pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2006-3-5-13pulmo-1452Research ArticleСтатьиАллергенная проницаемость барьерных
тканей - стратегическая проблема
аллергологииГущинИ.С.noemail@neicon.ru20062806200603513Copyright © Гущин
И., 20062006Гущин
И.Гущин
И.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/1452ReferencesKronec A., Ely I.M., Klinger T. еt al. Isocyanates in flexible polyurethane foams. Bull. Envirоn. Contam. Toxicol. 2003, 70; 328-335.Kronec A., Ely I.M., Klinger T. еt al. Isocyanates in flexible polyurethane foams. Bull. Envirоn. Contam. Toxicol. 2003, 70; 328-335.Kronec C.A., Klinger T.D. Isocyanates, polyurethane and children asthma. Pediatr. Allergy Immunol. 2005; 16: 368-379.Kronec C.A., Klinger T.D. Isocyanates, polyurethane and children asthma. Pediatr. Allergy Immunol. 2005; 16: 368-379.Платонова Н.С. Клиникоэпидемиологическая характеристика и пути медикосоциальной профилактики аллергических заболеваний у жителей Крайнего Севера (на модели региона Якутии): Автореф. дис. … д-ра. мед. наук. М.; 1999.Платонова Н.С. Клиникоэпидемиологическая характеристика и пути медикосоциальной профилактики аллергических заболеваний у жителей Крайнего Севера (на модели региона Якутии): Автореф. дис. … д-ра. мед. наук. М.; 1999.Marsh D.G., Lichtenstein L.M., Norman P.S. Induction of IgEmediated hypersensitivity to group I ruy grass pollen allergen and allergoids in nonallergic man. Immunology 1972; 22: 1013-1019.Marsh D.G., Lichtenstein L.M., Norman P.S. Induction of IgEmediated hypersensitivity to group I ruy grass pollen allergen and allergoids in nonallergic man. Immunology 1972; 22: 1013-1019.Гущин И.С. Немедленная аллергия клетки. М.; Медицина; 1976.Гущин И.С. Немедленная аллергия клетки. М.; Медицина; 1976.Гущин И.С. Об элементах биологической целесообразности аллергической реактивности. Пат. физиол. 1979; 4: 3-11.Гущин И.С. Об элементах биологической целесообразности аллергической реактивности. Пат. физиол. 1979; 4: 3-11.Jakobsson I., Lindberg T., Lothe L. et al. Human α-lactalbumin as a marker of macromolecular absorption. Gut 1986; 27: 1029-1034.Jakobsson I., Lindberg T., Lothe L. et al. Human α-lactalbumin as a marker of macromolecular absorption. Gut 1986; 27: 1029-1034.Мазо В.К., Гмошинский И.В. Нарушенная проницаемость кишечного барьера для макромолекул у детей раннего возраста. Вопр. дет. диетол. 2003; 1 (1): 75-78.Мазо В.К., Гмошинский И.В. Нарушенная проницаемость кишечного барьера для макромолекул у детей раннего возраста. Вопр. дет. диетол. 2003; 1 (1): 75-78.Poulsen L.K. In search of a new paradigm: mechanisms of sensitization and elicitation of food allergy. Allergy 2005; 60: 549-558.Poulsen L.K. In search of a new paradigm: mechanisms of sensitization and elicitation of food allergy. Allergy 2005; 60: 549-558.Taylor S.L., Hefle S.L., Bindslev-Jensen C. et al. Factors affecting the determination of threshold doses for allergenic foods: how much is too much? J.Allergy Clin. Immunol. 2002; 109: 24-30.Taylor S.L., Hefle S.L., Bindslev-Jensen C. et al. Factors affecting the determination of threshold doses for allergenic foods: how much is too much? J.Allergy Clin. Immunol. 2002; 109: 24-30.Ширина Л.И., Мазо В.К., Саламатова С.А. Толероген ный эффект продуктов переваривания овальбумина, образующихся в желудочнокишечном тракте крыс. Пат. физиол. 1989; 2: 54-56.Ширина Л.И., Мазо В.К., Саламатова С.А. Толероген ный эффект продуктов переваривания овальбумина, образующихся в желудочнокишечном тракте крыс. Пат. физиол. 1989; 2: 54-56.Marcucci F., Sensi L., Di Cara G. et al. Dose dependence of immunological response to sublingual immunotherapy. Allergy 2005: 60: 952-956.Marcucci F., Sensi L., Di Cara G. et al. Dose dependence of immunological response to sublingual immunotherapy. Allergy 2005: 60: 952-956.Hollander D. Intestinal permeability, leaky gut, and intestin al disorders. Curr. Gastroenterol. Rep. 1999; 1: 410-416.Hollander D. Intestinal permeability, leaky gut, and intestin al disorders. Curr. Gastroenterol. Rep. 1999; 1: 410-416.Парфенов А.И., Екисенина Н.И., Мазо В.К. и др. Барьерная функция желудочнокишечного тракта. Тер. арх. 2000: 2: 64-66.Парфенов А.И., Екисенина Н.И., Мазо В.К. и др. Барьерная функция желудочнокишечного тракта. Тер. арх. 2000: 2: 64-66.Беюл Е.А., Ногаллер А.М., Мазо В.К. и др. Проницаемость кишечной стенки для белка у больных пищевой аллергией. Клин. мед. 1988; 7: 96-100.Беюл Е.А., Ногаллер А.М., Мазо В.К. и др. Проницаемость кишечной стенки для белка у больных пищевой аллергией. Клин. мед. 1988; 7: 96-100.Knutson T.W., Bengtsson U., Dannaeus A. et al. Effects of luminal antigen on intestinal albumin and hyaluronan per meability and ion transport in atopic patients. J. Allergy Clin. Immunol. 1996; 97: 1225-1232.Knutson T.W., Bengtsson U., Dannaeus A. et al. Effects of luminal antigen on intestinal albumin and hyaluronan per meability and ion transport in atopic patients. J. Allergy Clin. Immunol. 1996; 97: 1225-1232.Watanabe J., Fukumoto K., Fukushi E. et al. Isolation of tryptophan as an inhibitor of ovalbumin permeation and analysis of its suppressive effect on oral sensitization. Biosci. Biotechnol. Biochem. 2004; 68: 59-65.Watanabe J., Fukumoto K., Fukushi E. et al. Isolation of tryptophan as an inhibitor of ovalbumin permeation and analysis of its suppressive effect on oral sensitization. Biosci. Biotechnol. Biochem. 2004; 68: 59-65.Mine Y., Zhang J.W. Surfactants enhance the tightjunction permeability of food allergens in human intestinal epithelial Caco2 cells. Int. Arch. Allergy Immunol. 2003; 130: 135-142.Mine Y., Zhang J.W. Surfactants enhance the tightjunction permeability of food allergens in human intestinal epithelial Caco2 cells. Int. Arch. Allergy Immunol. 2003; 130: 135-142.Falagiani P., Mistrello G. Pharmacokinetics of allergens after local administration. Allergy 1997;.55: 17-21.Falagiani P., Mistrello G. Pharmacokinetics of allergens after local administration. Allergy 1997;.55: 17-21.Mori L., Kleimberg J., Mancini C. et al. Bronchial epithelial cells of atopic patients with asthma lack the ability to inactivate allergens. Biochem. Biophys. Res. Commun. 1995; 217: 817-822.Mori L., Kleimberg J., Mancini C. et al. Bronchial epithelial cells of atopic patients with asthma lack the ability to inactivate allergens. Biochem. Biophys. Res. Commun. 1995; 217: 817-822.Greiff L., Andersson M., Svensson J. et al. Absorption across the nasal airway mucosa in house dust mite perennial allergic rhinitis. Clin. Physiol. Funct. Imag. 2002; 22: 55-57.Greiff L., Andersson M., Svensson J. et al. Absorption across the nasal airway mucosa in house dust mite perennial allergic rhinitis. Clin. Physiol. Funct. Imag. 2002; 22: 55-57.Thompson P.J. Unique role of allergens and epithelium in asthma. Clin. Exp. Allergy 1998; 28 (suppl. 5): 110-116.Thompson P.J. Unique role of allergens and epithelium in asthma. Clin. Exp. Allergy 1998; 28 (suppl. 5): 110-116.Antony A.B., Tepper R.S., Mohammed K.A. Cockroach extract antigen increases bronchial airway epithelial permeability. J. Allergy Clin. Immunol. 2002; 110: 589-595.Antony A.B., Tepper R.S., Mohammed K.A. Cockroach extract antigen increases bronchial airway epithelial permeability. J. Allergy Clin. Immunol. 2002; 110: 589-595.Hong W., Winton H.L., Soeller Ch. et al. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J. Clin. Invest. 1999; 104: 123-133.Hong W., Winton H.L., Soeller Ch. et al. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J. Clin. Invest. 1999; 104: 123-133.Anderson J.M., Van Itallie C.M. Tight junctions and molec ular basis for regulation of paracellular permeability. Am. J. Physiol. 1995; 269: G467-G475.Anderson J.M., Van Itallie C.M. Tight junctions and molec ular basis for regulation of paracellular permeability. Am. J. Physiol. 1995; 269: G467-G475.Farquhar M., Palade G.E. Junctional complexes in various epithelia. J.Cell Biol. 1963; 17: 375-412.Farquhar M., Palade G.E. Junctional complexes in various epithelia. J.Cell Biol. 1963; 17: 375-412.Haskins J., Gu L., Wittchen E.S. et al. ZO3, a novel mem ber of the MAGUK protein family found at the tight junction, interacts with ZO1 and occludin. J.Cell Biol. 1998; 141: 199-208.Haskins J., Gu L., Wittchen E.S. et al. ZO3, a novel mem ber of the MAGUK protein family found at the tight junction, interacts with ZO1 and occludin. J.Cell Biol. 1998; 141: 199-208.Denker B.M., Nigam S.K. Molecular structure and assembly of the tight junction. Am. J.Physiol. 1998; 274: F1-F9.Denker B.M., Nigam S.K. Molecular structure and assembly of the tight junction. Am. J.Physiol. 1998; 274: F1-F9.McCarthy K.M. et al. Occludin is a functional component of the tight junction. J. Cell Sci. 1996; 109: 2287-2298.McCarthy K.M. et al. Occludin is a functional component of the tight junction. J. Cell Sci. 1996; 109: 2287-2298.Furuse M., Fujita K., Hiragi T. et al. Claudin1 and claudin 2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J.Cell Biol. 1998; 141: 1539-1550.Furuse M., Fujita K., Hiragi T. et al. Claudin1 and claudin 2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J.Cell Biol. 1998; 141: 1539-1550.Van Itallie C.M., Anderson J.M. Occludin confers adhesiveness when expressed in fibroblasts. J.Cell Sci. 1997; 110: 1113-1121.Van Itallie C.M., Anderson J.M. Occludin confers adhesiveness when expressed in fibroblasts. J.Cell Sci. 1997; 110: 1113-1121.Furuse M., Sasaki H., Fujomoto K. et al. A single gene product, claudin1 or 2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J. Cell Biol. 1998; 143: 391-401.Furuse M., Sasaki H., Fujomoto K. et al. A single gene product, claudin1 or 2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J. Cell Biol. 1998; 143: 391-401.Wan H., Winton H.L., Soeller C. et al. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronissinus. Clin. Exp. Allergy 2001; 31: 279-294.Wan H., Winton H.L., Soeller C. et al. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronissinus. Clin. Exp. Allergy 2001; 31: 279-294.Sigurs N., Bjarnason R., Sigurbergsson F., Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at the 7. Am. J. Respir. Crit. Care Med. 2000; 161: 1501-1507.Sigurs N., Bjarnason R., Sigurbergsson F., Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at the 7. Am. J. Respir. Crit. Care Med. 2000; 161: 1501-1507.Stein R.T., Sherrill D., Morgan W.J. et al. Respiratory syncy tial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999; 354: 541-545.Stein R.T., Sherrill D., Morgan W.J. et al. Respiratory syncy tial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999; 354: 541-545.Frick O.L., German D.F., Mills J. Development of allergy in children. I. Association with virus infections. J. Allergy Clin. Immunol. 1979; 63: 228-241.Frick O.L., German D.F., Mills J. Development of allergy in children. I. Association with virus infections. J. Allergy Clin. Immunol. 1979; 63: 228-241.Sigurs N., Bjarnason R., Sigurbergsson F. et al. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: prospective cohort study with matched controls. Pediatrics 1995; 95: 500-505.Sigurs N., Bjarnason R., Sigurbergsson F. et al. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: prospective cohort study with matched controls. Pediatrics 1995; 95: 500-505.Murray M., Webb M.S., O'Callaghan C. et al. Respiratory status and allergy after bronchiolitis. Arch. Dis. Child. 1992; 67: 482-487.Murray M., Webb M.S., O'Callaghan C. et al. Respiratory status and allergy after bronchiolitis. Arch. Dis. Child. 1992; 67: 482-487.Pullan C.R., Hey E.N. Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncy tial virus in infancy. Br. Med. J. 1982; 284; 1665-1669.Pullan C.R., Hey E.N. Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncy tial virus in infancy. Br. Med. J. 1982; 284; 1665-1669.Schwarze J., Gelfand E.W. Respiratory virus infections as promoters of allergic sensitization and asthma in animal models. Eur. Respir. J. 2002, 19: 341-349.Schwarze J., Gelfand E.W. Respiratory virus infections as promoters of allergic sensitization and asthma in animal models. Eur. Respir. J. 2002, 19: 341-349.Yamamoto N., Suzuki S., Shirai A. et al. Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice. Eur. J. Immunol. 2000; 30: 316-326.Yamamoto N., Suzuki S., Shirai A. et al. Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice. Eur. J. Immunol. 2000; 30: 316-326.Holt P.G., Vines J., Bilyk N. et al. Effect of influenza virus infection on allergic sensitization to inhaled allergen in mice. Int. Arch. Allergy Appl. Immunol. 1988; 86: 121-123.Holt P.G., Vines J., Bilyk N. et al. Effect of influenza virus infection on allergic sensitization to inhaled allergen in mice. Int. Arch. Allergy Appl. Immunol. 1988; 86: 121-123.Tsitoura D.C., Kim S., Dabbagh K. et al. Respiratory infec tion with influenza A virus interferes with the induction of tolerance to aeroallergens. J. Immunol. 2000; 165: 3484-3491.Tsitoura D.C., Kim S., Dabbagh K. et al. Respiratory infec tion with influenza A virus interferes with the induction of tolerance to aeroallergens. J. Immunol. 2000; 165: 3484-3491.Freihorst J., Piedra P.A., Okamoto Y., Ogra P.L. Effect of respiratory syncytial virus infection on the uptake of immune response to other inhaled antigens. Proc. Soc. Exp. Biol. (N. Y.) 1988; 188: 191-197.Freihorst J., Piedra P.A., Okamoto Y., Ogra P.L. Effect of respiratory syncytial virus infection on the uptake of immune response to other inhaled antigens. Proc. Soc. Exp. Biol. (N. Y.) 1988; 188: 191-197.Ltibovitz E., Freihorst J., Piedra P.A., Ogra P.L. Modulation of systemic and mucosal immune responses to inhaled rag weed antigen in experimentally induced infection with res piratory syncytial virus implication in virally induced allergy. Int. Arch. Allergy Appl. Immunol. 1988; 86: 112-116.Ltibovitz E., Freihorst J., Piedra P.A., Ogra P.L. Modulation of systemic and mucosal immune responses to inhaled rag weed antigen in experimentally induced infection with res piratory syncytial virus implication in virally induced allergy. Int. Arch. Allergy Appl. Immunol. 1988; 86: 112-116.Oumouna M., Mapletoft J.W., Karvonen B.C. et al. Formulation with CpG oligodeoxynucleotides prevents induction of pulmonary immunopathology following priming with formalininactivated or commercial killed bovine respiratory syncytial virus vaccine. J. Virol. 2005; 79: 2024-2032.Oumouna M., Mapletoft J.W., Karvonen B.C. et al. Formulation with CpG oligodeoxynucleotides prevents induction of pulmonary immunopathology following priming with formalininactivated or commercial killed bovine respiratory syncytial virus vaccine. J. Virol. 2005; 79: 2024-2032.Riedel F., Krause A., Slenczka W., Rieger C.H. Parainfluenza3virus infection enhances allergic sensitization in the guineapig. Clin. Exp. Allergy 1996; 26: 603-609.Riedel F., Krause A., Slenczka W., Rieger C.H. Parainfluenza3virus infection enhances allergic sensitization in the guineapig. Clin. Exp. Allergy 1996; 26: 603-609.Daghama A., Bramley A.M., Chan N.G. et al. Effect of respiratory syncytial virus on subsequent allergic sensitization to ovalbumin in guineapigs. Eur. Respir. J. 1999; 13: 976-982.Daghama A., Bramley A.M., Chan N.G. et al. Effect of respiratory syncytial virus on subsequent allergic sensitization to ovalbumin in guineapigs. Eur. Respir. J. 1999; 13: 976-982.Dakhama A., Lee Y.M., Gelfand E.W. Virusinduced airway dysfunction: pathogenesis and biomechanisms. Pediatr. Infect. Dis. 2005; 24 (suppl. 11): S159-S169; discus.: S166-S167.Dakhama A., Lee Y.M., Gelfand E.W. Virusinduced airway dysfunction: pathogenesis and biomechanisms. Pediatr. Infect. Dis. 2005; 24 (suppl. 11): S159-S169; discus.: S166-S167.Piedimonte G. Contribution of neuroimmune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infection. Pediatr. Infect. Dis. 2003; 22 (suppl. 2): S66-S74; discus.: S74-S75.Piedimonte G. Contribution of neuroimmune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infection. Pediatr. Infect. Dis. 2003; 22 (suppl. 2): S66-S74; discus.: S74-S75.Baker G., Chetwin K., Hayward K. et al. The effect of nitric oxide on the permeability of nasal epithelial cells from healthy and asthmatic donors. Med. Sci. Monit. 2003; 9: BR276-BR282.Baker G., Chetwin K., Hayward K. et al. The effect of nitric oxide on the permeability of nasal epithelial cells from healthy and asthmatic donors. Med. Sci. Monit. 2003; 9: BR276-BR282.Madison K.C. Barrier function of the skin: "Ia raison d`etre" of the epidermis. J. Invest. Dermatol. 2003: 121: 231-241.Madison K.C. Barrier function of the skin: "Ia raison d`etre" of the epidermis. J. Invest. Dermatol. 2003: 121: 231-241.Hata M., Torurqa Y., Takigawa M. et al. Assesment of epi dermal barrier function by photoacoustic spectrometry in relation to its importance in the pathogenesis of atopic dermatitis. Lab. Invest. 2002; 82: 1451-1461.Hata M., Torurqa Y., Takigawa M. et al. Assesment of epi dermal barrier function by photoacoustic spectrometry in relation to its importance in the pathogenesis of atopic dermatitis. Lab. Invest. 2002; 82: 1451-1461.Strid J., Strobel S. Skin barrier dysfunction and systemic sensitization to allergens through the skin. Curr. Drug Targets Inflamm. Allergy 2005; 4: 531-541.Strid J., Strobel S. Skin barrier dysfunction and systemic sensitization to allergens through the skin. Curr. Drug Targets Inflamm. Allergy 2005; 4: 531-541.Berard F., Marty J.-P., Nicolas J.-F. Allergen penetration through the skin. Eur. J. Dermatol. 2003; 4: 324-330.Berard F., Marty J.-P., Nicolas J.-F. Allergen penetration through the skin. Eur. J. Dermatol. 2003; 4: 324-330.Inoue J., Yotsumoto S., Sakamoto T. et al. Changes in immune responses to mite antigen sensitized through barrierdisrupted skin with CpGoligodeoxynucleotide in mice. Biol. Pharm. Bull. 2006; 29: 385-387.Inoue J., Yotsumoto S., Sakamoto T. et al. Changes in immune responses to mite antigen sensitized through barrierdisrupted skin with CpGoligodeoxynucleotide in mice. Biol. Pharm. Bull. 2006; 29: 385-387.Proksch E., Brasch J., Sterry W. Integrity of the permeabili ty barrier regulates epidermal Langerhans cell density. Br. J. Dermatol. 1996; 134: 630-638.Proksch E., Brasch J., Sterry W. Integrity of the permeabili ty barrier regulates epidermal Langerhans cell density. Br. J. Dermatol. 1996; 134: 630-638.Proksch E., Brasch J. Influence of epidermal permeability barrier disruption and Langerhans` cell density on allergic contact dermatitis. Acta Dermato Venerol. 1997; 77: 102-104.Proksch E., Brasch J. Influence of epidermal permeability barrier disruption and Langerhans` cell density on allergic contact dermatitis. Acta Dermato Venerol. 1997; 77: 102-104.Kondo H., Ichikawa Y., Imokawa G. Percutaneous sensitization with allergens through barrierdisrupted skin elicits a Th2dominant cytokine response. Eur. J. Immunol. 1998; 28: 769-779.Kondo H., Ichikawa Y., Imokawa G. Percutaneous sensitization with allergens through barrierdisrupted skin elicits a Th2dominant cytokine response. Eur. J. Immunol. 1998; 28: 769-779.Huss-Marp J., Eberlein-Konig B., Breuer K. et al. Influence of shortterm exposure to airborn Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals. Clin. Exp. Allergy 2006; 36: 338-345.Huss-Marp J., Eberlein-Konig B., Breuer K. et al. Influence of shortterm exposure to airborn Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals. Clin. Exp. Allergy 2006; 36: 338-345.Hachem J.P., Crumrine D., Fluhr J. et al. pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J. Invest. Dermatol. 2003; 121: 345-353.Hachem J.P., Crumrine D., Fluhr J. et al. pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J. Invest. Dermatol. 2003; 121: 345-353.Jensen J.-M., Folster-Holst R., Baranowsky A. et al. Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. J. Invest. Dermatol. 2004; 122: 1423-1431.Jensen J.-M., Folster-Holst R., Baranowsky A. et al. Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. J. Invest. Dermatol. 2004; 122: 1423-1431.Garg A., Chren M.M., Sands L.P. et al. Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stressassociated skin disorders. Arch. Dermatol. 2001; 137: 78-82.Garg A., Chren M.M., Sands L.P. et al. Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stressassociated skin disorders. Arch. Dermatol. 2001; 137: 78-82.
The authors declare that there are no conflicts of interest present.