pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2006-5-74-79pulmo-1497Research ArticleСтатьиНейтрофильная эластаза и болезни органов дыханияАверьяновА.В.noemail@neicon.ruПоливановаА.Э.noemail@neicon.ru200628102006057479Copyright © Аверьянов
А., Поливанова
А., 20062006Аверьянов
А., Поливанова
А.Аверьянов
А., Поливанова
А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/1497ReferencesLaurell C. B., Eriksson S. The electrophoretic alpha1-globulin pattern of serum in alpha1-antitrypsin deficiency. Scand. J. Clin. Lab. Invest.1963;15: 132-140.Laurell C. B., Eriksson S. The electrophoretic alpha1-globulin pattern of serum in alpha1-antitrypsin deficiency. Scand. J. Clin. Lab. Invest.1963;15: 132-140.Gross P., Babjak M., Tolker E. et al. Enzymatically produced pulmonary emphysema: A preliminary report. J. Occup. Med. 1964; 6: 481-484.Gross P., Babjak M., Tolker E. et al. Enzymatically produced pulmonary emphysema: A preliminary report. J. Occup. Med. 1964; 6: 481-484.Mercer R., Crapo J. D. Structural changes in elastic fibers after pancreatic elastase administration in hamsters. J. Appl. Physiol. 1992; 72: 1473-1479.Mercer R., Crapo J. D. Structural changes in elastic fibers after pancreatic elastase administration in hamsters. J. Appl. Physiol. 1992; 72: 1473-1479.Zimmer M., Medcalf R.L., Fink T.M. et al. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. Proc. Natl. Acad. Sci. USA 1992; 89: 8215-8219.Zimmer M., Medcalf R.L., Fink T.M. et al. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. Proc. Natl. Acad. Sci. USA 1992; 89: 8215-8219.Owen C.A., Campbell M.A., Boukedes S.S., Campbell E.J. Cytokines regulate membranebound leukocyte elastase on neutrophils: a novel mechanism for effector activity. Am. J. Physiol. 1997; 272: L385-L393.Owen C.A., Campbell M.A., Boukedes S.S., Campbell E.J. Cytokines regulate membranebound leukocyte elastase on neutrophils: a novel mechanism for effector activity. Am. J. Physiol. 1997; 272: L385-L393.Sadallah S., Hess C., Miot S. et al. Elastase and metalloproteinase activities regulate soluble complement receptor 1 release. Eur. J. Immunol. 1999; 29: 3754-3761.Sadallah S., Hess C., Miot S. et al. Elastase and metalloproteinase activities regulate soluble complement receptor 1 release. Eur. J. Immunol. 1999; 29: 3754-3761.LeBarillec K., SiTahar M., Balloy V., Chignard M. Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharidemediated cell activation. J. Clin. Invest. 1999; 103: 1039-1046.LeBarillec K., SiTahar M., Balloy V., Chignard M. Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharidemediated cell activation. J. Clin. Invest. 1999; 103: 1039-1046.Vandivier R.W., Fadok V.A., Hoffmann P.R. et al. Elastase mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J. Clin. Invest. 2002; 109: 661-670.Vandivier R.W., Fadok V.A., Hoffmann P.R. et al. Elastase mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J. Clin. Invest. 2002; 109: 661-670.Champagne B., Tremblay P., Cantin A., St. Pierre Y. Proteolytic cleavage of ICAM-1 by human neutrophil elastase. J. Immunol. 1998; 161: 6398-6405.Champagne B., Tremblay P., Cantin A., St. Pierre Y. Proteolytic cleavage of ICAM-1 by human neutrophil elastase. J. Immunol. 1998; 161: 6398-6405.Bedard M., McCLure C.D., Schiller N.L. et al. Release of interleukin-8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells: implications for cystic fibrosis. Am. J. Respir. Cell. Mol. Biol. 1993; 9: 455-462.Bedard M., McCLure C.D., Schiller N.L. et al. Release of interleukin-8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells: implications for cystic fibrosis. Am. J. Respir. Cell. Mol. Biol. 1993; 9: 455-462.Banda M.J., Rice A.G., Griffin G.L., Senior R.M. Alpha1- proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase. J. Biol. Chem. 1988; 263: 4481-4484.Banda M.J., Rice A.G., Griffin G.L., Senior R.M. Alpha1- proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase. J. Biol. Chem. 1988; 263: 4481-4484.Rubio F., Cooley J., Accurso F.J., Remold-O'Donnell E. Linkage of neutrophil serine proteases and decreased surfactant protein-A (SP-A) levels in inflammatory lung disease. Thorax 2004; 59: 318-323.Rubio F., Cooley J., Accurso F.J., Remold-O'Donnell E. Linkage of neutrophil serine proteases and decreased surfactant protein-A (SP-A) levels in inflammatory lung disease. Thorax 2004; 59: 318-323.Vassalli J.D., GranelliPiperno A., Griscelli C., Reich E. Specific protease deficiency in polymorphonuclear leukocite of Chediak-Higashi syndrome and beige mice. J. Exp. Med. 1979; 147: 1285-1290.Vassalli J.D., GranelliPiperno A., Griscelli C., Reich E. Specific protease deficiency in polymorphonuclear leukocite of Chediak-Higashi syndrome and beige mice. J. Exp. Med. 1979; 147: 1285-1290.Belaaouaj A.A., McCarthy R., Baumann M. et al. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat. Med. 1998; 4: 615-618.Belaaouaj A.A., McCarthy R., Baumann M. et al. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat. Med. 1998; 4: 615-618.Weinrauch Y., Drujan D., Shapiro S.D. et al. Neutrophil elastase targets virulence factors of enterobaceria. Nature 2002; 417: 91-94.Weinrauch Y., Drujan D., Shapiro S.D. et al. Neutrophil elastase targets virulence factors of enterobaceria. Nature 2002; 417: 91-94.Rice W.G., Weiss S.J. Regulation of proteolysis at the neutrophil-substrate interface by secretory leukoprotease inhibitor. Science 1990; 249: 178-181.Rice W.G., Weiss S.J. Regulation of proteolysis at the neutrophil-substrate interface by secretory leukoprotease inhibitor. Science 1990; 249: 178-181.Boudier C., Bieth J.G. Oxidized mucus proteinase inhibitor: a fairly potent neutrophil elastase inhibitor. Biochem. J. 1994; 303: 61-68.Boudier C., Bieth J.G. Oxidized mucus proteinase inhibitor: a fairly potent neutrophil elastase inhibitor. Biochem. J. 1994; 303: 61-68.Morrison H.M., Welgus H.G., Stockley R.A. et al. Inhibition of human leukocyte elastase bound to elastin: relative ineffectiveness and two mechanisms of inhibitory activity. Am. J. Respir. Cell. Mol. Biol.1990; 2: 263-269.Morrison H.M., Welgus H.G., Stockley R.A. et al. Inhibition of human leukocyte elastase bound to elastin: relative ineffectiveness and two mechanisms of inhibitory activity. Am. J. Respir. Cell. Mol. Biol.1990; 2: 263-269.Lucatelly M., Bartalesi B. et al. Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models. Resp. Res. 2005; 6: 83.Lucatelly M., Bartalesi B. et al. Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models. Resp. Res. 2005; 6: 83.Taipale J., Lohi J., Saharinen J. et al. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells. J. Biol. Chem. 1995; 270:4689-4696.Taipale J., Lohi J., Saharinen J. et al. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells. J. Biol. Chem. 1995; 270:4689-4696.Chung Y., Kercsmar C.M., Davis P.B. Ferret tracheal epithelial cells grown in vitro are resistant to lethal injury by activated neutrophils. Am. J. Respir. Cell. Mol. Biol. 1991; 5: 125-132.Chung Y., Kercsmar C.M., Davis P.B. Ferret tracheal epithelial cells grown in vitro are resistant to lethal injury by activated neutrophils. Am. J. Respir. Cell. Mol. Biol. 1991; 5: 125-132.Smedly L.A., Tonnesen M.G., Sandhaus R.A. et al. Neutrophil-mediated injury to endothelial cells enhancement by endotoxin and essential role of neutrophil elastase. J. Clin. Invest. 1986; 77: 1233-1243.Smedly L.A., Tonnesen M.G., Sandhaus R.A. et al. Neutrophil-mediated injury to endothelial cells enhancement by endotoxin and essential role of neutrophil elastase. J. Clin. Invest. 1986; 77: 1233-1243.Harlan J.M., Killen P.D., Harker L.A. et al. Neutrophil- mediated endothelial injury in vitro. J. Clin. Invest. 1981; 68: 1394-1403.Harlan J.M., Killen P.D., Harker L.A. et al. Neutrophil- mediated endothelial injury in vitro. J. Clin. Invest. 1981; 68: 1394-1403.Taggart C., CervantesLaurean D., Kim G. Oxidation of either methionine 351 or methionine 358 in 1-antitrypsin causes loss of antineutrophil elastase activity. J. Biol. Chem. 2000; 275 (35): 27258-27265.Taggart C., CervantesLaurean D., Kim G. Oxidation of either methionine 351 or methionine 358 in 1-antitrypsin causes loss of antineutrophil elastase activity. J. Biol. Chem. 2000; 275 (35): 27258-27265.Damiano V.V., Tsang A., Kucich U. et al. Immunolocalization of elastase in human emphysematous lungs. J. Clin. Invest. 1986; 78(2): 482-493.Damiano V.V., Tsang A., Kucich U. et al. Immunolocalization of elastase in human emphysematous lungs. J. Clin. Invest. 1986; 78(2): 482-493.Finkelstein R., Fraser R.S., Ghezzo H. et al. Alveolar inflammation and its relation to emphysema in smokers. Am. J. Respir. Crit. Care Med. 1995; 152:1666-1672.Finkelstein R., Fraser R.S., Ghezzo H. et al. Alveolar inflammation and its relation to emphysema in smokers. Am. J. Respir. Crit. Care Med. 1995; 152:1666-1672.Fera T., Abboud R.T., Richter A. et al. Acute effect of smoking on elastaselike esterase activity and immunologic neutrophil elastase levels in bronchoalveolar lavage fluid. Am. Rev. Respir. Dis. 1986; 133: 568-573.Fera T., Abboud R.T., Richter A. et al. Acute effect of smoking on elastaselike esterase activity and immunologic neutrophil elastase levels in bronchoalveolar lavage fluid. Am. Rev. Respir. Dis. 1986; 133: 568-573.Retamales I., Elliott W.M., Meshi B. et al. Amplification of inflammation in emphysema and its association with latent adenoviral infection. Am. J. Respir.Crit. Care Med. 2001; 164: 469-473; comments 2001; 164: 339; correspondence 2001; 165: 730-731.Retamales I., Elliott W.M., Meshi B. et al. Amplification of inflammation in emphysema and its association with latent adenoviral infection. Am. J. Respir.Crit. Care Med. 2001; 164: 469-473; comments 2001; 164: 339; correspondence 2001; 165: 730-731.Senior R.M., Griffin G.L., Mecham R.P. Chemotactic activity of elastin-derived peptides. J. Clin. Invest. 1980; 66: 859-862.Senior R.M., Griffin G.L., Mecham R.P. Chemotactic activity of elastin-derived peptides. J. Clin. Invest. 1980; 66: 859-862.Saunders W.B., Bayless K.J., Davis G.E. MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices. J. Cell. Sci. 2005; 118 (pt. 10): 2325-2340.Saunders W.B., Bayless K.J., Davis G.E. MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices. J. Cell. Sci. 2005; 118 (pt. 10): 2325-2340.Shapiro S.D., Senior R.M. Matrix metalloproteinases. Matrix degradation and more. Am. J. Respir. Cell Mol. Biol. 1999; 20: 1100-1102.Shapiro S.D., Senior R.M. Matrix metalloproteinases. Matrix degradation and more. Am. J. Respir. Cell Mol. Biol. 1999; 20: 1100-1102.Birrer P. Proteases and antiproteases in cystic fibrosis: pathogenetic considerations and therapeutic strategies. Respiration 1995; 62 (suppl. 1): 25-28.Birrer P. Proteases and antiproteases in cystic fibrosis: pathogenetic considerations and therapeutic strategies. Respiration 1995; 62 (suppl. 1): 25-28.Idell S.,Kucich U., Fein A. et al. Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome. Am. Rev. Respir. Dis. 1985; 132 (5): 1098-1105.Idell S.,Kucich U., Fein A. et al. Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome. Am. Rev. Respir. Dis. 1985; 132 (5): 1098-1105.Eden E., Hammel J., Rouhani F.N. et al. Asthma features in severe alpha1-antitrypsin deficiency: experience of the National Heart, Lung, and Blood Institute. Reg. Chest. 2003; 123 (3): 765-771.Eden E., Hammel J., Rouhani F.N. et al. Asthma features in severe alpha1-antitrypsin deficiency: experience of the National Heart, Lung, and Blood Institute. Reg. Chest. 2003; 123 (3): 765-771.Vignola A.M., Bonanno A., Mirabella A. et al. Increased levels of elastase and alpha1-antitrypsin in sputum of asthmatic patients. Am. J. Respir. Crit. Care Med. 1998; 157 (2): 505-1145.Vignola A.M., Bonanno A., Mirabella A. et al. Increased levels of elastase and alpha1-antitrypsin in sputum of asthmatic patients. Am. J. Respir. Crit. Care Med. 1998; 157 (2): 505-1145.Hubbard R.C., Fells A., Gadek J. et al. Neutrophil accumulation in the lung in 1-antitrypsin deficiency: spontaneous release of Leukotriene B4 by alveolar macrophages. J. Clin. Invest. 1991; 88: 891-897.Hubbard R.C., Fells A., Gadek J. et al. Neutrophil accumulation in the lung in 1-antitrypsin deficiency: spontaneous release of Leukotriene B4 by alveolar macrophages. J. Clin. Invest. 1991; 88: 891-897.Jatakanon A., Uasuf C., Maziak W. et al. Neutrophilic inflammation in severe persistent asthma. Am. J. Respir. Crit. Care Med. 1999; 160 (5 pt 1): 1532-1539.Jatakanon A., Uasuf C., Maziak W. et al. Neutrophilic inflammation in severe persistent asthma. Am. J. Respir. Crit. Care Med. 1999; 160 (5 pt 1): 1532-1539.Mauad T., Silva L.F., Santos M.A. et al. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am. J. Respir. Crit. Care Med. 2004; 170 (8): 857-862.Mauad T., Silva L.F., Santos M.A. et al. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am. J. Respir. Crit. Care Med. 2004; 170 (8): 857-862.Chapman K.R., Stockley R.A., Dawkins C. et al. Augmentation therapy for α1-antitrypsin deficiency: a meta-analysis of randomized and nonrandomized clinical studies. Eur. Respir. J. 2005; 26 (49): 288.Chapman K.R., Stockley R.A., Dawkins C. et al. Augmentation therapy for α1-antitrypsin deficiency: a meta-analysis of randomized and nonrandomized clinical studies. Eur. Respir. J. 2005; 26 (49): 288.McElvaney N.G., Doujaiji B., Moan M.J. Pharmacokinetics of recombinant secretory leukoprotease inhibitor aerosolized to normals and individuals with cystic fibrosis. Am. Rev. Respir. Dis. 1993; 148 (4 pt 1): 1056-1060.McElvaney N.G., Doujaiji B., Moan M.J. Pharmacokinetics of recombinant secretory leukoprotease inhibitor aerosolized to normals and individuals with cystic fibrosis. Am. Rev. Respir. Dis. 1993; 148 (4 pt 1): 1056-1060.Fujimoto K., Kubo K., Shinozaki S. et al. Neutrophil elastase inhibitor reduces asthmatic responses in allergic sheep. Respir.Physiol.1995; 100 (1): 91-100.Fujimoto K., Kubo K., Shinozaki S. et al. Neutrophil elastase inhibitor reduces asthmatic responses in allergic sheep. Respir.Physiol.1995; 100 (1): 91-100.Ariel A., Hershkoviz R., Altbaum-Weiss I. et al. Cell surface-expressed moesin-like receptor regulates T cell interactions with tissue components and binds an adhesion-modulating IL-2 peptide generated by elastase. J. Immunol. 2001; 166 (5): 3052-3060.Ariel A., Hershkoviz R., Altbaum-Weiss I. et al. Cell surface-expressed moesin-like receptor regulates T cell interactions with tissue components and binds an adhesion-modulating IL-2 peptide generated by elastase. J. Immunol. 2001; 166 (5): 3052-3060.Bank U., Kupper B., Reinhold D., Hoffman T., Ansorge S. Evidence for crucial role of neutrophil-derived serine proteases in the inactivation of interleukin-6 at sites of inflammation. FEBS Lett 1999; 461: 235-240.Bank U., Kupper B., Reinhold D., Hoffman T., Ansorge S. Evidence for crucial role of neutrophil-derived serine proteases in the inactivation of interleukin-6 at sites of inflammation. FEBS Lett 1999; 461: 235-240.Breuer R., Christensen T.G., Lucey E.C. et al. An ultrastructural morphometric analysis of elastase-treated hamster bronchi shows discharge followed by progressive accumulation of secretory granules. Am. Rev. Resp. Dis. 1987; 136: 698-703Breuer R., Christensen T.G., Lucey E.C. et al. An ultrastructural morphometric analysis of elastase-treated hamster bronchi shows discharge followed by progressive accumulation of secretory granules. Am. Rev. Resp. Dis. 1987; 136: 698-703Voynow J.A., Young L.R., Wang Y. et al. Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am. J. Physiol. 1999; 276: L835-L843.Voynow J.A., Young L.R., Wang Y. et al. Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am. J. Physiol. 1999; 276: L835-L843.Renesto P., Balloy V., Kamimura T. et al. Inhibition by recombinant SLPI and half-SLPI of elastase and cathepsin G activities: Consequence for neutrophilplatelet cooperation. Br. J. Pharmacol. 1993; 108: 1100-1106.Renesto P., Balloy V., Kamimura T. et al. Inhibition by recombinant SLPI and half-SLPI of elastase and cathepsin G activities: Consequence for neutrophilplatelet cooperation. Br. J. Pharmacol. 1993; 108: 1100-1106.Kohri K., Ueki I.F., Nadel J.A. Neutrophil elastase induces mucin production by liganddependent epidermal growth factor receptor activation. J. Immunol. 2001; 167: 5948-5954.Kohri K., Ueki I.F., Nadel J.A. Neutrophil elastase induces mucin production by liganddependent epidermal growth factor receptor activation. J. Immunol. 2001; 167: 5948-5954.Fischer B.M., Voynov J.A. Neutrophil elastase increases MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am. J. Respir. Cell. Mol. Biol.2002; 26: 447-452.Fischer B.M., Voynov J.A. Neutrophil elastase increases MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am. J. Respir. Cell. Mol. Biol.2002; 26: 447-452.Hiemstra P.S., van Wetering S., Stolk J. Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Eur. Respir. J. 1998; 12 (5): 1200-1208.Hiemstra P.S., van Wetering S., Stolk J. Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Eur. Respir. J. 1998; 12 (5): 1200-1208.Liou T.G., Campbell E.J. Quantum proteolysis resulting from release of single granules by neutrophils: a novel, nonoxidative mechanism of extracellular proteolytic activity. J. Immunol. 1996; 157: 2624-2631.Liou T.G., Campbell E.J. Quantum proteolysis resulting from release of single granules by neutrophils: a novel, nonoxidative mechanism of extracellular proteolytic activity. J. Immunol. 1996; 157: 2624-2631.Polivanova A., Zykov K., Averyanov A. et al. Neutrophil elastase in severe COPD and asthma exacerbation. Eur. Respir. J. 2006; 28 (suppl. 50): 36s-e319.Polivanova A., Zykov K., Averyanov A. et al. Neutrophil elastase in severe COPD and asthma exacerbation. Eur. Respir. J. 2006; 28 (suppl. 50): 36s-e319.
The authors declare that there are no conflicts of interest present.