pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2019-29-5-525-552pulmo-1223Research ArticleКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИCLINICAL GUIDELINESИдиопатический легочный фиброз: новые международные клинические рекомендацииIdiopathic pulmonary fibrosis: a new international clinical guidelinehttps://orcid.org/0000-0002-5999-2150АвдеевС. Н.AvdeevS. N.

Авдеев Сергей Николаевич – доктор медицинских наук, член-корреспондент Российской академии наук, профессор, заведующий кафедрой пульмонологии Первого МГМУ им.И.М.Сеченова (Сеченовский Университет); руководитель  клинического отдела НИИ пульмонологии ФМБА.

119991,  Москва,  ул. Трубецкая, 8, стр. 2; 115682,  Москва,  Ореховый бульвар, 28.

тел.: (495) 708-35-76

Sergey N. Avdeev – Doctor of Medicine,  Professor, Corresponding  Member of Russian Academy of Sciences, Head of Department of Pulmonology,  I.M.Sechenov First Moscow State Medical  University,  Healthcare Ministry of Russia (Sechenov  University);  Deputy  Director  for Science,  Federal  Pulmonology  Research Institute, Federal Medical and Biological Agency of Russia; Chief Pulmonologist, Healthcare Ministry of Russia.

ul. Trubetskaya 8, build 2, Moscow, 119991; Orekhovyy  bul'var 28,  Moscow, 115682.

tel.: (495) 708-35-76

serg_avdeev@list.ruЧикинаС. Ю.ChikinaS. Yu.

Чикина Светлана Юрьевна – кандидат медицинских наук, ассистент  кафедры пульмонологии.

119991,  Москва,  ул. Трубецкая, 8, стр. 2.

тел.: (916) 116-04-03

Svetlana Yu. Chikina – Candidate of Medicine; Assistant Lecturer, I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia (Sechenov University).

ul. Trubetskaya 8, build 2, Moscow, 119991.

tel.: (916) 116-04-03

svch@list.ruНагаткинаО. В.NagatkinaO. V.

Нагаткина Ольга Владимировна – кандидат медицинских наук, врач-пульмонолог I категории.

443095,  Самара, ул. Ташкентская, 159.

тел.: (846) 956-23-61

Ol'ga V. Nagatkina – Candidate  of Medicine,  pulmonologist,  V.D.Seredavin Samara Regional Teaching Hospital.

ul. Tashkentskaya 159, Samara, 443096.

tel.: (846) 956-23-61

vakhono_o@mail.ruПервый Московский государственный медицинский университет имени И.М.Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Научно-исследовательский институт пульмонологии Федерального медико-биологического агентстваРоссияI.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia (Sechenov University); Federal Pulmonology Research Institute, Federal Medical and Biological Agency of RussiaRussian FederationПервый Московский государственный медицинский университет имени И.М.Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияI.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia (Sechenov University)Russian FederationСамарская областная клиническая больница им. В.Д.СередавинаРоссияV.D.Seredavin Samara Regional Teaching HospitalRussian Federation201925122019295525552Copyright © Авдеев С.Н., Чикина С.Ю., Нагаткина О.В., 20192019Авдеев С.Н., Чикина С.Ю., Нагаткина О.В.Avdeev S.N., Chikina S.Y., Nagatkina O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/1223

Данныеклиническиерекомендацииподиагностикеидиопатическоголегочногофиброза (ИЛФ)  явилисьрезультатомсовместной  работыАмериканскоготоракального (American Thoracic Society – ATS), Европейскогореспираторного (European Respiratory Society – ERS), Японскогореспираторного (Japanese Respiratory Society – JRS) иЛатиноамериканскоготоракального (Latin American Thoracic Society – ALAT) обществ.  Методы. Экспертами многопрофильного комитета  по ИЛФ  обсуждена  доказательная база и сформулированы рекомендации. Проанализированные  доказательства   и  рекомендации  сформулированы,  написаны  и  оценены   по  системе  GRADE.   Результаты. Экспертами Рабочей группы обновлены  диагностические критерии  ИЛФ.  Ранее описанные паттерны  обычной  интерстициальной пневмонии  (ОИП) уточнены и обозначены как паттерны  ОИП, вероятной ОИП, неопределенный и альтернативный диагнозы.  Для больных с впервые выявленным интерстициальным заболеванием легких (ИЗЛ) с паттернами  вероятной ОИП, неопределенного или альтернативного диагнозов  по данным компьютерной томографии легких высокого разрешения (КТВР)  разработана условная рекомендация выполнения бронхоальвеолярного лаважа (БАЛ) и хирургической биопсии  легких. Рекомендации «за» или «против» выполнения трансбронхиальной биопсии  (ТББЛ)  или криобиопсии (КБЛ) легких не разработаны по причине  недостаточности доказательств. Напротив, для больных с впервые выявленным ИЗЛ и паттерном ОИП по данным КТВР выработана сильная рекомендация НЕ выполнять хирургическую биопсию, ТББЛ и КБЛ; выработана условная рекомендация против использования БАЛ. Дополнительные рекомендации включают условную рекомендацию по многопрофильному обсуждению и сильную рекомендацию против измерения сывороточных биомаркеров с целью дифференциации ИЛФ от других ИЗЛ. Заключение. Экспертами Рабочей группы разработаны рекомендации по диагностике ИЛФ.

This is clinical recommendations for the diagnosis of idiopathic  pulmonary  fibrosis (IPF). The document  was developed by American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Latin American Thoracic Society. Methods: The evidence syntheses were discussed and recommendations formulated  by a multidisciplinary  committee  of IPF  experts. The evidence was appraised and recommendations were formulated,  written, and graded using the GRADE  approach.  Results: The guideline panel updated the diagnostic criteria for IPF. Previously defined patterns of usual interstitial pneumonia (UIP)  were refined to patterns of UIP,  probable UIP,  indeterminate, and alternate  diagnosis. For patients with newly detected interstitial lung disease (ILD)  who have a high-resolution computed  tomography scan pattern of probable UIP,  indeterminate, or an alternative diagnosis, conditional recommendations were made for performing BAL and surgical lung biopsy; because of lack of evidence, no recommendation was made for or against performing transbronchial lung biopsy or lung cryobiopsy. In contrast,  for patients with newly detected ILD who have a high-resolution computed  tomography scan pattern of UIP,  strong recommendations were made against performing surgical lung biopsy, transbronchial lung biopsy, and lung cryobiopsy, and a conditional recommendation was made against performing BAL. Additional recommendations included a conditional  recommendation for multidisciplinary  discussion and a strong recommendation against measurement  of serum biomarkers for the sole purpose of distinguishing IPF from other ILDs. Conclusions: The guideline panel provided recommendations related to the diagnosis of IPF.

идиопатический легочный фиброзинтерстициальные заболевания легкихлегочный фиброзidiopathic pulmonary fibrosisinterstitial lung diseasepulmonary fibrosisReferencesЧучалин А.Г., Авдеев С.Н., Айсанов З.Р. и др. Диагностика и лечение идиопатического легочного фиброза: Федеральные клинические рекомендации. Пульмонология. 2016; 26 (4): 399–419. DOI: 10.18093/0869-0189-2016-26-4-399-419.Chuchalin A.G., Avdeev S.N., Aisanov Z.R. et al. Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis. Federal Guidelines. Pul'monologiya. 2016; 26 (4): 399–419. DOI: 10.18093/0869-0189-2016-26-4-399-419 (in Russian).Thomeer M., Demedts M., Vandeurzen K. et al. Registration of interstitial lung diseases by 20 centres of respiratory medicine in Flanders. Acta Clin. Belg. 2001; 56 (3): 163–172. DOI: 10.1179/acb.2001.026.Thomeer M., Demedts M., Vandeurzen K. et al. Registration of interstitial lung diseases by 20 centres of respiratory medicine in Flanders. Acta Clin. Belg. 2001; 56 (3): 163–172. DOI: 10.1179/acb.2001.026.Tinelli C., De Silvestri A., Richeldi L., Oggionni T. The Italian register for diffuse inf iltrative lung disorders (RIPID): a four-year report. Sarcoidosis Vasc. Diffuse Lung Dis. 2005; 22 (Suppl. 1): S4–8.Tinelli C., De Silvestri A., Richeldi L., Oggionni T. The Italian register for diffuse inf iltrative lung disorders (RIPID): a four-year report. Sarcoidosis Vasc. Diffuse Lung Dis. 2005; 22 (Suppl. 1): S4–8.Navaratnam V., Fleming K.M., West J. et al. The rising incidence of idiopathic pulmonary fibrosis in the UK. Thorax. 2011; 66 (6): 462–467. DOI: 10.1136/thx.2010.148031.Navaratnam V., Fleming K.M., West J. et al. The rising incidence of idiopathic pulmonary fibrosis in the UK. Thorax. 2011; 66 (6): 462–467. DOI: 10.1136/thx.2010.148031.Richeldi L., Rubin A.S., Avdeev S. et al. Idiopathic pulmonary fibrosis in BRIC countries: the cases of Brazil, Russia, India, and China. BMC Medicine. 2015; 13: 237. DOI: 10.1186/s12916-015-0495-0.Richeldi L., Rubin A.S., Avdeev S. et al. Idiopathic pulmonary fibrosis in BRIC countries: the cases of Brazil, Russia, India, and China. BMC Medicine. 2015; 13: 237. DOI: 10.1186/s12916-015-0495-0.Vancheri C., Failla M., Crimi N., Raghu G. Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology. Eur. Respir. J. 2010; 35 (3): 496–504. DOI: 10.1183/09031936.00077309.Vancheri C., Failla M., Crimi N., Raghu G. Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology. Eur. Respir. J. 2010; 35 (3): 496–504. DOI: 10.1183/09031936.00077309.American Thoracic Society (ATS) and the European Respiratory Society (ERS). Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. Am. J. Respir. Crit. Care Med. 2000; 161 (2, Pt 1): 646–664. DOI: 10.1164/ajrccm.161.2.ats3-00.American Thoracic Society (ATS) and the European Respiratory Society (ERS). Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. Am. J. Respir. Crit. Care Med. 2000; 161 (2, Pt 1): 646–664. DOI: 10.1164/ajrccm.161.2.ats3-00.Raghu G., Collard H.R., Egan J. et al. An off icial ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis; evidence-based guidelines for diagnosis and management. Am. J. Respir. Crit. Care Med. 2011; 183 (6): 788–824. DOI: 10.1164/rccm.2009-040GL.Raghu G., Collard H.R., Egan J. et al. An off icial ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis; evidence-based guidelines for diagnosis and management. Am. J. Respir. Crit. Care Med. 2011; 183 (6): 788–824. DOI: 10.1164/rccm.2009-040GL.Raghu G., Remy-Jardin M., Myers J.L. et al. Diagnosis of Idiopathic Pulmonary Fibrosis: An Official ATS/ERS/ JRS/ALAT Clinical Practice Guideline. Am. J. Respir. Crit. Care Med. 2018; 198 (5): e44–e68. DOI: 10.1164/rccm.201807-1255ST.Raghu G., Remy-Jardin M., Myers J.L. et al. Diagnosis of Idiopathic Pulmonary Fibrosis: An Official ATS/ERS/ JRS/ALAT Clinical Practice Guideline. Am. J. Respir. Crit. Care Med. 2018; 198 (5): e44–e68. DOI: 10.1164/rccm.201807-1255ST.Schünemann H.J., Jaeschke R., Cook D.J. et al. An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations. Am. J. Respir. Crit. Care Med. 2006; 174 (5): 605–614. DOI: 10.1164/rccm.200602-197ST.Schünemann H.J., Jaeschke R., Cook D.J. et al. An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations. Am. J. Respir. Crit. Care Med. 2006; 174 (5): 605–614. DOI: 10.1164/rccm.200602-197ST.Raghu G., Weycker D., Edelsberg J. et al. Incidence and prevalence of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2006; 174 (7): 810–816. DOI: 10.1164/rccm.200602-163OC.Raghu G., Weycker D., Edelsberg J. et al. Incidence and prevalence of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2006; 174 (7): 810–816. DOI: 10.1164/rccm.200602-163OC.Raghu G., Chen S.Y., Yeh W.S. et al. Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001–11. Lancet Respir. Med. 2014; 2 (7): 566–572. DOI: 10.1016/S2213-2600(14)70101-8.Raghu G., Chen S.Y., Yeh W.S. et al. Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001–11. Lancet Respir. Med. 2014; 2 (7): 566–572. DOI: 10.1016/S2213-2600(14)70101-8.Collard H.R., Ryerson C.J., Corte T.J. et al. Acute exacerbation of idiopathic pulmonary fibrosis. An international working group report. Am. J. Respir. Crit. Care Med. 2016; 194 (3): 265–275. DOI: 10.1164/rccm.201604-0801CI.Collard H.R., Ryerson C.J., Corte T.J. et al. Acute exacerbation of idiopathic pulmonary fibrosis. An international working group report. Am. J. Respir. Crit. Care Med. 2016; 194 (3): 265–275. DOI: 10.1164/rccm.201604-0801CI.Nadrous H.F., Myers J.L., Decker P.A., Ryu J.H. Idiopathic pulmonary fibrosis in patients younger than 50 years. Mayo Clin. Proc. 2005; 80 (1): 37–40. DOI: 10.1016/S0025-6196(11)62955-8.Nadrous H.F., Myers J.L., Decker P.A., Ryu J.H. Idiopathic pulmonary fibrosis in patients younger than 50 years. Mayo Clin. Proc. 2005; 80 (1): 37–40. DOI: 10.1016/S0025-6196(11)62955-8.Armanios M. Telomerase and idiopathic pulmonary fibrosis. Mutat. Res. 2012; 730 (1): 52–58. DOI: 10.1016/j.mrfmmm.2011.10.013.Armanios M. Telomerase and idiopathic pulmonary fibrosis. Mutat. Res. 2012; 730 (1): 52–58. DOI: 10.1016/j.mrfmmm.2011.10.013.Behr J., Kreuter M., Hoeper M.M. et al. Management of patients with idiopathic pulmonary fibrosis in clinical practice: the INSIGHTS-IPF registry. Eur. Respir. J. 2015; 46 (1): 186–196. DOI: 10.1183/09031936.00217614.Behr J., Kreuter M., Hoeper M.M. et al. Management of patients with idiopathic pulmonary fibrosis in clinical practice: the INSIGHTS-IPF registry. Eur. Respir. J. 2015; 46 (1): 186–196. DOI: 10.1183/09031936.00217614.Raghu G., Freudenberger T.D., Yang S. et al. High prevalence of abnormal acid gastro-oesophageal ref lux in idiopathic pulmonary fibrosis. Eur. Respir. J. 2006; 27 (1): 136–142. DOI: 10.1183/09031936.06.00037005Raghu G., Freudenberger T.D., Yang S. et al. High prevalence of abnormal acid gastro-oesophageal ref lux in idiopathic pulmonary fibrosis. Eur. Respir. J. 2006; 27 (1): 136–142. DOI: 10.1183/09031936.06.00037005Tobin R.W., Pope C.E. 2nd, Pellegrini C.A. et al. Increased prevalence of gastroesophageal ref lux in patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 1998; 158 (6): 1804–1808. DOI: 10.1164/ajrccm.158.6.9804105.Tobin R.W., Pope C.E. 2nd, Pellegrini C.A. et al. Increased prevalence of gastroesophageal ref lux in patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 1998; 158 (6): 1804–1808. DOI: 10.1164/ajrccm.158.6.9804105.Patti M.G., Tedesco P., Golden J. et al. Idiopathic pulmonary fibrosis: how often is it really idiopathic? J. Gastrointest. Surg. 2005; 9 (8): 1053–1056. Discussion: 1056–1058. DOI: 10.1016/j.gassur.2005.06.027.Patti M.G., Tedesco P., Golden J. et al. Idiopathic pulmonary fibrosis: how often is it really idiopathic? J. Gastrointest. Surg. 2005; 9 (8): 1053–1056. Discussion: 1056–1058. DOI: 10.1016/j.gassur.2005.06.027.Raghu G., Meyer K.C. Silent gastro-oesophageal ref lux and microaspiration in IPF: mounting evidence for antiref lux therapy? Eur. Respir. J. 2012; 39 (2): 242–245. DOI: 10.1183/09031936.00211311.Raghu G., Meyer K.C. Silent gastro-oesophageal ref lux and microaspiration in IPF: mounting evidence for antiref lux therapy? Eur. Respir. J. 2012; 39 (2): 242–245. DOI: 10.1183/09031936.00211311.Egan J.J., Stewart J.P., Hasleton P.S. et al. Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic f ibrosing alveolitis. Thorax. 1995; 50 (12): 1234–1239. DOI: 10.1136/thx.50.12.1234.Egan J.J., Stewart J.P., Hasleton P.S. et al. Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic f ibrosing alveolitis. Thorax. 1995; 50 (12): 1234–1239. DOI: 10.1136/thx.50.12.1234.Kuwano K., Nomoto Y., Kunitake R. et al. Detection of adenovirus E1A DNA in pulmonary fibrosis using nested polymerase chain reaction. Eur. Respir. J. 1997; 10 (7): 1445–1449. DOI: 10.1183/09031936.97.10071445.Kuwano K., Nomoto Y., Kunitake R. et al. Detection of adenovirus E1A DNA in pulmonary fibrosis using nested polymerase chain reaction. Eur. Respir. J. 1997; 10 (7): 1445–1449. DOI: 10.1183/09031936.97.10071445.Wangoo A., Shaw R.J., Diss T.C. et al. Cryptogenic fibrosing alveolitis: lack of association with Epstein-Barr virus infection. Thorax. 1997; 52 (10): 888–891. DOI: 10.1136/thx.52.10.888.Wangoo A., Shaw R.J., Diss T.C. et al. Cryptogenic fibrosing alveolitis: lack of association with Epstein-Barr virus infection. Thorax. 1997; 52 (10): 888–891. DOI: 10.1136/thx.52.10.888.Stewart J.P., Egan J.J., Ross A.J. et al. The detection of Epstein-Barr virus DNA in lung tissue from patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 1999; 159 (4, Pt 1): 1336–1341. DOI: 10.1164/ajrc-cm.159.4.9807077Stewart J.P., Egan J.J., Ross A.J. et al. The detection of Epstein-Barr virus DNA in lung tissue from patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 1999; 159 (4, Pt 1): 1336–1341. DOI: 10.1164/ajrc-cm.159.4.9807077Tsukamoto K., Hayakawa H., Sato A. et al. Involvement of Epstein-Barr virus latent membrane protein 1 in disease progression in patients with idiopathic pulmonary fibrosis. Thorax. 2000; 55 (11): 958–961. DOI: 10.1136/tho-rax.55.11.958.Tsukamoto K., Hayakawa H., Sato A. et al. Involvement of Epstein-Barr virus latent membrane protein 1 in disease progression in patients with idiopathic pulmonary fibrosis. Thorax. 2000; 55 (11): 958–961. DOI: 10.1136/tho-rax.55.11.958.Lok S.S., Stewart J.P., Kelly B.G. et al. Epstein-Barr virus and wild p53 in idiopathic pulmonary fibrosis. Respir. Med. 2001; 95 (10): 787–791. DOI: 10.1053/rmed.2001.1152.Lok S.S., Stewart J.P., Kelly B.G. et al. Epstein-Barr virus and wild p53 in idiopathic pulmonary fibrosis. Respir. Med. 2001; 95 (10): 787–791. DOI: 10.1053/rmed.2001.1152.Kelly B.G., Lok S.S., Hasleton P.S. et al. A rearranged form of Epstein-Barr virus DNA is associated with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2002; 166 (4): 510–513. DOI: 10.1164/rccm.2103058Kelly B.G., Lok S.S., Hasleton P.S. et al. A rearranged form of Epstein-Barr virus DNA is associated with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2002; 166 (4): 510–513. DOI: 10.1164/rccm.2103058Tang Y.W., Johnson J.E., Browning P.J. et al. Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis. J. Clin. Microbiol. 2003; 41 (6): 2633–2640. DOI: 10.1128/jcm.41.6.2633-2640.2003.Tang Y.W., Johnson J.E., Browning P.J. et al. Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis. J. Clin. Microbiol. 2003; 41 (6): 2633–2640. DOI: 10.1128/jcm.41.6.2633-2640.2003.Zamó A., Poletti V., Reghellin D. et al. HHV-8 and EBV are not commonly found in idiopathic pulmonary fibrosis. Sarcoidosis Vasc. Diffuse Lung Dis. 2005; 22 (2): 123–128.Zamó A., Poletti V., Reghellin D. et al. HHV-8 and EBV are not commonly found in idiopathic pulmonary fibrosis. Sarcoidosis Vasc. Diffuse Lung Dis. 2005; 22 (2): 123–128.Miyake Y., Sasaki S., Yokoyama T. et al. Occupational and environmental factors and idiopathic pulmonary fibrosis in Japan. Ann. Occup. Hyg. 2005; 49 (3): 259–265. DOI: 10.1093/annhyg/meh090.Miyake Y., Sasaki S., Yokoyama T. et al. Occupational and environmental factors and idiopathic pulmonary fibrosis in Japan. Ann. Occup. Hyg. 2005; 49 (3): 259–265. DOI: 10.1093/annhyg/meh090.Ueda T., Ohta K., Suzuki N. et al. Idiopathic pulmonary fibrosis and high prevalence of serum antibodies to hepatitis C virus. Am. Rev. Respir. Dis. 1992; 146 (1): 266–268. DOI: 10.1164/ajrccm/146.1.266.Ueda T., Ohta K., Suzuki N. et al. Idiopathic pulmonary fibrosis and high prevalence of serum antibodies to hepatitis C virus. Am. Rev. Respir. Dis. 1992; 146 (1): 266–268. DOI: 10.1164/ajrccm/146.1.266.Irving W.L., Day S., Johnston I.D. Idiopathic pulmonary fibrosis and hepatitis C virus infection. Am. Rev. Respir. Dis. 1993; 148 (6, Pt 1): 1683–1684. DOI: 10.1164/ajrc-cm/148.6_Pt_1.1683.Irving W.L., Day S., Johnston I.D. Idiopathic pulmonary fibrosis and hepatitis C virus infection. Am. Rev. Respir. Dis. 1993; 148 (6, Pt 1): 1683–1684. DOI: 10.1164/ajrc-cm/148.6_Pt_1.1683.Meliconi R., Andreone P., Fasano L. et al. Incidence of hepatitis C virus infection in Italian patients with idiopathic pulmonary fibrosis. Thorax. 1996; 51: 315–317.Meliconi R., Andreone P., Fasano L. et al. Incidence of hepatitis C virus infection in Italian patients with idiopathic pulmonary fibrosis. Thorax. 1996; 51: 315–317.Yamaguchi S., Kubo K., Fujimoto K. et al. Analysis of bronchoalveolar lavage f luid in patients with chronic hepatitis C before and after treatment with interferon alpha. Thorax. 1997; 52: 33–37. DOI: 10.1136/thx.52.1.33.Yamaguchi S., Kubo K., Fujimoto K. et al. Analysis of bronchoalveolar lavage f luid in patients with chronic hepatitis C before and after treatment with interferon alpha. Thorax. 1997; 52: 33–37. DOI: 10.1136/thx.52.1.33.Idilman R., Cetinkaya H., Savaş I. et al. Bronchoalveolar lavage f luid analysis in individuals with chronic hepatitis C. J. Med. Virol. 2002; 66 (1): 34–39.Idilman R., Cetinkaya H., Savaş I. et al. Bronchoalveolar lavage f luid analysis in individuals with chronic hepatitis C. J. Med. Virol. 2002; 66 (1): 34–39.Arase Y., Ikeda K., Tsubota A. et al. Usefulness of serum KL-6 for early diagnosis of idiopathic pulmonary fibrosis in patients with hepatitis C virus. Hepatol. Res. 2003; 27 (2): 89–94.Arase Y., Ikeda K., Tsubota A. et al. Usefulness of serum KL-6 for early diagnosis of idiopathic pulmonary fibrosis in patients with hepatitis C virus. Hepatol. Res. 2003; 27 (2): 89–94.Raghu G., Amatto V.C., Behr J., Stowasser S. Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review. Eur. Respir. J. 2015; 46 (4): 1113–1130. DOI: 10.1183/13993003.02316-2014Raghu G., Amatto V.C., Behr J., Stowasser S. Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review. Eur. Respir. J. 2015; 46 (4): 1113–1130. DOI: 10.1183/13993003.02316-2014Parry E.M., Alder J.K., Qi X. et al. Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood. 2011; 117 (21): 5607–5611. DOI: 10.1182/blood-2010-11-322149.Parry E.M., Alder J.K., Qi X. et al. Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood. 2011; 117 (21): 5607–5611. DOI: 10.1182/blood-2010-11-322149.Gorgy A.I., Jonassaint N.L., Stanley S.E. et al. Hepatopulmonary syndrome is a frequent cause of dyspnea in the short telomere disorders. Chest. 2015; 148 (4): 1019–1026. DOI: 10.1378/chest.15-0825.Gorgy A.I., Jonassaint N.L., Stanley S.E. et al. Hepatopulmonary syndrome is a frequent cause of dyspnea in the short telomere disorders. Chest. 2015; 148 (4): 1019–1026. DOI: 10.1378/chest.15-0825.Fingerlin T.E., Murphy E., Zhang W. et al. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat. Genet. 2013; 45 (6): 613–620. DOI: 10.1038/ng.2609.Fingerlin T.E., Murphy E., Zhang W. et al. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat. Genet. 2013; 45 (6): 613–620. DOI: 10.1038/ng.2609.Peljto A.L., Zhang Y., Fingerlin T.E. et al. Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA. 2013; 309 (21): 2232–2239. DOI: 10.1001/jama.2013.5827.Peljto A.L., Zhang Y., Fingerlin T.E. et al. Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA. 2013; 309 (21): 2232–2239. DOI: 10.1001/jama.2013.5827.Allen R.J., Porte J., Braybrooke R. et al. Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. Lancet Respir. Med. 2017; 5 (11): 869–880. DOI: 10.1016/S2213-2600(17)30387-9.Allen R.J., Porte J., Braybrooke R. et al. Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. Lancet Respir. Med. 2017; 5 (11): 869–880. DOI: 10.1016/S2213-2600(17)30387-9.Newton C.A., Batra K., Torrealba J. et al. Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive. Eur. Respir. J. 2016; 48 (6): 1710–1720. DOI: 10.1183/13993003.00308-2016.Newton C.A., Batra K., Torrealba J. et al. Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive. Eur. Respir. J. 2016; 48 (6): 1710–1720. DOI: 10.1183/13993003.00308-2016.Borie R., Tabéze L., Thabut G. et al. Prevalence and characteristics of TERT and TERC mutations in suspected genetic pulmonary fibrosis. Eur. Respir. J. 2016; 48 (6): 1721–1731. DOI: 10.1183/13993003.02115-2015.Borie R., Tabéze L., Thabut G. et al. Prevalence and characteristics of TERT and TERC mutations in suspected genetic pulmonary fibrosis. Eur. Respir. J. 2016; 48 (6): 1721–1731. DOI: 10.1183/13993003.02115-2015.Ley B., Newton C.A., Arnould I. et al. The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohortcontrol study. Lancet Respir. Med. 2017; 5 (8): 639–647. DOI: 10.1016/S2213-2600(17)30216-3.Ley B., Newton C.A., Arnould I. et al. The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohortcontrol study. Lancet Respir. Med. 2017; 5 (8): 639–647. DOI: 10.1016/S2213-2600(17)30216-3.Armanios M.Y., Chen J.J., Cogan J.D. et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. N. Engl. J. Med. 2007; 356 (13): 1317–1326. DOI: 10.1056/NEJMoa066157.Armanios M.Y., Chen J.J., Cogan J.D. et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. N. Engl. J. Med. 2007; 356 (13): 1317–1326. DOI: 10.1056/NEJMoa066157.Kubo T., Lin P.J.P., Stiller W. et al. Radiation dose reduction in chest CT: a review. Am. J. Roentgenol. 2008; 190 (2): 335–343. DOI: 10.2214/AJR.07.2556.Kubo T., Lin P.J.P., Stiller W. et al. Radiation dose reduction in chest CT: a review. Am. J. Roentgenol. 2008; 190 (2): 335–343. DOI: 10.2214/AJR.07.2556.Braun F.M., Johnson T.R., Sommer W.H. et al. Chest CT using spectral filtration: radiation dose, image quality, and spectrum of clinical utility. Eur. Radiol. 2015; 25 (6): 1598–1606. DOI: 10.1007/s00330-014-3559-1.Braun F.M., Johnson T.R., Sommer W.H. et al. Chest CT using spectral filtration: radiation dose, image quality, and spectrum of clinical utility. Eur. Radiol. 2015; 25 (6): 1598–1606. DOI: 10.1007/s00330-014-3559-1.Pontana F., Billard A.S., Duhamel A. et al. Effect of iterative reconstruction on the detection of systemic sclerosis-related interstitial lung diseases: clinical experience in 55 patients. Radiology. 2016; 279 (1): 297–305. DOI: 10.1148/radiol.2015150849.Pontana F., Billard A.S., Duhamel A. et al. Effect of iterative reconstruction on the detection of systemic sclerosis-related interstitial lung diseases: clinical experience in 55 patients. Radiology. 2016; 279 (1): 297–305. DOI: 10.1148/radiol.2015150849.de Margerie-Mellon C., de Bazelaire C., Montlahuc C. et al. Reducing Radiation Dose at Chest CT: Comparison among model-based type iterative reconstruction, hybrid iterative reconstruction and filtered back projection. Acad. Radiol. 2016; 23 (10): 1246–1254. DOI: 10.1016/j.acra.2016.05.019.de Margerie-Mellon C., de Bazelaire C., Montlahuc C. et al. Reducing Radiation Dose at Chest CT: Comparison among model-based type iterative reconstruction, hybrid iterative reconstruction and filtered back projection. Acad. Radiol. 2016; 23 (10): 1246–1254. DOI: 10.1016/j.acra.2016.05.019.Miller W.T. Jr, Chatzkel J., Hewitt M.G. Expiratory air trapping on thoracic computed tomography: a diagnostic subclassification. Ann. Am. Thorac. Soc. 2014; 11 (6): 874–881. DOI: 10.1513/AnnalsATS.201311-390OC.Miller W.T. Jr, Chatzkel J., Hewitt M.G. Expiratory air trapping on thoracic computed tomography: a diagnostic subclassification. Ann. Am. Thorac. Soc. 2014; 11 (6): 874–881. DOI: 10.1513/AnnalsATS.201311-390OC.Tokura S., Okuma T., Akira M. et al. Utility of expiratory thin-section CT for fibrotic interstitial pneumonia. Acta Radiol. 2014; 55 (9): 1050–1055. DOI: 10.1177/0284185113512300.Tokura S., Okuma T., Akira M. et al. Utility of expiratory thin-section CT for fibrotic interstitial pneumonia. Acta Radiol. 2014; 55 (9): 1050–1055. DOI: 10.1177/0284185113512300.Kim M., Lee S.M., Song J.W. et al. Added value of prone CT in the assessment of honeycombing and classification of usual interstitial pneumonia pattern. Eur. J. Radiol. 2017; 91: 66–70. DOI: 10.1016/j.ejrad.2017.03.018.Kim M., Lee S.M., Song J.W. et al. Added value of prone CT in the assessment of honeycombing and classification of usual interstitial pneumonia pattern. Eur. J. Radiol. 2017; 91: 66–70. DOI: 10.1016/j.ejrad.2017.03.018.Bankier A.A., O’Donnell C.R., Boiselle P.M. Quality initiatives. Respiratory instructions for CT examinations of the lungs: a hands-on guide. Radiographics. 2008; 28 (4): 919–931. DOI: 10.1148/rg.284085035.Bankier A.A., O’Donnell C.R., Boiselle P.M. Quality initiatives. Respiratory instructions for CT examinations of the lungs: a hands-on guide. Radiographics. 2008; 28 (4): 919–931. DOI: 10.1148/rg.284085035.Hansell D.M., Bankier A.A., MacMahon H. et al. Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008; 246 (3): 697–722. DOI: 10.1148/radiol.2462070712.Hansell D.M., Bankier A.A., MacMahon H. et al. Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008; 246 (3): 697–722. DOI: 10.1148/radiol.2462070712.Watadani T., Sakai F., Johkoh T. et al. Interobserver variability in the CT assessment of honeycombing in the lungs. Radiology. 2013; 266 (3): 936–944. DOI: 0.1148/radiol.12112516.Watadani T., Sakai F., Johkoh T. et al. Interobserver variability in the CT assessment of honeycombing in the lungs. Radiology. 2013; 266 (3): 936–944. DOI: 0.1148/radiol.12112516.Lynch D.A., Godwin J.D., Safrin S. et al. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am. J. Respir. Crit. Care Med. 2005; 172 (4): 488–493. DOI: 10.1164/rccm.200412-1756OC.Lynch D.A., Godwin J.D., Safrin S. et al. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am. J. Respir. Crit. Care Med. 2005; 172 (4): 488–493. DOI: 10.1164/rccm.200412-1756OC.Sundaram B., Gross B.H., Martinez F.J. et al. Accuracy of high-resolution CT in the diagnosis of diffuse lung disease: effect of predominance and distribution of findings. Am. J. Roentgenol. 2008; 191 (4): 1032–1039. DOI: 10.2214/AJR.07.3177.Sundaram B., Gross B.H., Martinez F.J. et al. Accuracy of high-resolution CT in the diagnosis of diffuse lung disease: effect of predominance and distribution of findings. Am. J. Roentgenol. 2008; 191 (4): 1032–1039. DOI: 10.2214/AJR.07.3177.Goldin J., Elashoff R., Kim H.J. et al. Treatment of scleroderma-interstitial lung disease with cyclophosphamide is associated with less progressive fibrosis on serial thoracic high-resolution CT scan than placebo: findings from the scleroderma lung study. Chest. 2009; 136 (5): 1333–1340. DOI: 10.1378/chest.09-0108.Goldin J., Elashoff R., Kim H.J. et al. Treatment of scleroderma-interstitial lung disease with cyclophosphamide is associated with less progressive fibrosis on serial thoracic high-resolution CT scan than placebo: findings from the scleroderma lung study. Chest. 2009; 136 (5): 1333–1340. DOI: 10.1378/chest.09-0108.Walsh S.L., Sverzellati N., Devaraj A. et al. Chronic hypersensitivity pneumonitis: high resolution computed tomography patterns and pulmonary function indices as prognostic determinants. Eur. Radiol. 2012; 22 (8): 1672–1679. DOI: 10.1007/s00330-012-2427-0.Walsh S.L., Sverzellati N., Devaraj A. et al. Chronic hypersensitivity pneumonitis: high resolution computed tomography patterns and pulmonary function indices as prognostic determinants. Eur. Radiol. 2012; 22 (8): 1672–1679. DOI: 10.1007/s00330-012-2427-0.Walsh S.L., Sverzellati N., Devaraj A. et al. Connective tissue disease related fibrotic lung disease: high resolution computed tomographic and pulmonary function indices as prognostic determinants. Thorax. 2014; 69 (3): 216–222. DOI: 10.1136/thoraxjnl-2013-203843.Walsh S.L., Sverzellati N., Devaraj A. et al. Connective tissue disease related fibrotic lung disease: high resolution computed tomographic and pulmonary function indices as prognostic determinants. Thorax. 2014; 69 (3): 216–222. DOI: 10.1136/thoraxjnl-2013-203843.Edey A.J., Devaraj A.A., Barker R.P. et al. Fibrotic idiopathic interstitial pneumonias: HRCT findings that predict mortality. Eur. Radiol. 2011; 21 (8): 1586–1593. DOI: 10.1007/s00330-011-2098-2.Edey A.J., Devaraj A.A., Barker R.P. et al. Fibrotic idiopathic interstitial pneumonias: HRCT findings that predict mortality. Eur. Radiol. 2011; 21 (8): 1586–1593. DOI: 10.1007/s00330-011-2098-2.Sumikawa H., Johkoh T., Colby T.V. et al. Computed tomography f indings in pathological usual interstitial pneumonia: relationship to survival. Am. J. Respir. Crit. Care Med. 2008; 177 (4): 433–439. DOI: 10.1164/rccm.200611-1696OC.Sumikawa H., Johkoh T., Colby T.V. et al. Computed tomography f indings in pathological usual interstitial pneumonia: relationship to survival. Am. J. Respir. Crit. Care Med. 2008; 177 (4): 433–439. DOI: 10.1164/rccm.200611-1696OC.Remy-Jardin M., Giraud F., Remy J. et al. Importance of ground-glass attenuation in chronic diffuse infiltrative lung disease: pathologic-CT correlation. Radiology. 1993; 189 (3): 693–698. DOI: 10.1148/radiology.189.3.8234692.Remy-Jardin M., Giraud F., Remy J. et al. Importance of ground-glass attenuation in chronic diffuse infiltrative lung disease: pathologic-CT correlation. Radiology. 1993; 189 (3): 693–698. DOI: 10.1148/radiology.189.3.8234692.Akira M., Kozuka T., Yamamoto S., Sakatani M. Computed tomography findings in acute exacerbation of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2008; 178 (4): 372–378. DOI: 10.1164/rccm.200709-1365OC.Akira M., Kozuka T., Yamamoto S., Sakatani M. Computed tomography findings in acute exacerbation of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2008; 178 (4): 372–378. DOI: 10.1164/rccm.200709-1365OC.Collard H.R., Moore B.B., Flaherty K.R. et al. Acute exacerbations of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2007; 176 (7): 636–643. DOI: 10.1164/rccm.200703-463PP.Collard H.R., Moore B.B., Flaherty K.R. et al. Acute exacerbations of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2007; 176 (7): 636–643. DOI: 10.1164/rccm.200703-463PP.Hunninghake G.W., Lynch D.A., Galvin J.R. et al. Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia. Chest. 2003; 124 (4): 1215–1223. DOI: 10.1378/chest.124.4.1215.Hunninghake G.W., Lynch D.A., Galvin J.R. et al. Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia. Chest. 2003; 124 (4): 1215–1223. DOI: 10.1378/chest.124.4.1215.Gruden J.F., Panse P.M., Leslie K.O. et al. UIP diagnosed at surgical lung biopsy, 2000–2009: HRCT patterns and proposed classification system. Am. J. Roentgenol. 2013; 200 (5): W458-467. DOI: 10.2214/AJR.12.9437.Gruden J.F., Panse P.M., Leslie K.O. et al. UIP diagnosed at surgical lung biopsy, 2000–2009: HRCT patterns and proposed classification system. Am. J. Roentgenol. 2013; 200 (5): W458-467. DOI: 10.2214/AJR.12.9437.Tcherakian C., Cottin V., Brillet P.Y. et al. Progression of idiopathic pulmonary fibrosis: lessons from asymmetrical disease. Thorax. 2011; 66 (3): 226–231. DOI: 10.1136/thx.2010.137190.Tcherakian C., Cottin V., Brillet P.Y. et al. Progression of idiopathic pulmonary fibrosis: lessons from asymmetrical disease. Thorax. 2011; 66 (3): 226–231. DOI: 10.1136/thx.2010.137190.Johkoh T., Müller N.L., Cartier Y. et al. Idiopathic interstitial pneumonias: diagnostic accuracy of thinsection CT in 129 patients. Radiology. 1999; 211 (2): 555–560. DOI: 10.1148/radiology.211.2.r99ma01555.Johkoh T., Müller N.L., Cartier Y. et al. Idiopathic interstitial pneumonias: diagnostic accuracy of thinsection CT in 129 patients. Radiology. 1999; 211 (2): 555–560. DOI: 10.1148/radiology.211.2.r99ma01555.Hunninghake G.W., Zimmerman M.B., Schwartz D.A. et al. Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2001; 164 (2): 193–196. DOI: 10.1164/ajrccm.164.2.2101090.Hunninghake G.W., Zimmerman M.B., Schwartz D.A. et al. Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2001; 164 (2): 193–196. DOI: 10.1164/ajrccm.164.2.2101090.Nishimura K., Izumi T., Kitaichi M. et al. The diagnostic accuracy of high-resolution computed tomography in diffuse inf iltrative lung diseases. Chest. 1993; 10 4 (4): 1149–1155. DOI: 10.1378/chest.104.4.1149.Nishimura K., Izumi T., Kitaichi M. et al. The diagnostic accuracy of high-resolution computed tomography in diffuse inf iltrative lung diseases. Chest. 1993; 10 4 (4): 1149–1155. DOI: 10.1378/chest.104.4.1149.Mathieson J.R., Mayo J.R., Staples C.A., Müller N.L. Chronic diffuse infiltrative lung disease: comparison of diagnostic accuracy of CT and chest radiography. Radiology. 1989; 171 (1): 111–116. DOI: 10.1148/radiology.171.1.2928513.Mathieson J.R., Mayo J.R., Staples C.A., Müller N.L. Chronic diffuse infiltrative lung disease: comparison of diagnostic accuracy of CT and chest radiography. Radiology. 1989; 171 (1): 111–116. DOI: 10.1148/radiology.171.1.2928513.Swensen S.J., Aughenbaugh G.L., Myers J.L. Diffuse lung disease: diagnostic accuracy of CT in patients undergoing surgical biopsy of the lung. Radiology. 1997; 205 (1): 229–234. DOI: 10.1148/radiology.205.1.9314990.Swensen S.J., Aughenbaugh G.L., Myers J.L. Diffuse lung disease: diagnostic accuracy of CT in patients undergoing surgical biopsy of the lung. Radiology. 1997; 205 (1): 229–234. DOI: 10.1148/radiology.205.1.9314990.Raghu G., Mageto Y.N., Lockhart D. et al. The accuracy of the clinical diagnosis of new-onset idiopathic pulmonary f ibrosis and other interstitial lung disease: a prospective study. Chest. 1999; 116 (5): 1168–1174. DOI: 10.1378/chest.116.5.1168.Raghu G., Mageto Y.N., Lockhart D. et al. The accuracy of the clinical diagnosis of new-onset idiopathic pulmonary f ibrosis and other interstitial lung disease: a prospective study. Chest. 1999; 116 (5): 1168–1174. DOI: 10.1378/chest.116.5.1168.Souza C.A., Müller N.L., Lee K.S. et al. Idiopathic interstitial pneumonias: prevalence of mediastinal lymph node enlargement in 206 patients. Am. J. Roentgenol. 2006; 186 (4): 995–999. DOI: 10.2214/AJR.04.1663.Souza C.A., Müller N.L., Lee K.S. et al. Idiopathic interstitial pneumonias: prevalence of mediastinal lymph node enlargement in 206 patients. Am. J. Roentgenol. 2006; 186 (4): 995–999. DOI: 10.2214/AJR.04.1663.Egashira R., Jacob J., Kokosi M.A. et al. Diffuse pulmonary ossification in fibrosing interstitial lung diseases: prevalence and associations. Radiology. 2017; 284 (1): 255–263. DOI: 10.1148/radiol.2017152419.Egashira R., Jacob J., Kokosi M.A. et al. Diffuse pulmonary ossification in fibrosing interstitial lung diseases: prevalence and associations. Radiology. 2017; 284 (1): 255–263. DOI: 10.1148/radiol.2017152419.Reddy T.L., von der Thüsen J., Walsh S.L. Idiopathic dendriform pulmonary ossification. J. Thorac. Imag. 2012; 27 (5): W108–110. DOI: 10.1097/RTI.0b013e3182326c38.Reddy T.L., von der Thüsen J., Walsh S.L. Idiopathic dendriform pulmonary ossification. J. Thorac. Imag. 2012; 27 (5): W108–110. DOI: 10.1097/RTI.0b013e3182326c38.Reddy T.L., Tominaga M., Hansell D.M. et al. Pleuro-parenchymal fibroelastosis: a spectrum of histopathological and imaging phenotypes. Eur. Respir. J. 2012; 40 (2): 377–385. DOI: 10.1183/09031936.00165111Reddy T.L., Tominaga M., Hansell D.M. et al. Pleuro-parenchymal fibroelastosis: a spectrum of histopathological and imaging phenotypes. Eur. Respir. J. 2012; 40 (2): 377–385. DOI: 10.1183/09031936.00165111Chung J.H., Chawla A., Peljto A.L. et al. CT scan findings of probable usual interstitial pneumonitis have a high predictive value for histologic usual interstitial pneumonitis. Chest. 2015; 147 (2): 450–459. DOI: 10.1378/chest.14-0976.Chung J.H., Chawla A., Peljto A.L. et al. CT scan findings of probable usual interstitial pneumonitis have a high predictive value for histologic usual interstitial pneumonitis. Chest. 2015; 147 (2): 450–459. DOI: 10.1378/chest.14-0976.Salisbury M.L., Xia M., Murray S. et al. Predictors of idiopathic pulmonary fibrosis in absence of radiologic honeycombing: a cross sectional analysis in ILD patients undergoing lung tissue sampling. Respir. Med. 2016; 118: 88–95. DOI: 10.1016/j.rmed.2016.07.016.Salisbury M.L., Xia M., Murray S. et al. Predictors of idiopathic pulmonary fibrosis in absence of radiologic honeycombing: a cross sectional analysis in ILD patients undergoing lung tissue sampling. Respir. Med. 2016; 118: 88–95. DOI: 10.1016/j.rmed.2016.07.016.Brownell R., Moua T., Henry T.S. et al. The use of pretest probability increases the value of high-resolution CT in diagnosing usual interstitial pneumonia. Thorax. 2017; 72 (5): 424–429. DOI: 10.1136/thoraxjnl-2016-209671.Brownell R., Moua T., Henry T.S. et al. The use of pretest probability increases the value of high-resolution CT in diagnosing usual interstitial pneumonia. Thorax. 2017; 72 (5): 424–429. DOI: 10.1136/thoraxjnl-2016-209671.Raghu G., Wells A.U., Nicholson A.G. et al. Effect of nintedanib in subgroups of idiopathic pulmonary fibrosis by diagnostic criteria. Am. J. Respir. Crit. Care Med. 2017; 195 (1): 78–85. DOI: 10.1164/rccm.201602-0402OC.Raghu G., Wells A.U., Nicholson A.G. et al. Effect of nintedanib in subgroups of idiopathic pulmonary fibrosis by diagnostic criteria. Am. J. Respir. Crit. Care Med. 2017; 195 (1): 78–85. DOI: 10.1164/rccm.201602-0402OC.Yagihashi K., Huckleberry J., Colby T.V. et al. Radiologic-pathologic discordance in biopsy-proven usual interstitial pneumonia. Eur. Respir. J. 2016; 47 (4): 1189–1197. DOI: 10.1183/13993003.01680-2015.Yagihashi K., Huckleberry J., Colby T.V. et al. Radiologic-pathologic discordance in biopsy-proven usual interstitial pneumonia. Eur. Respir. J. 2016; 47 (4): 1189–1197. DOI: 10.1183/13993003.01680-2015.Lynch D.A., Sverzellati N., Travis W.D. et al. Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper. Lancet Respir. Med. 2018; 6 (2): 138–153. DOI: 10.1016/S2213-2600(17)30433-2.Lynch D.A., Sverzellati N., Travis W.D. et al. Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper. Lancet Respir. Med. 2018; 6 (2): 138–153. DOI: 10.1016/S2213-2600(17)30433-2.Hutchinson J.P., Fogarty A.W., McKeever T.M., Hubbard R.B. In-hospital mortality after surgical lung biopsy for interstitial lung disease in the United States: 2000 to 2011. Am. J. Respir. Crit. Care Med. 2016; 193 (10): 1161–1167. DOI: 10.1164/rccm.201508-1632OC.Hutchinson J.P., Fogarty A.W., McKeever T.M., Hubbard R.B. In-hospital mortality after surgical lung biopsy for interstitial lung disease in the United States: 2000 to 2011. Am. J. Respir. Crit. Care Med. 2016; 193 (10): 1161–1167. DOI: 10.1164/rccm.201508-1632OC.Flaherty K.R., King T.E. Jr, Raghu G. et al. Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis? Am. J. Respir. Crit. Care Med. 2004; 170 (8): 904–910. DOI: 10.1164/rccm.200402-147OC.Flaherty K.R., King T.E. Jr, Raghu G. et al. Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis? Am. J. Respir. Crit. Care Med. 2004; 170 (8): 904–910. DOI: 10.1164/rccm.200402-147OC.Singh S., Collins B.F., Sharma B.B. et al. Interstitial lung disease in India: results of a prospective registry. Am. J. Respir. Crit. Care Med. 2017; 195 (6): 801–813. DOI: 10.1164/rccm.201607-1484OC.Singh S., Collins B.F., Sharma B.B. et al. Interstitial lung disease in India: results of a prospective registry. Am. J. Respir. Crit. Care Med. 2017; 195 (6): 801–813. DOI: 10.1164/rccm.201607-1484OC.Salisbury M.L., Myers J.L., Belloli E.A. et al. Diagnosis and treatment of fibrotic hypersensitivity pneumonia: where we stand and where we need to go. Am. J. Respir. Crit. Care Med. 2017; 196 (6): 690–699. DOI: 10.1164/rccm.201608-1675PP.Salisbury M.L., Myers J.L., Belloli E.A. et al. Diagnosis and treatment of fibrotic hypersensitivity pneumonia: where we stand and where we need to go. Am. J. Respir. Crit. Care Med. 2017; 196 (6): 690–699. DOI: 10.1164/rccm.201608-1675PP.Vasakova M., Morell F., Walsh S. et al. Hypersensitivity pneumonitis: perspectives in diagnosis and management. Am. J. Respir. Crit. Care Med. 2017; 196 (6): 680–689. DOI: 10.1164/rccm.201611-2201PP.Vasakova M., Morell F., Walsh S. et al. Hypersensitivity pneumonitis: perspectives in diagnosis and management. Am. J. Respir. Crit. Care Med. 2017; 196 (6): 680–689. DOI: 10.1164/rccm.201611-2201PP.Iwai K., Mori T., Yamada N. et al. Idiopathic pulmonary fibrosis. Epidemiologic approaches to occupational exposure. Am. J. Respir. Crit. Care Med. 1994; 150 (3): 670–675. DOI: 10.1164/ajrccm.150.3.8087336.Iwai K., Mori T., Yamada N. et al. Idiopathic pulmonary fibrosis. Epidemiologic approaches to occupational exposure. Am. J. Respir. Crit. Care Med. 1994; 150 (3): 670–675. DOI: 10.1164/ajrccm.150.3.8087336.Hubbard R., Lewis S., Richards K. et al. Occupational exposure to metal or wood dust and aetiology of cryptogenic f ibrosing alveolitis. Lancet. 1996; 347 (8997): 284–289. DOI: 10.1016/s0140-6736(96)90465-1.Hubbard R., Lewis S., Richards K. et al. Occupational exposure to metal or wood dust and aetiology of cryptogenic f ibrosing alveolitis. Lancet. 1996; 347 (8997): 284–289. DOI: 10.1016/s0140-6736(96)90465-1.Baumgartner K.B., Samet J.M., Stidley C.A. et al. Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 1997; 155 (1): 242–248. DOI: 10.1164/ajrccm.155.1.9001319.Baumgartner K.B., Samet J.M., Stidley C.A. et al. Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 1997; 155 (1): 242–248. DOI: 10.1164/ajrccm.155.1.9001319.Johnston I.D., Prescott R.J., Chalmers J.C. et al. British Thoracic Society study of cryptogenic fibrosing alveolitis: current presentation and initial management. Fibrosing Alveolitis Subcommittee of the Research Committee of the British Thoracic Society. Thorax. 1997; 52 (1): 38–44. DOI: 10.1136/thx.52.1.38.Johnston I.D., Prescott R.J., Chalmers J.C. et al. British Thoracic Society study of cryptogenic fibrosing alveolitis: current presentation and initial management. Fibrosing Alveolitis Subcommittee of the Research Committee of the British Thoracic Society. Thorax. 1997; 52 (1): 38–44. DOI: 10.1136/thx.52.1.38.Hubbard R., Cooper M., Antoniak M. et al. Risk of cryptogenic fibrosing alveolitis in metal workers. Lancet. 2000; 355 (9202): 466–467. DOI: 10.1016/S0140-6736(00)82017-6.Hubbard R., Cooper M., Antoniak M. et al. Risk of cryptogenic fibrosing alveolitis in metal workers. Lancet. 2000; 355 (9202): 466–467. DOI: 10.1016/S0140-6736(00)82017-6.Gustafson T., Dahlman-Höglund A., Nilsson K. et al. Occupational exposure and severe pulmonary fibrosis. Respir. Med. 2007; 101 (10): 2207–2212. DOI: 10.1016/j.rmed.2007.02.027.Gustafson T., Dahlman-Höglund A., Nilsson K. et al. Occupational exposure and severe pulmonary fibrosis. Respir. Med. 2007; 101 (10): 2207–2212. DOI: 10.1016/j.rmed.2007.02.027.Lega J.C., Reynaud Q., Belot A. et al. Idiopathic inf lammatory myopathies and the lung. Eur. Respir. Rev. 2015; 24 (136): 216–238. DOI: 0.1183/16000617.00002015.Lega J.C., Reynaud Q., Belot A. et al. Idiopathic inf lammatory myopathies and the lung. Eur. Respir. Rev. 2015; 24 (136): 216–238. DOI: 0.1183/16000617.00002015.Fischer A., Antoniou K.M., Brown K.K. et al. An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features. Eur. Respir. J. 2015; 46 (4): 976–987. DOI: 10.1183/13993003.00150-2015.Fischer A., Antoniou K.M., Brown K.K. et al. An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features. Eur. Respir. J. 2015; 46 (4): 976–987. DOI: 10.1183/13993003.00150-2015.Lee W., Chung W.S., Hong K.S., Huh J. Clinical usefulness of bronchoalveolar lavage cellular analysis and lymphocyte subsets in diffuse interstitial lung diseases. Ann. Lab. Med. 2015; 35 (2): 220–225. DOI: 10.3343/alm.2015.35.2.220.Lee W., Chung W.S., Hong K.S., Huh J. Clinical usefulness of bronchoalveolar lavage cellular analysis and lymphocyte subsets in diffuse interstitial lung diseases. Ann. Lab. Med. 2015; 35 (2): 220–225. DOI: 10.3343/alm.2015.35.2.220.Schildge J., Frank J., Klar B. [The role of bronchoalveolar lavage in the diagnosis of idiopathic pulmonary fibrosis: an investigation of the relevance of the protein content]. Pneumologie. 2016; 70 (7): 435–441. DOI: 10.1055/s-0042-107267 (in German).Schildge J., Frank J., Klar B. [The role of bronchoalveolar lavage in the diagnosis of idiopathic pulmonary fibrosis: an investigation of the relevance of the protein content]. Pneumologie. 2016; 70 (7): 435–441. DOI: 10.1055/s-0042-107267 (in German).Nagai S., Kitaichi M., Itoh H. et al. Idiopathic nonspecific interstitial pneumonia/fibrosis: comparison with idiopathic pulmonary fibrosis and BOOP. Eur. Respir. J. 1998; 12 (5): 1010–1019. DOI: 10.1183/09031936.98.12051010.Nagai S., Kitaichi M., Itoh H. et al. Idiopathic nonspecific interstitial pneumonia/fibrosis: comparison with idiopathic pulmonary fibrosis and BOOP. Eur. Respir. J. 1998; 12 (5): 1010–1019. DOI: 10.1183/09031936.98.12051010.Ohshimo S., Bonella F., Cui A. et al. Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2009; 179 (11): 1043–1047. DOI: 10.1164/rccm.200808-1313OC.Ohshimo S., Bonella F., Cui A. et al. Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2009; 179 (11): 1043–1047. DOI: 10.1164/rccm.200808-1313OC.Efared B., Ebang-Atsame G., Rabiou S. et al. The diagnostic value of the bronchoalveolar lavage in interstitial lung diseases. J. Negat. Results Biomed. 2017; 16 (1): 4. DOI: 10.1186/s12952-017-0069-0.Efared B., Ebang-Atsame G., Rabiou S. et al. The diagnostic value of the bronchoalveolar lavage in interstitial lung diseases. J. Negat. Results Biomed. 2017; 16 (1): 4. DOI: 10.1186/s12952-017-0069-0.Welker L., Jörres R.A., Costabel U., Magnussen H. Predictive value of BAL cell differentials in the diagnosis of interstitial lung diseases. Eur. Respir. J. 2004; 24 (6): 1000–1006. DOI: 10.1183/09031936.04.00101303.Welker L., Jörres R.A., Costabel U., Magnussen H. Predictive value of BAL cell differentials in the diagnosis of interstitial lung diseases. Eur. Respir. J. 2004; 24 (6): 1000–1006. DOI: 10.1183/09031936.04.00101303.Ryu Y.J., Chung M.P., Han J. et al. Bronchoalveolar lavage in fibrotic idiopathic interstitial pneumonias. Respir. Med. 2007; 101 (3): 655–660. DOI: 10.1016/j.rmed.2006.06.003.Ryu Y.J., Chung M.P., Han J. et al. Bronchoalveolar lavage in fibrotic idiopathic interstitial pneumonias. Respir. Med. 2007; 101 (3): 655–660. DOI: 10.1016/j.rmed.2006.06.003.Veeraraghavan S., Latsi P.I., Wells A.U. et al. BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. Eur. Respir. J. 2003; 22 (2): 239–244. DOI: 10.1183/09031936.03.00105202.Veeraraghavan S., Latsi P.I., Wells A.U. et al. BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. Eur. Respir. J. 2003; 22 (2): 239–244. DOI: 10.1183/09031936.03.00105202.Ayed A.K. Video-assisted thoracoscopic lung biopsy in the diagnosis of diffuse interstitial lung disease: a prospective study. J. Cardiovasc. Surg. (Torino). 2003; 44 (1): 115–118.Ayed A.K. Video-assisted thoracoscopic lung biopsy in the diagnosis of diffuse interstitial lung disease: a prospective study. J. Cardiovasc. Surg. (Torino). 2003; 44 (1): 115–118.Morris D., Zamvar V. The efficacy of video-assisted thoracoscopic surgery lung biopsies in patients with interstitial lung disease: a retrospective study of 66 patients. J. Cardiothorac. Surg. 2014; 9: 45–52. DOI: 10.1186/1749-8090-9-45.Morris D., Zamvar V. The efficacy of video-assisted thoracoscopic surgery lung biopsies in patients with interstitial lung disease: a retrospective study of 66 patients. J. Cardiothorac. Surg. 2014; 9: 45–52. DOI: 10.1186/1749-8090-9-45.Bagheri R., Haghi S.Z., Attaran D. et al. Efficacy of minimally invasive surgery in diagnosis of interstitial lung disease. Asian. Cardiovasc. Thorac. Ann. 2015; 23 (7): 851–854. DOI: 10.1177/0218492315593694.Bagheri R., Haghi S.Z., Attaran D. et al. Efficacy of minimally invasive surgery in diagnosis of interstitial lung disease. Asian. Cardiovasc. Thorac. Ann. 2015; 23 (7): 851–854. DOI: 10.1177/0218492315593694.Bando M., Ohno S., Hosono T. et al. Risk of acute exacerbation after video-assisted thoracoscopic lung biopsy for interstitial lung disease. J. Bronchol. Interv. Pulmonol. 2009; 16 (4): 229–235. DOI: 10.1097/LBR.0b013e3181b767cc.Bando M., Ohno S., Hosono T. et al. Risk of acute exacerbation after video-assisted thoracoscopic lung biopsy for interstitial lung disease. J. Bronchol. Interv. Pulmonol. 2009; 16 (4): 229–235. DOI: 10.1097/LBR.0b013e3181b767cc.Blackhall V., Asif M., Renieri A. et al. The role of surgical lung biopsy in the management of interstitial lung disease: experience from a single institution in the UK. Interact. Cardiovasc. Thorac. Surg. 2013; 17 (2): 253–257. DOI: 10.1093/icvts/ivt217.Blackhall V., Asif M., Renieri A. et al. The role of surgical lung biopsy in the management of interstitial lung disease: experience from a single institution in the UK. Interact. Cardiovasc. Thorac. Surg. 2013; 17 (2): 253–257. DOI: 10.1093/icvts/ivt217.Blanco M., Obeso G.A., Durán J.C. et al. Surgical lung biopsy for diffuse lung disease: our experience in the last 15 years. Rev. Port. Pneumol. 2013; 19 (2): 59–64. DOI: 10.1016/j.rppneu.2012.11.003.Blanco M., Obeso G.A., Durán J.C. et al. Surgical lung biopsy for diffuse lung disease: our experience in the last 15 years. Rev. Port. Pneumol. 2013; 19 (2): 59–64. DOI: 10.1016/j.rppneu.2012.11.003.Blewett C.J., Bennett W.F., Miller J.D., Urschel J.D. Open lung biopsy as an outpatient procedure. Ann. Thorac. Surg. 2001; 71 (4): 1113–1115. DOI: 10.1016/s0003-4975(00)02657-6.Blewett C.J., Bennett W.F., Miller J.D., Urschel J.D. Open lung biopsy as an outpatient procedure. Ann. Thorac. Surg. 2001; 71 (4): 1113–1115. DOI: 10.1016/s0003-4975(00)02657-6.Fibla J.J., Brunelli A., Allen M.S. et al. Do the number and volume of surgical lung biopsies inf luence the diagnostic yield in interstitial lung disease? A propensity score analysis. Arch. Bronconeumol. 2015; 51 (2): 76–79. DOI: 10.1016/j.arbres.2014.05.011 (in English, Spanish).Fibla J.J., Brunelli A., Allen M.S. et al. Do the number and volume of surgical lung biopsies inf luence the diagnostic yield in interstitial lung disease? A propensity score analysis. Arch. Bronconeumol. 2015; 51 (2): 76–79. DOI: 10.1016/j.arbres.2014.05.011 (in English, Spanish).Findikcioglu A., Karadayi S. Is surgical biopsy necessary for diagnosis of interstitial lung diseases: a retrospective clinical study. J. Clin. Anal. Med. 2014; 5: 204–208.Findikcioglu A., Karadayi S. Is surgical biopsy necessary for diagnosis of interstitial lung diseases: a retrospective clinical study. J. Clin. Anal. Med. 2014; 5: 204–208.Guerra M., Miranda J.A., Leal F., Vouga L. Interstitial lung disease: diagnostic accuracy and safety of surgical lung biopsy. Rev. Port. Pneumol. 2009; 15 (3): 433–442 (in English, Portuguese).Guerra M., Miranda J.A., Leal F., Vouga L. Interstitial lung disease: diagnostic accuracy and safety of surgical lung biopsy. Rev. Port. Pneumol. 2009; 15 (3): 433–442 (in English, Portuguese).Ishie R.T., Cardoso J.J.D., Silveira R.J., Stocco L. Video-assisted thoracoscopy for the diagnosis of diffuse parenchymal lung disease. J. Bras. Pneumol. 2009; 35 (3): 234–241 (in English, Portuguese).Ishie R.T., Cardoso J.J.D., Silveira R.J., Stocco L. Video-assisted thoracoscopy for the diagnosis of diffuse parenchymal lung disease. J. Bras. Pneumol. 2009; 35 (3): 234–241 (in English, Portuguese).Kayatta M.O., Ahmed S., Hammel J.A. et al. Surgical biopsy of suspected interstitial lung disease is superior to radiographic diagnosis. Ann. Thorac. Surg. 2013; 96 (2): 399–401. DOI: 10.1016/j.athoracsur.2013.04.065.Kayatta M.O., Ahmed S., Hammel J.A. et al. Surgical biopsy of suspected interstitial lung disease is superior to radiographic diagnosis. Ann. Thorac. Surg. 2013; 96 (2): 399–401. DOI: 10.1016/j.athoracsur.2013.04.065.Khalil M., Cowen M., Chaudhry M., Loubani M. Single versus multiple lung biopsies for suspected interstitial lung disease. Asian Cardiovasc. Thorac. Ann. 2016; 24 (8): 788–791. DOI: 10.1177/0218492316665551.Khalil M., Cowen M., Chaudhry M., Loubani M. Single versus multiple lung biopsies for suspected interstitial lung disease. Asian Cardiovasc. Thorac. Ann. 2016; 24 (8): 788–791. DOI: 10.1177/0218492316665551.Kreider M.E., Hansen-Flaschen J., Ahmad N.N. et al. Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung disease. Ann. Thorac. Surg. 2007; 83 (3): 1140–1144. DOI: 10.1016/j.athoracsur.2006.10.002.Kreider M.E., Hansen-Flaschen J., Ahmad N.N. et al. Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung disease. Ann. Thorac. Surg. 2007; 83 (3): 1140–1144. DOI: 10.1016/j.athoracsur.2006.10.002.Luo Q., Han Q., Chen X. et al. The diagnosis efficacy and safety of video-assisted thoracoscopy surgery (VATS) in undefined interstitial lung diseases: a retrospective study. J. Thorac. Dis. 2013; 5 (3): 283–288. DOI: 10.3978/j.issn.2072-1439.2013.04.12.Luo Q., Han Q., Chen X. et al. The diagnosis efficacy and safety of video-assisted thoracoscopy surgery (VATS) in undefined interstitial lung diseases: a retrospective study. J. Thorac. Dis. 2013; 5 (3): 283–288. DOI: 10.3978/j.issn.2072-1439.2013.04.12.Miller J.D., Urschel J.D.A., Cox G. et al. A randomized, controlled trial comparing thoracoscopy and limited thoracotomy for lung biopsy in interstitial lung disease. Ann. Thorac. Surg. 2000; 70 (5): 1647–1650. DOI: 10.1016/s0003-4975(00)01913-5.Miller J.D., Urschel J.D.A., Cox G. et al. A randomized, controlled trial comparing thoracoscopy and limited thoracotomy for lung biopsy in interstitial lung disease. Ann. Thorac. Surg. 2000; 70 (5): 1647–1650. DOI: 10.1016/s0003-4975(00)01913-5.Ooi A., Iyenger S., Ferguson J., Ritchie A.J. VATS lung biopsy in suspected, diffuse interstitial lung disease provides diagnosis, and alters management strategies. Heart Lung Circ. 2005; 14 (2): 90–92. DOI: 10.1016/j.hlc.2005.01.002.Ooi A., Iyenger S., Ferguson J., Ritchie A.J. VATS lung biopsy in suspected, diffuse interstitial lung disease provides diagnosis, and alters management strategies. Heart Lung Circ. 2005; 14 (2): 90–92. DOI: 10.1016/j.hlc.2005.01.002.Pompeo E., Rogliani P., Cristino B. et al. Awake thoracoscopic biopsy of interstitial lung disease. Ann. Thorac. Surg. 2013; 95 (2): 445–452. DOI: 10.1016/j.athoracsur.2012.10.043.Pompeo E., Rogliani P., Cristino B. et al. Awake thoracoscopic biopsy of interstitial lung disease. Ann. Thorac. Surg. 2013; 95 (2): 445–452. DOI: 10.1016/j.athoracsur.2012.10.043.Qureshi R.A., Ahmed T.A., Grayson A.D. et al. Does lung biopsy help patients with interstitial lung disease? Eur. J. Cardiothorac. Surg. 2002; 21 (4): 621–626; discussion 626. DOI: 10.1016/s1010-7940(02)00021-0.Qureshi R.A., Ahmed T.A., Grayson A.D. et al. Does lung biopsy help patients with interstitial lung disease? Eur. J. Cardiothorac. Surg. 2002; 21 (4): 621–626; discussion 626. DOI: 10.1016/s1010-7940(02)00021-0.Rotolo N., Imperatori A., Dominioni L. et al. Efficacy and safety of surgical lung biopsy for interstitial disease: experience of 161 consecutive patients from a single institution in Italy. Sarcoidosis Vasc. Diffuse Lung Dis. 2015; 32 (3): 251–258.Rotolo N., Imperatori A., Dominioni L. et al. Efficacy and safety of surgical lung biopsy for interstitial disease: experience of 161 consecutive patients from a single institution in Italy. Sarcoidosis Vasc. Diffuse Lung Dis. 2015; 32 (3): 251–258.Samejima J., Tajiri M., Ogura T. et al. Thoracoscopic lung biopsy in 285 patients with diffuse pulmonary disease. Asian Cardiovasc. Thorac. Ann. 2015; 23 (2): 191–197. DOI: 10.1177/0218492314550724.Samejima J., Tajiri M., Ogura T. et al. Thoracoscopic lung biopsy in 285 patients with diffuse pulmonary disease. Asian Cardiovasc. Thorac. Ann. 2015; 23 (2): 191–197. DOI: 10.1177/0218492314550724.Sigurdsson M.I., Isaksson H.J., Gudmundsson G., Gudbjartsson T. Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study. Ann. Thorac. Surg. 2009; 88 (1): 227–232. DOI: 10.1016/j.athoracsur.2009.04.002.Sigurdsson M.I., Isaksson H.J., Gudmundsson G., Gudbjartsson T. Diagnostic surgical lung biopsies for suspected interstitial lung diseases: a retrospective study. Ann. Thorac. Surg. 2009; 88 (1): 227–232. DOI: 10.1016/j.athoracsur.2009.04.002.Sonobe M., Handa T., Tanizawa K. et al. Videothoracoscopy-assisted surgical lung biopsy for interstitial lung diseases. Gen. Thorac. Cardiovasc. Surg. 2014; 62 (6): 376–382. DOI: 10.1007/s11748-014-0383-0.Sonobe M., Handa T., Tanizawa K. et al. Videothoracoscopy-assisted surgical lung biopsy for interstitial lung diseases. Gen. Thorac. Cardiovasc. Surg. 2014; 62 (6): 376–382. DOI: 10.1007/s11748-014-0383-0.Tomassetti S., Wells A.U., Costabel U. et al. Bronchoscopic lung cryobiopsy increases diagnostic confidence in the multidisciplinary diagnosis of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2016; 193 (7): 745–752. DOI: 10.1164/rccm.201504-0711OC.Tomassetti S., Wells A.U., Costabel U. et al. Bronchoscopic lung cryobiopsy increases diagnostic confidence in the multidisciplinary diagnosis of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2016; 193 (7): 745–752. DOI: 10.1164/rccm.201504-0711OC.Ravaglia C., Bonifazi M., Wells A.U. et al. Safety and diagnostic yield of transbronchial lung cryobiopsy in diffuse parenchymal lung diseases: a comparative study versus video-assisted thoracoscopic lung biopsy and a systematic review of the literature. Respiration. 2016; 91 (3): 215–227. DOI: 10.1159/000444089.Ravaglia C., Bonifazi M., Wells A.U. et al. Safety and diagnostic yield of transbronchial lung cryobiopsy in diffuse parenchymal lung diseases: a comparative study versus video-assisted thoracoscopic lung biopsy and a systematic review of the literature. Respiration. 2016; 91 (3): 215–227. DOI: 10.1159/000444089.Morell F., Reyes L., Doménech G. et al. [Diagnoses and diagnostic procedures in 500 consecutive patients with clinical suspicion of interstitial lung disease]. Arch. Bronconeumol. 2008; 44 (4): 185–191 (in Spanish).Morell F., Reyes L., Doménech G. et al. [Diagnoses and diagnostic procedures in 500 consecutive patients with clinical suspicion of interstitial lung disease]. Arch. Bronconeumol. 2008; 44 (4): 185–191 (in Spanish).Raghu G., Rochwerg B., Zhang Y. et al. An official ATS/ERS/JRS/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline. Am. J. Respir. Crit. Care Med. 2015; 192 (2): e3–e19. DOI: 10.1164/rccm.201506-1063ST.Raghu G., Rochwerg B., Zhang Y. et al. An official ATS/ERS/JRS/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline. Am. J. Respir. Crit. Care Med. 2015; 192 (2): e3–e19. DOI: 10.1164/rccm.201506-1063ST.Han Q., Luo Q., Chen X. et al. The evaluation of clinical usefulness of transbrochoscopic lung biopsy in undefined interstitial lung diseases: a retrospective study. Clin. Respir. J. 2017; 11 (2): 168–175. DOI: 10.1111/crj.12318.Han Q., Luo Q., Chen X. et al. The evaluation of clinical usefulness of transbrochoscopic lung biopsy in undefined interstitial lung diseases: a retrospective study. Clin. Respir. J. 2017; 11 (2): 168–175. DOI: 10.1111/crj.12318.Sindhwani G., Shirazi N., Sodhi R. et al. Transbronchial lung biopsy in patients with diffuse parenchymal lung disease without ‘idiopathic pulmonary fibrosis pattern’ on HRCT scan: experience from a tertiary care center of North India. Lung India. 2015; 32 (5): 453–456. DOI: 10.4103/0970-2113.164148.Sindhwani G., Shirazi N., Sodhi R. et al. Transbronchial lung biopsy in patients with diffuse parenchymal lung disease without ‘idiopathic pulmonary fibrosis pattern’ on HRCT scan: experience from a tertiary care center of North India. Lung India. 2015; 32 (5): 453–456. DOI: 10.4103/0970-2113.164148.Sheth J.S., Belperio J.A., Fishbein M.C. et al. Utility of transbronchial vs surgical lung biopsy in the diagnosis of suspected fibrotic interstitial lung disease. Chest. 2017; 151 (2): 389–399. DOI: 10.1016/j.chest.2016.09.028.Sheth J.S., Belperio J.A., Fishbein M.C. et al. Utility of transbronchial vs surgical lung biopsy in the diagnosis of suspected fibrotic interstitial lung disease. Chest. 2017; 151 (2): 389–399. DOI: 10.1016/j.chest.2016.09.028.Pajares V., Puzo C., Castillo D. et al. Diagnostic yield of transbronchial cryobiopsy in interstitial lung disease: a randomized trial. Respirology. 2014; 19 (6): 900–906. DOI: 10.1111/resp.12322.Pajares V., Puzo C., Castillo D. et al. Diagnostic yield of transbronchial cryobiopsy in interstitial lung disease: a randomized trial. Respirology. 2014; 19 (6): 900–906. DOI: 10.1111/resp.12322.Pourabdollah M., Shamaei M., Karimi S. et al. Transbronchial lung biopsy: the pathologist’s point of view. Clin. Respir. J. 2014;10 (2): 211–216. DOI: 10.1111/crj.12207.Pourabdollah M., Shamaei M., Karimi S. et al. Transbronchial lung biopsy: the pathologist’s point of view. Clin. Respir. J. 2014;10 (2): 211–216. DOI: 10.1111/crj.12207.Ramaswamy A., Homer R., Killam J. et al. Comparison of transbronchial and cryobiopsies in evaluation of diffuse parenchymal lung disease. J. Bronchology Interv. Pulmonol. 2016; 23 (1): 14–21. DOI: 10.1097/LBR.0000000000000246.Ramaswamy A., Homer R., Killam J. et al. Comparison of transbronchial and cryobiopsies in evaluation of diffuse parenchymal lung disease. J. Bronchology Interv. Pulmonol. 2016; 23 (1): 14–21. DOI: 10.1097/LBR.0000000000000246.Kim S.Y., Diggans J., Pankratz D. et al. Classification of usual interstitial pneumonia in patients with interstitial lung disease: assessment of a machine learning approach using high-dimensional transcriptional data. Lancet Respir. Med. 2015; 3 (6): 473–482. DOI: 10.1016/S2213-2600(15)00140-X.Kim S.Y., Diggans J., Pankratz D. et al. Classification of usual interstitial pneumonia in patients with interstitial lung disease: assessment of a machine learning approach using high-dimensional transcriptional data. Lancet Respir. Med. 2015; 3 (6): 473–482. DOI: 10.1016/S2213-2600(15)00140-X.Pankratz D.G., Choi Y., Imtiaz U. et al. Usual interstitial pneumonia can be detected in transbronchial biopsies using machine learning. Ann. Am. Thorac. Soc. 2017; 14 (11): 1646–1654. DOI: 10.1513/AnnalsATS.201612-947OC.Pankratz D.G., Choi Y., Imtiaz U. et al. Usual interstitial pneumonia can be detected in transbronchial biopsies using machine learning. Ann. Am. Thorac. Soc. 2017; 14 (11): 1646–1654. DOI: 10.1513/AnnalsATS.201612-947OC.Cascante J.A., Cebollero P., Herrero S. et al. Transbronchial cryobiopsy in interstitial lung disease: are we on the right path? J. Bronchology Interv. Pulmonol. 2016; 23 (3): 204–209. DOI: 10.1097/LBR.0000000000000292.Cascante J.A., Cebollero P., Herrero S. et al. Transbronchial cryobiopsy in interstitial lung disease: are we on the right path? J. Bronchology Interv. Pulmonol. 2016; 23 (3): 204–209. DOI: 10.1097/LBR.0000000000000292.Fruchter O., Fridel L., El Raouf B.A. et al. Histological diagnosis of interstitial lung diseases by cryo-transbronchial biopsy. Respirology. 2014; 19 (5): 683–688. DOI: 10.1111/resp.12296.Fruchter O., Fridel L., El Raouf B.A. et al. Histological diagnosis of interstitial lung diseases by cryo-transbronchial biopsy. Respirology. 2014; 19 (5): 683–688. DOI: 10.1111/resp.12296.Griff S., Schönfeld N., Ammenwerth W. et al. Diagnostic yield of transbronchial cryobiopsy in non-neoplastic lung disease: a retrospective case series. BMC Pulm. Med. 2014; 14: 171. DOI: 10.1186/1471-2466-14-171.Griff S., Schönfeld N., Ammenwerth W. et al. Diagnostic yield of transbronchial cryobiopsy in non-neoplastic lung disease: a retrospective case series. BMC Pulm. Med. 2014; 14: 171. DOI: 10.1186/1471-2466-14-171.Hagmeyer L., Theegarten D., Treml M. et al. Validation of transbronchial cryobiopsy in interstitial lung disease – interim analysis of a prospective trial and critical review of the literature. Sarcoidosis Vasc. Diffuse Lung Dis. 2016; 33 (1): 2–9.Hagmeyer L., Theegarten D., Treml M. et al. Validation of transbronchial cryobiopsy in interstitial lung disease – interim analysis of a prospective trial and critical review of the literature. Sarcoidosis Vasc. Diffuse Lung Dis. 2016; 33 (1): 2–9.Hernández-González F., Lucena C.M., Ramírez J. et al. Cryobiopsy in the diagnosis of diffuse interstitial lung disease: yield and cost-effectiveness analysis. Arch. Bronconeumol. 2015; 51 (6): 261–267. DOI: 10.1016/j.arbres.2014.09.009 (in English, Spanish).Hernández-González F., Lucena C.M., Ramírez J. et al. Cryobiopsy in the diagnosis of diffuse interstitial lung disease: yield and cost-effectiveness analysis. Arch. Bronconeumol. 2015; 51 (6): 261–267. DOI: 10.1016/j.arbres.2014.09.009 (in English, Spanish).Kronborg-White S., Folkersen B., Rasmussen T.R. et al. Introduction of cryobiopsies in the diagnostics of interstitial lung diseases – experiences in a referral center. Eur. Clin. Respir. J. 2017; 4 (1): 1274099. DOI: 10.1080/20018525.2016.1274099.Kronborg-White S., Folkersen B., Rasmussen T.R. et al. Introduction of cryobiopsies in the diagnostics of interstitial lung diseases – experiences in a referral center. Eur. Clin. Respir. J. 2017; 4 (1): 1274099. DOI: 10.1080/20018525.2016.1274099.Kropski J.A., Pritchett J.M., Mason W.R. et al. Bronchoscopic cryobiopsy for the diagnosis of diffuse parenchymal lung disease. PLoS One. 2013; 8 (11): e78674. DOI: 10.1371/journal.pone.0078674.Kropski J.A., Pritchett J.M., Mason W.R. et al. Bronchoscopic cryobiopsy for the diagnosis of diffuse parenchymal lung disease. PLoS One. 2013; 8 (11): e78674. DOI: 10.1371/journal.pone.0078674.Pourabdollah M., Shamaei M., Karimi S. et al. Transbronchial lung biopsy: the pathologist’s point of view. Clin. Respir. J. 2016; 10 (2): 211–216. DOI: 10.1111/crj.12207.Pourabdollah M., Shamaei M., Karimi S. et al. Transbronchial lung biopsy: the pathologist’s point of view. Clin. Respir. J. 2016; 10 (2): 211–216. DOI: 10.1111/crj.12207.Ussavarungsi K., Kern R.M., Roden A.C. et al. Transbronchial cryobiopsy in diffuse parenchymal lung disease: retrospective analysis of 74 cases. Chest. 2017; 151 (2): 400–408. DOI: 10.1016/j.chest.2016.09.002.Ussavarungsi K., Kern R.M., Roden A.C. et al. Transbronchial cryobiopsy in diffuse parenchymal lung disease: retrospective analysis of 74 cases. Chest. 2017; 151 (2): 400–408. DOI: 10.1016/j.chest.2016.09.002.Sharp C., McCabe M., Adamali H., Medford A.R. Use of transbronchial cryobiopsy in the diagnosis of interstitial lung disease: a systematic review and cost analysis. QJM. 2017; 110 (4): 207–214. DOI: 10.1093/qjmed/hcw142.Sharp C., McCabe M., Adamali H., Medford A.R. Use of transbronchial cryobiopsy in the diagnosis of interstitial lung disease: a systematic review and cost analysis. QJM. 2017; 110 (4): 207–214. DOI: 10.1093/qjmed/hcw142.Ganganah O., Guo S.L., Chiniah M., Li Y.S. Efficacy and safety of cryobiopsy versus forceps biopsy for interstitial lung diseases and lung tumours: a systematic review and meta-analysis. Respirology. 2016; 21 (5): 834–841. DOI: 10.1111/resp.12770.Ganganah O., Guo S.L., Chiniah M., Li Y.S. Efficacy and safety of cryobiopsy versus forceps biopsy for interstitial lung diseases and lung tumours: a systematic review and meta-analysis. Respirology. 2016; 21 (5): 834–841. DOI: 10.1111/resp.12770.Hetzel J., Maldonado F., Ravaglia C. et al. Transbronchial cryobiopsies for the diagnosis of diffuse parenchymal lung diseases: expert statement from the Cryobiopsy Working Group on Safety and Utility and a call for standardization of the procedure. Respiration. 2018; 95 (3): 188–200. DOI: 10.1159/000484055.Hetzel J., Maldonado F., Ravaglia C. et al. Transbronchial cryobiopsies for the diagnosis of diffuse parenchymal lung diseases: expert statement from the Cryobiopsy Working Group on Safety and Utility and a call for standardization of the procedure. Respiration. 2018; 95 (3): 188–200. DOI: 10.1159/000484055.Chaudhuri N., Spencer L., Greaves M. et al. A review of the multidisciplinary diagnosis of interstitial lung diseases: a retrospective analysis in a single UK specialist centre. J. Clin. Med. 2016; 5 (8): pii: E66. DOI: 10.3390/jcm5080066.Chaudhuri N., Spencer L., Greaves M. et al. A review of the multidisciplinary diagnosis of interstitial lung diseases: a retrospective analysis in a single UK specialist centre. J. Clin. Med. 2016; 5 (8): pii: E66. DOI: 10.3390/jcm5080066.Thomeer M., Demedts M., Behr J. et al. Multidisciplinary interobserver agreement in the diagnosis of idiopathic pulmonary fibrosis. Eur. Respir. J. 2008; 31 (3): 585–591. DOI: 10.1183/09031936.00063706.Thomeer M., Demedts M., Behr J. et al. Multidisciplinary interobserver agreement in the diagnosis of idiopathic pulmonary fibrosis. Eur. Respir. J. 2008; 31 (3): 585–591. DOI: 10.1183/09031936.00063706.Jo H.E., Glaspole I.N., Levin K.C. et al. Clinical impact of the interstitial lung disease multidisciplinary service. Respirology. 2016; 21 (8): 1438–1444. DOI: 10.1111/resp.12850.Jo H.E., Glaspole I.N., Levin K.C. et al. Clinical impact of the interstitial lung disease multidisciplinary service. Respirology. 2016; 21 (8): 1438–1444. DOI: 10.1111/resp.12850.Theegarten D., Müller H.M., Bonella F. et al. Diagnostic approach to interstitial pneumonias in a single centre: report on 88 cases. Diagn. Pathol. 2012; 7: 160. DOI: 10.1186/1746-1596-7-160.Theegarten D., Müller H.M., Bonella F. et al. Diagnostic approach to interstitial pneumonias in a single centre: report on 88 cases. Diagn. Pathol. 2012; 7: 160. DOI: 10.1186/1746-1596-7-160.White E.S., Xia M., Murray S. et al. Plasma surfactant protein-D, matrix metalloproteinase-7, and osteopontin index distinguishes idiopathic pulmonary fibrosis from other idiopathic interstitial pneumonias. Am. J. Respir. Crit. Care Med. 2016; 194 (10): 1242–1251. DOI: 10.1164/rccm.201505-0862OC.White E.S., Xia M., Murray S. et al. Plasma surfactant protein-D, matrix metalloproteinase-7, and osteopontin index distinguishes idiopathic pulmonary fibrosis from other idiopathic interstitial pneumonias. Am. J. Respir. Crit. Care Med. 2016; 194 (10): 1242–1251. DOI: 10.1164/rccm.201505-0862OC.Morais A., Beltrão M., Sokhatska O. et al. Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibrosis and other interstitial pneumonias. Respir. Med. 2015; 109 (8): 1063–1068. DOI: 10.1016/j.rmed.2015.06.003.Morais A., Beltrão M., Sokhatska O. et al. Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibrosis and other interstitial pneumonias. Respir. Med. 2015; 109 (8): 1063–1068. DOI: 10.1016/j.rmed.2015.06.003.

The authors declare that there are no conflicts of interest present.