pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2009-2-113-119pulmo-1539Research ArticleСтатьиМеханизмы формирования конденсата выдыхаемого
воздуха и маркеры оксидативного стресса при патологиях
респираторного трактаКлимановИ.А.noemail@neicon.ruСоодаеваС.К.noemail@neicon.ruФГУ НИИ пульмонологии ФМБА РоссииRussian Federation20092804200902113119Copyright © Климанов
И., Соодаева
С., 20092009Климанов
И., Соодаева
С.Климанов
И., Соодаева
С.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/1539Конденсат выдыхаемого воздухаоксидативный стрессактивные формы кислородамаркеры воспаленияReferencesKharitonov S.A., Barnes P.J. Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers 2002; 7 (1): 1-32.Kharitonov S.A., Barnes P.J. Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers 2002; 7 (1): 1-32.Griese M., Noss J., von Bredow C. Protein pattern of exhaled breath condensate and saliva. Proteomics 2002; 2 (6): 690-696.Griese M., Noss J., von Bredow C. Protein pattern of exhaled breath condensate and saliva. Proteomics 2002; 2 (6): 690-696.Ganas K., Loukides S., Papatheodorou G. et al. Total nitrite / nitrate in expired breath condensate of patients with asthma. Respir. Med. 2001; 95 (8): 649-654.Ganas K., Loukides S., Papatheodorou G. et al. Total nitrite / nitrate in expired breath condensate of patients with asthma. Respir. Med. 2001; 95 (8): 649-654.Запрудова Е.А. Изучение динамики метаболитов оксида азота в конденсате выдыхаемого воздуха у детей при атопии. Автореф. дис. … канд. мед. наук. М.; 2002.Запрудова Е.А. Изучение динамики метаболитов оксида азота в конденсате выдыхаемого воздуха у детей при атопии. Автореф. дис. … канд. мед. наук. М.; 2002.Effros R.M., Peterson B., Casaburi R. et al. Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects. J. Appl. Physiol. 2005; 99 (4): 1286-1292.Effros R.M., Peterson B., Casaburi R. et al. Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects. J. Appl. Physiol. 2005; 99 (4): 1286-1292.Райс П. Аэрозоли. М.: Мир: 1987.Райс П. Аэрозоли. М.: Мир: 1987.Гриппи М.А. Патофизиология легких. 3-е изд. М.: Изд-во "БИНОМ"; СПб.: Невский Диалект; 2001. 33.Гриппи М.А. Патофизиология легких. 3-е изд. М.: Изд-во "БИНОМ"; СПб.: Невский Диалект; 2001. 33.Александров О.В., Добрынина О.В., Севрунова О.А. и др. О методе исследования легочного сурфактанта в конденсате паров выдыхаемого воздуха. Тер. архив 1992; 64 (10): 105-107.Александров О.В., Добрынина О.В., Севрунова О.А. и др. О методе исследования легочного сурфактанта в конденсате паров выдыхаемого воздуха. Тер. архив 1992; 64 (10): 105-107.Бюль Э.В., Фомич Л.Г., Серебровская И.А. Зависимость поверхностноактивных свойств конденсата выдыхаемого воздуха от глубины дыхания. Л.; 1988. 73-74.Бюль Э.В., Фомич Л.Г., Серебровская И.А. Зависимость поверхностноактивных свойств конденсата выдыхаемого воздуха от глубины дыхания. Л.; 1988. 73-74.Fairchild C.I., Stampfer J.F. Particle concentration in exhaled breath. Am. Industr. Hyg. Assoc. J. 1987; 48 (11): 948-949.Fairchild C.I., Stampfer J.F. Particle concentration in exhaled breath. Am. Industr. Hyg. Assoc. J. 1987; 48 (11): 948-949.Мотавкин П.А., Гельцер Б.И. Клиническая и экспериментальная патофизиология легких. М.: Наука; 1998. 169-179.Мотавкин П.А., Гельцер Б.И. Клиническая и экспериментальная патофизиология легких. М.: Наука; 1998. 169-179.Человек. Медико-биологические данные. Пер. с англ. М.: Медицина; 1976.Человек. Медико-биологические данные. Пер. с англ. М.: Медицина; 1976.McCafferty J.B., Bradshaw T.A., Tate S. et al. Effects of breathing pattern and inspired air conditions on breath condensate volume, pH, nitrite, and protein concentration. Thorax 2004; 59: 694-698.McCafferty J.B., Bradshaw T.A., Tate S. et al. Effects of breathing pattern and inspired air conditions on breath condensate volume, pH, nitrite, and protein concentration. Thorax 2004; 59: 694-698.Яковлева О.А., Баяк Н.Ю., Зорин С.М. Патогенетическое значение конденсата выдыхаемого воздуха в патологии органов дыхания. В кн.: Нереспираторные функции легких: Сборник научных трудов ВНИИ пульмонологии. Л.; 1988. 67-70.Яковлева О.А., Баяк Н.Ю., Зорин С.М. Патогенетическое значение конденсата выдыхаемого воздуха в патологии органов дыхания. В кн.: Нереспираторные функции легких: Сборник научных трудов ВНИИ пульмонологии. Л.; 1988. 67-70.Анаев Э.Х., Чучалин А.Г. Исследование конденсата выдыхаемого воздуха в пульмонологии (обзор зарубежной литературы). Пульмонология 2002; 2: 57-65.Анаев Э.Х., Чучалин А.Г. Исследование конденсата выдыхаемого воздуха в пульмонологии (обзор зарубежной литературы). Пульмонология 2002; 2: 57-65.Итоги науки и техники. Сер.: Биофизика. М.; 1991; т. 29.Итоги науки и техники. Сер.: Биофизика. М.; 1991; т. 29.Millar T.M., Kanczler J.M., Bodamyali T. et al. Nitric oxide. Its generation, reactions and role in physiology. In: Tomasi A., Özben T., Skulachev V.P., eds. Free radicals, nitric oxide, and inflammation: Molecular, biochemical, and clinical aspects. Amsterdam: IOS Press; 2003. 71-88.Millar T.M., Kanczler J.M., Bodamyali T. et al. Nitric oxide. Its generation, reactions and role in physiology. In: Tomasi A., Özben T., Skulachev V.P., eds. Free radicals, nitric oxide, and inflammation: Molecular, biochemical, and clinical aspects. Amsterdam: IOS Press; 2003. 71-88.Latzin P., Griese M. Exhaled hydrogen peroxide, nitrite and nitric oxide in healthy children: decrease of hydrogen peroxide by atmospheric nitric oxide. Eur. J. Med. Res. 2002; 7 (8): 353-358Latzin P., Griese M. Exhaled hydrogen peroxide, nitrite and nitric oxide in healthy children: decrease of hydrogen peroxide by atmospheric nitric oxide. Eur. J. Med. Res. 2002; 7 (8): 353-358Emelyanov A., Fedoseev G., Abulimity A. et al. Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. Chest 2001; 120 (4): 1136-1139.Emelyanov A., Fedoseev G., Abulimity A. et al. Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. Chest 2001; 120 (4): 1136-1139.Horvath I., Donnely L., Kiss A., Kharitonov S. Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am. J. Respir. Crit. Care Med. 1998; 158: 1042-1046.Horvath I., Donnely L., Kiss A., Kharitonov S. Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am. J. Respir. Crit. Care Med. 1998; 158: 1042-1046.Ferreira I.M., Hazari S.М., Gutierrez C. et al. Exhaled nitric oxide and hydrogen peroxide in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 164 (6): 1012-1015.Ferreira I.M., Hazari S.М., Gutierrez C. et al. Exhaled nitric oxide and hydrogen peroxide in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 164 (6): 1012-1015.Dekhuijzen P.N., Aben K.K., Dekker I. et al. Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1996; 154 (3, pt. 1): 813-816.Dekhuijzen P.N., Aben K.K., Dekker I. et al. Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1996; 154 (3, pt. 1): 813-816.van Beurden W.J., Dekhuijzen P.N., Harff G.A., Smeenk F.W. Variability of exhaled hydrogen peroxide in stable COPD patients and matched healthy controls. Respiration 2002; 69 (3): 211-216.van Beurden W.J., Dekhuijzen P.N., Harff G.A., Smeenk F.W. Variability of exhaled hydrogen peroxide in stable COPD patients and matched healthy controls. Respiration 2002; 69 (3): 211-216.Loukides S., Horvath I., Wodehouse T. et al. Elevated levels of expired breath hydrogen peroxide in bronchiectasis. Am. J. Respir. Crit. Care Med. 1998; 158 (3): 991-994.Loukides S., Horvath I., Wodehouse T. et al. Elevated levels of expired breath hydrogen peroxide in bronchiectasis. Am. J. Respir. Crit. Care Med. 1998; 158 (3): 991-994.Majewska E., Kasielski M., Luczynski R. et al. Elevated exhalation of hydrogen peroxide and thiobarbituric acid reactive substances in patients with community acquired pneumonia. Respir. Med. 2004; 98 (7): 669-676.Majewska E., Kasielski M., Luczynski R. et al. Elevated exhalation of hydrogen peroxide and thiobarbituric acid reactive substances in patients with community acquired pneumonia. Respir. Med. 2004; 98 (7): 669-676.Szkudlarek U., Maria L., Kasielski M. et al. Exhaled hydrogen peroxide correlates with the release of reactive oxygen species by blood phagocytes in healthy subjects. Respir. Med. 2003; 97 (6): 718-725.Szkudlarek U., Maria L., Kasielski M. et al. Exhaled hydrogen peroxide correlates with the release of reactive oxygen species by blood phagocytes in healthy subjects. Respir. Med. 2003; 97 (6): 718-725.Antczak A., Nowak D., Bialasiewicz P., Kasielski M. Hydrogen peroxide in expired air condensate correlates positively with early steps of peripheral neutrophil activation in asthmatic patients. Arch. Immunol. Ther. Exp. (Warsz.) 1999; 47 (2): 119-126.Antczak A., Nowak D., Bialasiewicz P., Kasielski M. Hydrogen peroxide in expired air condensate correlates positively with early steps of peripheral neutrophil activation in asthmatic patients. Arch. Immunol. Ther. Exp. (Warsz.) 1999; 47 (2): 119-126.Ho L.P., Faccenda J., Innes J.A., Greening A.P. Expired hydrogen peroxide in breath condensate of cystic fibrosis patients. Eur. Respir. J. 1999; 13 (1): 103-106.Ho L.P., Faccenda J., Innes J.A., Greening A.P. Expired hydrogen peroxide in breath condensate of cystic fibrosis patients. Eur. Respir. J. 1999; 13 (1): 103-106.Вознесенский Н.А. Выдыхаемый оксид азота - биомаркер бронхиальной астмы: Автореф. дис. … канд. мед. наук. М.; 2000.Вознесенский Н.А. Выдыхаемый оксид азота - биомаркер бронхиальной астмы: Автореф. дис. … канд. мед. наук. М.; 2000.Hanazawa T., Kharitonov S., Barnes P.J. Increased nitrotyrosine in exhaled breath condensate of patients with asthma. Am. J. Respir. Crit. Care Med. 2000; 162 (4): 1273-1276.Hanazawa T., Kharitonov S., Barnes P.J. Increased nitrotyrosine in exhaled breath condensate of patients with asthma. Am. J. Respir. Crit. Care Med. 2000; 162 (4): 1273-1276.Corradi M., Montuschi P., Donnelly L.E. et al. Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases. Am. J. Respir. Crit. Care Med. 2001;163 (4): 854-858.Corradi M., Montuschi P., Donnelly L.E. et al. Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases. Am. J. Respir. Crit. Care Med. 2001;163 (4): 854-858.Formanek W., Inci D., Lauener R.P. et al. Elevated nitrite in breath condensates of children with respiratory disease. Eur. Respir. J. 2002; 19 (3): 487-491.Formanek W., Inci D., Lauener R.P. et al. Elevated nitrite in breath condensates of children with respiratory disease. Eur. Respir. J. 2002; 19 (3): 487-491.Ho L.P., Innes J.A., Greening A.P. Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide Thorax 1998; 53: 680-684.Ho L.P., Innes J.A., Greening A.P. Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide Thorax 1998; 53: 680-684.Formanek W., Inci D., Lauener R.P. et al. Elevated nitrite in breath condensates of children with respiratory disease. Eur. Respir. J. 2002; 19 (3): 487-489.Formanek W., Inci D., Lauener R.P. et al. Elevated nitrite in breath condensates of children with respiratory disease. Eur. Respir. J. 2002; 19 (3): 487-489.Ярилин А.А. Основы иммунологии. М.: Медицина; 1999.Ярилин А.А. Основы иммунологии. М.: Медицина; 1999.Csoma Z., Kharitonov S.A., Balint B. et al. Increased leukotrienes in exhaled breath condensate in childhood asthma. Am. J. Respir. Crit. Care Med. 2002; 166 (10): 1345-1349.Csoma Z., Kharitonov S.A., Balint B. et al. Increased leukotrienes in exhaled breath condensate in childhood asthma. Am. J. Respir. Crit. Care Med. 2002; 166 (10): 1345-1349.Corradi M., Folesani G., Andreoli R. et al. Aldehydes and glutathione in exhaled breath condensate of children with asthma exacerbation. Am. J. Respir. Crit. Care Med. 2003; 167 (3): 395-399.Corradi M., Folesani G., Andreoli R. et al. Aldehydes and glutathione in exhaled breath condensate of children with asthma exacerbation. Am. J. Respir. Crit. Care Med. 2003; 167 (3): 395-399.Corradi M., Rubinstein I., Andreoli R. et al. Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2003; 167 (10): 1380-1386.Corradi M., Rubinstein I., Andreoli R. et al. Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2003; 167 (10): 1380-1386.
The authors declare that there are no conflicts of interest present.