pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2019-29-5-596-603pulmo-1229Research ArticleОБЗОРЫREVIEWРоль полиморфизма генов в чувствительности к саркоидозу легкихA role оf gene polymorphism for susceptibility to pulmonary sarcoidosisМалышеваИ. Е.MalyshevaI. E.

Малышева Ирина Евгеньевна – кандидат биологических наук, старший  научный  сотрудник  лаборатории генетики.

185910,  Петрозаводск,  ул. Пушкинская, 11.

тел.: (8142) 57-18-79

Irina E. Malysheva - Candidate  of Biology, Senior Researcher,  Laboratory of Genetics,  Institute  of Biology, Karelian Federal Research Center,  Russian Academy of Science.

ul. Pushkinskaya 11, Petrozavodsk, 185910.

i.e.malysheva@yandex.ruТопчиеваЛ. В.TopchiyevaL. V.

Топчиева Людмила Владимировна – кандидат биологических наук, ведущий научный  сотрудник  лаборатории генетики.

185910,  Петрозаводск,  ул. Пушкинская, 11.

тел.: (8142)57-18-79

Lyudmila V. Topchiyeva - Candidate  of Biology, the Leading Researcher,  Laboratory of Genetics,  Institute of Biology, Karelian Federal Research Center,  Russian Academy of Science.

ul. Pushkinskaya 11, Petrozavodsk, 185910.

topchieva67@mail.ruТихоновичЭ. Л.TikhonovichE. L.

Тихонович Элла Леонидовна – заведующая отделением  респираторной терапии.

185019, Петрозаводск, ул. Пирогова, 3.

тел.: (8142) 76-39-10

Ella L. Tikhonovich - Head of Department of Respiratory Therapy, V.A.Baranov Republic Hospital of Kareliya Republic.

ul. Pirogova 3, Petrozavodsk, 185019.

tikhonovich.ella@mail.ruИнститут биологии Федерального государственного бюджетного учреждения науки «Федеральный исследовательский центр “Карельский научный центр Российской академии наук”»РоссияInstitute of Biology, Karelian Federal Research Center, Russian Academy of ScienceRussian FederationРеспубликанская больница им. В.А.БарановаРоссияV.A.Baranov Republic Hospital of Kareliya RepublicRussian Federation201925122019295596603Copyright © Малышева И.Е., Топчиева Л.В., Тихонович Э.Л., 20192019Малышева И.Е., Топчиева Л.В., Тихонович Э.Л.Malysheva I.E., Topchiyeva L.V., Tikhonovich E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/1229

В обзоре обобщены  сведения  о роли полиморфных вариантов  генов в формировании иммунного  ответа при саркоидозе.  Обозначены основные  гены-кандидаты, однонуклеотидные замены,  которые могут оказывать  модулирующее действие на развитие иммунных реакций при данной патологии, а также определять не только восприимчивость людей к возникновению саркоидоза  легких, но и оказывать влияние  на клинические характеристики течения заболевания.

Authors of this review described gene polymorphism  involved in the development  of the immune  response in sarcoidosis. Gene background could determine not only the subject’s susceptibility to sarcoidosis, but also a clinical course of the disease. Currently,  allele variants that could be used as prognostic markers to reveal subjects susceptible to sarcoidosis and to predict a clinical course of sarcoidosis are investigated. Published data on a relationship between the carriage of certain allele variants and the subject’s susceptibility to sarcoidosis are scarce and controversial. Nevertheless, those data could be used to detect potential goals for targeted therapy of sarcoidosis and to develop measures to prevent this disease.

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The authors declare that there are no conflicts of interest present.