pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2018-28-6-754-761pulmo-1093Research ArticleОБЗОРЫREVIEWОсобенности заболеваний верхних дыхательных путей при муковисцидозе: методы леченияTreatment of upper airway diseases in patients with cystic fibrosisШумковаГ. Л.ShumkovaG. L.

Шумкова Галина Леонидовна – научный сотрудник Центра муковисцидоза НИИП; аспирант кафедры болезней уха, горла и носа, Сеченовский Университет.

119991, Москва, ул. Трубецкая, 8, стр. 2; 115682, Москва, Ореховый бульвар, 28, тел.: (499) 248-55-38

Galina L. Shumkova - Researcher, Center of Cystic Fibrosis, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; Postgraduate Student at Department of Ear, Nose, and Throat Diseases Sechenov University, Healthcare MR

Trubetskaya ul. 8, build. 2, Moscow, 119991, Orekhovyy bul'var 28, Moscow, 115682,tel.: (499) 248-55-38

galina2212@yandex.ruАмелинаЕ. Л.AmelinaE. L.

Амелина Елена Львовна – кандидат медицинских наук, заведующая лабораторией муковисцидоза.

115682, Москва, Ореховый бульвар, 28, тел.: (926) 205-03-91

Elena L. Amelina - Candidate of Medicine, Head of Laboratory of Cystic Fibrosis.

Orekhovyy bul'var 28, Moscow, 115682, tel.: (926) 205-03-91

 

eamelina@mail.ruСвистушкинВ. М.SvistushkinV. M.

Свистушкин Валерий Михайлович – доктор медицинских наук, профессор, директор Клиники болезней уха, горла и носа, заведующий кафедрой болезней уха, горла и носа, Сеченовский Университет, Главный внештатный оториноларинголог Центрального федерального округа России.

119991, Москва, ул. Трубецкая, 8, стр. 2, тел.: (499) 248-55-11

Valeriy M. Svistushkin - Doctor of Medicine, Professor, Director of Clinics of Ear, Nose, and Throat Diseases, Head of Department of Ear, Nose, and Throat Diseases, Sechenov University; Chief Otolaryngologist at the Central Federal District of Russia.

Trubetskaya ul. 8, build. 2, Moscow, 119991, tel.: 499) 248-55-11

svvm3@yandex.ruКрасовскийС. А.KrasovskiyS. A.

Красовский Станислав Александрович – кандидат медицинских наук, старший научный сотрудник лаборатории муковисцидоза.

115682, Москва, Ореховый бульвар, 28, тел.: (495) 965-23-24

Stanislav A. Krasovskiy - Candidate of Medicine, Senior Researcher, Laboratory of Cystic Fibrosis.

Orekhovyy bul'var 28, Moscow, 115682, tel.: (495) 965-23-24

sa_krasovsky@mail.ruКаширскаяН. Ю.KashirskayaN. Yu.

Каширская Наталия Юрьевна – доктор медицинских наук, профессор, главный научный сотрудник лаборатории генетической эпидемиологии.

115478, Москва, ул. Москворечье, 1, тел.: (910) 440-05-63

Nataliya Yu. Kashirskaya - Doctor of Medicine, Professor, Principal Researcher at Laboratory of Genetic Epidemiology.

Ul. Moskvorech'e 1, Moscow, 1115478, tel.: (910) 440-05-63

kashirskayanj@mail.ruСиньковЭ. В.Sin’kovE. V.

Синьков Эдуард Викторович – кандидат медицинских наук, доцент кафедры болезней уха, горла и носа.

119991, Москва, ул. Трубецкая, 8, стр. 2, тел.: (499) 248-55-38

Eduard V. Sin’kov - Candidate of Medicine, Associate Professor, Department of Ear, Nose, and Throat Diseases.

Trubetskaya ul. 8, build. 2, Moscow, 119991, tel.: (499) 248-55-38

1178461@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М.Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет); Федеральное государственное бюджетное учреждение «Научно-исследовательский институт пульмонологии» Федерального медико-биологического агентстваРоссияI.M.Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia; Federal Pulmonology Research Institute, Federal Medical and Biological Agency of RussiaRussian FederationФедеральное государственное бюджетное учреждение «Научно-исследовательский институт пульмонологии» Федерального медико-биологического агентстваРоссияFederal Pulmonology Research Institute, Federal Medical and Biological Agency of RussiaRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М.Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияI.M.Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of RussiaRussian FederationФедеральное государственное бюджетное научное учреждение Медико-генетический научный центрРоссияFederal Medical Genetic Academic Center, Russian Academy of ScienceRussian Federation201816022019286754761Copyright © Шумкова Г.Л., Амелина Е.Л., Свистушкин В.М., Красовский С.А., Каширская Н.Ю., Синьков Э.В., 20192019Шумкова Г.Л., Амелина Е.Л., Свистушкин В.М., Красовский С.А., Каширская Н.Ю., Синьков Э.В.Shumkova G.L., Amelina E.L., Svistushkin V.M., Krasovskiy S.A., Kashirskaya N.Y., Sin’kov E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/1093

Основной патологией верхних дыхательных путей (ВДП) при муковисцидозе (МВ) является полипозно-гнойный риносинусит. Эта патология развивается в детстве и является следствием микробной контаминации застойной слизи околоносовых пазух с дальнейшим развитием инфекционно-воспалительного процесса и формированием назальных полипов. Наличие хронического очага инфекции в ВДП отрицательно сказывается на течении легочной патологии. Наблюдение оториноларингологом больных данной категории должно проводиться пожизненно, обследование должно включать в себя объективные методы обследования – компьютерную томографию пазух носа, эндоскопию, микробиологическое исследование содержимого назальных синусов. Для повышения эффективности лечения риносинусита при МВ следует объединять топическую ингаляционную терапию и эндоскопические малоинвазивные хирургические методы.

Chronic rhinosinusitis with nasal polyps (CRS NP) is the most prevalent ear, nose, and throat (ENT) disorder in cystic fibrosis (CF) patients. CRS NP can occur in CF children at the age of ≥ 8 months and becomes the chronic disease. Tenacious secret and bacterial infection cause obstruction, edema and hypoxia of paranasal sinuses and contribute to significant morbidity in CF patients. The active monitoring and treatment of CRS NP aimed at improvement of the aeration of paranasal sinuses, mucociliary clearance, and the control of chronic upper airway infection are necessary. Functional Endoscopic Sinus Surgery (FESS) may be the method of choice if surgical treatment is considered. FESS facilitates paranasal sinuses drainage. Due to recurrent course of CRS NP in most CF patients, lifelong follow-up by an ENT specialist and postoperative management using topical steroids and/or antibiotics are required.

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The authors declare that there are no conflicts of interest present.