pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2019-29-2-199-206pulmo-1146Research ArticleОБЗОРЫREVIEWТройная терапия в лечении хронической обструктивной болезни легкихTriple therapy in chronic obstructive pulmonary diseaseАвдеевС. Н.AvdeevSergey N.

Авдеев Сергей Николаевич – д. м. н., член-корр. Российской академии наук, профессор, заведующий кафедрой пульмонологии Федерального государственного автономного образовательного учреждения высшего образования «Первый Московский государственный медицинский университет имени И.М.Сеченова» Министерства здравоохранения Российской Федерации, руководитель клинического отдела Федерального государственного бюджетного учреждения «Научно-исследовательский институт пульмонологии» Федерального медико-биологического агентства; тел.: (495) 708-35-76;

119991, Москва, ул. Трубецкая, 8, стр. 2;115682, Москва, Ореховый бульвар, 28

Sergey N. Avdeev, Doctor of Medicine, Professor, Corresponding Member of Russian Academy of Sciences, Head of Department of Pulmonology, I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia (Sechenov University); Head of Clinical Division, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel.: (495) 708-35-76;

Trubetskaya ul. 8, build. 2, Moscow, 119991Orekhovyy bul'var 28, Moscow, 115682

serg_avdeev@list.ruТрушенкоН. В.TrushenkoNatal’ya V.

Трушенко Наталья Владимировна – к. м. н., научный сотрудник научно-методического центра мониторинга и контроля болезней органов дыхания Федерального государственного бюджетного учреждения «Научно-исследовательский институт пульмонологии» Федерального медико-биологического агентства, ассистент кафедры пульмонологии Федерального государственного автономного образовательного учреждения высшего образования «Первый Московский государственный медицинский университет имени И.М.Сеченова» Министерства здравоохранения Российской Федерации; тел.: (495) 395-63-93;

119991, Москва, ул. Трубецкая, 8, стр. 2;115682, Москва, Ореховый бульвар, 28

Natal’ya V. Trushenko, Candidate of Medicine, Researcher, Research Center for Monitoring and Control of Respiratory Diseases, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; Assistant Lecturer, Department of Pulmonology, I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia (Sechenov University); tel.: (495) 395-63-93;

Trubetskaya ul. 8, build. 2, Moscow, 119991Orekhovyy bul'var 28, Moscow, 115682

trushenko.natalia@yandex.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М.Сеченова» Министерства здравоохранения Российской Федерации; Федеральное государственное автономное учреждение «Научно-исследовательский институт пульмонологии» Федерального медико-биологического агентстваРоссияI.M.Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia; Federal Pulmonology Research Institute, Federal Medical and Biological Agency of RussiaRussian Federation201901072019292199206Copyright © Авдеев С.Н., Трушенко Н.В., 20192019Авдеев С.Н., Трушенко Н.В.Avdeev S.N., Trushenko N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/1146

Терапевтические возможности для лечения хронической обструктивной болезни легких (ХОБЛ) за последние годы существенно расширились, в первую очередь – за счет появления новых комбинированных препаратов, содержащих в одном ингаляторе 2 или 3 компонента. К двойным комбинациям для лечения ХОБЛ относятся длительно действующие β2-агонисты (ДДБА) / длительно действующие антихолинергические препараты (ДДАХП) и ДДБА / ингаляционные глюкокортикостероиды (иГКС), в то время как под т. н. тройной терапией подразумевается комбинация ДДБА, ДДАХП и иГКС в одном ингаляторе. В настоящей статье приводятся показания к назначению тройной комбинации ДДБА / ДДАХП / иГКС, представленные в разных согласительных документах и национальных рекомендациях, а также обзор последних литературных данных по эффективности и профилю безопасности данной терапии.

Recently, therapeutic options for treatment of chronic obstructive pulmonary disease (COPD) has been significantly extended, mainly due to new double and triple drug combinations in a single inhaler. Double combinations for treatment of COPD include long-term acting beta-2-agonists (LABA)/long-term acting muscarinic antagonists (LAMA) and LABA/inhaled corticosteroids (ICS); a triple combination is a combination of LABA, LAMA and ICS in a single inhaler. A review of consensus statements, national guidelines and recently published data about use of triple therapy in COPD, efficacy and safety of a triple combination is given in the article.

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The authors declare that there are no conflicts of interest present.