References

pulmo

Пульмонология

PULMONOLOGIYA

0869-01892541-9617

Scientific and Practical Journal “PULMONOLOGIYA” LLC

10.18093/0869-0189-2018-28-5-602-612

pulmo-1059

Research Article

ОБЗОРЫ

REVIEW

Возможности и ограничения применения ингаляционных глюкокортикостероидов в терапии хронической обструктивной болезни легких

Possibilities and limitations of inhaled corticosteroids in the treatment of chronic obstructive pulmonary disease

Лещенко

И. В.

Leshchenko

I. V.

620028, Екатеринбург, ул. Репина, 3, 620109, Екатеринбург, ул. Заводская, 29

Igor' V. Leshchenko, Professor, Department of Phthisiology, Pulmonology and Thoracic Surgery, Ural Federal State Medical University, Healthcare Ministry of Russia; Chief Pulmonologist of Sverdlovsk region and Ekaterinburg, Academic Advisor of “Novaya bol'nitsa” clinical association

ul. Repina 3, Ekaterinburg, 620028, ul. Zavodskaya 29, Ekaterinburg, 620109

leshchenkoiv@mail.ru

Федеральное государственное бюджетное образовательное учреждение высшего образования «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Общество с ограниченной ответственностью «Медицинское объединение "Новая больница"»РоссияUral State Medical University, Healthcare Ministry of Russia; “Novaya bol’nitsa” Clinical Association LLCRussian Federation

2018

24122018

285602612

2018

Лещенко И.В.

Leshchenko I.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.pulmonology.ru/pulm/article/view/1059

Ингаляционные глюкокортикостероиды (иГКС) в сочетании с длительно действующими бронходилататорами (ДДБД) являются одними из основных лекарственных средств для лечения пациентов с хронической обструктивной болезнью легких (ХОБЛ) при отсутствии эффекта на фоне постоянной терапии ДДБД. Установлено, что при включении иГКС в программу терапии больных ХОБЛ риск развития пневмонии увеличивается у пожилых (старше 55 лет) лиц; курильщиков; пациентов с обострениями, пневмониями в анамнезе и индексом массы тела < 25 кг / м2, одышкой или тяжелым ограничением воздушного потока. При назначении больным ХОБЛ иГКС следует учитывать соотношение показателя пользы и риска возникновения возможных нежелательных явлений, особенно у лиц с повышенными факторами риска осложнений, связанных с приемом иГКС.

Combinations of inhaled corticosteroids (ICS) and long-acting bronchodilators are recommended for those patients with chronic obstructive pulmonary disease (COPD) who did not improve significantly with regular long-acting bronchodilators. ICS are known to increase the risk of pneumonia in elderly patients (over 55 years), current smokers, patients with acute exacerbation of COPD, patients with history of previous pneumonia, patients with body mass index < 25 kg/m2, and patients with dyspnea or severe airflow limitation. The risk-benefit ratio should be considered before initiating the treatment with ICS in COPD patients, particularly in patients with the risk factors of adverse events associated with ICS.

хроническая обструктивная болезнь легкихингаляционные глюкокортикостероидыэффективностьбезопасность

chronic obstructive pulmonary diseaseinhaled corticosteroidsefficacysafety

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The authors declare that there are no conflicts of interest present.