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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2006-4-116-122</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-1485</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Роль формотерола в лечении бронхиальной астмы</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Емельянов</surname><given-names>А.В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2006</year></pub-date><volume>0</volume><issue>4</issue><fpage>116</fpage><lpage>122</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Емельянов
                 А., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Емельянов
                 А.</copyright-holder><copyright-holder xml:lang="en">Емельянов
                 А.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/1485">https://journal.pulmonology.ru/pulm/article/view/1485</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Global initiative for asthma. NHLB / WHO Workshop Report. National Heart Lung Blood Institute, Publication number 95!3659. 2004. Chapter 7; 93-148.</mixed-citation><mixed-citation xml:lang="en">Global initiative for asthma. NHLB / WHO Workshop Report. National Heart Lung Blood Institute, Publication number 95!3659. 2004. Chapter 7; 93-148.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ueki J., Rhodes C.G., Hughes J.M.B. et al. In vivo quantification of pulmonary !adrenoceptor density in humans with (S)-11C-CGP12177 and PET. J. Appl. Physiol. 1993; 75: 559-565.</mixed-citation><mixed-citation xml:lang="en">Ueki J., Rhodes C.G., Hughes J.M.B. et al. In vivo quantification of pulmonary !adrenoceptor density in humans with (S)-11C-CGP12177 and PET. J. Appl. Physiol. 1993; 75: 559-565.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Qing F., Rahman S.U., Rhodes C.G. et al. -adrenergic receptors in vivo and lung function in drug!free asthmatic subjects. Am. J. Respir. Crit. Care Med 1997; 155: A855.</mixed-citation><mixed-citation xml:lang="en">Qing F., Rahman S.U., Rhodes C.G. et al. -adrenergic receptors in vivo and lung function in drug!free asthmatic subjects. Am. J. Respir. Crit. Care Med 1997; 155: A855.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P. Beta-adrenergic receptors and their regulation. Am. J. Respir. Crit. Care Med. 1995; 152 (3): 838-860.</mixed-citation><mixed-citation xml:lang="en">Barnes P. Beta-adrenergic receptors and their regulation. Am. J. Respir. Crit. Care Med. 1995; 152 (3): 838-860.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson M. The -adrenoceptor. Am. J. Respir. Crit. Care Med. 1998; 158 (5, pt 3): 146-153.</mixed-citation><mixed-citation xml:lang="en">Johnson M. The -adrenoceptor. Am. J. Respir. Crit. Care Med. 1998; 158 (5, pt 3): 146-153.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hall I.P. Beta-2 adrenergic receptor dysfunction and polymorphism in asthma. In: Rose B.D. ed Up To Date. Waltham, MA, 2006. 35-41.</mixed-citation><mixed-citation xml:lang="en">Hall I.P. Beta-2 adrenergic receptor dysfunction and polymorphism in asthma. In: Rose B.D. ed Up To Date. Waltham, MA, 2006. 35-41.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kotani Y., Nishimura Y., Maeda H., Yokoyama M. Beta2-adrenergic receptor polymorphisms affect airways respon! siveness to salbutamol in asthmatic. J. Asthma 1999; 36 (7): 583-590.</mixed-citation><mixed-citation xml:lang="en">Kotani Y., Nishimura Y., Maeda H., Yokoyama M. Beta2-adrenergic receptor polymorphisms affect airways respon! siveness to salbutamol in asthmatic. J. Asthma 1999; 36 (7): 583-590.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Liggett S.B. Polymorphism of the 2-adrenergic receptor and asthma. Am. J. Respir. Crit. Care Med. 1997; 156 (4, pt. 2): 156-162.</mixed-citation><mixed-citation xml:lang="en">Liggett S.B. Polymorphism of the 2-adrenergic receptor and asthma. Am. J. Respir. Crit. Care Med. 1997; 156 (4, pt. 2): 156-162.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lima J.J., Thomasson D.B., Mohamed M.H. et al. Impact of genetic polymorphism of the beta2!adrenergic receptor on albuterol bronchodilator pharmacodynamics. Clin. Pharmacol. 1999; 65 (5): 519-525.</mixed-citation><mixed-citation xml:lang="en">Lima J.J., Thomasson D.B., Mohamed M.H. et al. Impact of genetic polymorphism of the beta2!adrenergic receptor on albuterol bronchodilator pharmacodynamics. Clin. Pharmacol. 1999; 65 (5): 519-525.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Israel E., Drazen J.M., Liggett S.B. et al. The effect of polymorphisms of the beta (2)!adrenergic receptor on the response to regular use of albuterol in asthma. Am. J. Respir. Crit. Care Med. 2000; 162 (1): 75-80.</mixed-citation><mixed-citation xml:lang="en">Israel E., Drazen J.M., Liggett S.B. et al. The effect of polymorphisms of the beta (2)!adrenergic receptor on the response to regular use of albuterol in asthma. Am. J. Respir. Crit. Care Med. 2000; 162 (1): 75-80.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lipworth B.J., Hall I.P., Aziz I. et al. Beta2-adrenoceptor polymorphism and bronchoprotective sensitivity with regular short! and long-acting beta2-agonist therapy. Clin. Sci. 1999; 96 (3): 253-259.</mixed-citation><mixed-citation xml:lang="en">Lipworth B.J., Hall I.P., Aziz I. et al. Beta2-adrenoceptor polymorphism and bronchoprotective sensitivity with regular short! and long-acting beta2-agonist therapy. Clin. Sci. 1999; 96 (3): 253-259.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson G.P., Linden A., Rabe K.F. Why are long-acting beta-adreno!ceptor agonists long acting? Eur. Respir. J. 1994; 7 (3): 569-578.</mixed-citation><mixed-citation xml:lang="en">Anderson G.P., Linden A., Rabe K.F. Why are long-acting beta-adreno!ceptor agonists long acting? Eur. Respir. J. 1994; 7 (3): 569-578.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Palmqvist M., Persson G., Lazer L. et al. Inhaled dry-powder formoterol and salmeterol in asthmatic patients: onset of action, duration of effect and potency. Eur. Respir. J.1997; 10 (11): 2484-2489.</mixed-citation><mixed-citation xml:lang="en">Palmqvist M., Persson G., Lazer L. et al. Inhaled dry-powder formoterol and salmeterol in asthmatic patients: onset of action, duration of effect and potency. Eur. Respir. J.1997; 10 (11): 2484-2489.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Palmqvist M., Ibsen T., Mellen A., Lotvall J. Comparison of the relative efficacy of formoterol and salmeterol in asthmatic patients. Am. J. Respir. Crit. Care Med. 1999; 160 (1): 244-249.</mixed-citation><mixed-citation xml:lang="en">Palmqvist M., Ibsen T., Mellen A., Lotvall J. Comparison of the relative efficacy of formoterol and salmeterol in asthmatic patients. Am. J. Respir. Crit. Care Med. 1999; 160 (1): 244-249.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenborg J., Larsson P., Tenger K., Hallstrom G. Mass balance and metabolism of [3H] Formoterol in healthy men after combined i.v. and oral administration!mimicking inhalation. Drug Metab. Dispos. 1999; 27 (10): 1104-1116.</mixed-citation><mixed-citation xml:lang="en">Rosenborg J., Larsson P., Tenger K., Hallstrom G. Mass balance and metabolism of [3H] Formoterol in healthy men after combined i.v. and oral administration!mimicking inhalation. Drug Metab. Dispos. 1999; 27 (10): 1104-1116.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Handley D.A., Anderson A.J., Koester J., Snider M.E. New mellenium bronchodilators for asthma: single isomer beta agonists. Curr. Opin. Pulm. Med. 2000; 6 (1): 43-49.</mixed-citation><mixed-citation xml:lang="en">Handley D.A., Anderson A.J., Koester J., Snider M.E. New mellenium bronchodilators for asthma: single isomer beta agonists. Curr. Opin. Pulm. Med. 2000; 6 (1): 43-49.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Lotvall J., Mellen A., Arvidsson P. et al. Similar bronchodilation with formoterol delivered by aerolizer or turbuhaler. Can. Respir. J. 1999; 6 (5): 412-416.</mixed-citation><mixed-citation xml:lang="en">Lotvall J., Mellen A., Arvidsson P. et al. Similar bronchodilation with formoterol delivered by aerolizer or turbuhaler. Can. Respir. J. 1999; 6 (5): 412-416.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bartow R.A., Brogden R.N. Formoterol. An update of its pharmacological properties and therapeutic efficacy in the management of asthma. Drugs. 1998; 55 (2): 303-322.</mixed-citation><mixed-citation xml:lang="en">Bartow R.A., Brogden R.N. Formoterol. An update of its pharmacological properties and therapeutic efficacy in the management of asthma. Drugs. 1998; 55 (2): 303-322.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrari M., Balestreri F., Baratieri S. et al. Evidence of the rapid protective effect of formoterol dry!powder inhalation against exercise!induced bronchospasm in athletes with asthma. Respiration 2000; 67 (5): 510-513.</mixed-citation><mixed-citation xml:lang="en">Ferrari M., Balestreri F., Baratieri S. et al. Evidence of the rapid protective effect of formoterol dry!powder inhalation against exercise!induced bronchospasm in athletes with asthma. Respiration 2000; 67 (5): 510-513.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Nightingale J.A., Rogers D.F., Barnes P.J. Differential effect of formoterol on adenosine monophosphate and histamine reactivity in asthma. Am. J. Respir. Crit. Care Med. 1999; 159 (6): 1786-1790.</mixed-citation><mixed-citation xml:lang="en">Nightingale J.A., Rogers D.F., Barnes P.J. Differential effect of formoterol on adenosine monophosphate and histamine reactivity in asthma. Am. J. Respir. Crit. Care Med. 1999; 159 (6): 1786-1790.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">van Noord J.A., Smeets J.J., Raaijmakers J.A. et al. Salmeterol versus formoterol in patients with moderately severe asthma: onset and duration of action. Eur. Respir. J. 1996; 9 (8): 1684-1688.</mixed-citation><mixed-citation xml:lang="en">van Noord J.A., Smeets J.J., Raaijmakers J.A. et al. Salmeterol versus formoterol in patients with moderately severe asthma: onset and duration of action. Eur. Respir. J. 1996; 9 (8): 1684-1688.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Bench G., Lapidus R., Levine B.E. et al. A randomized, 12 week, double!blind, placebo!controlled study comparing formoterol dry powder inhaler with albuterol metered - dose inhaler. Ann. Allergy Asthma Immunol. 2001; 86 (1): 19-27.</mixed-citation><mixed-citation xml:lang="en">Bench G., Lapidus R., Levine B.E. et al. A randomized, 12 week, double!blind, placebo!controlled study comparing formoterol dry powder inhaler with albuterol metered - dose inhaler. Ann. Allergy Asthma Immunol. 2001; 86 (1): 19-27.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Malimard M., Bourcereau J., Le Gros V. et al. Comparison between formoterol 12 microg b.i.d. and on!demand salbutamol in moderate persistent asthma. Respir. Med. 2001; 95 (1): 64-70.</mixed-citation><mixed-citation xml:lang="en">Malimard M., Bourcereau J., Le Gros V. et al. Comparison between formoterol 12 microg b.i.d. and on!demand salbutamol in moderate persistent asthma. Respir. Med. 2001; 95 (1): 64-70.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tatersfield A.E., Lofdahl C.G., Postma D.S. et al. Comparison of formoterol and terbutaline for asneeded treatment of asthma: a randomized trial. Lancet 2001; 357 (9252): 257-261.</mixed-citation><mixed-citation xml:lang="en">Tatersfield A.E., Lofdahl C.G., Postma D.S. et al. Comparison of formoterol and terbutaline for asneeded treatment of asthma: a randomized trial. Lancet 2001; 357 (9252): 257-261.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Konermann M., Luck G., Rawert B., Pirsig W. Effect of the long-acting beta-2 agonist inhalant formoterol on quality of sleep of patients with bronchial asthma. Pneumologie 2000; 54 (3): 104-109.</mixed-citation><mixed-citation xml:lang="en">Konermann M., Luck G., Rawert B., Pirsig W. Effect of the long-acting beta-2 agonist inhalant formoterol on quality of sleep of patients with bronchial asthma. Pneumologie 2000; 54 (3): 104-109.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bouros D., Bachlitzanakis N., Kottakis J. et al. Formoterol and beclomethasone versus higher dose beclomethasone as maintenance therapy in adult asthma. Eur. Respir. J.1999; 14 (3): 627-632.</mixed-citation><mixed-citation xml:lang="en">Bouros D., Bachlitzanakis N., Kottakis J. et al. Formoterol and beclomethasone versus higher dose beclomethasone as maintenance therapy in adult asthma. Eur. Respir. J.1999; 14 (3): 627-632.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kips J.C., O'Connor B.J., Inman M.D. et al. A long term study of the antiinflammatory effect of low-dose budesonide plus formoterol versus high dose budesonide in asthma. Am. J. Respir. Crit. Care Med. 2000; 161 (3, pt 1): 996-1001.</mixed-citation><mixed-citation xml:lang="en">Kips J.C., O'Connor B.J., Inman M.D. et al. A long term study of the antiinflammatory effect of low-dose budesonide plus formoterol versus high dose budesonide in asthma. Am. J. Respir. Crit. Care Med. 2000; 161 (3, pt 1): 996-1001.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Juniper E., Svensson K., O'Burne P.M. et al. Asthma quality of life during 1 year of treatment with budesonide with and without formoterol. Eur. Respir. J. 1999; 14 (5): 1038-1043.</mixed-citation><mixed-citation xml:lang="en">Juniper E., Svensson K., O'Burne P.M. et al. Asthma quality of life during 1 year of treatment with budesonide with and without formoterol. Eur. Respir. J. 1999; 14 (5): 1038-1043.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Pauwels R.A., Lofdahl C.G., Postma D.S. et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and corticosteroids establishing therapy (FACET) international study group. N. Engl. J. Med. 1997; 337 (20): 1405-1411.</mixed-citation><mixed-citation xml:lang="en">Pauwels R.A., Lofdahl C.G., Postma D.S. et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and corticosteroids establishing therapy (FACET) international study group. N. Engl. J. Med. 1997; 337 (20): 1405-1411.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J. Scientific rationale for inhaled combination therapy with long!acting 2-agonists and corticosteroids. Eur. Respir. J. 2002; 19: 182-191.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J. Scientific rationale for inhaled combination therapy with long!acting 2-agonists and corticosteroids. Eur. Respir. J. 2002; 19: 182-191.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">FitGerald J.M., Chapman K.R., Della Cioppa G. et al. Sustained bronchoprotection, bronchodilatation, and symptom control during regular formoterol use in asthma of moderate or greater severity. The Canadian FO / ODI Study Group. J. Allergy. Clin. Immunol. 1999; 103 (3, pt 1): 427-443.</mixed-citation><mixed-citation xml:lang="en">FitGerald J.M., Chapman K.R., Della Cioppa G. et al. Sustained bronchoprotection, bronchodilatation, and symptom control during regular formoterol use in asthma of moderate or greater severity. The Canadian FO / ODI Study Group. J. Allergy. Clin. Immunol. 1999; 103 (3, pt 1): 427-443.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Stahl E., Postma D.S., Svensson K. et al. Formoterol used as needed improves health!related quality of life in asthmatic patients uncontrolled with inhaled corticosteroids. Respir. Med. 2003; 97 (9): 1061-1066.</mixed-citation><mixed-citation xml:lang="en">Stahl E., Postma D.S., Svensson K. et al. Formoterol used as needed improves health!related quality of life in asthmatic patients uncontrolled with inhaled corticosteroids. Respir. Med. 2003; 97 (9): 1061-1066.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ind P.W., Villasante C., Shiner R.J. et al. Safety of for! moterol by Turbuhaled as reliver medication compared with terbutaline in moderate asthma. Eur. Respir. J. 2002; 20 (4): 859-866.</mixed-citation><mixed-citation xml:lang="en">Ind P.W., Villasante C., Shiner R.J. et al. Safety of for! moterol by Turbuhaled as reliver medication compared with terbutaline in moderate asthma. Eur. Respir. J. 2002; 20 (4): 859-866.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kaik G., Kattakis I., Anagnostopoulou O. et al. Sequential flexible therapy with formoterol (Foradil) plus budesonide (Miflonide) versus a fixed combination of salmeterol and fluticasone (Seretide) in asthma self!management. Eur. Respir. J. 2002; 20 (suppl. 38): 388 s.</mixed-citation><mixed-citation xml:lang="en">Kaik G., Kattakis I., Anagnostopoulou O. et al. Sequential flexible therapy with formoterol (Foradil) plus budesonide (Miflonide) versus a fixed combination of salmeterol and fluticasone (Seretide) in asthma self!management. Eur. Respir. J. 2002; 20 (suppl. 38): 388 s.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P. Effect of beta!agonists on inflammatory cells. J. Allergy. Clin. Immunol. 1999; 104 (2, pt 2): S.10-17.</mixed-citation><mixed-citation xml:lang="en">Barnes P. Effect of beta!agonists on inflammatory cells. J. Allergy. Clin. Immunol. 1999; 104 (2, pt 2): S.10-17.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Moore R.H., Khan A., Dickey B.F. Long-acting inhaled 2-agonists in asthma therapy. Chest. 1998; 113 (4): 1095-1108.</mixed-citation><mixed-citation xml:lang="en">Moore R.H., Khan A., Dickey B.F. Long-acting inhaled 2-agonists in asthma therapy. Chest. 1998; 113 (4): 1095-1108.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Maneechotesuwan K., Essilfie-Quaye S., Meah S. et al. Formoterol attenuates neutrophilic airway inflammation in asthma. Chest. 2005; 128 (4): 1936-1942.</mixed-citation><mixed-citation xml:lang="en">Maneechotesuwan K., Essilfie-Quaye S., Meah S. et al. Formoterol attenuates neutrophilic airway inflammation in asthma. Chest. 2005; 128 (4): 1936-1942.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Wallin A., Sandstorm T., Soderberg M. et al. The effect of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indicies in mild asthma. Am. J. Respir. Crit. Care Med. 1999; 159 (1): 79-86.</mixed-citation><mixed-citation xml:lang="en">Wallin A., Sandstorm T., Soderberg M. et al. The effect of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indicies in mild asthma. Am. J. Respir. Crit. Care Med. 1999; 159 (1): 79-86.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Aziz I., Wilson A.M., Lipworth B.J. Effect of once!daily for! moterol and budesonide given alone and in combination on surrogate inflammatory markers in asthmatic adults. Chest 2000; 118 (4): 1049-1058.</mixed-citation><mixed-citation xml:lang="en">Aziz I., Wilson A.M., Lipworth B.J. Effect of once!daily for! moterol and budesonide given alone and in combination on surrogate inflammatory markers in asthmatic adults. Chest 2000; 118 (4): 1049-1058.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Overbeek S.E., Mulder P.G., Baelemans S.M. et al. Formoterol added to low!dose budesonide has no additional anti!inflammatory effect in asthmatic patients. Chest 2005; 128 (3): 1121-1127.</mixed-citation><mixed-citation xml:lang="en">Overbeek S.E., Mulder P.G., Baelemans S.M. et al. Formoterol added to low!dose budesonide has no additional anti!inflammatory effect in asthmatic patients. Chest 2005; 128 (3): 1121-1127.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Centanni S., Carlucci P., Santus P. et al. Nonpulmonary effects induced by addition of formoterol to budesonide therapy in patients with mild or moderate persistent asthma. Respiration. 2000; 67 (1): 60-64.</mixed-citation><mixed-citation xml:lang="en">Centanni S., Carlucci P., Santus P. et al. Nonpulmonary effects induced by addition of formoterol to budesonide therapy in patients with mild or moderate persistent asthma. Respiration. 2000; 67 (1): 60-64.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Guhan A.R., Cooper S., Oborne J. et al. Systemic effects of formoterol and salmeterol: a dose!response comparison in healthy subjects. Thorax 2000; 55 (8): 650-656.</mixed-citation><mixed-citation xml:lang="en">Guhan A.R., Cooper S., Oborne J. et al. Systemic effects of formoterol and salmeterol: a dose!response comparison in healthy subjects. Thorax 2000; 55 (8): 650-656.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Cazzola M., Imperatore F., Salzillo A. et al. Cardiac effects of formoterol and salmeterol in patients suffering from COPD with preexisting cardiac arrythmias and hypoxemia. Chest 1998; 114: 411-415.</mixed-citation><mixed-citation xml:lang="en">Cazzola M., Imperatore F., Salzillo A. et al. Cardiac effects of formoterol and salmeterol in patients suffering from COPD with preexisting cardiac arrythmias and hypoxemia. Chest 1998; 114: 411-415.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Cazzola M., Matera M.G., Donner C.F. Inhaled beta2-adrenoreceptor agonists: cardiovascular safety in patients with obstructive lung disease. Drugs 2005; 65 (12): 1595-1610.</mixed-citation><mixed-citation xml:lang="en">Cazzola M., Matera M.G., Donner C.F. Inhaled beta2-adrenoreceptor agonists: cardiovascular safety in patients with obstructive lung disease. Drugs 2005; 65 (12): 1595-1610.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson H.S., Weiss S., Bleeker E.R. et al. The Salmeterol Multicenter Asthma Research Trial. A comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest. 2006; 129 (1): 15-26.</mixed-citation><mixed-citation xml:lang="en">Nelson H.S., Weiss S., Bleeker E.R. et al. The Salmeterol Multicenter Asthma Research Trial. A comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest. 2006; 129 (1): 15-26.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Wolfe J., LaForce C., Friedman B. et al. Formoterol, 24 mg bid and serious asthma exacerbations. Similar rates compared with formoterol, 12 mg bid, with and without extra doses taken on demand, and placebo. Chest. 2006; 129 (1): 27-38.</mixed-citation><mixed-citation xml:lang="en">Wolfe J., LaForce C., Friedman B. et al. Formoterol, 24 mg bid and serious asthma exacerbations. Similar rates compared with formoterol, 12 mg bid, with and without extra doses taken on demand, and placebo. Chest. 2006; 129 (1): 27-38.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
