pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2019-29-4-477-485pulmo-1201Research ArticleОБЗОРЫREVIEWЗагрязнение атмосферного воздуха взвешенными веществами как фактор риска рака легкихParticle pollution as a risk factor for lung carcinomaКолпаковаА. Ф.KolpakovaA. F.

Колпакова Алла Федоровна – доктор медицинских наук, профессор, ведущий научный сотрудник лаборатории биоинформатики

630090, Новосибирск, ул. Академика Ржанова, 6

Alla F. Kolpakova, Doctor of Medicine, Professor, Leading Researcher, Laboratory of Bioinformatics

ul. Akademika Rzhanova 6, Novosibirsk, 630090

kolpakova44@mail.ruШариповР. Н.SharipovR. N.

Шарипов Руслан Нильевич – руководитель проектов Общества с ограниченной ответственностью «БИОСОФТ.РУ»; старший преподаватель Федерального государственного автономного образовательного учреждения высшего образования «Новосибирский национальный исследовательский государственный университет»

630058, Новосибирск, ул. Русская, 41 / 1, 

630090, Новосибирск, ул. Пирогова, 2

Ruslan N. Sharipov, Head of Projects, BIOSOFT.RU LLC, Senior Teacher, Novosibirsk National Research University

ul. Russkaya 41/1, Novosibirsk, 630058, 

ul. Pirogova 2, Novosibirsk, 630090

shrus79@yandex.ruВолковаО. А.VolkovaO. A.

Волкова Оксана Анатольевна – кандидат биологических наук, научный сотрудник лаборатории генной инженерии

630090, Новосибирск, пр. Академика Лаврентьева, 10

 

Oksana A. Volkova, Candidate of Biology, Researcher, Laboratory of Genetic Engineering

ul. Akademika Lavrent’yeva 10, Novosibirsk, 630090

ov@bionet.nsc.ruКолпаковФ. А.KolpakovF. A.

Колпаков Федор Анатольевич – кандидат биологических наук, заведующий лабораторией биоинформатики Федерального государственного бюджетного учреждения науки «Институт вычислительных технологий» Сибирского отделения Российской академии наук; технический директор Общества с ограниченной ответственностью «БИОСОФТ.РУ»

630090, Новосибирск, ул. Академика Ржанова, 6, 

630058, Новосибирск, ул. Русская, 41 / 1

Fedor A. Kolpakov, Candidate of Biology, Head of Laboratory of Bioinformatics, Federal Research Institute of Computational Technologies, Siberian Department of Russian Academy of Science; Engineering Director, BIOSOFT.RU LLC

ul. Akademika Rzhanova 6, Novosibirsk, 630090, 

ul. Russkaya 41/1, Novosibirsk, 630058

fkolpakov@gmail.comФедеральное государственное бюджетное учреждение науки «Институт вычислительных технологий» Сибирского отделения Российской академии наукРоссияFederal Research Institute of Computational Technologies, Siberian Department of Russian Academy of ScienceRussian FederationОбщество с ограниченной ответственностью «БИОСОФТ.РУ»; Федеральное государственное автономное образовательное учреждение высшего образования «Новосибирский национальный исследовательский государственный университет»РоссияBIOSOFT.RU LLC; Novosibirsk National Research UniversityRussian FederationФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр "Институт цитологии и генетики"» Сибирского отделения Российской академии наукРоссия"Institute of Cytology and Genetics" Federal Research Center, Siberian Department of Russian Academy of ScienceRussian FederationФедеральное государственное бюджетное учреждение науки «Институт вычислительных технологий» Сибирского отделения Российской академии наук; Общество с ограниченной ответственностью «БИОСОФТ.РУ»РоссияFederal Research Institute of Computational Technologies, Siberian Department of Russian Academy of Science; BIOSOFT.RU LLCRussian Federation201924102019294477485Copyright © Колпакова А.Ф., Шарипов Р.Н., Волкова О.А., Колпаков Ф.А., 20192019Колпакова А.Ф., Шарипов Р.Н., Волкова О.А., Колпаков Ф.А.Kolpakova A.F., Sharipov R.N., Volkova O.A., Kolpakov F.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/1201

В статье освещены современные представления о связи загрязнения атмосферного воздуха взвешенными частицами (ВЧ) с заболеваемостью и смертностью от рака легких (РЛ). По результатам эпидемиологических, клинических и экспериментальных исследований подтверждено, что загрязнение воздуха ВЧ, особенно содержащими металлы, является фактором риска РЛ. Повреждение генома эпителиальной клетки и эпигенетические изменения при действии ВЧ являются важным звеном патогенеза РЛ. Систематизированные научные данные в виде формализованных описаний способствуют понятию патогенеза РЛ и могут быть использованы в практической медицине для оценки риска возникновения, ранней диагностики, прогноза и повышения эффективности лечения больных РЛ.

 

Current view on a relationship between particle pollution, morbidity and mortality of lung carcinoma were discussed in the article. Published epidemiological, clinical and laboratory studies suggest particle pollution, especially metal containing particulate matter (PM), to be a risk factor for lung carcinoma occurrence. PM-associated injury of epithelial cell genome and epigenetic lesions are an important part of pathogenesis of lung carcinoma. Systemic research findings and formalized reports could improve our knowledge on lung cancer pathogenesis and could be used in clinical practice for risk assessment, early detection and prognosis of lung cancer and improvement in treatment efficacy.

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The authors declare that there are no conflicts of interest present.