney W.M., Wolinsky F.D. Further evidence supporting an SEM-based criterion for identifying meaningful intra-individual changes in health-related quality of life. J. Clin. Epidemiol. 1999; 52: 861-873.</mixed-citation></citation-alternatives></ref><ref id="cit119"><label>119</label><citation-alternatives><mixed-citation xml:lang="ru">Jones P.W., Quirk F.H., Baveystock C.M., Littlejohns P. A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am. Rev. Respir. Dis. 1992; 145: 1321-1327.</mixed-citation><mixed-citation xml:lang="en">Jones P.W., Quirk F.H., Baveystock C.M., Littlejohns P. A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am. Rev. Respir. Dis. 1992; 145: 1321-1327.</mixed-citation></citation-alternatives></ref><ref id="cit120"><label>120</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson C.B., Jones P.W., O'Leary C.J. et al. Validation of the St. George's Respiratory Questionnaire in bronchiectasis. Am. J. Respir. Crit. Care Med. 1997; 156: 536-541.</mixed-citation><mixed-citation xml:lang="en">Wilson C.B., Jones P.W., O'Leary C.J. et al. Validation of the St. George's Respiratory Questionnaire in bronchiectasis. Am. J. Respir. Crit. Care Med. 1997; 156: 536-541.</mixed-citation></citation-alternatives></ref><ref id="cit121"><label>121</label><citation-alternatives><mixed-citation xml:lang="ru">Maille A.R., Koning C.J., Zwinderman A.H. et al. The development of the ''Quality-of-life for Respiratory Illness Questionnaire (QoL-RIQ)'': a disease-specific quality-of-life questionnaire for patients with mild to moderate chronic nonspecific lung disease. Respir. Med. 1997; 91: 297-309.</mixed-citation><mixed-citation xml:lang="en">Maille A.R., Koning C.J., Zwinderman A.H. et al. The development of the ''Quality-of-life for Respiratory Illness Questionnaire (QoL-RIQ)'': a disease-specific quality-of-life questionnaire for patients with mild to moderate chronic nonspecific lung disease. Respir. Med. 1997; 91: 297-309.</mixed-citation></citation-alternatives></ref><ref id="cit122"><label>122</label><citation-alternatives><mixed-citation xml:lang="ru">Jacobs J.E., Maille A.R., Akkermans R.P. et al. Assessing the quality of life of adults with chronic respiratory diseases in routine primary care: construction and first validation of the 10-Item Respiratory Illness Questionnaire-Monitoring 10 (RIQMON10). Qual. Life Res. 2004; 13: 1117-1127.</mixed-citation><mixed-citation xml:lang="en">Jacobs J.E., Maille A.R., Akkermans R.P. et al. Assessing the quality of life of adults with chronic respiratory diseases in routine primary care: construction and first validation of the 10-Item Respiratory Illness Questionnaire-Monitoring 10 (RIQMON10). Qual. Life Res. 2004; 13: 1117-1127.</mixed-citation></citation-alternatives></ref><ref id="cit123"><label>123</label><citation-alternatives><mixed-citation xml:lang="ru">Barley E.A., Quirk F.H., Jones P.W. Asthma health status measurement in clinical practice: validity of a new short and simple instrument. Respir. Med. 1998; 92: 1207-1214.</mixed-citation><mixed-citation xml:lang="en">Barley E.A., Quirk F.H., Jones P.W. Asthma health status measurement in clinical practice: validity of a new short and simple instrument. Respir. Med. 1998; 92: 1207-1214.</mixed-citation></citation-alternatives></ref><ref id="cit124"><label>124</label><citation-alternatives><mixed-citation xml:lang="ru">Hajiro T., Nishimura K., Jones P.W. et al. A novel, short, and simple questionnaire to measure health-related quality of life in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1999; 159: 1874-1878.</mixed-citation><mixed-citation xml:lang="en">Hajiro T., Nishimura K., Jones P.W. et al. A novel, short, and simple questionnaire to measure health-related quality of life in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1999; 159: 1874-1878.</mixed-citation></citation-alternatives></ref><ref id="cit125"><label>125</label><citation-alternatives><mixed-citation xml:lang="ru">Alemayehu B., Aubert R.E., Feifer R.A., Paul L.D. Comparative analysis of two quality-of-life instruments for patients with chronic obstructive pulmonary disease. Value Hlth 2002; 5: 436-441.</mixed-citation><mixed-citation xml:lang="en">Alemayehu B., Aubert R.E., Feifer R.A., Paul L.D. Comparative analysis of two quality-of-life instruments for patients with chronic obstructive pulmonary disease. Value Hlth 2002; 5: 436-441.</mixed-citation></citation-alternatives></ref><ref id="cit126"><label>126</label><citation-alternatives><mixed-citation xml:lang="ru">Hyland M.E., Bott J., Singh S., Kenyon C.A. Domains, constructs and the development of the breathing problems questionnaire. Qual. Life Res. 1994; 3: 245-256.</mixed-citation><mixed-citation xml:lang="en">Hyland M.E., Bott J., Singh S., Kenyon C.A. Domains, constructs and the development of the breathing problems questionnaire. Qual. Life Res. 1994; 3: 245-256.</mixed-citation></citation-alternatives></ref><ref id="cit127"><label>127</label><citation-alternatives><mixed-citation xml:lang="ru">Hyland M.E., Singh S.J., Sodergren S.C., Morgan M.P. Development of a shortened version of the Breathing Problems Questionnaire suitable for use in a pulmonary rehabilitation clinic: a purpose-specific, disease-specific questionnaire. Qual. Life Res. 1998; 7: 227-233.</mixed-citation><mixed-citation xml:lang="en">Hyland M.E., Singh S.J., Sodergren S.C., Morgan M.P. Development of a shortened version of the Breathing Problems Questionnaire suitable for use in a pulmonary rehabilitation clinic: a purpose-specific, disease-specific questionnaire. Qual. Life Res. 1998; 7: 227-233.</mixed-citation></citation-alternatives></ref><ref id="cit128"><label>128</label><citation-alternatives><mixed-citation xml:lang="ru">Carone M., Bertolotti G., Anchisi F. et al. Analysis of factors that characterize health impairment in patients with chronic respiratory failure. Quality of Life in Chronic Respiratory Failure Group. Eur. Respir. J. 1999; 13: 1293-1300.</mixed-citation><mixed-citation xml:lang="en">Carone M., Bertolotti G., Anchisi F. et al. Analysis of factors that characterize health impairment in patients with chronic respiratory failure. Quality of Life in Chronic Respiratory Failure Group. Eur. Respir. J. 1999; 13: 1293-1300.</mixed-citation></citation-alternatives></ref><ref id="cit129"><label>129</label><citation-alternatives><mixed-citation xml:lang="ru">van der Molen T., Willemse B.W., Schokker S. et al. Development, validity and responsiveness of the Clinical COPD Questionnaire. Hlth Qual. Life Outcomes 2003; 1: 13.</mixed-citation><mixed-citation xml:lang="en">van der Molen T., Willemse B.W., Schokker S. et al. Development, validity and responsiveness of the Clinical COPD Questionnaire. Hlth Qual. Life Outcomes 2003; 1: 13.</mixed-citation></citation-alternatives></ref><ref id="cit130"><label>130</label><citation-alternatives><mixed-citation xml:lang="ru">Lareau S.C., Meek P.M., Roos P.J. Development and testing of the modified version of the pulmonary functional status and dyspnoea questionnaire (PFSDQ-M). Heart Lung 1998; 27: 159-168.</mixed-citation><mixed-citation xml:lang="en">Lareau S.C., Meek P.M., Roos P.J. Development and testing of the modified version of the pulmonary functional status and dyspnoea questionnaire (PFSDQ-M). Heart Lung 1998; 27: 159-168.</mixed-citation></citation-alternatives></ref><ref id="cit131"><label>131</label><citation-alternatives><mixed-citation xml:lang="ru">Weaver T.E., Narsavage G.L., Guilfoyle M.J. The development and psychometric evaluation of the Pulmonary Functional Status Scale: an instrument to assess functional status in pulmonary disease. J. Cardiopulm. Rehabil. 1998; 18: 105-111.</mixed-citation><mixed-citation xml:lang="en">Weaver T.E., Narsavage G.L., Guilfoyle M.J. The development and psychometric evaluation of the Pulmonary Functional Status Scale: an instrument to assess functional status in pulmonary disease. J. Cardiopulm. Rehabil. 1998; 18: 105-111.</mixed-citation></citation-alternatives></ref><ref id="cit132"><label>132</label><citation-alternatives><mixed-citation xml:lang="ru">Nouri F.M., Lincoln N.B. An extended activities of daily living scale for stroke patients. Clin. Rehabil. 1987; 1: 301-305.</mixed-citation><mixed-citation xml:lang="en">Nouri F.M., Lincoln N.B. An extended activities of daily living scale for stroke patients. Clin. Rehabil. 1987; 1: 301-305.</mixed-citation></citation-alternatives></ref><ref id="cit133"><label>133</label><citation-alternatives><mixed-citation xml:lang="ru">Okubadejo A.A., O'Shea L., Jones P.W., Wedzicha J.A. Home assessment of activities of daily living in patients with severe chronic obstructive pulmonary disease on longterm oxygen therapy. Eur. Respir. J. 1997; 10: 1572-1575.</mixed-citation><mixed-citation xml:lang="en">Okubadejo A.A., O'Shea L., Jones P.W., Wedzicha J.A. Home assessment of activities of daily living in patients with severe chronic obstructive pulmonary disease on longterm oxygen therapy. Eur. Respir. J. 1997; 10: 1572-1575.</mixed-citation></citation-alternatives></ref><ref id="cit134"><label>134</label><citation-alternatives><mixed-citation xml:lang="ru">Garrod R., Bestall J.C., Paul E.A. et al. Development and validation of a standardized measure of activity of daily living in patients with severe COPD: the London Chest Activity of Daily Living scale (LCADL). Respir. Med. 2000; 94: 589-596.</mixed-citation><mixed-citation xml:lang="en">Garrod R., Bestall J.C., Paul E.A. et al. Development and validation of a standardized measure of activity of daily living in patients with severe COPD: the London Chest Activity of Daily Living scale (LCADL). Respir. Med. 2000; 94: 589-596.</mixed-citation></citation-alternatives></ref><ref id="cit135"><label>135</label><citation-alternatives><mixed-citation xml:lang="ru">Schunemann H.J., Goldstein R., Mador M.J. et al. Do clinical marker states improve responsiveness and construct validity of the standard gamble and feeling thermometer: a randomized multi-center trial in patients with chronic respiratory disease. Qual. Life Res. 2006; 15: 1-14.</mixed-citation><mixed-citation xml:lang="en">Schunemann H.J., Goldstein R., Mador M.J. et al. Do clinical marker states improve responsiveness and construct validity of the standard gamble and feeling thermometer: a randomized multi-center trial in patients with chronic respiratory disease. Qual. Life Res. 2006; 15: 1-14.</mixed-citation></citation-alternatives></ref><ref id="cit136"><label>136</label><citation-alternatives><mixed-citation xml:lang="ru">Schunemann H.J., Griffith L., Stubbing D. et al. A clinical trial to evaluate the measurement properties of 2 direct preference instruments administered with and without hypothetical marker states. Med. Decis Making 2003; 23: 140-149.</mixed-citation><mixed-citation xml:lang="en">Schunemann H.J., Griffith L., Stubbing D. et al. A clinical trial to evaluate the measurement properties of 2 direct preference instruments administered with and without hypothetical marker states. Med. Decis Making 2003; 23: 140-149.</mixed-citation></citation-alternatives></ref><ref id="cit137"><label>137</label><citation-alternatives><mixed-citation xml:lang="ru">Schunemann H.J., Griffith L., Jaeschke R. et al. Evaluation of the minimal important difference for the feeling thermometer and the St. George's Respiratory Questionnaire in patients with chronic airflow obstruction. J. Clin. Epidemiol. 2003; 56: 1170-1176.</mixed-citation><mixed-citation xml:lang="en">Schunemann H.J., Griffith L., Jaeschke R. et al. Evaluation of the minimal important difference for the feeling thermometer and the St. George's Respiratory Questionnaire in patients with chronic airflow obstruction. J. Clin. Epidemiol. 2003; 56: 1170-1176.</mixed-citation></citation-alternatives></ref><ref id="cit138"><label>138</label><citation-alternatives><mixed-citation xml:lang="ru">Puhan M.A., Guyatt G.H., Montori V.M. et al. The standard gamble demonstrated lower reliability than the feeling thermometer. J. Clin. Epidemiol. 2005; 58: 458-465.</mixed-citation><mixed-citation xml:lang="en">Puhan M.A., Guyatt G.H., Montori V.M. et al. The standard gamble demonstrated lower reliability than the feeling thermometer. J. Clin. Epidemiol. 2005; 58: 458-465.</mixed-citation></citation-alternatives></ref><ref id="cit139"><label>139</label><citation-alternatives><mixed-citation xml:lang="ru">Kaplan R.M., Atkins C.J., Timms R. Validity of a quality of well-being scale as an outcome measure in chronic obstructive pulmonary disease. J. Chron. Dis. 1984; 37: 85-95.</mixed-citation><mixed-citation xml:lang="en">Kaplan R.M., Atkins C.J., Timms R. Validity of a quality of well-being scale as an outcome measure in chronic obstructive pulmonary disease. J. Chron. Dis. 1984; 37: 85-95.</mixed-citation></citation-alternatives></ref><ref id="cit140"><label>140</label><citation-alternatives><mixed-citation xml:lang="ru">EuroQol Group. EQ-5D. http://www.euroqol.org. Date last accessed: October 25, 2007.</mixed-citation><mixed-citation xml:lang="en">EuroQol Group. EQ-5D. http://www.euroqol.org. Date last accessed: October 25, 2007.</mixed-citation></citation-alternatives></ref><ref id="cit141"><label>141</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A. Measurement of dyspnea: clinical ratings. In: Mahler D.A., ed. Dyspnea: Mechanisms, measurement and management. 2nd ed. New York: Taylor &amp; Francis Inc.; 2005. 147-164.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A. Measurement of dyspnea: clinical ratings. In: Mahler D.A., ed. Dyspnea: Mechanisms, measurement and management. 2nd ed. New York: Taylor &amp; Francis Inc.; 2005. 147-164.</mixed-citation></citation-alternatives></ref><ref id="cit142"><label>142</label><citation-alternatives><mixed-citation xml:lang="ru">Fletcher C.M., Elmes P.C., Fairbairn A.S., Wood C.H. The significance of respiratory symptoms and the diagnosis of chronic bronchitis in a working population. Br. Med. J. 1959; 5147: 257-266.</mixed-citation><mixed-citation xml:lang="en">Fletcher C.M., Elmes P.C., Fairbairn A.S., Wood C.H. The significance of respiratory symptoms and the diagnosis of chronic bronchitis in a working population. Br. Med. J. 1959; 5147: 257-266.</mixed-citation></citation-alternatives></ref><ref id="cit143"><label>143</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A., Weinberg D.H., Wells C.K., Feinstein A.R. The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 1984; 85: 751-758.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A., Weinberg D.H., Wells C.K., Feinstein A.R. The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 1984; 85: 751-758.</mixed-citation></citation-alternatives></ref><ref id="cit144"><label>144</label><citation-alternatives><mixed-citation xml:lang="ru">Bestall J.C., Paul E.A., Garrod R. et al. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax 1999; 54: 581-586.</mixed-citation><mixed-citation xml:lang="en">Bestall J.C., Paul E.A., Garrod R. et al. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax 1999; 54: 581-586.</mixed-citation></citation-alternatives></ref><ref id="cit145"><label>145</label><citation-alternatives><mixed-citation xml:lang="ru">Hajiro T., Nishimura K., Tsukino M. et al. Analysis of clinical methods used to evaluate dyspnea in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 158: 1185-1189.</mixed-citation><mixed-citation xml:lang="en">Hajiro T., Nishimura K., Tsukino M. et al. Analysis of clinical methods used to evaluate dyspnea in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 158: 1185-1189.</mixed-citation></citation-alternatives></ref><ref id="cit146"><label>146</label><citation-alternatives><mixed-citation xml:lang="ru">Ries A.L., Kaplan R.M., Blumberg E. Use of factor analysis to consolidate multiple outcome measures in chronic obstructive pulmonary disease. J. Clin. Epidemiol. 1991; 44: 497-503.</mixed-citation><mixed-citation xml:lang="en">Ries A.L., Kaplan R.M., Blumberg E. Use of factor analysis to consolidate multiple outcome measures in chronic obstructive pulmonary disease. J. Clin. Epidemiol. 1991; 44: 497-503.</mixed-citation></citation-alternatives></ref><ref id="cit147"><label>147</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A., Harver A. A factor analysis of dyspnea ratings, respiratory muscle strength, and lung function in patients with chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1992; 145: 467-470.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A., Harver A. A factor analysis of dyspnea ratings, respiratory muscle strength, and lung function in patients with chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1992; 145: 467-470.</mixed-citation></citation-alternatives></ref><ref id="cit148"><label>148</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A., Ward J., Fierro-Carrion G. et al. Development of self-administered versions of modified baseline and transition dyspnea indexes in COPD. J. COPD 2004; 1: 1-8.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A., Ward J., Fierro-Carrion G. et al. Development of self-administered versions of modified baseline and transition dyspnea indexes in COPD. J. COPD 2004; 1: 1-8.</mixed-citation></citation-alternatives></ref><ref id="cit149"><label>149</label><citation-alternatives><mixed-citation xml:lang="ru">Witek T.J. Jr., Mahler D.A. Meaningful effect size and patterns of response of the transition dyspnea index. J. Clin. Epidemiol. 2003; 56: 248-255.</mixed-citation><mixed-citation xml:lang="en">Witek T.J. Jr., Mahler D.A. Meaningful effect size and patterns of response of the transition dyspnea index. J. Clin. Epidemiol. 2003; 56: 248-255.</mixed-citation></citation-alternatives></ref><ref id="cit150"><label>150</label><citation-alternatives><mixed-citation xml:lang="ru">Witek T.J. Jr., Mahler D.A. Minimal important difference of the transition dyspnoea index in a multinational clinical trial. Eur. Respir. J. 2003; 21: 267-272.</mixed-citation><mixed-citation xml:lang="en">Witek T.J. Jr., Mahler D.A. Minimal important difference of the transition dyspnoea index in a multinational clinical trial. Eur. Respir. J. 2003; 21: 267-272.</mixed-citation></citation-alternatives></ref><ref id="cit151"><label>151</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A., Tomlinson D., Olmstead E.M. et al. Changes in dyspnea, health status, and lung function in chronic airway disease. Am. J. Respir. Crit. Care Med. 1995; 151: 61-65.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A., Tomlinson D., Olmstead E.M. et al. Changes in dyspnea, health status, and lung function in chronic airway disease. Am. J. Respir. Crit. Care Med. 1995; 151: 61-65.</mixed-citation></citation-alternatives></ref><ref id="cit152"><label>152</label><citation-alternatives><mixed-citation xml:lang="ru">Casaburi R., Mahler D.A., Jones P.W. et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur. Respir. J. 2002; 19: 217-224.</mixed-citation><mixed-citation xml:lang="en">Casaburi R., Mahler D.A., Jones P.W. et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur. Respir. J. 2002; 19: 217-224.</mixed-citation></citation-alternatives></ref><ref id="cit153"><label>153</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler DA. Dyspnea. In: Celli BR, ed. Pharmacotherapy of COPD. New York: Marcel Dekker Inc.; 2003. 145-158.</mixed-citation><mixed-citation xml:lang="en">Mahler DA. Dyspnea. In: Celli BR, ed. Pharmacotherapy of COPD. New York: Marcel Dekker Inc.; 2003. 145-158.</mixed-citation></citation-alternatives></ref><ref id="cit154"><label>154</label><citation-alternatives><mixed-citation xml:lang="ru">Brusasco V., Hodder R., Miravitlles M. et al. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003; 58: 399-404.</mixed-citation><mixed-citation xml:lang="en">Brusasco V., Hodder R., Miravitlles M. et al. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003; 58: 399-404.</mixed-citation></citation-alternatives></ref><ref id="cit155"><label>155</label><citation-alternatives><mixed-citation xml:lang="ru">ZuWallack R.L., Mahler D.A., Reilly D. et al. Salmeterol plus theophylline combination therapy in the treatment of COPD. Chest 2001; 119: 1661-1670.</mixed-citation><mixed-citation xml:lang="en">ZuWallack R.L., Mahler D.A., Reilly D. et al. Salmeterol plus theophylline combination therapy in the treatment of COPD. Chest 2001; 119: 1661-1670.</mixed-citation></citation-alternatives></ref><ref id="cit156"><label>156</label><citation-alternatives><mixed-citation xml:lang="ru">Vincken W., van Noord J.A., Greefhorst A.P. et al. Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium. Eur. Respir. J. 2002; 19: 209-216.</mixed-citation><mixed-citation xml:lang="en">Vincken W., van Noord J.A., Greefhorst A.P. et al. Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium. Eur. Respir. J. 2002; 19: 209-216.</mixed-citation></citation-alternatives></ref><ref id="cit157"><label>157</label><citation-alternatives><mixed-citation xml:lang="ru">Donohue J.F., Kalberg C., Emmett A. et al. A short-term comparison of fluticasone propionate / salmeterol with ipratropium bromide / albuterol for the treatment of COPD. Treat Respir. Med. 2004; 3: 173-181.</mixed-citation><mixed-citation xml:lang="en">Donohue J.F., Kalberg C., Emmett A. et al. A short-term comparison of fluticasone propionate / salmeterol with ipratropium bromide / albuterol for the treatment of COPD. Treat Respir. Med. 2004; 3: 173-181.</mixed-citation></citation-alternatives></ref><ref id="cit158"><label>158</label><citation-alternatives><mixed-citation xml:lang="ru">Donohue J.F., van Noord J.A., Bateman E.D. et al. A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest 2002; 122: 47-55.</mixed-citation><mixed-citation xml:lang="en">Donohue J.F., van Noord J.A., Bateman E.D. et al. A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest 2002; 122: 47-55.</mixed-citation></citation-alternatives></ref><ref id="cit159"><label>159</label><citation-alternatives><mixed-citation xml:lang="ru">Hanania N.A., Darken P., Horstman D. et al. The efficacy and safety of fluticasone propionate (250 mg) / salmeterol (50 mg) combined in the Diskus inhaler for the treatment of COPD. Chest 2003; 124: 834-843.</mixed-citation><mixed-citation xml:lang="en">Hanania N.A., Darken P., Horstman D. et al. The efficacy and safety of fluticasone propionate (250 mg) / salmeterol (50 mg) combined in the Diskus inhaler for the treatment of COPD. Chest 2003; 124: 834-843.</mixed-citation></citation-alternatives></ref><ref id="cit160"><label>160</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A., Wire P., Horstman D. et al. Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2002; 166: 1084-1091.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A., Wire P., Horstman D. et al. Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2002; 166: 1084-1091.</mixed-citation></citation-alternatives></ref><ref id="cit161"><label>161</label><citation-alternatives><mixed-citation xml:lang="ru">Aaron S.D., Vandemheen K.L., Hebert P. et al. Outpatient oral prednisone after emergency treatment of chronic obstructive pulmonary disease. N. Engl. J. Med. 2003; 348: 2618-2625.</mixed-citation><mixed-citation xml:lang="en">Aaron S.D., Vandemheen K.L., Hebert P. et al. Outpatient oral prednisone after emergency treatment of chronic obstructive pulmonary disease. N. Engl. J. Med. 2003; 348: 2618-2625.</mixed-citation></citation-alternatives></ref><ref id="cit162"><label>162</label><citation-alternatives><mixed-citation xml:lang="ru">Guyatt G.H., Townsend M., Pugsley S.O. et al. Bronchodilators in chronic air-flow limitation. Effects on airway function, exercise capacity, and quality of life. Am. Rev. Respir. Dis. 1987; 135: 1069-1074.</mixed-citation><mixed-citation xml:lang="en">Guyatt G.H., Townsend M., Pugsley S.O. et al. Bronchodilators in chronic air-flow limitation. Effects on airway function, exercise capacity, and quality of life. Am. Rev. Respir. Dis. 1987; 135: 1069-1074.</mixed-citation></citation-alternatives></ref><ref id="cit163"><label>163</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A., Donohue J.F., Barbee R.A. et al. Efficacy of salmeterol xinafoate in the treatment of COPD. Chest 1999; 115: 957-965.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A., Donohue J.F., Barbee R.A. et al. Efficacy of salmeterol xinafoate in the treatment of COPD. Chest 1999; 115: 957-965.</mixed-citation></citation-alternatives></ref><ref id="cit164"><label>164</label><citation-alternatives><mixed-citation xml:lang="ru">Rennard S.I., Anderson W., ZuWallack R. et al. Use of a long-acting inhaled b2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 163: 1087-1092.</mixed-citation><mixed-citation xml:lang="en">Rennard S.I., Anderson W., ZuWallack R. et al. Use of a long-acting inhaled b2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 163: 1087-1092.</mixed-citation></citation-alternatives></ref><ref id="cit165"><label>165</label><citation-alternatives><mixed-citation xml:lang="ru">Rutten-van Mölken M., Roos B., van Noord J.A. An empirical comparison of the St George's Respiratory Questionnaire (SGRQ) and the Chronic Respiratory Disease Questionnaire (CRQ) in a clinical trial setting. Thorax 1999; 54: 995-1003.</mixed-citation><mixed-citation xml:lang="en">Rutten-van Mölken M., Roos B., van Noord J.A. An empirical comparison of the St George's Respiratory Questionnaire (SGRQ) and the Chronic Respiratory Disease Questionnaire (CRQ) in a clinical trial setting. Thorax 1999; 54: 995-1003.</mixed-citation></citation-alternatives></ref><ref id="cit166"><label>166</label><citation-alternatives><mixed-citation xml:lang="ru">Borg G.A. Psychophysical bases of perceived exertion. Med. Sci Sports Exerc. 1982; 14: 377-381.</mixed-citation><mixed-citation xml:lang="en">Borg G.A. Psychophysical bases of perceived exertion. Med. Sci Sports Exerc. 1982; 14: 377-381.</mixed-citation></citation-alternatives></ref><ref id="cit167"><label>167</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A., Mejia-Alfaro R., Ward J., Baird J.C. Continuous measurement of breathlessness during exercise: validity, reliability, and responsiveness. J. Appl. Physiol. 2001; 90: 2188-2196.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A., Mejia-Alfaro R., Ward J., Baird J.C. Continuous measurement of breathlessness during exercise: validity, reliability, and responsiveness. J. Appl. Physiol. 2001; 90: 2188-2196.</mixed-citation></citation-alternatives></ref><ref id="cit168"><label>168</label><citation-alternatives><mixed-citation xml:lang="ru">Fierro-Carrion G., Mahler D.A., Ward J., Baird J.C. Comparison of continuous and discrete measurements of dyspnea during exercise in patients with COPD and normal subjects. Chest 2004; 125: 77-84.</mixed-citation><mixed-citation xml:lang="en">Fierro-Carrion G., Mahler D.A., Ward J., Baird J.C. Comparison of continuous and discrete measurements of dyspnea during exercise in patients with COPD and normal subjects. Chest 2004; 125: 77-84.</mixed-citation></citation-alternatives></ref><ref id="cit169"><label>169</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A., Fierro-Carrion G., Mejia-Alfaro R. et al. Responsiveness of continuous ratings of dyspnea during exercise in patients with COPD. Med. Sci. Sports Exerc. 2005; 37: 529-535.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A., Fierro-Carrion G., Mejia-Alfaro R. et al. Responsiveness of continuous ratings of dyspnea during exercise in patients with COPD. Med. Sci. Sports Exerc. 2005; 37: 529-535.</mixed-citation></citation-alternatives></ref><ref id="cit170"><label>170</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A. Clinical measurement of dyspnea. In: Mahler D.A., ed. Dyspnea. Lung Biology in Health and Disease. New York, Marcel Dekker Inc.; 1998. 149-198.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A. Clinical measurement of dyspnea. In: Mahler D.A., ed. Dyspnea. Lung Biology in Health and Disease. New York, Marcel Dekker Inc.; 1998. 149-198.</mixed-citation></citation-alternatives></ref><ref id="cit171"><label>171</label><citation-alternatives><mixed-citation xml:lang="ru">Hamilton A.L., Killian K.J., Summers E., Jones N.L. Symptom intensity and subjective limitation to exercise in patients with cardiorespiratory disorders. Chest 1996; 110: 1255-1263.</mixed-citation><mixed-citation xml:lang="en">Hamilton A.L., Killian K.J., Summers E., Jones N.L. Symptom intensity and subjective limitation to exercise in patients with cardiorespiratory disorders. Chest 1996; 110: 1255-1263.</mixed-citation></citation-alternatives></ref><ref id="cit172"><label>172</label><citation-alternatives><mixed-citation xml:lang="ru">Teramoto S., Fukuchi Y., Orimo H. Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease. Chest 1993; 103: 1774-1782.</mixed-citation><mixed-citation xml:lang="en">Teramoto S., Fukuchi Y., Orimo H. Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease. Chest 1993; 103: 1774-1782.</mixed-citation></citation-alternatives></ref><ref id="cit173"><label>173</label><citation-alternatives><mixed-citation xml:lang="ru">Ayers M.L., Mejia R., Ward J. et al. Effectiveness of salmeterol versus ipratropium bromide on exertional dyspnoea in COPD. Eur. Respir. J. 2001; 17: 1132-1137.</mixed-citation><mixed-citation xml:lang="en">Ayers M.L., Mejia R., Ward J. et al. Effectiveness of salmeterol versus ipratropium bromide on exertional dyspnoea in COPD. Eur. Respir. J. 2001; 17: 1132-1137.</mixed-citation></citation-alternatives></ref><ref id="cit174"><label>174</label><citation-alternatives><mixed-citation xml:lang="ru">Jones P.W. Health status measurement in chronic obstructive pulmonary disease. Thorax 2001; 56: 880-887.</mixed-citation><mixed-citation xml:lang="en">Jones P.W. Health status measurement in chronic obstructive pulmonary disease. Thorax 2001; 56: 880-887.</mixed-citation></citation-alternatives></ref><ref id="cit175"><label>175</label><citation-alternatives><mixed-citation xml:lang="ru">Jones P.W., Quirk F.H., Baveystock C.M. Why quality of life measures should be used in the treatment of patients with respiratory illness. Monaldi Arch. Chest Dis. 1994; 49: 79-82.</mixed-citation><mixed-citation xml:lang="en">Jones P.W., Quirk F.H., Baveystock C.M. Why quality of life measures should be used in the treatment of patients with respiratory illness. Monaldi Arch. Chest Dis. 1994; 49: 79-82.</mixed-citation></citation-alternatives></ref><ref id="cit176"><label>176</label><citation-alternatives><mixed-citation xml:lang="ru">Campbell M., Eliraz A., Johansson G. et al. Formoterol for maintenance and as-needed treatment of chronic obstructive pulmonary disease. Respir. Med. 2005; 99: 1511-1520.</mixed-citation><mixed-citation xml:lang="en">Campbell M., Eliraz A., Johansson G. et al. Formoterol for maintenance and as-needed treatment of chronic obstructive pulmonary disease. Respir. Med. 2005; 99: 1511-1520.</mixed-citation></citation-alternatives></ref><ref id="cit177"><label>177</label><citation-alternatives><mixed-citation xml:lang="ru">Franciosi L.G., Page C.P., Celli B.R. et al. Markers of disease severity in chronic obstructive pulmonary disease. Pulm. Pharmacol. Ther. 2006; 19: 189-199.</mixed-citation><mixed-citation xml:lang="en">Franciosi L.G., Page C.P., Celli B.R. et al. Markers of disease severity in chronic obstructive pulmonary disease. Pulm. Pharmacol. Ther. 2006; 19: 189-199.</mixed-citation></citation-alternatives></ref><ref id="cit178"><label>178</label><citation-alternatives><mixed-citation xml:lang="ru">Seemungal T.A., Donaldson G.C., Paul E.A. et al. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 157: 1418-1422.</mixed-citation><mixed-citation xml:lang="en">Seemungal T.A., Donaldson G.C., Paul E.A. et al. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 157: 1418-1422.</mixed-citation></citation-alternatives></ref><ref id="cit179"><label>179</label><citation-alternatives><mixed-citation xml:lang="ru">Miravitlles M., Ferrer M., Pont A. et al. Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study. Thorax 2004; 59: 387-395.</mixed-citation><mixed-citation xml:lang="en">Miravitlles M., Ferrer M., Pont A. et al. Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study. Thorax 2004; 59: 387-395.</mixed-citation></citation-alternatives></ref><ref id="cit180"><label>180</label><citation-alternatives><mixed-citation xml:lang="ru">Doll H., Miravitlles M. Health-related QoL in acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease: a review of the literature. Pharmacoeconomics 2005; 23: 345-363.</mixed-citation><mixed-citation xml:lang="en">Doll H., Miravitlles M. Health-related QoL in acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease: a review of the literature. Pharmacoeconomics 2005; 23: 345-363.</mixed-citation></citation-alternatives></ref><ref id="cit181"><label>181</label><citation-alternatives><mixed-citation xml:lang="ru">Schmier J.K., Halpern M.T., Higashi M.K., Bakst A. The quality of life impact of acute exacerbations of chronic bronchitis (AECB): a literature review. Qual. Life Res. 2005; 14: 329-347.</mixed-citation><mixed-citation xml:lang="en">Schmier J.K., Halpern M.T., Higashi M.K., Bakst A. The quality of life impact of acute exacerbations of chronic bronchitis (AECB): a literature review. Qual. Life Res. 2005; 14: 329-347.</mixed-citation></citation-alternatives></ref><ref id="cit182"><label>182</label><citation-alternatives><mixed-citation xml:lang="ru">Burrows B., Earle R.H. Course and prognosis of chronic obstructive lung disease. A prospective study of 200 patients. N. Engl. J. Med. 1969; 280: 397-404.</mixed-citation><mixed-citation xml:lang="en">Burrows B., Earle R.H. Course and prognosis of chronic obstructive lung disease. A prospective study of 200 patients. N. Engl. J. Med. 1969; 280: 397-404.</mixed-citation></citation-alternatives></ref><ref id="cit183"><label>183</label><citation-alternatives><mixed-citation xml:lang="ru">Hurst J.R., Donaldson G.C., Perera W.R. et al. Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2006; 174: 867-874.</mixed-citation><mixed-citation xml:lang="en">Hurst J.R., Donaldson G.C., Perera W.R. et al. Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2006; 174: 867-874.</mixed-citation></citation-alternatives></ref><ref id="cit184"><label>184</label><citation-alternatives><mixed-citation xml:lang="ru">Pauwels R., Calverley P., Buist A.S. et al. COPD exacerbations: the importance of a standard definition. Respir. Med. 2004; 98: 99-107.</mixed-citation><mixed-citation xml:lang="en">Pauwels R., Calverley P., Buist A.S. et al. COPD exacerbations: the importance of a standard definition. Respir. Med. 2004; 98: 99-107.</mixed-citation></citation-alternatives></ref><ref id="cit185"><label>185</label><citation-alternatives><mixed-citation xml:lang="ru">Anthonisen N.R., Manfreda J., Warren C.P. et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann. Intern. Med. 1987; 106: 196-204.</mixed-citation><mixed-citation xml:lang="en">Anthonisen N.R., Manfreda J., Warren C.P. et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann. Intern. Med. 1987; 106: 196-204.</mixed-citation></citation-alternatives></ref><ref id="cit186"><label>186</label><citation-alternatives><mixed-citation xml:lang="ru">Rodriguez-Roisin R. Toward a consensus definition for COPD exacerbations. Chest 2000; 117 (suppl. 2): 398S-401S.</mixed-citation><mixed-citation xml:lang="en">Rodriguez-Roisin R. Toward a consensus definition for COPD exacerbations. Chest 2000; 117 (suppl. 2): 398S-401S.</mixed-citation></citation-alternatives></ref><ref id="cit187"><label>187</label><citation-alternatives><mixed-citation xml:lang="ru">Decramer M., Rutten-van M#ölken M., Dekhuijzen P.N. et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomized placebo-controlled trial. Lancet 2005; 365: 1552-1560.</mixed-citation><mixed-citation xml:lang="en">Decramer M., Rutten-van M#ölken M., Dekhuijzen P.N. et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomized placebo-controlled trial. Lancet 2005; 365: 1552-1560.</mixed-citation></citation-alternatives></ref><ref id="cit188"><label>188</label><citation-alternatives><mixed-citation xml:lang="ru">Fabbri L., Beghe B., Caramori G. et al. Similarities and discrepancies between exacerbations of asthma and chronic obstructive pulmonary disease. Thorax 1998; 53: 803-808.</mixed-citation><mixed-citation xml:lang="en">Fabbri L., Beghe B., Caramori G. et al. Similarities and discrepancies between exacerbations of asthma and chronic obstructive pulmonary disease. Thorax 1998; 53: 803-808.</mixed-citation></citation-alternatives></ref><ref id="cit189"><label>189</label><citation-alternatives><mixed-citation xml:lang="ru">Wilkinson T.M., Donaldson G.C., Hurst J.R. et al. Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2004; 169: 1298-1303.</mixed-citation><mixed-citation xml:lang="en">Wilkinson T.M., Donaldson G.C., Hurst J.R. et al. Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2004; 169: 1298-1303.</mixed-citation></citation-alternatives></ref><ref id="cit190"><label>190</label><citation-alternatives><mixed-citation xml:lang="ru">Burge P.S., Calverley P.M., Jones P.W. et al. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. Br. Med. J. 2000; 320: 1297-1303.</mixed-citation><mixed-citation xml:lang="en">Burge P.S., Calverley P.M., Jones P.W. et al. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. Br. Med. J. 2000; 320: 1297-1303.</mixed-citation></citation-alternatives></ref><ref id="cit191"><label>191</label><citation-alternatives><mixed-citation xml:lang="ru">Calverley P.M., Boonsawat W., Cseke Z. et al. Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease. Eur. Respir. J. 2003; 22: 912-919.</mixed-citation><mixed-citation xml:lang="en">Calverley P.M., Boonsawat W., Cseke Z. et al. Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease. Eur. Respir. J. 2003; 22: 912-919.</mixed-citation></citation-alternatives></ref><ref id="cit192"><label>192</label><citation-alternatives><mixed-citation xml:lang="ru">Kessler R., Stahl E., Vogelmeier C. et al. Patient understanding, detection, and experience of COPD exacerbations: an observational, interview-based study. Chest 2006; 130: 133-142.</mixed-citation><mixed-citation xml:lang="en">Kessler R., Stahl E., Vogelmeier C. et al. Patient understanding, detection, and experience of COPD exacerbations: an observational, interview-based study. Chest 2006; 130: 133-142.</mixed-citation></citation-alternatives></ref><ref id="cit193"><label>193</label><citation-alternatives><mixed-citation xml:lang="ru">Allegra L., Grassi C., Grossi E. et al. Ruolo degli antibiotici nel trattamento delle riacutizzazioni della bronchite cronica: risultati di uno studio italiano multicentrico. [Role of antibiotics in the treatment of acute exacerbations of chronic bronchitis: results from an Italian multicentre trial.] Ital J. Chest Dis. 1991; 45: 138-148.</mixed-citation><mixed-citation xml:lang="en">Allegra L., Grassi C., Grossi E. et al. Ruolo degli antibiotici nel trattamento delle riacutizzazioni della bronchite cronica: risultati di uno studio italiano multicentrico. [Role of antibiotics in the treatment of acute exacerbations of chronic bronchitis: results from an Italian multicentre trial.] Ital J. Chest Dis. 1991; 45: 138-148.</mixed-citation></citation-alternatives></ref><ref id="cit194"><label>194</label><citation-alternatives><mixed-citation xml:lang="ru">Donaldson G.C., Seemungal T.A., Patel I.S. et al. Longitudinal changes in the nature, severity and frequency of COPD exacerbations. Eur. Respir. J. 2003; 22: 931-936.</mixed-citation><mixed-citation xml:lang="en">Donaldson G.C., Seemungal T.A., Patel I.S. et al. Longitudinal changes in the nature, severity and frequency of COPD exacerbations. Eur. Respir. J. 2003; 22: 931-936.</mixed-citation></citation-alternatives></ref><ref id="cit195"><label>195</label><citation-alternatives><mixed-citation xml:lang="ru">Szafranski W., Cukier A., Ramirez A. et al. Efficacy and safety of budesonide / formoterol in the management of chronic obstructive pulmonary disease. Eur. Respir. J. 2003; 21: 74-81.</mixed-citation><mixed-citation xml:lang="en">Szafranski W., Cukier A., Ramirez A. et al. Efficacy and safety of budesonide / formoterol in the management of chronic obstructive pulmonary disease. Eur. Respir. J. 2003; 21: 74-81.</mixed-citation></citation-alternatives></ref><ref id="cit196"><label>196</label><citation-alternatives><mixed-citation xml:lang="ru">Vestbo J. The TORCH (towards a revolution in COPD health) survival study protocol. Eur. Respir. J. 2004; 24: 206-210.</mixed-citation><mixed-citation xml:lang="en">Vestbo J. The TORCH (towards a revolution in COPD health) survival study protocol. Eur. Respir. J. 2004; 24: 206-210.</mixed-citation></citation-alternatives></ref><ref id="cit197"><label>197</label><citation-alternatives><mixed-citation xml:lang="ru">Calverley P., Pauwels R., Vestbo J. et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003; 361: 449-456.</mixed-citation><mixed-citation xml:lang="en">Calverley P., Pauwels R., Vestbo J. et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003; 361: 449-456.</mixed-citation></citation-alternatives></ref><ref id="cit198"><label>198</label><citation-alternatives><mixed-citation xml:lang="ru">Jones P.W., Willits L.R., Burge P.S., Calverley P.M. Disease severity and the effect of fluticasone propionate on chronic obstructive pulmonary disease exacerbations. Eur. Respir. J. 2003; 21: 68-73.</mixed-citation><mixed-citation xml:lang="en">Jones P.W., Willits L.R., Burge P.S., Calverley P.M. Disease severity and the effect of fluticasone propionate on chronic obstructive pulmonary disease exacerbations. Eur. Respir. J. 2003; 21: 68-73.</mixed-citation></citation-alternatives></ref><ref id="cit199"><label>199</label><citation-alternatives><mixed-citation xml:lang="ru">Gompertz S., Bayley D.L., Hill S.L., Stockley R.A. Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD. Thorax 2001; 56: 36-41.</mixed-citation><mixed-citation xml:lang="en">Gompertz S., Bayley D.L., Hill S.L., Stockley R.A. Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD. Thorax 2001; 56: 36-41.</mixed-citation></citation-alternatives></ref><ref id="cit200"><label>200</label><citation-alternatives><mixed-citation xml:lang="ru">Spencer S., Calverley P.M., Burge P.S., Jones P.W. Impact of preventing exacerbations on deterioration of health status in COPD. Eur. Respir. J. 2004; 23: 698-702.</mixed-citation><mixed-citation xml:lang="en">Spencer S., Calverley P.M., Burge P.S., Jones P.W. Impact of preventing exacerbations on deterioration of health status in COPD. Eur. Respir. J. 2004; 23: 698-702.</mixed-citation></citation-alternatives></ref><ref id="cit201"><label>201</label><citation-alternatives><mixed-citation xml:lang="ru">Miravitlles M., Murio C., Guerrero T. Factors associated with relapse after ambulatory treatment of acute exacerbations of chronic bronchitis. DAFNE Study Group. Eur. Respir. J. 2001; 17: 928-933.</mixed-citation><mixed-citation xml:lang="en">Miravitlles M., Murio C., Guerrero T. Factors associated with relapse after ambulatory treatment of acute exacerbations of chronic bronchitis. DAFNE Study Group. Eur. Respir. J. 2001; 17: 928-933.</mixed-citation></citation-alternatives></ref><ref id="cit202"><label>202</label><citation-alternatives><mixed-citation xml:lang="ru">Suissa S. Statistical treatment of exacerbations in therapeutic trials of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2006; 173: 842-846.</mixed-citation><mixed-citation xml:lang="en">Suissa S. Statistical treatment of exacerbations in therapeutic trials of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2006; 173: 842-846.</mixed-citation></citation-alternatives></ref><ref id="cit203"><label>203</label><citation-alternatives><mixed-citation xml:lang="ru">Miravitlles M., Murio C., Guerrero T., Gisbert R. Pharmacoeconomic evaluation of acute exacerbations of chronic bronchitis and COPD. Chest 2002; 121: 1449-1455.</mixed-citation><mixed-citation xml:lang="en">Miravitlles M., Murio C., Guerrero T., Gisbert R. Pharmacoeconomic evaluation of acute exacerbations of chronic bronchitis and COPD. Chest 2002; 121: 1449-1455.</mixed-citation></citation-alternatives></ref><ref id="cit204"><label>204</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia-Aymerich J., Monso E., Marrades R.M. et al. Risk factors for hospitalization for a chronic obstructive pulmonary disease exacerbation. EFRAM study. Am. J. Respir. Crit. Care Med. 2001; 164: 1002-1007.</mixed-citation><mixed-citation xml:lang="en">Garcia-Aymerich J., Monso E., Marrades R.M. et al. Risk factors for hospitalization for a chronic obstructive pulmonary disease exacerbation. EFRAM study. Am. J. Respir. Crit. Care Med. 2001; 164: 1002-1007.</mixed-citation></citation-alternatives></ref><ref id="cit205"><label>205</label><citation-alternatives><mixed-citation xml:lang="ru">Miravitlles M., Guerrero T., Mayordomo C. et al. Factors associated with increased risk of exacerbation and hospital admission in a cohort of ambulatory COPD patients: a multiple logistic regression analysis. The EOLO Study Group. Respiration 2000; 67: 495-501.</mixed-citation><mixed-citation xml:lang="en">Miravitlles M., Guerrero T., Mayordomo C. et al. Factors associated with increased risk of exacerbation and hospital admission in a cohort of ambulatory COPD patients: a multiple logistic regression analysis. The EOLO Study Group. Respiration 2000; 67: 495-501.</mixed-citation></citation-alternatives></ref><ref id="cit206"><label>206</label><citation-alternatives><mixed-citation xml:lang="ru">Antonelli I., Fuso L., De Rosa M. et al. Comorbidity contributes to predict mortality of patients with chronic obstructive pulmonary disease. Eur. Respir. J. 1997; 10: 2794-2800.</mixed-citation><mixed-citation xml:lang="en">Antonelli I., Fuso L., De Rosa M. et al. Comorbidity contributes to predict mortality of patients with chronic obstructive pulmonary disease. Eur. Respir. J. 1997; 10: 2794-2800.</mixed-citation></citation-alternatives></ref><ref id="cit207"><label>207</label><citation-alternatives><mixed-citation xml:lang="ru">Dowson L.J., Newall C., Guest P.J. et al. Exercise capacity predicts health status in a1-antitrypsin deficiency. Am. J. Respir. Crit. Care Med. 2001; 163: 936-941.</mixed-citation><mixed-citation xml:lang="en">Dowson L.J., Newall C., Guest P.J. et al. Exercise capacity predicts health status in a1-antitrypsin deficiency. Am. J. Respir. Crit. Care Med. 2001; 163: 936-941.</mixed-citation></citation-alternatives></ref><ref id="cit208"><label>208</label><citation-alternatives><mixed-citation xml:lang="ru">Clinical exercise testing with reference to lung diseases: indications, standardization and interpretation strategies. ERS Task Force on Standardization of Clinical Exercise Testing. European Respiratory Society. Eur. Respir. J. 1997; 10: 2662-2689. 209. ATS / ACCP Statement on cardiopulmonary exercise testing. Am. J. Respir. Crit. Care Med. 2003; 167: 211-277.</mixed-citation><mixed-citation xml:lang="en">Clinical exercise testing with reference to lung diseases: indications, standardization and interpretation strategies. ERS Task Force on Standardization of Clinical Exercise Testing. European Respiratory Society. Eur. Respir. J. 1997; 10: 2662-2689. 209. ATS / ACCP Statement on cardiopulmonary exercise testing. Am. J. Respir. Crit. Care Med. 2003; 167: 211-277.</mixed-citation></citation-alternatives></ref><ref id="cit209"><label>209</label><citation-alternatives><mixed-citation xml:lang="ru">Saey D., Michaud A., Couillard A. et al. Contractile fatigue, muscle morphometry, and blood lactate in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2005; 171: 1109-1115.</mixed-citation><mixed-citation xml:lang="en">Saey D., Michaud A., Couillard A. et al. Contractile fatigue, muscle morphometry, and blood lactate in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2005; 171: 1109-1115.</mixed-citation></citation-alternatives></ref><ref id="cit210"><label>210</label><citation-alternatives><mixed-citation xml:lang="ru">Bowen J.B., Votto J.J., Thrall R.S. et al. Functional status and survival following pulmonary rehabilitation. Chest 2000; 118: 697-703.</mixed-citation><mixed-citation xml:lang="en">Bowen J.B., Votto J.J., Thrall R.S. et al. Functional status and survival following pulmonary rehabilitation. Chest 2000; 118: 697-703.</mixed-citation></citation-alternatives></ref><ref id="cit211"><label>211</label><citation-alternatives><mixed-citation xml:lang="ru">Oga T., Nishimura K., Tsukino M. et al. Analysis of the factors related to mortality in chronic obstructive pulmonary disease: role of exercise capacity and health status. Am. J. Respir. Crit. Care Med. 2003; 167: 544-549.</mixed-citation><mixed-citation xml:lang="en">Oga T., Nishimura K., Tsukino M. et al. Analysis of the factors related to mortality in chronic obstructive pulmonary disease: role of exercise capacity and health status. Am. J. Respir. Crit. Care Med. 2003; 167: 544-549.</mixed-citation></citation-alternatives></ref><ref id="cit212"><label>212</label><citation-alternatives><mixed-citation xml:lang="ru">Oga T., Nishimura K., Tsukino M. et al. The effects of oxitropiumbromide on exercise performance in patients with stable chronic obstructive pulmonary disease. A comparison of three different exercise tests. Am. J. Respir. Crit. Care Med. 2000; 161: 1897-1901.</mixed-citation><mixed-citation xml:lang="en">Oga T., Nishimura K., Tsukino M. et al. The effects of oxitropiumbromide on exercise performance in patients with stable chronic obstructive pulmonary disease. A comparison of three different exercise tests. Am. J. Respir. Crit. Care Med. 2000; 161: 1897-1901.</mixed-citation></citation-alternatives></ref><ref id="cit213"><label>213</label><citation-alternatives><mixed-citation xml:lang="ru">Palange P., Crimi E., Pellegrino R., Brusasco V. Supplemental oxygen and heliox: ''new'' tools for exercise training in chronic obstructive pulmonary disease. Curr. Opin. Pulm. Med. 2005; 11: 145-148.</mixed-citation><mixed-citation xml:lang="en">Palange P., Crimi E., Pellegrino R., Brusasco V. Supplemental oxygen and heliox: ''new'' tools for exercise training in chronic obstructive pulmonary disease. Curr. Opin. Pulm. Med. 2005; 11: 145-148.</mixed-citation></citation-alternatives></ref><ref id="cit214"><label>214</label><citation-alternatives><mixed-citation xml:lang="ru">Butland R.J., Pang J., Gross E.R. et al. Two-, six-, and 12-minute walking tests in respiratory disease. Br. Med. J. (Clin. Res. Ed.) 1982; 284: 1607-1608.</mixed-citation><mixed-citation xml:lang="en">Butland R.J., Pang J., Gross E.R. et al. Two-, six-, and 12-minute walking tests in respiratory disease. Br. Med. J. (Clin. Res. Ed.) 1982; 284: 1607-1608.</mixed-citation></citation-alternatives></ref><ref id="cit215"><label>215</label><citation-alternatives><mixed-citation xml:lang="ru">Palange P., Forte S., Onorati P. et al. Ventilatory and metabolic adaptations to walking and cycling in patients with COPD. J. Appl. Physiol. 2000; 88: 1715-1720.</mixed-citation><mixed-citation xml:lang="en">Palange P., Forte S., Onorati P. et al. Ventilatory and metabolic adaptations to walking and cycling in patients with COPD. J. Appl. Physiol. 2000; 88: 1715-1720.</mixed-citation></citation-alternatives></ref><ref id="cit216"><label>216</label><citation-alternatives><mixed-citation xml:lang="ru">Man W.D., Soliman M.G., Gearing J. et al. Symptoms and quadriceps fatigability after walking and cycling in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2003; 168: 562-567.</mixed-citation><mixed-citation xml:lang="en">Man W.D., Soliman M.G., Gearing J. et al. Symptoms and quadriceps fatigability after walking and cycling in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2003; 168: 562-567.</mixed-citation></citation-alternatives></ref><ref id="cit217"><label>217</label><citation-alternatives><mixed-citation xml:lang="ru">Fishman A., Martinez F., Naunheim K. et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N. Engl. J. Med. 2003; 348: 2059-2073.</mixed-citation><mixed-citation xml:lang="en">Fishman A., Martinez F., Naunheim K. et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N. Engl. J. Med. 2003; 348: 2059-2073.</mixed-citation></citation-alternatives></ref><ref id="cit218"><label>218</label><citation-alternatives><mixed-citation xml:lang="ru">Sue D.Y., Wasserman K., Moricca R.B., Casaburi R. Metabolic acidosis during exercise in patients with chronic obstructive pulmonary disease. Use of the Vslope method for anaerobic threshold determination. Chest 1988; 94: 931-938.</mixed-citation><mixed-citation xml:lang="en">Sue D.Y., Wasserman K., Moricca R.B., Casaburi R. Metabolic acidosis during exercise in patients with chronic obstructive pulmonary disease. Use of the Vslope method for anaerobic threshold determination. Chest 1988; 94: 931-938.</mixed-citation></citation-alternatives></ref><ref id="cit219"><label>219</label><citation-alternatives><mixed-citation xml:lang="ru">Aliverti A., Stevenson N., Dellaca R.L. et al. Regional chest wall volumes during exercise in chronic obstructive pulmonary disease. Thorax 2004; 59: 210-216.</mixed-citation><mixed-citation xml:lang="en">Aliverti A., Stevenson N., Dellaca R.L. et al. Regional chest wall volumes during exercise in chronic obstructive pulmonary disease. Thorax 2004; 59: 210-216.</mixed-citation></citation-alternatives></ref><ref id="cit220"><label>220</label><citation-alternatives><mixed-citation xml:lang="ru">Myers J., Prakash M., Froelicher V. et al. Exercise capacity and mortality among men referred for exercise testing. N. Engl. J. Med. 2002; 346: 793-801.</mixed-citation><mixed-citation xml:lang="en">Myers J., Prakash M., Froelicher V. et al. Exercise capacity and mortality among men referred for exercise testing. N. Engl. J. Med. 2002; 346: 793-801.</mixed-citation></citation-alternatives></ref><ref id="cit221"><label>221</label><citation-alternatives><mixed-citation xml:lang="ru">Pellegrino R., Villosio C., Milanese U. et al. Breathing during exercise in subjects with mild-to-moderate airflow obstruction: effects of physical training. J. Appl. Physiol. 1999; 87: 1697-1704.</mixed-citation><mixed-citation xml:lang="en">Pellegrino R., Villosio C., Milanese U. et al. Breathing during exercise in subjects with mild-to-moderate airflow obstruction: effects of physical training. J. Appl. Physiol. 1999; 87: 1697-1704.</mixed-citation></citation-alternatives></ref><ref id="cit222"><label>222</label><citation-alternatives><mixed-citation xml:lang="ru">Casaburi R., Porszasz J., Burns M.R. et al. Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1997; 155: 1541-1551.</mixed-citation><mixed-citation xml:lang="en">Casaburi R., Porszasz J., Burns M.R. et al. Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1997; 155: 1541-1551.</mixed-citation></citation-alternatives></ref><ref id="cit223"><label>223</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez F.J., de Oca M.M., Whyte R.I. et al. Lung-volume reduction improves dyspnea, dynamic hyperinflation, and respiratory muscle function. Am. J. Respir. Crit. Care Med. 1997; 155: 1984-1990.</mixed-citation><mixed-citation xml:lang="en">Martinez F.J., de Oca M.M., Whyte R.I. et al. Lung-volume reduction improves dyspnea, dynamic hyperinflation, and respiratory muscle function. Am. J. Respir. Crit. Care Med. 1997; 155: 1984-1990.</mixed-citation></citation-alternatives></ref><ref id="cit224"><label>224</label><citation-alternatives><mixed-citation xml:lang="ru">Somfay A., Porszasz J., Lee S.M., Casaburi R. Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patients. Eur. Respir. J. 2001; 18: 77-84.</mixed-citation><mixed-citation xml:lang="en">Somfay A., Porszasz J., Lee S.M., Casaburi R. Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patients. Eur. Respir. J. 2001; 18: 77-84.</mixed-citation></citation-alternatives></ref><ref id="cit225"><label>225</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell D.E., D'Arsigny C., Webb K.A. Effects of hyperoxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 163: 892-898.</mixed-citation><mixed-citation xml:lang="en">O'Donnell D.E., D'Arsigny C., Webb K.A. Effects of hyperoxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 163: 892-898.</mixed-citation></citation-alternatives></ref><ref id="cit226"><label>226</label><citation-alternatives><mixed-citation xml:lang="ru">Palange P., Valli G., Onorati P. et al. Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients. J. Appl. Physiol. 2004; 97: 1637-1642.</mixed-citation><mixed-citation xml:lang="en">Palange P., Valli G., Onorati P. et al. Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients. J. Appl. Physiol. 2004; 97: 1637-1642.</mixed-citation></citation-alternatives></ref><ref id="cit227"><label>227</label><citation-alternatives><mixed-citation xml:lang="ru">McGavin C.R., Gupta S.P., McHardy G.J. Twelve-minute walking test for assessing disability in chronic bronchitis. Br. Med. J. 1976; 1: 822-823.</mixed-citation><mixed-citation xml:lang="en">McGavin C.R., Gupta S.P., McHardy G.J. Twelve-minute walking test for assessing disability in chronic bronchitis. Br. Med. J. 1976; 1: 822-823.</mixed-citation></citation-alternatives></ref><ref id="cit228"><label>228</label><citation-alternatives><mixed-citation xml:lang="ru">Morgan A.D., Peck D.F., Buchanan D.R., McHardy G.J. Effect of attitudes and beliefs on exercise tolerance in chronic bronchitis. Br. Med. J. (Clin. Res. Ed.) 1983; 286: 171-173.</mixed-citation><mixed-citation xml:lang="en">Morgan A.D., Peck D.F., Buchanan D.R., McHardy G.J. Effect of attitudes and beliefs on exercise tolerance in chronic bronchitis. Br. Med. J. (Clin. Res. Ed.) 1983; 286: 171-173.</mixed-citation></citation-alternatives></ref><ref id="cit229"><label>229</label><citation-alternatives><mixed-citation xml:lang="ru">Sciurba F., Criner G.J., Lee S.M. et al. Six-minute walk distance in chronic obstructive pulmonary disease: reproducibility and effect of walking course layout and length. Am. J. Respir. Crit. Care Med. 2003; 167: 1522-1527.</mixed-citation><mixed-citation xml:lang="en">Sciurba F., Criner G.J., Lee S.M. et al. Six-minute walk distance in chronic obstructive pulmonary disease: reproducibility and effect of walking course layout and length. Am. J. Respir. Crit. Care Med. 2003; 167: 1522-1527.</mixed-citation></citation-alternatives></ref><ref id="cit230"><label>230</label><citation-alternatives><mixed-citation xml:lang="ru">Guyatt G.H., Sullivan M.J., Thompson P.J. et al. The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can. Med. Assoc. J. 1985; 132: 919-923.</mixed-citation><mixed-citation xml:lang="en">Guyatt G.H., Sullivan M.J., Thompson P.J. et al. The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can. Med. Assoc. J. 1985; 132: 919-923.</mixed-citation></citation-alternatives></ref><ref id="cit231"><label>231</label><citation-alternatives><mixed-citation xml:lang="ru">Knox A.J., Morrison J.F., Muers M.F. Reproducibility of walking test results in chronic obstructive airways disease. Thorax 1988; 43: 388-392.</mixed-citation><mixed-citation xml:lang="en">Knox A.J., Morrison J.F., Muers M.F. Reproducibility of walking test results in chronic obstructive airways disease. Thorax 1988; 43: 388-392.</mixed-citation></citation-alternatives></ref><ref id="cit232"><label>232</label><citation-alternatives><mixed-citation xml:lang="ru">Gerardi D.A., Lovett L., Benoit-Connors M.L. et al. Variables related to increased mortality following outpatient pulmonary rehabilitation. Eur. Respir. J. 1996; 9: 431-435.</mixed-citation><mixed-citation xml:lang="en">Gerardi D.A., Lovett L., Benoit-Connors M.L. et al. Variables related to increased mortality following outpatient pulmonary rehabilitation. Eur. Respir. J. 1996; 9: 431-435.</mixed-citation></citation-alternatives></ref><ref id="cit233"><label>233</label><citation-alternatives><mixed-citation xml:lang="ru">Geddes D., Davies M., Koyama H. et al. Effect of lungvolume-reduction surgery in patients with severe emphysema. N. Engl. J. Med. 2000; 343: 239-245.</mixed-citation><mixed-citation xml:lang="en">Geddes D., Davies M., Koyama H. et al. Effect of lungvolume-reduction surgery in patients with severe emphysema. N. Engl. J. Med. 2000; 343: 239-245.</mixed-citation></citation-alternatives></ref><ref id="cit234"><label>234</label><citation-alternatives><mixed-citation xml:lang="ru">Young J., Fry-Smith A., Hyde C. Lung volume reduction surgery (LVRS) for chronic obstructive pulmonary disease (COPD) with underlying severe emphysema. Thorax 1999; 54: 779-789.</mixed-citation><mixed-citation xml:lang="en">Young J., Fry-Smith A., Hyde C. Lung volume reduction surgery (LVRS) for chronic obstructive pulmonary disease (COPD) with underlying severe emphysema. Thorax 1999; 54: 779-789.</mixed-citation></citation-alternatives></ref><ref id="cit235"><label>235</label><citation-alternatives><mixed-citation xml:lang="ru">Griffiths T.L., Burr M.L., Campbell I.A. et al. Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomised controlled trial. Lancet 2000; 355: 362-368.</mixed-citation><mixed-citation xml:lang="en">Griffiths T.L., Burr M.L., Campbell I.A. et al. Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomised controlled trial. Lancet 2000; 355: 362-368.</mixed-citation></citation-alternatives></ref><ref id="cit236"><label>236</label><citation-alternatives><mixed-citation xml:lang="ru">Leach R.M., Davidson A.C., Chinn S. et al. Portable liquid oxygen and exercise ability in severe respiratory disability. Thorax 1992; 47: 781-789.</mixed-citation><mixed-citation xml:lang="en">Leach R.M., Davidson A.C., Chinn S. et al. Portable liquid oxygen and exercise ability in severe respiratory disability. Thorax 1992; 47: 781-789.</mixed-citation></citation-alternatives></ref><ref id="cit237"><label>237</label><citation-alternatives><mixed-citation xml:lang="ru">Corris P.A., Neville E., Nariman S., Gibson G.J. Dose-response study of inhaled salbutamol powder in chronic airflow obstruction. Thorax 1983; 38: 292-296.</mixed-citation><mixed-citation xml:lang="en">Corris P.A., Neville E., Nariman S., Gibson G.J. Dose-response study of inhaled salbutamol powder in chronic airflow obstruction. Thorax 1983; 38: 292-296.</mixed-citation></citation-alternatives></ref><ref id="cit238"><label>238</label><citation-alternatives><mixed-citation xml:lang="ru">Onorati P., Antonucci R., Valli G. et al. Non-invasive evaluation of gas exchange during a shuttle walking test versus a 6-min walking test to assess exercise tolerance in COPD patients. Eur. J. Appl. Physiol. 2003; 89: 331-336.</mixed-citation><mixed-citation xml:lang="en">Onorati P., Antonucci R., Valli G. et al. Non-invasive evaluation of gas exchange during a shuttle walking test versus a 6-min walking test to assess exercise tolerance in COPD patients. Eur. J. Appl. Physiol. 2003; 89: 331-336.</mixed-citation></citation-alternatives></ref><ref id="cit239"><label>239</label><citation-alternatives><mixed-citation xml:lang="ru">Singh S.J., Morgan M.D., Scott S. et al. Development of a shuttle walking test of disability in patients with chronic airways obstruction. Thorax 1992; 47: 1019-1024.</mixed-citation><mixed-citation xml:lang="en">Singh S.J., Morgan M.D., Scott S. et al. Development of a shuttle walking test of disability in patients with chronic airways obstruction. Thorax 1992; 47: 1019-1024.</mixed-citation></citation-alternatives></ref><ref id="cit240"><label>240</label><citation-alternatives><mixed-citation xml:lang="ru">Revill S.M., Morgan M.D., Singh S.J. et al. The endurance shuttle walk: a new field test for the assessment of endurance capacity in chronic obstructive pulmonary disease. Thorax 1999; 54: 213-222.</mixed-citation><mixed-citation xml:lang="en">Revill S.M., Morgan M.D., Singh S.J. et al. The endurance shuttle walk: a new field test for the assessment of endurance capacity in chronic obstructive pulmonary disease. Thorax 1999; 54: 213-222.</mixed-citation></citation-alternatives></ref><ref id="cit241"><label>241</label><citation-alternatives><mixed-citation xml:lang="ru">Man W.D., Polkey M.I., Donaldson N. et al.Community pulmonary rehabilitation after hospitalization for acute exacerbations of chronic obstructive pulmonary disease: a randomised controlled study. Br. Med. J. 2004; 329: 1209.</mixed-citation><mixed-citation xml:lang="en">Man W.D., Polkey M.I., Donaldson N. et al.Community pulmonary rehabilitation after hospitalization for acute exacerbations of chronic obstructive pulmonary disease: a randomised controlled study. Br. Med. J. 2004; 329: 1209.</mixed-citation></citation-alternatives></ref><ref id="cit242"><label>242</label><citation-alternatives><mixed-citation xml:lang="ru">Fuld J.P., Kilduff L.P., Neder J.A. et al. Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease. Thorax 2005; 60: 531-537.</mixed-citation><mixed-citation xml:lang="en">Fuld J.P., Kilduff L.P., Neder J.A. et al. Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease. Thorax 2005; 60: 531-537.</mixed-citation></citation-alternatives></ref><ref id="cit243"><label>243</label><citation-alternatives><mixed-citation xml:lang="ru">Steiner M.C., Barton R.L., Singh S.J., Morgan M.D. Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: a randomised controlled trial. Thorax 2003; 58: 745-751.</mixed-citation><mixed-citation xml:lang="en">Steiner M.C., Barton R.L., Singh S.J., Morgan M.D. Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: a randomised controlled trial. Thorax 2003; 58: 745-751.</mixed-citation></citation-alternatives></ref><ref id="cit244"><label>244</label><citation-alternatives><mixed-citation xml:lang="ru">Eiser N., Willsher D., Dore C.J. Reliability, repeatability and sensitivity to change of externally and self-paced walking tests in COPD patients. Respir. Med. 2003; 97: 407-414.</mixed-citation><mixed-citation xml:lang="en">Eiser N., Willsher D., Dore C.J. Reliability, repeatability and sensitivity to change of externally and self-paced walking tests in COPD patients. Respir. Med. 2003; 97: 407-414.</mixed-citation></citation-alternatives></ref><ref id="cit245"><label>245</label><citation-alternatives><mixed-citation xml:lang="ru">Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Nocturnal Oxygen Therapy Trial Group. Ann. Intern. Med. 1980; 93: 391-398.</mixed-citation><mixed-citation xml:lang="en">Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Nocturnal Oxygen Therapy Trial Group. Ann. Intern. Med. 1980; 93: 391-398.</mixed-citation></citation-alternatives></ref><ref id="cit246"><label>246</label><citation-alternatives><mixed-citation xml:lang="ru">Long-term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. Lancet 1981; 1: 681-686.</mixed-citation><mixed-citation xml:lang="en">Long-term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. Lancet 1981; 1: 681-686.</mixed-citation></citation-alternatives></ref><ref id="cit247"><label>247</label><citation-alternatives><mixed-citation xml:lang="ru">Sin D.D., Wu L., Anderson J.A. et al. Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease. Thorax 2005; 60: 992-997.</mixed-citation><mixed-citation xml:lang="en">Sin D.D., Wu L., Anderson J.A. et al. Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease. Thorax 2005; 60: 992-997.</mixed-citation></citation-alternatives></ref><ref id="cit248"><label>248</label><citation-alternatives><mixed-citation xml:lang="ru">Hansell A.L., Walk J.A., Soriano J.B. What do chronic obstructive pulmonary disease patients die from? A multiple cause coding analysis. Eur. Respir. J. 2003; 22: 809-814.</mixed-citation><mixed-citation xml:lang="en">Hansell A.L., Walk J.A., Soriano J.B. What do chronic obstructive pulmonary disease patients die from? A multiple cause coding analysis. Eur. Respir. J. 2003; 22: 809-814.</mixed-citation></citation-alternatives></ref><ref id="cit249"><label>249</label><citation-alternatives><mixed-citation xml:lang="ru">Camilli A.E., Robbins D.R., Lebowitz MD. Death certificate reporting of confirmed airways obstructive disease. Am. J. Epidemiol. 1991; 133: 795-800.</mixed-citation><mixed-citation xml:lang="en">Camilli A.E., Robbins D.R., Lebowitz MD. Death certificate reporting of confirmed airways obstructive disease. Am. J. Epidemiol. 1991; 133: 795-800.</mixed-citation></citation-alternatives></ref><ref id="cit250"><label>250</label><citation-alternatives><mixed-citation xml:lang="ru">Anthonisen N.R., Skeans M.A., Wise R.A. et al. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann. Intern. Med. 2005; 142: 233-239.</mixed-citation><mixed-citation xml:lang="en">Anthonisen N.R., Skeans M.A., Wise R.A. et al. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann. Intern. Med. 2005; 142: 233-239.</mixed-citation></citation-alternatives></ref><ref id="cit251"><label>251</label><citation-alternatives><mixed-citation xml:lang="ru">Sin D.D., Man S.F. Chronic obstructive pulmonary disease: a novel risk factor for cardiovascular disease. Can. J. Physiol. Pharmacol. 2005; 83: 8-13.</mixed-citation><mixed-citation xml:lang="en">Sin D.D., Man S.F. Chronic obstructive pulmonary disease: a novel risk factor for cardiovascular disease. Can. J. Physiol. Pharmacol. 2005; 83: 8-13.</mixed-citation></citation-alternatives></ref><ref id="cit252"><label>252</label><citation-alternatives><mixed-citation xml:lang="ru">Solomon S.D., Wang D., Finn P. et al. Effect of candesartan on cause-specific mortality in heart failure patients: the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM) program. Circulation 2004; 110: 2180-2183.</mixed-citation><mixed-citation xml:lang="en">Solomon S.D., Wang D., Finn P. et al. Effect of candesartan on cause-specific mortality in heart failure patients: the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM) program. Circulation 2004; 110: 2180-2183.</mixed-citation></citation-alternatives></ref><ref id="cit253"><label>253</label><citation-alternatives><mixed-citation xml:lang="ru">Curb J.D., McTiernan A., Heckbert S.R. et al. Outcomes ascertainment and adjudication methods in the Women's Health Initiative. Ann. Epidemiol. 2003; 13 (suppl. 9): S122-S128.</mixed-citation><mixed-citation xml:lang="en">Curb J.D., McTiernan A., Heckbert S.R. et al. Outcomes ascertainment and adjudication methods in the Women's Health Initiative. Ann. Epidemiol. 2003; 13 (suppl. 9): S122-S128.</mixed-citation></citation-alternatives></ref><ref id="cit254"><label>254</label><citation-alternatives><mixed-citation xml:lang="ru">Remington R.D. Who should code cause of death in a clinical trial? Control Clin. Trials 1984; 5: 241-244.</mixed-citation><mixed-citation xml:lang="en">Remington R.D. Who should code cause of death in a clinical trial? Control Clin. Trials 1984; 5: 241-244.</mixed-citation></citation-alternatives></ref><ref id="cit255"><label>255</label><citation-alternatives><mixed-citation xml:lang="ru">Walter S.D., Cook D.J., Guyatt G.H. et al. Outcome assessment for clinical trials: how many adjudicators do we need? Canadian Lung Oncology Group. Control Clin. Trials 1997; 18: 27-42.</mixed-citation><mixed-citation xml:lang="en">Walter S.D., Cook D.J., Guyatt G.H. et al. Outcome assessment for clinical trials: how many adjudicators do we need? Canadian Lung Oncology Group. Control Clin. Trials 1997; 18: 27-42.</mixed-citation></citation-alternatives></ref><ref id="cit256"><label>256</label><citation-alternatives><mixed-citation xml:lang="ru">Anthonisen N.R., Wright E.C., Hodgkin J.E. Prognosis in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1986; 133: 14-20.</mixed-citation><mixed-citation xml:lang="en">Anthonisen N.R., Wright E.C., Hodgkin J.E. Prognosis in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1986; 133: 14-20.</mixed-citation></citation-alternatives></ref><ref id="cit257"><label>257</label><citation-alternatives><mixed-citation xml:lang="ru">Anthonisen N.R., Connett J.E., Enright P..L, Manfreda J. Hospitalizations and mortality in the Lung Health Study. Am. J. Respir. Crit. Care Med. 2002; 166: 333-339.</mixed-citation><mixed-citation xml:lang="en">Anthonisen N.R., Connett J.E., Enright P..L, Manfreda J. Hospitalizations and mortality in the Lung Health Study. Am. J. Respir. Crit. Care Med. 2002; 166: 333-339.</mixed-citation></citation-alternatives></ref><ref id="cit258"><label>258</label><citation-alternatives><mixed-citation xml:lang="ru">Celli B.R., Cote C.G., Marin J.M. et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N. Engl. J. Med. 2004; 350: 1005-1012.</mixed-citation><mixed-citation xml:lang="en">Celli B.R., Cote C.G., Marin J.M. et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N. Engl. J. Med. 2004; 350: 1005-1012.</mixed-citation></citation-alternatives></ref><ref id="cit259"><label>259</label><citation-alternatives><mixed-citation xml:lang="ru">Hansen E.F., Phanareth K., Laursen L.C. et al. Reversible and irreversible airflow obstruction as predictor of overall mortality in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1999; 159: 1267-1271.</mixed-citation><mixed-citation xml:lang="en">Hansen E.F., Phanareth K., Laursen L.C. et al. Reversible and irreversible airflow obstruction as predictor of overall mortality in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1999; 159: 1267-1271.</mixed-citation></citation-alternatives></ref><ref id="cit260"><label>260</label><citation-alternatives><mixed-citation xml:lang="ru">Landbo C., Prescott E., Lange P. et al. Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1999; 160: 1856-1861.</mixed-citation><mixed-citation xml:lang="en">Landbo C., Prescott E., Lange P. et al. Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1999; 160: 1856-1861.</mixed-citation></citation-alternatives></ref><ref id="cit261"><label>261</label><citation-alternatives><mixed-citation xml:lang="ru">Mannino D.M., Buist A.S., Petty T.L. et al.Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study. Thorax 2003; 58: 388-393.</mixed-citation><mixed-citation xml:lang="en">Mannino D.M., Buist A.S., Petty T.L. et al.Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study. Thorax 2003; 58: 388-393.</mixed-citation></citation-alternatives></ref><ref id="cit262"><label>262</label><citation-alternatives><mixed-citation xml:lang="ru">Nishimura K., Izumi T., Tsukino M., Oga T. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest 2002; 121: 1434-1440.</mixed-citation><mixed-citation xml:lang="en">Nishimura K., Izumi T., Tsukino M., Oga T. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest 2002; 121: 1434-1440.</mixed-citation></citation-alternatives></ref><ref id="cit263"><label>263</label><citation-alternatives><mixed-citation xml:lang="ru">Oga T., Nishimura K., Tsukino M. et al. Health status measured with the CRQ does not predict mortality in COPD. Eur. Respir. J. 2002; 20: 1147-1151.</mixed-citation><mixed-citation xml:lang="en">Oga T., Nishimura K., Tsukino M. et al. Health status measured with the CRQ does not predict mortality in COPD. Eur. Respir. J. 2002; 20: 1147-1151.</mixed-citation></citation-alternatives></ref><ref id="cit264"><label>264</label><citation-alternatives><mixed-citation xml:lang="ru">Prescott E., Almdal T., Mikkelsen K.L. et al. Prognostic value of weight change in chronic obstructive pulmonary disease: results from the Copenhagen City Heart Study. Eur. Respir. J. 2002; 20: 539-544.</mixed-citation><mixed-citation xml:lang="en">Prescott E., Almdal T., Mikkelsen K.L. et al. Prognostic value of weight change in chronic obstructive pulmonary disease: results from the Copenhagen City Heart Study. Eur. Respir. J. 2002; 20: 539-544.</mixed-citation></citation-alternatives></ref><ref id="cit265"><label>265</label><citation-alternatives><mixed-citation xml:lang="ru">Schols A.M., Slangen J., Volovics L., Wouters E.F. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 157: 1791-1797.</mixed-citation><mixed-citation xml:lang="en">Schols A.M., Slangen J., Volovics L., Wouters E.F. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 157: 1791-1797.</mixed-citation></citation-alternatives></ref><ref id="cit266"><label>266</label><citation-alternatives><mixed-citation xml:lang="ru">Soriano J.B., Vestbo J., Pride N.B. et al. Survival in COPD patients after regular use of fluticasone propionate and salmeterol in general practice. Eur. Respir. J. 2002; 20: 819-825.</mixed-citation><mixed-citation xml:lang="en">Soriano J.B., Vestbo J., Pride N.B. et al. Survival in COPD patients after regular use of fluticasone propionate and salmeterol in general practice. Eur. Respir. J. 2002; 20: 819-825.</mixed-citation></citation-alternatives></ref><ref id="cit267"><label>267</label><citation-alternatives><mixed-citation xml:lang="ru">Sin D.D., Man S.F. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 2003; 107: 1514-1519.</mixed-citation><mixed-citation xml:lang="en">Sin D.D., Man S.F. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 2003; 107: 1514-1519.</mixed-citation></citation-alternatives></ref><ref id="cit268"><label>268</label><citation-alternatives><mixed-citation xml:lang="ru">Mannino D.M., Ford E.S., Redd S.C. Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination. Am. J. Med. 2003; 114: 758-762.</mixed-citation><mixed-citation xml:lang="en">Mannino D.M., Ford E.S., Redd S.C. Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination. Am. J. Med. 2003; 114: 758-762.</mixed-citation></citation-alternatives></ref><ref id="cit269"><label>269</label><citation-alternatives><mixed-citation xml:lang="ru">Cote C.G., Celli B.R. Pulmonary rehabilitation and the BODE index in COPD. Eur. Respir. J. 2005; 26: 630-636.</mixed-citation><mixed-citation xml:lang="en">Cote C.G., Celli B.R. Pulmonary rehabilitation and the BODE index in COPD. Eur. Respir. J. 2005; 26: 630-636.</mixed-citation></citation-alternatives></ref><ref id="cit270"><label>270</label><citation-alternatives><mixed-citation xml:lang="ru">Imfeld S., Bloch K.E., Weder W., Russi E.W. The BODE index after lung volume reduction surgery correlates with survival. Chest 2006; 129: 873-878.</mixed-citation><mixed-citation xml:lang="en">Imfeld S., Bloch K.E., Weder W., Russi E.W. The BODE index after lung volume reduction surgery correlates with survival. Chest 2006; 129: 873-878.</mixed-citation></citation-alternatives></ref><ref id="cit271"><label>271</label><citation-alternatives><mixed-citation xml:lang="ru">Gold M.R., Siegel J.E., Russell L.B., Weinstein M.C. eds. Cost-effectiveness in health and medicine. 1-st ed. New York: Oxford University Press; 1996.</mixed-citation><mixed-citation xml:lang="en">Gold M.R., Siegel J.E., Russell L.B., Weinstein M.C. eds. Cost-effectiveness in health and medicine. 1-st ed. New York: Oxford University Press; 1996.</mixed-citation></citation-alternatives></ref><ref id="cit272"><label>272</label><citation-alternatives><mixed-citation xml:lang="ru">Drummond M.F., O'Brien B., Stoddart G.L., Torrance G.W., eds. Methods for the economic evaluation of health care programmes. 1-st ed. New York: Oxford University Press; 1997.</mixed-citation><mixed-citation xml:lang="en">Drummond M.F., O'Brien B., Stoddart G.L., Torrance G.W., eds. Methods for the economic evaluation of health care programmes. 1-st ed. New York: Oxford University Press; 1997.</mixed-citation></citation-alternatives></ref><ref id="cit273"><label>273</label><citation-alternatives><mixed-citation xml:lang="ru">National Institute for Clinical Excellence (NICE). Guide to the methods of technology appraisal. London: NICE; 2004.</mixed-citation><mixed-citation xml:lang="en">National Institute for Clinical Excellence (NICE). Guide to the methods of technology appraisal. London: NICE; 2004.</mixed-citation></citation-alternatives></ref><ref id="cit274"><label>274</label><citation-alternatives><mixed-citation xml:lang="ru">Molken M.P., Van Doorslaer E.K., Rutten F.F. Economic appraisal of asthma and COPD care: a literature review 1980-1991. Soc. Sci. Med. 1992; 35: 161-175.</mixed-citation><mixed-citation xml:lang="en">Molken M.P., Van Doorslaer E.K., Rutten F.F. Economic appraisal of asthma and COPD care: a literature review 1980-1991. Soc. Sci. Med. 1992; 35: 161-175.</mixed-citation></citation-alternatives></ref><ref id="cit275"><label>275</label><citation-alternatives><mixed-citation xml:lang="ru">Ruchlin H.S., Dasbach E.J. An economic overview of chronic obstructive pulmonary disease. Pharmacoeconomics 2001; 19: 623-642.</mixed-citation><mixed-citation xml:lang="en">Ruchlin H.S., Dasbach E.J. An economic overview of chronic obstructive pulmonary disease. Pharmacoeconomics 2001; 19: 623-642.</mixed-citation></citation-alternatives></ref><ref id="cit276"><label>276</label><citation-alternatives><mixed-citation xml:lang="ru">Rutten-van Mölken M.P., Postma M.J., Joore M.A. et al.Current and future medical costs of asthma and chronic obstructive pulmonary disease in the Netherlands. Respir. Med. 1999; 93: 779-787.</mixed-citation><mixed-citation xml:lang="en">Rutten-van Mölken M.P., Postma M.J., Joore M.A. et al.Current and future medical costs of asthma and chronic obstructive pulmonary disease in the Netherlands. Respir. Med. 1999; 93: 779-787.</mixed-citation></citation-alternatives></ref><ref id="cit277"><label>277</label><citation-alternatives><mixed-citation xml:lang="ru">Sullivan S.D., Ramsey S.D., Lee T.A. The economic burden of COPD. Chest 2000; 117 (suppl. 2): 5S-9S.</mixed-citation><mixed-citation xml:lang="en">Sullivan S.D., Ramsey S.D., Lee T.A. The economic burden of COPD. Chest 2000; 117 (suppl. 2): 5S-9S.</mixed-citation></citation-alternatives></ref><ref id="cit278"><label>278</label><citation-alternatives><mixed-citation xml:lang="ru">Strassels S.A., Smith D.H., Sullivan S.D., Mahajan P.S. The costs of treating COPD in the United States. Chest 2001; 119: 344-352.</mixed-citation><mixed-citation xml:lang="en">Strassels S.A., Smith D.H., Sullivan S.D., Mahajan P.S. The costs of treating COPD in the United States. Chest 2001; 119: 344-352.</mixed-citation></citation-alternatives></ref><ref id="cit279"><label>279</label><citation-alternatives><mixed-citation xml:lang="ru">Jansson S.A., Andersson F., Borg S. et al. Costs of COPD in Sweden according to disease severity. Chest 2002; 122: 1994-2002.</mixed-citation><mixed-citation xml:lang="en">Jansson S.A., Andersson F., Borg S. et al. Costs of COPD in Sweden according to disease severity. Chest 2002; 122: 1994-2002.</mixed-citation></citation-alternatives></ref><ref id="cit280"><label>280</label><citation-alternatives><mixed-citation xml:lang="ru">Miravitlles M., Murio C., Guerrero T., Gisbert R. Costs of chronic bronchitis and COPD: a 1-year follow-up study. Chest 2003; 123: 784-791.</mixed-citation><mixed-citation xml:lang="en">Miravitlles M., Murio C., Guerrero T., Gisbert R. Costs of chronic bronchitis and COPD: a 1-year follow-up study. Chest 2003; 123: 784-791.</mixed-citation></citation-alternatives></ref><ref id="cit281"><label>281</label><citation-alternatives><mixed-citation xml:lang="ru">Andersson F., Borg S., Jansson S.A. et al. The costs of exacerbations in chronic obstructive pulmonary disease (COPD). Respir. Med. 2002; 96: 700-708.</mixed-citation><mixed-citation xml:lang="en">Andersson F., Borg S., Jansson S.A. et al. The costs of exacerbations in chronic obstructive pulmonary disease (COPD). Respir. Med. 2002; 96: 700-708.</mixed-citation></citation-alternatives></ref><ref id="cit282"><label>282</label><citation-alternatives><mixed-citation xml:lang="ru">Oostenbrink J.B., Rutten-van M#ölken M.P. Resource use and risk factors in high-cost exacerbations of COPD. Respir. Med. 2004; 98: 883-891.</mixed-citation><mixed-citation xml:lang="en">Oostenbrink J.B., Rutten-van M#ölken M.P. Resource use and risk factors in high-cost exacerbations of COPD. Respir. Med. 2004; 98: 883-891.</mixed-citation></citation-alternatives></ref><ref id="cit283"><label>283</label><citation-alternatives><mixed-citation xml:lang="ru">van den Berg B., Brouwer W.B., Koopmanschap M.A. Economic valuation of informal care. An overview of methods and applications. Eur. J. Hlth Econ. 2004; 5: 36-45.</mixed-citation><mixed-citation xml:lang="en">van den Berg B., Brouwer W.B., Koopmanschap M.A. Economic valuation of informal care. An overview of methods and applications. Eur. J. Hlth Econ. 2004; 5: 36-45.</mixed-citation></citation-alternatives></ref><ref id="cit284"><label>284</label><citation-alternatives><mixed-citation xml:lang="ru">Koopmanschap M.A. PRODISQ: a modular questionnaire on productivity and disease for economic evaluation studies. Expert. Rev. Pharmacoeconom. Outcomes Res. 2005; 5: 23-28.</mixed-citation><mixed-citation xml:lang="en">Koopmanschap M.A. PRODISQ: a modular questionnaire on productivity and disease for economic evaluation studies. Expert. Rev. Pharmacoeconom. Outcomes Res. 2005; 5: 23-28.</mixed-citation></citation-alternatives></ref><ref id="cit285"><label>285</label><citation-alternatives><mixed-citation xml:lang="ru">Koopmanschap M.A., Rutten F.F., van Ineveld B.M., van Roijen L. The friction cost method for measuring indirect costs of disease. J. Hlth Econ. 1995; 14: 171-189.</mixed-citation><mixed-citation xml:lang="en">Koopmanschap M.A., Rutten F.F., van Ineveld B.M., van Roijen L. The friction cost method for measuring indirect costs of disease. J. Hlth Econ. 1995; 14: 171-189.</mixed-citation></citation-alternatives></ref><ref id="cit286"><label>286</label><citation-alternatives><mixed-citation xml:lang="ru">Ramsey S.D., Patrick D.L., Albert R.K. et al.The cost-effectiveness of lung transplantation. A pilot study. University of Washington Medical Center Lung Transplant Study Group. Chest 1995; 108: 1594-1601.</mixed-citation><mixed-citation xml:lang="en">Ramsey S.D., Patrick D.L., Albert R.K. et al.The cost-effectiveness of lung transplantation. A pilot study. University of Washington Medical Center Lung Transplant Study Group. Chest 1995; 108: 1594-1601.</mixed-citation></citation-alternatives></ref><ref id="cit287"><label>287</label><citation-alternatives><mixed-citation xml:lang="ru">Al M.J., Koopmanschap M.A., van Enckevort P.J. et al. Cost-effectiveness of lung transplantation in the Netherlands: a scenario analysis. Chest 1998; 113: 124-130.</mixed-citation><mixed-citation xml:lang="en">Al M.J., Koopmanschap M.A., van Enckevort P.J. et al. Cost-effectiveness of lung transplantation in the Netherlands: a scenario analysis. Chest 1998; 113: 124-130.</mixed-citation></citation-alternatives></ref><ref id="cit288"><label>288</label><citation-alternatives><mixed-citation xml:lang="ru">Groen H., van der B.W., Koeter G.H., TenVergert E.M. Cost-effectiveness of lung transplantation in relation to type of end-stage pulmonary disease. Am. J. Transplant. 2004; 4: 1155-1162.</mixed-citation><mixed-citation xml:lang="en">Groen H., van der B.W., Koeter G.H., TenVergert E.M. Cost-effectiveness of lung transplantation in relation to type of end-stage pulmonary disease. Am. J. Transplant. 2004; 4: 1155-1162.</mixed-citation></citation-alternatives></ref><ref id="cit289"><label>289</label><citation-alternatives><mixed-citation xml:lang="ru">Ramsey S.D., Berry K., Etzioni R. et al. Cost-effectiveness of lung-volume-reduction surgery for patients with severe emphysema. N. Engl. J. Med. 2003; 348: 2092-2102.</mixed-citation><mixed-citation xml:lang="en">Ramsey S.D., Berry K., Etzioni R. et al. Cost-effectiveness of lung-volume-reduction surgery for patients with severe emphysema. N. Engl. J. Med. 2003; 348: 2092-2102.</mixed-citation></citation-alternatives></ref><ref id="cit290"><label>290</label><citation-alternatives><mixed-citation xml:lang="ru">Anon J.M., Garcia de Lorenzo A., Zarazaga A. et al. Mechanical ventilation of patients on longterm oxygen therapy with acute exacerbations of chronic obstructive pulmonary disease: prognosis and cost-utility analysis. Intensive Care Med. 1999; 25: 452-457.</mixed-citation><mixed-citation xml:lang="en">Anon J.M., Garcia de Lorenzo A., Zarazaga A. et al. Mechanical ventilation of patients on longterm oxygen therapy with acute exacerbations of chronic obstructive pulmonary disease: prognosis and cost-utility analysis. Intensive Care Med. 1999; 25: 452-457.</mixed-citation></citation-alternatives></ref><ref id="cit291"><label>291</label><citation-alternatives><mixed-citation xml:lang="ru">Goldstein R.S., Gort E.H., Guyatt G.H., Feeny D. Economic analysis of respiratory rehabilitation. Chest 1997; 112: 370-379.</mixed-citation><mixed-citation xml:lang="en">Goldstein R.S., Gort E.H., Guyatt G.H., Feeny D. Economic analysis of respiratory rehabilitation. Chest 1997; 112: 370-379.</mixed-citation></citation-alternatives></ref><ref id="cit292"><label>292</label><citation-alternatives><mixed-citation xml:lang="ru">Griffiths T.L., Phillips C.J., Davies S. et al. Cost-effectiveness of an outpatient multidisciplinary pulmonary rehabilitation programme. Thorax 2001; 56: 779-784.</mixed-citation><mixed-citation xml:lang="en">Griffiths T.L., Phillips C.J., Davies S. et al. Cost-effectiveness of an outpatient multidisciplinary pulmonary rehabilitation programme. Thorax 2001; 56: 779-784.</mixed-citation></citation-alternatives></ref><ref id="cit293"><label>293</label><citation-alternatives><mixed-citation xml:lang="ru">Hoogendoorn M., Rutten-van Mölken M.P., Hoogenveen R.T. et al. A dynamic population model of disease progression in COPD. Eur. Respir. J. 2005; 26: 223-233.</mixed-citation><mixed-citation xml:lang="en">Hoogendoorn M., Rutten-van Mölken M.P., Hoogenveen R.T. et al. A dynamic population model of disease progression in COPD. Eur. Respir. J. 2005; 26: 223-233.</mixed-citation></citation-alternatives></ref><ref id="cit294"><label>294</label><citation-alternatives><mixed-citation xml:lang="ru">van den B.G., Rutten-van Mölken M.P., Folgering H. et al. The economic effects of screening for obstructive airway disease: an economic analysis of the DIMCA program. Prev. Med. 2000; 30: 302-308.</mixed-citation><mixed-citation xml:lang="en">van den B.G., Rutten-van Mölken M.P., Folgering H. et al. The economic effects of screening for obstructive airway disease: an economic analysis of the DIMCA program. Prev. Med. 2000; 30: 302-308.</mixed-citation></citation-alternatives></ref><ref id="cit295"><label>295</label><citation-alternatives><mixed-citation xml:lang="ru">Oostenbrink J.B., Rutten-van Mölken M.P., Al M.J. et al. One-year cost-effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease. Eur. Respir. J. 2004; 23: 241-249.</mixed-citation><mixed-citation xml:lang="en">Oostenbrink J.B., Rutten-van Mölken M.P., Al M.J. et al. One-year cost-effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease. Eur. Respir. J. 2004; 23: 241-249.</mixed-citation></citation-alternatives></ref><ref id="cit296"><label>296</label><citation-alternatives><mixed-citation xml:lang="ru">van Hout B.A., Al M.J., Gordon G.S., Rutten F.F. Costs, effects and C / E-ratios alongside a clinical trial. Hlth Econ. 1994; 3: 309-319.</mixed-citation><mixed-citation xml:lang="en">van Hout B.A., Al M.J., Gordon G.S., Rutten F.F. Costs, effects and C / E-ratios alongside a clinical trial. Hlth Econ. 1994; 3: 309-319.</mixed-citation></citation-alternatives></ref><ref id="cit297"><label>297</label><citation-alternatives><mixed-citation xml:lang="ru">Briggs A., Fenn P. Confidence intervals or surfaces? Uncertainty on the cost-effectiveness plane. Hlth Econ. 1998; 7: 723-740.</mixed-citation><mixed-citation xml:lang="en">Briggs A., Fenn P. Confidence intervals or surfaces? Uncertainty on the cost-effectiveness plane. Hlth Econ. 1998; 7: 723-740.</mixed-citation></citation-alternatives></ref><ref id="cit298"><label>298</label><citation-alternatives><mixed-citation xml:lang="ru">Briggs A.H., Wonderling D.E., Mooney C.Z. Pulling cost-effectiveness analysis up by its bootstraps: a nonparametric approach to confidence interval estimation. Hlth Econ. 1997; 6: 327-340.</mixed-citation><mixed-citation xml:lang="en">Briggs A.H., Wonderling D.E., Mooney C.Z. Pulling cost-effectiveness analysis up by its bootstraps: a nonparametric approach to confidence interval estimation. Hlth Econ. 1997; 6: 327-340.</mixed-citation></citation-alternatives></ref><ref id="cit299"><label>299</label><citation-alternatives><mixed-citation xml:lang="ru">Langley P.C. The NICE reference case requirement: implications for drug manufacturers and health systems. Pharmacoeconomics 2004; 22: 267-271.</mixed-citation><mixed-citation xml:lang="en">Langley P.C. The NICE reference case requirement: implications for drug manufacturers and health systems. Pharmacoeconomics 2004; 22: 267-271.</mixed-citation></citation-alternatives></ref><ref id="cit300"><label>300</label><citation-alternatives><mixed-citation xml:lang="ru">Fenwick E., Claxton K., Sculpher M. Representing uncertainty: the role of cost-effectiveness acceptability curves. Hlth Econ. 2001; 10: 779-787.</mixed-citation><mixed-citation xml:lang="en">Fenwick E., Claxton K., Sculpher M. Representing uncertainty: the role of cost-effectiveness acceptability curves. Hlth Econ. 2001; 10: 779-787.</mixed-citation></citation-alternatives></ref><ref id="cit301"><label>301</label><citation-alternatives><mixed-citation xml:lang="ru">Sin D.D., Golmohammadi K., Jacobs P. Cost-effectiveness of inhaled corticosteroids for chronic obstructive pulmonary disease according to disease severity. Am. J. Med. 2004; 116: 325-331.</mixed-citation><mixed-citation xml:lang="en">Sin D.D., Golmohammadi K., Jacobs P. Cost-effectiveness of inhaled corticosteroids for chronic obstructive pulmonary disease according to disease severity. Am. J. Med. 2004; 116: 325-331.</mixed-citation></citation-alternatives></ref><ref id="cit302"><label>302</label><citation-alternatives><mixed-citation xml:lang="ru">Borg S., Ericsson A., Wedzicha J. et al. A computer simulation model of the natural history and economic impact of chronic obstructive pulmonary disease. Value Hlth 2004; 7: 153-167.</mixed-citation><mixed-citation xml:lang="en">Borg S., Ericsson A., Wedzicha J. et al. A computer simulation model of the natural history and economic impact of chronic obstructive pulmonary disease. Value Hlth 2004; 7: 153-167.</mixed-citation></citation-alternatives></ref><ref id="cit303"><label>303</label><citation-alternatives><mixed-citation xml:lang="ru">Oostenbrink J.B., Rutten-van M#ölken M.P., Monz B.U., FitzGerald J.M. Probabilistic Markov model to assess the cost-effectiveness of bronchodilator therapy in COPD patients in different countries. Value Hlth 2005; 8: 32-46.</mixed-citation><mixed-citation xml:lang="en">Oostenbrink J.B., Rutten-van M#ölken M.P., Monz B.U., FitzGerald J.M. Probabilistic Markov model to assess the cost-effectiveness of bronchodilator therapy in COPD patients in different countries. Value Hlth 2005; 8: 32-46.</mixed-citation></citation-alternatives></ref><ref id="cit304"><label>304</label><citation-alternatives><mixed-citation xml:lang="ru">Spencer M., Briggs A.H., Grossman R.F., Rance L. Development of an economic model to assess the cost-effectiveness of treatment interventions for chronic obstructive pulmonary disease. Pharmacoeconomics 2005; 23: 619-637.</mixed-citation><mixed-citation xml:lang="en">Spencer M., Briggs A.H., Grossman R.F., Rance L. Development of an economic model to assess the cost-effectiveness of treatment interventions for chronic obstructive pulmonary disease. Pharmacoeconomics 2005; 23: 619-637.</mixed-citation></citation-alternatives></ref><ref id="cit305"><label>305</label><citation-alternatives><mixed-citation xml:lang="ru">Briggs A., Sculpher M. An introduction to Markov modelling for economic evaluation. Pharmacoeconomics 1998; 13: 397-409.</mixed-citation><mixed-citation xml:lang="en">Briggs A., Sculpher M. An introduction to Markov modelling for economic evaluation. Pharmacoeconomics 1998; 13: 397-409.</mixed-citation></citation-alternatives></ref><ref id="cit306"><label>306</label><citation-alternatives><mixed-citation xml:lang="ru">Hogg J.C. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 2004; 364: 709-721.</mixed-citation><mixed-citation xml:lang="en">Hogg J.C. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 2004; 364: 709-721.</mixed-citation></citation-alternatives></ref><ref id="cit307"><label>307</label><citation-alternatives><mixed-citation xml:lang="ru">Miniati M., Filippi E., Falaschi F. et al. Radiologic evaluation of emphysema in patients with chronic obstructive pulmonary disease. Chest radiography versus high resolution computed tomography. Am. J. Respir. Crit. Care Med. 1995; 151: 1359-1367.</mixed-citation><mixed-citation xml:lang="en">Miniati M., Filippi E., Falaschi F. et al. Radiologic evaluation of emphysema in patients with chronic obstructive pulmonary disease. Chest radiography versus high resolution computed tomography. Am. J. Respir. Crit. Care Med. 1995; 151: 1359-1367.</mixed-citation></citation-alternatives></ref><ref id="cit308"><label>308</label><citation-alternatives><mixed-citation xml:lang="ru">Kinsella M., Muller N.L., Staples C. et al. Hyperinflation in asthma and emphysema. Assessment by pulmonary function testing and computed tomography. Chest 1988; 94: 286-289.</mixed-citation><mixed-citation xml:lang="en">Kinsella M., Muller N.L., Staples C. et al. Hyperinflation in asthma and emphysema. Assessment by pulmonary function testing and computed tomography. Chest 1988; 94: 286-289.</mixed-citation></citation-alternatives></ref><ref id="cit309"><label>309</label><citation-alternatives><mixed-citation xml:lang="ru">Morrison N.J., Abboud R.T., Ramadan F. et al. Comparison of single breath carbon monoxide diffusing capacity and pressure-volume curves in detecting emphysema. Am. Rev. Respir. Dis. 1989; 139: 1179-1187.</mixed-citation><mixed-citation xml:lang="en">Morrison N.J., Abboud R.T., Ramadan F. et al. Comparison of single breath carbon monoxide diffusing capacity and pressure-volume curves in detecting emphysema. Am. Rev. Respir. Dis. 1989; 139: 1179-1187.</mixed-citation></citation-alternatives></ref><ref id="cit310"><label>310</label><citation-alternatives><mixed-citation xml:lang="ru">Parr D.G., Stoel B.C., Stolk J., Stockley R.A. Validation of computed tomographic lung densitometry for monitoring emphysema in a1-antitrypsin deficiency. Thorax 2006; 61: 485-490.</mixed-citation><mixed-citation xml:lang="en">Parr D.G., Stoel B.C., Stolk J., Stockley R.A. Validation of computed tomographic lung densitometry for monitoring emphysema in a1-antitrypsin deficiency. Thorax 2006; 61: 485-490.</mixed-citation></citation-alternatives></ref><ref id="cit311"><label>311</label><citation-alternatives><mixed-citation xml:lang="ru">Biernacki W., Ryan M., MacNee W., Flenley D.C. Can the quantitative CT scan detect progression of emphysema? Am. Rev. Respir. Dis. 1989; 131: A120.</mixed-citation><mixed-citation xml:lang="en">Biernacki W., Ryan M., MacNee W., Flenley D.C. Can the quantitative CT scan detect progression of emphysema? Am. Rev. Respir. Dis. 1989; 131: A120.</mixed-citation></citation-alternatives></ref><ref id="cit312"><label>312</label><citation-alternatives><mixed-citation xml:lang="ru">Dirksen A., Dijkman J.H., Madsen F. et al. A randomized clinical trial of a1-antitrypsin augmentation therapy. Am. J. Respir. Crit. Care Med. 1999; 160: 1468-1472.</mixed-citation><mixed-citation xml:lang="en">Dirksen A., Dijkman J.H., Madsen F. et al. A randomized clinical trial of a1-antitrypsin augmentation therapy. Am. J. Respir. Crit. Care Med. 1999; 160: 1468-1472.</mixed-citation></citation-alternatives></ref><ref id="cit313"><label>313</label><citation-alternatives><mixed-citation xml:lang="ru">Dowson L.J., Guest P.J., Stockley R.A. Longitudinal changes in physiological, radiological, and health status measurements in a1-antitrypsin deficiency and factors associated with decline. Am. J. Respir. Crit. Care Med. 2001; 164: 1805-1809.</mixed-citation><mixed-citation xml:lang="en">Dowson L.J., Guest P.J., Stockley R.A. Longitudinal changes in physiological, radiological, and health status measurements in a1-antitrypsin deficiency and factors associated with decline. Am. J. Respir. Crit. Care Med. 2001; 164: 1805-1809.</mixed-citation></citation-alternatives></ref><ref id="cit314"><label>314</label><citation-alternatives><mixed-citation xml:lang="ru">Soejima K., Yamaguchi K., Kohda E. et al. Longitudinal follow-up study of smoking-induced lung density changes by high-resolution computed tomography. Am. J. Respir. Crit. Care Med. 2000; 161: 1264-1273.</mixed-citation><mixed-citation xml:lang="en">Soejima K., Yamaguchi K., Kohda E. et al. Longitudinal follow-up study of smoking-induced lung density changes by high-resolution computed tomography. Am. J. Respir. Crit. Care Med. 2000; 161: 1264-1273.</mixed-citation></citation-alternatives></ref><ref id="cit315"><label>315</label><citation-alternatives><mixed-citation xml:lang="ru">Nakano Y., Muro S., Sakai H. et al. Computed tomographic measurements of airway dimensions and emphysema in smokers. Correlation with lung function. Am. J. Respir. Crit. Care Med. 2000; 162: 1102-1108.</mixed-citation><mixed-citation xml:lang="en">Nakano Y., Muro S., Sakai H. et al. Computed tomographic measurements of airway dimensions and emphysema in smokers. Correlation with lung function. Am. J. Respir. Crit. Care Med. 2000; 162: 1102-1108.</mixed-citation></citation-alternatives></ref><ref id="cit316"><label>316</label><citation-alternatives><mixed-citation xml:lang="ru">Orlandi I., Moroni C., Camiciottoli G. et al. Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation. Radiology 2005; 234: 604-610.</mixed-citation><mixed-citation xml:lang="en">Orlandi I., Moroni C., Camiciottoli G. et al. Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation. Radiology 2005; 234: 604-610.</mixed-citation></citation-alternatives></ref><ref id="cit317"><label>317</label><citation-alternatives><mixed-citation xml:lang="ru">Nakano Y., Muller N.L., King G.G. et al. Quantitative assessment of airway remodeling using high-resolution CT. Chest 2002; 122 (suppl. 6): 271S-275S.</mixed-citation><mixed-citation xml:lang="en">Nakano Y., Muller N.L., King G.G. et al. Quantitative assessment of airway remodeling using high-resolution CT. Chest 2002; 122 (suppl. 6): 271S-275S.</mixed-citation></citation-alternatives></ref><ref id="cit318"><label>318</label><citation-alternatives><mixed-citation xml:lang="ru">O'Donnell R.A., Peebles C., Ward J.A. et al. Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD. Thorax 2004; 59: 837-842.</mixed-citation><mixed-citation xml:lang="en">O'Donnell R.A., Peebles C., Ward J.A. et al. Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD. Thorax 2004; 59: 837-842.</mixed-citation></citation-alternatives></ref><ref id="cit319"><label>319</label><citation-alternatives><mixed-citation xml:lang="ru">Hayhurst M.D., MacNee W., Flenley D.C. et al. Diagnosis of pulmonary emphysema by computerised tomography. Lancet 1984; 2: 320-322.</mixed-citation><mixed-citation xml:lang="en">Hayhurst M.D., MacNee W., Flenley D.C. et al. Diagnosis of pulmonary emphysema by computerised tomography. Lancet 1984; 2: 320-322.</mixed-citation></citation-alternatives></ref><ref id="cit320"><label>320</label><citation-alternatives><mixed-citation xml:lang="ru">Guenard H., Diallo M.H., Laurent F., Vergeret J. Lung density and lung mass in emphysema. Chest 1992; 102: 198-203.</mixed-citation><mixed-citation xml:lang="en">Guenard H., Diallo M.H., Laurent F., Vergeret J. Lung density and lung mass in emphysema. Chest 1992; 102: 198-203.</mixed-citation></citation-alternatives></ref><ref id="cit321"><label>321</label><citation-alternatives><mixed-citation xml:lang="ru">Haraguchi M., Shimura S., Hida W., Shirato K. Pulmonary function and regional distribution of emphysema as determined by high-resolution computed tomography. Respiration 1998; 65: 125-129.</mixed-citation><mixed-citation xml:lang="en">Haraguchi M., Shimura S., Hida W., Shirato K. Pulmonary function and regional distribution of emphysema as determined by high-resolution computed tomography. Respiration 1998; 65: 125-129.</mixed-citation></citation-alternatives></ref><ref id="cit322"><label>322</label><citation-alternatives><mixed-citation xml:lang="ru">Heremans A., Verschakelen J.A., Van Fraeyenhoven L., Demedts M. Measurement of lung density by means of quantitative CT scanning. A study of correlations with pulmonary function tests. Chest 1992; 102: 805-811.</mixed-citation><mixed-citation xml:lang="en">Heremans A., Verschakelen J.A., Van Fraeyenhoven L., Demedts M. Measurement of lung density by means of quantitative CT scanning. A study of correlations with pulmonary function tests. Chest 1992; 102: 805-811.</mixed-citation></citation-alternatives></ref><ref id="cit323"><label>323</label><citation-alternatives><mixed-citation xml:lang="ru">Hartley P.G., Galvin J.R., Hunninghake G.W. et al. Highresolution CT-derived measures of lung density are valid indexes of interstitial lung disease. J. Appl. Physiol. 1994; 76: 271-277.</mixed-citation><mixed-citation xml:lang="en">Hartley P.G., Galvin J.R., Hunninghake G.W. et al. Highresolution CT-derived measures of lung density are valid indexes of interstitial lung disease. J. Appl. Physiol. 1994; 76: 271-277.</mixed-citation></citation-alternatives></ref><ref id="cit324"><label>324</label><citation-alternatives><mixed-citation xml:lang="ru">Rienmuller R.K., Behr J., Kalender W.A. et al. Standardized quantitative high resolution CT in lung diseases. J. Comput. Assist. Tomogr. 1991; 15: 742-749.</mixed-citation><mixed-citation xml:lang="en">Rienmuller R.K., Behr J., Kalender W.A. et al. Standardized quantitative high resolution CT in lung diseases. J. Comput. Assist. Tomogr. 1991; 15: 742-749.</mixed-citation></citation-alternatives></ref><ref id="cit325"><label>325</label><citation-alternatives><mixed-citation xml:lang="ru">Gould G.A., MacNee W., McLean A. et al. CT measurements of lung density in life can quantitate distal airspace enlargement - an essential defining feature of human emphysema. Am. Rev. Respir. Dis. 1988; 137: 380-392.</mixed-citation><mixed-citation xml:lang="en">Gould G.A., MacNee W., McLean A. et al. CT measurements of lung density in life can quantitate distal airspace enlargement - an essential defining feature of human emphysema. Am. Rev. Respir. Dis. 1988; 137: 380-392.</mixed-citation></citation-alternatives></ref><ref id="cit326"><label>326</label><citation-alternatives><mixed-citation xml:lang="ru">Gould G.A., Redpath A.T., Ryan M. et al. Lung CT density correlates with measurements of airflow limitation and the diffusing capacity. Eur. Respir. J. 1991; 4: 141-146.</mixed-citation><mixed-citation xml:lang="en">Gould G.A., Redpath A.T., Ryan M. et al. Lung CT density correlates with measurements of airflow limitation and the diffusing capacity. Eur. Respir. J. 1991; 4: 141-146.</mixed-citation></citation-alternatives></ref><ref id="cit327"><label>327</label><citation-alternatives><mixed-citation xml:lang="ru">Dirksen A., Friis M., Olesen K.P. et al. Progress of emphysema in severe a1-antitrypsin deficiency as assessed by annual CT. Acta Radiol. 1997; 38: 826-832.</mixed-citation><mixed-citation xml:lang="en">Dirksen A., Friis M., Olesen K.P. et al. Progress of emphysema in severe a1-antitrypsin deficiency as assessed by annual CT. Acta Radiol. 1997; 38: 826-832.</mixed-citation></citation-alternatives></ref><ref id="cit328"><label>328</label><citation-alternatives><mixed-citation xml:lang="ru">Bankier A.A., De Maertelaer V., Keyzer C., Gevenois P.A. Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology 1999; 211: 851-858.</mixed-citation><mixed-citation xml:lang="en">Bankier A.A., De Maertelaer V., Keyzer C., Gevenois P.A. Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology 1999; 211: 851-858.</mixed-citation></citation-alternatives></ref><ref id="cit329"><label>329</label><citation-alternatives><mixed-citation xml:lang="ru">Gevenois P.A., De Maertelaer V., De Vuyst P. et al. Comparison of computed density and macroscopic morphometry in pulmonary emphysema. Am. J. Respir. Crit. Care Med. 1995; 152: 653-657.</mixed-citation><mixed-citation xml:lang="en">Gevenois P.A., De Maertelaer V., De Vuyst P. et al. Comparison of computed density and macroscopic morphometry in pulmonary emphysema. Am. J. Respir. Crit. Care Med. 1995; 152: 653-657.</mixed-citation></citation-alternatives></ref><ref id="cit330"><label>330</label><citation-alternatives><mixed-citation xml:lang="ru">Gevenois P.A, De Vuyst P., Sy M. et al. Pulmonary emphysema: quantitative CT during expiration. Radiology 1996; 199: 825-829.</mixed-citation><mixed-citation xml:lang="en">Gevenois P.A, De Vuyst P., Sy M. et al. Pulmonary emphysema: quantitative CT during expiration. Radiology 1996; 199: 825-829.</mixed-citation></citation-alternatives></ref><ref id="cit331"><label>331</label><citation-alternatives><mixed-citation xml:lang="ru">Gevenois P.A., De Vuyst P., De Maertelaer V. et al. Comparison of computed density and microscopic morphometry in pulmonary emphysema. Am. J. Respir. Crit. Care Med. 1996; 154: 187-192.</mixed-citation><mixed-citation xml:lang="en">Gevenois P.A., De Vuyst P., De Maertelaer V. et al. Comparison of computed density and microscopic morphometry in pulmonary emphysema. Am. J. Respir. Crit. Care Med. 1996; 154: 187-192.</mixed-citation></citation-alternatives></ref><ref id="cit332"><label>332</label><citation-alternatives><mixed-citation xml:lang="ru">Muller N.L., Staples C.A., Miller R.R., Abboud R.T. ''Density mask''. An objective method to quantitate emphysema using computed tomography. Chest 1988; 94: 782-787.</mixed-citation><mixed-citation xml:lang="en">Muller N.L., Staples C.A., Miller R.R., Abboud R.T. ''Density mask''. An objective method to quantitate emphysema using computed tomography. Chest 1988; 94: 782-787.</mixed-citation></citation-alternatives></ref><ref id="cit333"><label>333</label><citation-alternatives><mixed-citation xml:lang="ru">Dowson L.J., Guest P.J., Hill S.L. et al. High-resolution computed tomography scanning in a1-antitrypsin deficiency: relationship to lung function and health status. Eur. Respir. J. 2001; 17: 1097-1104.</mixed-citation><mixed-citation xml:lang="en">Dowson L.J., Guest P.J., Hill S.L. et al. High-resolution computed tomography scanning in a1-antitrypsin deficiency: relationship to lung function and health status. Eur. Respir. J. 2001; 17: 1097-1104.</mixed-citation></citation-alternatives></ref><ref id="cit334"><label>334</label><citation-alternatives><mixed-citation xml:lang="ru">Parr D.G., Stoel B.C., Stolk J., Stockley R.A. Pattern of emphysema distribution in a1-antitrypsin deficiency influences lung function impairment. Am. J. Respir. Crit. Care Med. 2004; 170: 1172-1178.</mixed-citation><mixed-citation xml:lang="en">Parr D.G., Stoel B.C., Stolk J., Stockley R.A. Pattern of emphysema distribution in a1-antitrypsin deficiency influences lung function impairment. Am. J. Respir. Crit. Care Med. 2004; 170: 1172-1178.</mixed-citation></citation-alternatives></ref><ref id="cit335"><label>335</label><citation-alternatives><mixed-citation xml:lang="ru">Kinsella M., Muller N.L., Abboud R.T. et al. Quantitation of emphysema by computed tomography using a ''density mask'' program and correlation with pulmonary function tests. Chest 1990; 97: 315-321.</mixed-citation><mixed-citation xml:lang="en">Kinsella M., Muller N.L., Abboud R.T. et al. Quantitation of emphysema by computed tomography using a ''density mask'' program and correlation with pulmonary function tests. Chest 1990; 97: 315-321.</mixed-citation></citation-alternatives></ref><ref id="cit336"><label>336</label><citation-alternatives><mixed-citation xml:lang="ru">Park K.J., Bergin C.J., Clausen J.L. Quantitation of emphysema with three-dimensional CT densitometry: comparison with two-dimensional analysis, visual emphysema scores, and pulmonary function test results. Radiology 1999; 211: 541-547.</mixed-citation><mixed-citation xml:lang="en">Park K.J., Bergin C.J., Clausen J.L. Quantitation of emphysema with three-dimensional CT densitometry: comparison with two-dimensional analysis, visual emphysema scores, and pulmonary function test results. Radiology 1999; 211: 541-547.</mixed-citation></citation-alternatives></ref><ref id="cit337"><label>337</label><citation-alternatives><mixed-citation xml:lang="ru">Nakano Y., Wong J.C., de Jong P.A. et al. The prediction of small airway dimensions using computed tomography. Am. J. Respir. Crit. Care Med. 2005; 171: 142-146.</mixed-citation><mixed-citation xml:lang="en">Nakano Y., Wong J.C., de Jong P.A. et al. The prediction of small airway dimensions using computed tomography. Am. J. Respir. Crit. Care Med. 2005; 171: 142-146.</mixed-citation></citation-alternatives></ref><ref id="cit338"><label>338</label><citation-alternatives><mixed-citation xml:lang="ru">King G.G., Muller N.L., Whittall K.P. et al. An analysis algorhythm for measuring airway lumen and wall areas from high-resolution computed tomographic data. Am. J. Respir. Crit. Care Med. 2000; 161: 574-580.</mixed-citation><mixed-citation xml:lang="en">King G.G., Muller N.L., Whittall K.P. et al. An analysis algorhythm for measuring airway lumen and wall areas from high-resolution computed tomographic data. Am. J. Respir. Crit. Care Med. 2000; 161: 574-580.</mixed-citation></citation-alternatives></ref><ref id="cit339"><label>339</label><citation-alternatives><mixed-citation xml:lang="ru">Berger P., Perot V., Desbarats P. et al. Airway wall thickness in cigarette smokers: quantitative thin-section CT assessment. Radiology 2005; 235: 1055-1064.</mixed-citation><mixed-citation xml:lang="en">Berger P., Perot V., Desbarats P. et al. Airway wall thickness in cigarette smokers: quantitative thin-section CT assessment. Radiology 2005; 235: 1055-1064.</mixed-citation></citation-alternatives></ref><ref id="cit340"><label>340</label><citation-alternatives><mixed-citation xml:lang="ru">Matsuoka S., Kurihara Y., Nakajima Y. et al. Serial change in airway lumen and wall thickness at thin-section CT in asymptomatic subjects. Radiology 2005; 234: 595-603.</mixed-citation><mixed-citation xml:lang="en">Matsuoka S., Kurihara Y., Nakajima Y. et al. Serial change in airway lumen and wall thickness at thin-section CT in asymptomatic subjects. Radiology 2005; 234: 595-603.</mixed-citation></citation-alternatives></ref><ref id="cit341"><label>341</label><citation-alternatives><mixed-citation xml:lang="ru">Brillet P.Y., Fetita C.I., Beigelman-Aubry C. et al. Quantification of bronchial dimensions at MDCT using dedicated software. Eur. Radiol. 2007; 17: 1483-1489.</mixed-citation><mixed-citation xml:lang="en">Brillet P.Y., Fetita C.I., Beigelman-Aubry C. et al. Quantification of bronchial dimensions at MDCT using dedicated software. Eur. Radiol. 2007; 17: 1483-1489.</mixed-citation></citation-alternatives></ref><ref id="cit342"><label>342</label><citation-alternatives><mixed-citation xml:lang="ru">Kemerink G.J., Lamers R.J., Thelissen G.R., Van Engelshoven J.M. CT densitometry of the lungs: scanner performance. J. Comput. Assist. Tomogr. 1996; 20: 24-33.</mixed-citation><mixed-citation xml:lang="en">Kemerink G.J., Lamers R.J., Thelissen G.R., Van Engelshoven J.M. CT densitometry of the lungs: scanner performance. J. Comput. Assist. Tomogr. 1996; 20: 24-33.</mixed-citation></citation-alternatives></ref><ref id="cit343"><label>343</label><citation-alternatives><mixed-citation xml:lang="ru">Parr D.G., Stoel B.C., Stolk J. et al. Influence of calibration on densitometric studies of emphysema progression using computed tomography. Am. J. Respir. Crit. Care Med. 2004; 170: 883-890.</mixed-citation><mixed-citation xml:lang="en">Parr D.G., Stoel B.C., Stolk J. et al. Influence of calibration on densitometric studies of emphysema progression using computed tomography. Am. J. Respir. Crit. Care Med. 2004; 170: 883-890.</mixed-citation></citation-alternatives></ref><ref id="cit344"><label>344</label><citation-alternatives><mixed-citation xml:lang="ru">Kemerink G.J., Lamers R.J., Thelissen G.R., Van Engelshoven J.M. The nonlinear partial volume effect and computed tomography densitometry of foam and lung. Med. Phys. 1995; 22: 1445-1450.</mixed-citation><mixed-citation xml:lang="en">Kemerink G.J., Lamers R.J., Thelissen G.R., Van Engelshoven J.M. The nonlinear partial volume effect and computed tomography densitometry of foam and lung. Med. Phys. 1995; 22: 1445-1450.</mixed-citation></citation-alternatives></ref><ref id="cit345"><label>345</label><citation-alternatives><mixed-citation xml:lang="ru">Van Dyk J., Keane T.J., Rider W.D. Lung density as measured by computerized tomography: implications for radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 1982; 8: 1363-1372.</mixed-citation><mixed-citation xml:lang="en">Van Dyk J., Keane T.J., Rider W.D. Lung density as measured by computerized tomography: implications for radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 1982; 8: 1363-1372.</mixed-citation></citation-alternatives></ref><ref id="cit346"><label>346</label><citation-alternatives><mixed-citation xml:lang="ru">Wegener O.H., Koeppe P., Oeser H. Measurement of lung density by computed tomography. J. Comput. Assist. Tomogr. 1978; 2: 263-273.</mixed-citation><mixed-citation xml:lang="en">Wegener O.H., Koeppe P., Oeser H. Measurement of lung density by computed tomography. J. Comput. Assist. Tomogr. 1978; 2: 263-273.</mixed-citation></citation-alternatives></ref><ref id="cit347"><label>347</label><citation-alternatives><mixed-citation xml:lang="ru">Kalender W.A., Rienmuller R., Seissler W. et al. Measurement of pulmonary parenchymal attenuation: use of spirometric gating with quantitative CT. Radiology 1990; 175: 265-268.</mixed-citation><mixed-citation xml:lang="en">Kalender W.A., Rienmuller R., Seissler W. et al. Measurement of pulmonary parenchymal attenuation: use of spirometric gating with quantitative CT. Radiology 1990; 175: 265-268.</mixed-citation></citation-alternatives></ref><ref id="cit348"><label>348</label><citation-alternatives><mixed-citation xml:lang="ru">Gierada D.S., Yusen R.D., Pilgram T.K. et al. Repeatability of quantitative CT indexes of emphysema in patients evaluated for lung volume reduction surgery. Radiology 2001; 220: 448-454.</mixed-citation><mixed-citation xml:lang="en">Gierada D.S., Yusen R.D., Pilgram T.K. et al. Repeatability of quantitative CT indexes of emphysema in patients evaluated for lung volume reduction surgery. Radiology 2001; 220: 448-454.</mixed-citation></citation-alternatives></ref><ref id="cit349"><label>349</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffman E.A., McLennan G. Assessment of the pulmonary structure-function relationship and clinical outcomes measures: quantitative volumetric CT of the lung. Acad. Radiol. 1997; 4: 758-776.</mixed-citation><mixed-citation xml:lang="en">Hoffman E.A., McLennan G. Assessment of the pulmonary structure-function relationship and clinical outcomes measures: quantitative volumetric CT of the lung. Acad. Radiol. 1997; 4: 758-776.</mixed-citation></citation-alternatives></ref><ref id="cit350"><label>350</label><citation-alternatives><mixed-citation xml:lang="ru">Shaker S.B., Dirksen A., Laursen L. et al. Volume adjustment of lung density by computed tomography scans in patients with emphysema. Acta Radiol. 2004; 45: 417-423.</mixed-citation><mixed-citation xml:lang="en">Shaker S.B., Dirksen A., Laursen L. et al. Volume adjustment of lung density by computed tomography scans in patients with emphysema. Acta Radiol. 2004; 45: 417-423.</mixed-citation></citation-alternatives></ref><ref id="cit351"><label>351</label><citation-alternatives><mixed-citation xml:lang="ru">Stolk J., Dirksen A., van der Lugt A.A. et al. Repeatability of lung density measurements with low-dose computed tomography in subjects with a1-antitrypsin deficiencyassociated emphysema. Invest. Radiol. 2001; 36: 648-651.</mixed-citation><mixed-citation xml:lang="en">Stolk J., Dirksen A., van der Lugt A.A. et al. Repeatability of lung density measurements with low-dose computed tomography in subjects with a1-antitrypsin deficiencyassociated emphysema. Invest. Radiol. 2001; 36: 648-651.</mixed-citation></citation-alternatives></ref><ref id="cit352"><label>352</label><citation-alternatives><mixed-citation xml:lang="ru">Lamers R.J., Kemerink G.J., Drent M., Van Engelshoven J.M. Reproducibility of spirometrically controlled CT lung densitometry in a clinical setting. Eur. Respir. J. 1998; 11: 942-945.</mixed-citation><mixed-citation xml:lang="en">Lamers R.J., Kemerink G.J., Drent M., Van Engelshoven J.M. Reproducibility of spirometrically controlled CT lung densitometry in a clinical setting. Eur. Respir. J. 1998; 11: 942-945.</mixed-citation></citation-alternatives></ref><ref id="cit353"><label>353</label><citation-alternatives><mixed-citation xml:lang="ru">Moroni C., Mascalchi M., Camiciottoli G. et al. Comparison of spirometric-gated and -ungated HRCT in COPD. J. Comput. Assist. Tomogr. 2003; 27: 375-379.</mixed-citation><mixed-citation xml:lang="en">Moroni C., Mascalchi M., Camiciottoli G. et al. Comparison of spirometric-gated and -ungated HRCT in COPD. J. Comput. Assist. Tomogr. 2003; 27: 375-379.</mixed-citation></citation-alternatives></ref><ref id="cit354"><label>354</label><citation-alternatives><mixed-citation xml:lang="ru">Newell J.D., Hogg J.C., Snider G.L. Report of a workshop: quantitative computed tomography scanning in longitudinal studies of emphysema. Eur. Respir. J. 2004; 23: 769-775.</mixed-citation><mixed-citation xml:lang="en">Newell J.D., Hogg J.C., Snider G.L. Report of a workshop: quantitative computed tomography scanning in longitudinal studies of emphysema. Eur. Respir. J. 2004; 23: 769-775.</mixed-citation></citation-alternatives></ref><ref id="cit355"><label>355</label><citation-alternatives><mixed-citation xml:lang="ru">Robinson P.J., Kreel L. Pulmonary tissue attenuation with computed tomography: comparison of inspiration and expiration scans. J. Comput. Assist. Tomogr. 1979; 3: 740-748.</mixed-citation><mixed-citation xml:lang="en">Robinson P.J., Kreel L. Pulmonary tissue attenuation with computed tomography: comparison of inspiration and expiration scans. J. Comput. Assist. Tomogr. 1979; 3: 740-748.</mixed-citation></citation-alternatives></ref><ref id="cit356"><label>356</label><citation-alternatives><mixed-citation xml:lang="ru">Siegelman S. Pulmonary system: Practical approaches to pulmonary diagnosis. New York: Grune and Stratton; 1979.</mixed-citation><mixed-citation xml:lang="en">Siegelman S. Pulmonary system: Practical approaches to pulmonary diagnosis. New York: Grune and Stratton; 1979.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
