<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2012-0-4-71-77</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-104</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group></article-categories><title-group><article-title></article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузубова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzubova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>зам. директора </p><p>197022, Санкт-Петербург, ул. Рентгена, 12. Тел.: (812) 234-17-69, факс: (812) 234-90-46.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедева</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedeva</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>зав. лаб. экспериментальной пульмонологии и патоморфологии </p><p>197022, Санкт-Петербург, ул. Рентгена, 12. Тел.: (812) 499-68-20, факс: (812) 234-90-46.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Золотницкая</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Zolotnitskaya</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший научный сотрудник лаборатории хронической обструктивной патологии легких</p><p>197022, Санкт-Петербург, ул. Рентгена, 12. Тел.: (812) 234-17-69, факс: (812) 234-90-46.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Двораковская</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dvorakovskaya</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ведущий научный сотрудник лаборатории экспериментальной пульмонологии и патоморфологии</p><p>197022, Санкт-Петербург, ул. Рентгена, 12. Тел.: (812) 499-68-90, факс: (812) 234-90-46.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федин</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedin</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший научный сотрудник лаборатории медико-социальных проблем </p><p>197022, Санкт-Петербург, ул. Рентгена, 12. Тел.: (812) 552-85-54, факс: (812) 234-90-46.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Титова</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Titova</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>директор</p><p>197022, Санкт-Петербург, ул. Рентгена, 12. Тел. (812) 499-68-40, факс: (812) 234-90-46.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>НИИ пульмонологии ГОУ ВПО "Санкт-Петербургский государственный медицинский университет им. И.П.Павлова"</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2012</year></pub-date><volume>0</volume><issue>4</issue><fpage>71</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кузубова Н.А., Лебедева Е.С., Золотницкая В.П., Двораковская И.В., Федин А.Н., Титова О.Н., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Кузубова Н.А., Лебедева Е.С., Золотницкая В.П., Двораковская И.В., Федин А.Н., Титова О.Н.</copyright-holder><copyright-holder xml:lang="en">Kuzubova N.A., Lebedeva E.S., Zolotnitskaya V.P., Dvorakovskaya I.V., Fedin A.N., Titova O.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/104">https://journal.pulmonology.ru/pulm/article/view/104</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson C.K., Mori M., Bjermer L. et al. Alterations in lung cell populations in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2010; 181 (3): 206–217.</mixed-citation><mixed-citation xml:lang="en">Anderson C.K., Mori M., Bjermer L. et al. Alterations in lung cell populations in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2010; 181 (3): 206–217.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Morjaria J.B., Malerba M., Polosa R. Biologic and pharmacologic therapies in clinical development for the inflammatory response in COPD. Drug Discovery Today 2010. 15 (9–10): 396–405.</mixed-citation><mixed-citation xml:lang="en">Morjaria J.B., Malerba M., Polosa R. Biologic and pharmacologic therapies in clinical development for the inflammatory response in COPD. Drug Discovery Today 2010. 15 (9–10): 396–405.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Naeije R. Pulmonary hypertension and right heart failure in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2005. 2 (1): 20–22.</mixed-citation><mixed-citation xml:lang="en">Naeije R. Pulmonary hypertension and right heart failure in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2005. 2 (1): 20–22.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Кузубова Н.А., Перлей В.Е., Гичкин А.Ю. и др. Влияние ингаляционной глюкокортикоидной терапии на эндотелиальную функцию и состояние легочно-сердечной гемодинамики у больных хронической обструктивной болезнью легких. Пульмонология 2007; 5: 84–87.</mixed-citation><mixed-citation xml:lang="en">Кузубова Н.А., Перлей В.Е., Гичкин А.Ю. и др. Влияние ингаляционной глюкокортикоидной терапии на эндотелиальную функцию и состояние легочно-сердечной гемодинамики у больных хронической обструктивной болезнью легких. Пульмонология 2007; 5: 84–87.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chhabra S.K., Gupta M. Coexistent chronic obstructive pulmonary disease-heart failure: mechanisms, diagnostic and therapeutic dilemmas. Indian J. Chest Dis. Allied Sci. 2010. 52 (4): 225–338.</mixed-citation><mixed-citation xml:lang="en">Chhabra S.K., Gupta M. Coexistent chronic obstructive pulmonary disease-heart failure: mechanisms, diagnostic and therapeutic dilemmas. Indian J. Chest Dis. Allied Sci. 2010. 52 (4): 225–338.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Merx M.W., Weber C. Statins in the intensive care unit. Curr. Opin. Crit. Care 2006; 12 (4): 309–314.</mixed-citation><mixed-citation xml:lang="en">Merx M.W., Weber C. Statins in the intensive care unit. Curr. Opin. Crit. Care 2006; 12 (4): 309–314.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Blamoum A.I., Batty G.N., Debari V.A. et al. Statins may reduce episodes of exacerbation and the requirement for intubation in patients with COPD: evidence from a retrospective cohort study. Int. J. Clin. Pract. 2008. 62 (9): 1373–1378.</mixed-citation><mixed-citation xml:lang="en">Blamoum A.I., Batty G.N., Debari V.A. et al. Statins may reduce episodes of exacerbation and the requirement for intubation in patients with COPD: evidence from a retrospective cohort study. Int. J. Clin. Pract. 2008. 62 (9): 1373–1378.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Walsh G. Statins as emerging treatments for asthma and chronic obstructive pulmonary disease. Exp. Rev. Respir. Med. 2008; 2 (3): 329–335.</mixed-citation><mixed-citation xml:lang="en">Walsh G. Statins as emerging treatments for asthma and chronic obstructive pulmonary disease. Exp. Rev. Respir. Med. 2008; 2 (3): 329–335.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Лебедева Е. С., Кузубова Н. А., Данилов Л. Н. и др. Воспроизведение в эксперименте хронической обструктивной болезни легких. Бюл. экспер. биол. 2011. 152 (11): 596–601.</mixed-citation><mixed-citation xml:lang="en">Лебедева Е. С., Кузубова Н. А., Данилов Л. Н. и др. Воспроизведение в эксперименте хронической обструктивной болезни легких. Бюл. экспер. биол. 2011. 152 (11): 596–601.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lebedeva E.S., Kuzubova N.A., Danilov L.N. et al. Experimental modelling of chronic obstructive pulmonary disease. Bull. Exp. Biol. Med. 2012. doi: 10.1007/s10517-012-1601-3.</mixed-citation><mixed-citation xml:lang="en">Lebedeva E.S., Kuzubova N.A., Danilov L.N. et al. Experimental modelling of chronic obstructive pulmonary disease. Bull. Exp. Biol. Med. 2012. doi: 10.1007/s10517-012-1601-3.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Прониченко Л.В., Маль Г.С. Морфофункциональные особенности сердечно-сосудистой и дыхательной систем у пациентов с артериальной гипертензией и хронической обструктивной болезнью легких. Фундамент. исслед. 2011; 10 (ч. 1): 144–147.</mixed-citation><mixed-citation xml:lang="en">Прониченко Л.В., Маль Г.С. Морфофункциональные особенности сердечно-сосудистой и дыхательной систем у пациентов с артериальной гипертензией и хронической обструктивной болезнью легких. Фундамент. исслед. 2011; 10 (ч. 1): 144–147.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Qaisi M., Kharbanda R.K., Mittal T.K., Donald A.E. Measurement of endothelial function and its clinical utility for cardiovascular risk. Vasc. Hlth Risk Manag. 2008. 4 (3): 647–652.</mixed-citation><mixed-citation xml:lang="en">Al-Qaisi M., Kharbanda R.K., Mittal T.K., Donald A.E. Measurement of endothelial function and its clinical utility for cardiovascular risk. Vasc. Hlth Risk Manag. 2008. 4 (3): 647–652.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Задионченко В.С. Артериальная гипертония при хронической обструктивной болезни легких. М.: Изд-во Анахарсис; 2005.</mixed-citation><mixed-citation xml:lang="en">Задионченко В.С. Артериальная гипертония при хронической обструктивной болезни легких. М.: Изд-во Анахарсис; 2005.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Zakynthinos E., Daniil Z., Papanikolaou J., Makris D. Pulmonary hypertension in COPD : pathophysiology and therapeutic targets. Curr. Drug Targets 2011; 12 (4): 501–513.</mixed-citation><mixed-citation xml:lang="en">Zakynthinos E., Daniil Z., Papanikolaou J., Makris D. Pulmonary hypertension in COPD : pathophysiology and therapeutic targets. Curr. Drug Targets 2011; 12 (4): 501–513.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Илькович М.М., Кузубова Н.А. Патогенез хронической обструктивной болезни легких. В кн.: Чучалин А.Г. (ред.). Хроническая обструктивная болезнь легких. М.: Атмосфера; 2008. 82–112.</mixed-citation><mixed-citation xml:lang="en">Илькович М.М., Кузубова Н.А. Патогенез хронической обструктивной болезни легких. В кн.: Чучалин А.Г. (ред.). Хроническая обструктивная болезнь легких. М.: Атмосфера; 2008. 82–112.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Сироткин С.А., Прибылов С.А. Системная дисфункция эпителия у больных хронической обструктивной болезнью легких. Биомед. журн. Medline.ru 2007; 8 (5): 41–48.</mixed-citation><mixed-citation xml:lang="en">Сироткин С.А., Прибылов С.А. Системная дисфункция эпителия у больных хронической обструктивной болезнью легких. Биомед. журн. Medline.ru 2007; 8 (5): 41–48.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Soyseth V., Brekke P.H., Smith P. et al. Statin use is associated with reduced mortality in COPD. Eur. Respir. J. 2007. 29 (2): 279–283.</mixed-citation><mixed-citation xml:lang="en">Soyseth V., Brekke P.H., Smith P. et al. Statin use is associated with reduced mortality in COPD. Eur. Respir. J. 2007. 29 (2): 279–283.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Janda S., Park K., Fitz G.J.M. Statins in COPD. Chest 2009; 136 (3): 734–743.</mixed-citation><mixed-citation xml:lang="en">Janda S., Park K., Fitz G.J.M. Statins in COPD. Chest 2009; 136 (3): 734–743.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
